Suchergebnisse - "TAMOXIFEN"

Radiolabeling, quality control, and in vitro cell culture studies of [ ^99m Tc]Tc-tamoxifen citrate for estrogen receptor-positive breast cancer imaging.

Autoren: Okşaş H Ekinci M

Quelle: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2025 Nov; Vol. 225, pp. 112023. Date of Electronic Publication: 2025 Jul 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 9306253 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9800 (Electronic) Linking ISSN: 09698043 NLM ISO Abbreviation: Appl Radiat Isot Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/diagnostic imaging , Breast Neoplasms*/metabolism , Tamoxifen*/pharmacokinetics , Tamoxifen*/chemistry , Tamoxifen*/analogs & derivatives , Receptors, Estrogen*/metabolism , Radiopharmaceuticals*/chemical synthesis , Radiopharmaceuticals*/pharmacokinetics , Organotechnetium Compounds*/pharmacokinetics , Organotechnetium Compounds*/chemical synthesis , Organotechnetium Compounds*/chemistry , Technetium*/chemistry, Humans ; Female ; Isotope Labeling/methods ; Isotope Labeling/standards ; Quality Control ; Cell Line, Tumor ; MCF-7 Cells

From Genotype to Therapeutic Monitoring: Enhancing Tamoxifen Efficacy in Breast Cancer Treatment.

Autoren: Mendes Batista AF Petrolli LP Marques Pereira MP et al.

Quelle: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Dec; Vol. 65 (12), pp. 1712-1718. Date of Electronic Publication: 2025 Sep 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/therapeutic use , Tamoxifen*/analogs & derivatives , Tamoxifen*/blood , Tamoxifen*/pharmacokinetics , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/blood , Cytochrome P-450 CYP2D6*/genetics , Drug Monitoring*/methods , Antineoplastic Agents, Hormonal*/therapeutic use , Antineoplastic Agents, Hormonal*/blood , Antineoplastic Agents, Hormonal*/pharmacokinetics, Humans ; Female ; Middle Aged ; Genotype ; Aged ; Adult ; Phenotype

Severe retinopathy induced by low-dose tamoxifen: a 10-month follow-up analysis based on multimodal imaging.

Autoren: Zhang S Wang Y Liu Y et al.

Quelle: BMC ophthalmology [BMC Ophthalmol] 2025 Nov 26; Vol. 25 (1), pp. 669. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100967802 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2415 (Electronic) Linking ISSN: 14712415 NLM ISO Abbreviation: BMC Ophthalmol Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/adverse effects , Tamoxifen*/administration & dosage , Retinal Diseases*/chemically induced , Retinal Diseases*/diagnosis , Antineoplastic Agents, Hormonal*/adverse effects , Antineoplastic Agents, Hormonal*/administration & dosage, Humans ; Female ; Adult ; Tomography, Optical Coherence/methods ; Multimodal Imaging/methods ; Follow-Up Studies ; Fluorescein Angiography ; Visual Acuity ; Breast Neoplasms/drug therapy

Sustained-release of 4-hydroxytamoxifen inhibits capsular contracture after breast implant placement in a mouse model.

Autoren: Matsumoto N Muguruma M Horimoto Y et al.

Quelle: Breast cancer (Tokyo, Japan) [Breast Cancer] 2025 Nov; Vol. 32 (6), pp. 1290-1297. Date of Electronic Publication: 2025 Aug 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Maruzen Co Country of Publication: Japan NLM ID: 100888201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-4233 (Electronic) Linking ISSN: 13406868 NLM ISO Abbreviation: Breast Cancer Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/analogs & derivatives , Tamoxifen*/administration & dosage , Tamoxifen*/pharmacology , Breast Implants*/adverse effects , Implant Capsular Contracture*/prevention & control , Implant Capsular Contracture*/etiology , Implant Capsular Contracture*/pathology , Breast Implantation*/adverse effects, Animals ; Female ; Mice ; Delayed-Action Preparations/administration & dosage ; Disease Models, Animal ; Mice, Inbred ICR ; Humans

Combined experimental and DFT study of tamoxifen adsorption on PEG-modified graphene oxide for enhanced drug delivery.

Autoren: Almansour K Alsaab HO Pishnamazi M

Quelle: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Nov 01; Vol. 214, pp. 107293. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

MeSH-Schlagworte: Graphite*/chemistry , Tamoxifen*/chemistry , Tamoxifen*/administration & dosage , Polyethylene Glycols*/chemistry , Drug Carriers*/chemistry , Antineoplastic Agents, Hormonal*/chemistry , Antineoplastic Agents, Hormonal*/administration & dosage, Humans ; Adsorption ; Drug Liberation ; Density Functional Theory ; Hydrogen-Ion Concentration ; Nanocomposites/chemistry ; Drug Delivery Systems ; Breast Neoplasms/drug therapy ; Female

ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen.

Autoren: Yuan J Huang W Lin M et al.

