Výsledky vyhľadávania - "TEA Domain Transcription Factors"

TEAD3 + high-risk melanoma cells crosstalk with GAS6 + macrophages via the GAS6-TYRO3 ligand-receptor axis to modulate propionate metabolism and drive melanoma progression.

Autori: Fang Y Xu X Lu R a ďalší

Zdroj: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2025 Oct 01; Vol. 44 (1), pp. 279. Date of Electronic Publication: 2025 Oct 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Melanoma*/pathology , Melanoma*/metabolism , Melanoma*/genetics , Intercellular Signaling Peptides and Proteins*/metabolism , Intercellular Signaling Peptides and Proteins*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Macrophages*/metabolism , TEA Domain Transcription Factors*/metabolism , TEA Domain Transcription Factors*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics, Humans ; Animals ; Mice ; Disease Progression ; Tumor Microenvironment ; Cell Line, Tumor

Discovery of repurposed ethacrynic acid and its derivatives as novel TEAD inhibitors.

Autori: Chen W Nan Y Zhang Y a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2026 Jan 15; Vol. 302 (Pt 1), pp. 118299. Date of Electronic Publication: 2025 Oct 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Transcription Factors*/antagonists & inhibitors , Transcription Factors*/metabolism , Ethacrynic Acid*/pharmacology , Ethacrynic Acid*/chemistry , Ethacrynic Acid*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Drug Discovery* , TEA Domain Transcription Factors*/antagonists & inhibitors , TEA Domain Transcription Factors*/metabolism , Drug Repositioning* , DNA-Binding Proteins*/antagonists & inhibitors , DNA-Binding Proteins*/metabolism, Humans ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Molecular Structure ; Cell Line, Tumor ; Drug Screening Assays, Antitumor

Integrative analysis identifies TEAD4 as a universal prognostic biomarker in human cancers.

Autori: Liu M Song Y Kang Y a ďalší

Zdroj: Frontiers in immunology [Front Immunol] 2025 Sep 30; Vol. 16, pp. 1688563. Date of Electronic Publication: 2025 Sep 30 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: TEA Domain Transcription Factors*/genetics , TEA Domain Transcription Factors*/metabolism , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism , Neoplasms*/genetics , Neoplasms*/metabolism , Neoplasms*/mortality , Neoplasms*/pathology , Muscle Proteins*/genetics , Muscle Proteins*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism, Humans ; Prognosis ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Cell Line, Tumor ; Tumor Microenvironment ; Gene Expression Profiling ; Drug Resistance, Neoplasm/genetics ; Cell Movement

TEAD1 KNOCKDOWN IMPEDES THE INFLAMMATION AND FERROPTOSIS BY MEDIATING MMP3 IN CEREBRAL ISCHEMIA REPERFUSION.

Autori: Lu J Su J Zhu L a ďalší

Zdroj: Shock (Augusta, Ga.) [Shock] 2025 Aug 01; Vol. 64 (2), pp. 205-212. Date of Electronic Publication: 2025 Mar 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9421564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-0514 (Electronic) Linking ISSN: 10732322 NLM ISO Abbreviation: Shock Subsets: MEDLINE

Výrazy zo slovníka MeSH: TEA Domain Transcription Factors*/genetics , Reperfusion Injury*/metabolism , Reperfusion Injury*/genetics , Reperfusion Injury*/pathology , Matrix Metalloproteinase 3*/metabolism , Matrix Metalloproteinase 3*/genetics , Inflammation*/metabolism , Inflammation*/genetics , Transcription Factors*/genetics , Transcription Factors*/metabolism , Ferroptosis*/genetics , Ferroptosis*/physiology , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Brain Ischemia*/metabolism , Brain Ischemia*/genetics, Animals ; Rats ; Humans ; Male ; Rats, Sprague-Dawley ; Gene Knockdown Techniques ; Endothelial Cells/metabolism

TEAD4 promoted proliferation and metastasis of gallbladder cancer by regulation of TMPRSS4.