Quelle: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Nov; Vol. 398 (11), pp. 16081-16093. Date of Electronic Publication: 2025 May 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/drug effects , Tamoxifen*/pharmacology , Tamoxifen*/therapeutic use , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/antagonists & inhibitors , NF-E2-Related Factor 2*/genetics , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Heme Oxygenase-1*/metabolism , Antineoplastic Agents, Hormonal*/pharmacology, Humans ; Animals ; Mice, Nude ; Female ; MCF-7 Cells ; Reactive Oxygen Species/metabolism ; Drug Resistance, Neoplasm/drug effects ; Signal Transduction/drug effects ; Cell Proliferation/drug effects ; Mice, Inbred BALB C ; Mice ; Xenograft Model Antitumor Assays ; Acetamides ; Benzodioxoles

High-dose tamoxifen impairs the homeostasis of the intestinal stem cell niche by enhancing fatty acid degradation and damaging mitochondria.

Autoren: Xu L Liu X Feng J et al.

Quelle: Apoptosis : an international journal on programmed cell death [Apoptosis] 2025 Oct; Vol. 30 (9-10), pp. 2421-2434. Date of Electronic Publication: 2025 Sep 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/pharmacology , Tamoxifen*/adverse effects , Tamoxifen*/administration & dosage , Mitochondria*/drug effects , Mitochondria*/metabolism , Fatty Acids*/metabolism , Stem Cells*/drug effects , Stem Cells*/metabolism , Stem Cells*/cytology , Stem Cell Niche*/drug effects , Intestines*/drug effects , Intestines*/cytology, Animals ; Homeostasis/drug effects ; Mice ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Mice, Inbred C57BL ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Paneth Cells/drug effects ; Paneth Cells/metabolism ; Female

Design and comparative evaluation of liposomes and ultra-flexible combisomes incorporating stratum corneum lipids for the delivery of 4-hydroxytamoxifen and thymoquinone.

Autoren: Prabhu PP Lobo CL B VL et al.

Quelle: Journal of pharmaceutical sciences [J Pharm Sci] 2025 Oct; Vol. 114 (10), pp. 103959. Date of Electronic Publication: 2025 Aug 16.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

MeSH-Schlagworte: Liposomes*/chemistry , Tamoxifen*/analogs & derivatives , Tamoxifen*/administration & dosage , Tamoxifen*/chemistry , Benzoquinones*/administration & dosage , Benzoquinones*/chemistry , Lipids*/chemistry, Humans ; Animals ; Female ; Skin Absorption ; Administration, Cutaneous ; Drug Delivery Systems/methods ; Drug Liberation ; Molecular Docking Simulation ; Breast Neoplasms/drug therapy ; Cell Line, Tumor

Investigation of cytotoxic, molecular and in silico effects of chlorambucil and tamoxifen on 2D/3D MDA-MB-231 and HeLa cancer cell models.

Autoren: Demirkaya DB Arslan HS Azarkan SY

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Dec 03; Vol. 53 (1), pp. 159. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/pharmacology , Chlorambucil*/pharmacology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics, Humans ; HeLa Cells ; Female ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology ; Cell Survival/drug effects ; Cell Line, Tumor ; Molecular Docking Simulation ; Apoptosis/drug effects ; Cell Movement/drug effects ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Computer Simulation ; Cell Proliferation/drug effects

Endocrine therapies and mortality risk in postmenopausal women with breast cancer: benchmarking an observational analysis against a randomized trial.

Autoren: Al-Kassab-Córdova A Humphreys ABC Olarte Parra C et al.

Quelle: American journal of epidemiology [Am J Epidemiol] 2025 Dec 02; Vol. 194 (12), pp. 3483-3491.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7910653 Publication Model: Print Cited Medium: Internet ISSN: 1476-6256 (Electronic) Linking ISSN: 00029262 NLM ISO Abbreviation: Am J Epidemiol Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/drug therapy , Breast Neoplasms*/mortality , Tamoxifen*/therapeutic use , Tamoxifen*/adverse effects , Antineoplastic Agents, Hormonal*/therapeutic use , Antineoplastic Agents, Hormonal*/adverse effects , Aromatase Inhibitors*/therapeutic use , Aromatase Inhibitors*/adverse effects , Nitriles*/therapeutic use , Nitriles*/adverse effects , Triazoles*/therapeutic use , Triazoles*/adverse effects, Humans ; Female ; Postmenopause ; Benchmarking ; Letrozole ; Aged ; Randomized Controlled Trials as Topic ; Middle Aged ; Sweden/epidemiology

NSUN7 Suppression Reduces Metastatic Potential and Restores Sensitivity to 4-OH Tamoxifen in Resistant MCF-7 Cells.

Autoren: Mahmood S Chernov AV Khan S et al.