Autori: Lin C Wang C Li M a ďalší

Zdroj: Clinical & experimental metastasis [Clin Exp Metastasis] 2025 Apr 11; Vol. 42 (3), pp. 22. Date of Electronic Publication: 2025 Apr 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 8409970 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7276 (Electronic) Linking ISSN: 02620898 NLM ISO Abbreviation: Clin Exp Metastasis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Gallbladder Neoplasms*/pathology , Gallbladder Neoplasms*/genetics , Gallbladder Neoplasms*/metabolism , TEA Domain Transcription Factors*/genetics , TEA Domain Transcription Factors*/metabolism , Gene Expression Regulation, Neoplastic* , Serine Endopeptidases*/genetics , Serine Endopeptidases*/metabolism , Membrane Proteins*/genetics , Membrane Proteins*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Muscle Proteins*/genetics , Muscle Proteins*/metabolism , Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/genetics, Humans ; Cell Proliferation ; Animals ; Mice ; Female ; Male ; Cell Line, Tumor ; Mice, Nude ; Mice, Inbred BALB C ; Cell Movement ; Prognosis ; Middle Aged ; Neoplasm Metastasis ; Tumor Cells, Cultured

LncRNA MKLN1-AS promotes glioma tumorigenesis and growth via activating the Hippo pathway through miR-126-5p/TEAD1 axis.

Autori: Chen S Tu S Huang Y a ďalší

Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Jun; Vol. 398 (6), pp. 6787-6799. Date of Electronic Publication: 2024 Dec 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glioma*/etiology , Glioma*/metabolism , Brain Neoplasms*/etiology , Brain Neoplasms*/metabolism , RNA, Long Noncoding*/metabolism , TEA Domain Transcription Factors*/metabolism , MicroRNAs*/metabolism , Hippo Signaling Pathway*, Humans ; Cell Line, Tumor ; Carcinogenesis ; Cell Adhesion Molecules ; Intracellular Signaling Peptides and Proteins

TEAD3 and TEAD4 play overlapping role in bovine preimplantation development.

Autori: Yu H Shi Y Wu X a ďalší

Zdroj: Reproduction (Cambridge, England) [Reproduction] 2025 Feb 04; Vol. 169 (3). Date of Electronic Publication: 2025 Feb 04 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Published for the Society for Reproduction and Fertility by BioScientifica Country of Publication: England NLM ID: 100966036 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1741-7899 (Electronic) Linking ISSN: 14701626 NLM ISO Abbreviation: Reproduction Subsets: MEDLINE

Výrazy zo slovníka MeSH: TEA Domain Transcription Factors*/genetics , TEA Domain Transcription Factors*/metabolism , Blastocyst*/metabolism , Blastocyst*/cytology , Embryonic Development*/genetics , Embryonic Development*/physiology , Gene Expression Regulation, Developmental* , Transcription Factors*/genetics , Transcription Factors*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism, Animals ; Cattle ; Female ; Pregnancy

TEAD1-Mediated Trans-Differentiation of Vascular Smooth Muscle Cells into Fibroblast-Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques.

Autori: Zhai M Lei Z Shi Y a ďalší

Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Feb; Vol. 12 (5), pp. e2407408. Date of Electronic Publication: 2024 Dec 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Výrazy zo slovníka MeSH: TEA Domain Transcription Factors*/metabolism , TEA Domain Transcription Factors*/genetics , Cell Transdifferentiation*/genetics , Cell Transdifferentiation*/physiology , Muscle, Smooth, Vascular*/metabolism , Muscle, Smooth, Vascular*/cytology , Plaque, Atherosclerotic*/metabolism , Plaque, Atherosclerotic*/pathology , Plaque, Atherosclerotic*/genetics , Fibroblasts*/metabolism , Transcription Factors*/metabolism , Transcription Factors*/genetics , Myocytes, Smooth Muscle*/metabolism , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics, Animals ; Mice ; Disease Models, Animal ; Mice, Inbred C57BL ; Male

MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.

Autori: Heinrich T Schwarz D Petersson C a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Mar 27; Vol. 68 (6), pp. 6149-6164. Date of Electronic Publication: 2024 Dec 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: TEA Domain Transcription Factors* , Transcription Factors*/metabolism , Transcription Factors*/antagonists & inhibitors , Transcription Factors*/chemistry , Amides*/chemistry , Amides*/pharmacology , Amides*/chemical synthesis , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/chemistry, Humans ; Ligands ; Animals ; Mice ; Structure-Activity Relationship ; Binding Sites ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis

Selective Degradation of TEADs by a PROTAC Molecule Exhibited Robust Anticancer Efficacy In Vitro and In Vivo.

Autori: Lu Y Yan Z Sun J a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Mar 13; Vol. 68 (5), pp. 5616-5640. Date of Electronic Publication: 2025 Jan 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/therapeutic use , Transcription Factors*/metabolism , TEA Domain Transcription Factors*/metabolism, Humans ; Animals ; Mice ; DNA-Binding Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Adaptor Proteins, Signal Transducing/metabolism ; Proteolysis/drug effects ; Von Hippel-Lindau Tumor Suppressor Protein/metabolism ; Mice, Nude ; Cell Proliferation/drug effects

TEAD1 Prevents Necroptosis and Inflammation in Cisplatin-Induced Acute Kidney Injury Through Maintaining Mitochondrial Function.

Autori: Tran M Jiao B Du H a ďalší

Zdroj: International journal of biological sciences [Int J Biol Sci] 2025 Jan 01; Vol. 21 (2), pp. 565-578. Date of Electronic Publication: 2025 Jan 01 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cisplatin*/adverse effects , Cisplatin*/toxicity , Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/metabolism , TEA Domain Transcription Factors*/metabolism , Mitochondria*/metabolism , Inflammation*/metabolism , Transcription Factors*/metabolism , Transcription Factors*/genetics , Necroptosis* , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics, Animals ; Mice ; Mice, Knockout ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Male ; Mice, Inbred C57BL ; Reactive Oxygen Species/metabolism

TEAD transcription factor family emerges as a promising therapeutic target for oral squamous cell carcinoma.

Autori: Wang S Shao D Gao X a ďalší

Zdroj: Frontiers in immunology [Front Immunol] 2024 Oct 04; Vol. 15, pp. 1480701. Date of Electronic Publication: 2024 Oct 04 (Print Publication: 2024).

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mouth Neoplasms*/genetics , Mouth Neoplasms*/drug therapy , Mouth Neoplasms*/metabolism , TEA Domain Transcription Factors* , Molecular Targeted Therapy* , Transcription Factors*/metabolism , Transcription Factors*/genetics , Carcinoma, Squamous Cell*/drug therapy , Carcinoma, Squamous Cell*/genetics , Carcinoma, Squamous Cell*/metabolism, Humans ; Signal Transduction ; Animals ; Gene Expression Regulation, Neoplastic ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology

Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics.

Autori: Scalvini L Tagliazucchi L Elisi GM a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118056. Date of Electronic Publication: 2025 Aug 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Proteomics* , Transcription Factors*/metabolism , Transcription Factors*/antagonists & inhibitors , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/antagonists & inhibitors , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/antagonists & inhibitors , Muscle Proteins*/metabolism , Muscle Proteins*/antagonists & inhibitors, Humans ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; TEA Domain Transcription Factors ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Mass Spectrometry ; YAP-Signaling Proteins ; Cell Line, Tumor

Depalmitoylation of TEAD1 facilitates lipid droplet accumulation and resistance to oxidative stress by transactivating PP2Acα.

Autori: Sun X Xu S Ni Y a ďalší

Zdroj: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 01; Vol. 240, pp. 532-545. Date of Electronic Publication: 2025 Aug 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Transcription Factors*/genetics , Transcription Factors*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Lipid Droplets*/metabolism , Lipid Droplets*/drug effects , Protein Phosphatase 2*/genetics , Protein Phosphatase 2*/metabolism , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/genetics , Nuclear Proteins*/genetics , Nuclear Proteins*/metabolism, Animals ; Mice ; TEA Domain Transcription Factors ; Oxidative Stress/drug effects ; Mice, Knockout ; Acetaminophen/toxicity ; Acetaminophen/adverse effects ; Hepatocytes/metabolism ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Liver/metabolism ; Liver/pathology ; Liver/drug effects ; Humans ; Lipid Metabolism ; Male ; Transcriptional Activation ; Signal Transduction ; Reactive Oxygen Species/metabolism

Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate AKI after cardiac surgery by facilitating miR-21-5p targeting TEAD1.

Autori: Li Z He F Dai S a ďalší

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2537797. Date of Electronic Publication: 2025 Aug 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Exosomes*/metabolism , Acute Kidney Injury*/etiology , Acute Kidney Injury*/therapy , MicroRNAs*/metabolism , MicroRNAs*/genetics , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Transcription Factors*/metabolism , Transcription Factors*/genetics , Cardiac Surgical Procedures*/adverse effects , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , Nuclear Proteins*/metabolism , Nuclear Proteins*/genetics, Humans ; Animals ; TEA Domain Transcription Factors ; Male ; Umbilical Cord/cytology ; Apoptosis ; Hepatitis A Virus Cellular Receptor 1/metabolism ; Mice ; Disease Models, Animal

TEA domain transcription factor 3 suppresses aortic and left ventricular remodeling via transcriptional activation of PDZ domain containing 1.

Autori: Wang L Bai Y Ma D a ďalší

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117329. Date of Electronic Publication: 2025 Sep 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ventricular Remodeling*/physiology , Transcription Factors*/genetics , Transcription Factors*/biosynthesis , Transcription Factors*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/biosynthesis , DNA-Binding Proteins*/metabolism , Transcriptional Activation*/physiology , Aorta*/metabolism , Aorta*/pathology, Animals ; Rats, Inbred SHR ; Rats ; Male ; TEA Domain Transcription Factors ; Muscle, Smooth, Vascular/metabolism ; Rats, Inbred WKY ; Cells, Cultured

Insights and trends in development of TEAD-YAP/TAZ inhibitors: a review of PCT patents (2022 to June 2025).

Autori: Fan T Yu Z Xiao A a ďalší

Zdroj: Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2025 Dec; Vol. 35 (12), pp. 1209-1239. Date of Electronic Publication: 2025 Nov 07.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9516419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7674 (Electronic) Linking ISSN: 13543776 NLM ISO Abbreviation: Expert Opin Ther Pat Subsets: MEDLINE

Výrazy zo slovníka MeSH: Drug Development* , Transcription Factors*/antagonists & inhibitors , Transcription Factors*/metabolism , Neoplasms*/drug therapy , Neoplasms*/pathology , Antineoplastic Agents*/pharmacology, Patents as Topic ; Humans ; Animals ; Drug Design ; YAP-Signaling Proteins ; Molecular Targeted Therapy ; TEA Domain Transcription Factors/antagonists & inhibitors

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Autori: Heinrich T Gambardella A Schwarz D a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24603-24623. Date of Electronic Publication: 2025 Nov 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/therapeutic use , Transcription Factors*/antagonists & inhibitors , Transcription Factors*/metabolism, Humans ; Animals ; Structure-Activity Relationship ; Cell Line, Tumor ; Mice ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Xenograft Model Antitumor Assays ; TEA Domain Transcription Factors ; Mice, Nude

Design and biological evaluation of peptide disruptors targeting YAP1-TEAD interaction for oral cancer.

Autori: Wu Y Yang H Zhang X a ďalší

Zdroj: BMC oral health [BMC Oral Health] 2025 Nov 10; Vol. 25 (1), pp. 1765. Date of Electronic Publication: 2025 Nov 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mouth Neoplasms*/metabolism , Mouth Neoplasms*/drug therapy , Mouth Neoplasms*/pathology , Transcription Factors*/metabolism , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/antagonists & inhibitors , Carcinoma, Squamous Cell*/metabolism , Carcinoma, Squamous Cell*/pathology , Peptides*/pharmacology , DNA-Binding Proteins*/metabolism, Humans ; YAP-Signaling Proteins ; Cell Line, Tumor ; Molecular Dynamics Simulation ; Protein Binding/drug effects ; TEA Domain Transcription Factors ; Surface Plasmon Resonance ; Cell Proliferation/drug effects

Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models.

Autori: Ott CA Purwin TJ Chen PY a ďalší

Zdroj: Nature communications [Nat Commun] 2025 Nov 05; Vol. 16 (1), pp. 9655. Date of Electronic Publication: 2025 Nov 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Melanoma*/drug therapy , Melanoma*/genetics , Melanoma*/metabolism , Melanoma*/pathology , Transcription Factors*/metabolism , Transcription Factors*/genetics , Transcription Factors*/antagonists & inhibitors , Neoplasm, Residual*/drug therapy, Humans ; SOXE Transcription Factors/genetics ; SOXE Transcription Factors/metabolism ; Animals ; Cell Line, Tumor ; Mice ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Proto-Oncogene Proteins B-raf/metabolism ; Drug Resistance, Neoplasm/drug effects ; Xenograft Model Antitumor Assays ; Protein Kinase Inhibitors/pharmacology ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; Molecular Targeted Therapy ; Connective Tissue Growth Factor/metabolism ; Connective Tissue Growth Factor/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; TEA Domain Transcription Factors ; Female ; Trans-Activators