Quelle: Anticancer research [Anticancer Res] 2025 Dec; Vol. 45 (12), pp. 5321-5339.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/pharmacology , Drug Resistance, Neoplasm*/genetics , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Methyltransferases*/genetics , Methyltransferases*/metabolism , Antineoplastic Agents, Hormonal*/pharmacology, Humans ; MCF-7 Cells ; Cell Movement/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Cell Proliferation/drug effects ; Neoplasm Metastasis

Quality of life and Satisfaction With Ospemifene for Treating Vulvovaginal Atrophy in Breast Cancer Survivors: Six-Month Results From the PatiEnt SatisfactiON StudY (PEONY).

Autoren: Villa P Cassani C Nappi RE et al.

Quelle: Clinical breast cancer [Clin Breast Cancer] 2025 Dec; Vol. 25 (8), pp. 782-791.e2. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 100898731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-0666 (Electronic) Linking ISSN: 15268209 NLM ISO Abbreviation: Clin Breast Cancer Subsets: MEDLINE

MeSH-Schlagworte: Quality of Life* , Breast Neoplasms*/drug therapy , Breast Neoplasms*/complications , Cancer Survivors*/psychology , Cancer Survivors*/statistics & numerical data , Patient Satisfaction*/statistics & numerical data , Vagina*/pathology , Vagina*/drug effects , Tamoxifen*/analogs & derivatives , Tamoxifen*/therapeutic use , Vaginal Diseases*/drug therapy , Vaginal Diseases*/pathology , Vulva*/pathology , Vulva*/drug effects, Humans ; Female ; Middle Aged ; Atrophy/drug therapy ; Atrophy/chemically induced ; Prospective Studies ; Aged ; Postmenopause ; Surveys and Questionnaires

Inducible Avp knockout mouse line.

Autoren: Khan S Chen L Chou CL et al.

Quelle: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2025 Dec 01; Vol. 329 (6), pp. F784-F795. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1466 (Electronic) Linking ISSN: 15221466 NLM ISO Abbreviation: Am J Physiol Renal Physiol Subsets: MEDLINE

MeSH-Schlagworte: Arginine Vasopressin*/genetics , Arginine Vasopressin*/deficiency , Arginine Vasopressin*/metabolism , Tamoxifen*/pharmacology , Kidney*/metabolism , Kidney*/pathology, Animals ; Mice, Knockout ; Aquaporin 2/metabolism ; Aquaporin 2/genetics ; Mice ; Male ; Female ; Mice, Inbred C57BL ; CRISPR-Cas Systems

Supplementation of Tamoxifen with Low-Dose Endoxifen in Patients with Breast Cancer with Impaired Tamoxifen Metabolism (TAMENDOX): A Randomized Controlled Phase I/II Trial.

Autoren: Mürdter TE Schroth W Goetz MP et al.

Körperschaften: Mürdter TE Schroth W Goetz MP et al.

Quelle: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2025 Dec 01; Vol. 31 (23), pp. 4903-4911.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Clinical Trial, Phase I

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Tamoxifen*/administration & dosage , Tamoxifen*/analogs & derivatives , Tamoxifen*/pharmacokinetics , Tamoxifen*/adverse effects , Antineoplastic Agents, Hormonal*/administration & dosage , Antineoplastic Agents, Hormonal*/adverse effects, Humans ; Female ; Middle Aged ; Cytochrome P-450 CYP2D6/genetics ; Aged ; Adult ; Prospective Studies ; Treatment Outcome ; Aged, 80 and over ; Genotype

Oestrogen receptor beta in breast cancer prognosis and treatment.

Autoren: Božović A Nedeljković M Kožik B et al.

Quelle: Maturitas [Maturitas] 2025 Dec; Vol. 203, pp. 108762. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North Holland Biomedical Press Country of Publication: Ireland NLM ID: 7807333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4111 (Electronic) Linking ISSN: 03785122 NLM ISO Abbreviation: Maturitas Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Breast Neoplasms*/mortality , Breast Neoplasms*/therapy , Estrogen Receptor beta*/metabolism , Estrogen Receptor beta*/genetics , Tamoxifen*/therapeutic use , Antineoplastic Agents, Hormonal*/therapeutic use, Humans ; Female ; Middle Aged ; Prognosis ; Adult ; Aged ; Biomarkers, Tumor/metabolism ; DNA Methylation ; Disease-Free Survival ; Serbia ; Kaplan-Meier Estimate ; Promoter Regions, Genetic ; RNA, Messenger/metabolism

BMP9 knockout impairs pulmonary vessel muscularisation and confers aberrant tamoxifen sensitivity.

Autoren: Dunmore BJ Moore S Jones RJ et al.

Körperschaften: Dunmore BJ Moore S Jones RJ et al.

Quelle: Angiogenesis [Angiogenesis] 2025 Nov 12; Vol. 29 (1), pp. 5. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 9814575 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7209 (Electronic) Linking ISSN: 09696970 NLM ISO Abbreviation: Angiogenesis Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/pharmacology , Growth Differentiation Factor 2*/genetics , Growth Differentiation Factor 2*/metabolism , Growth Differentiation Factor 2*/deficiency , Muscle, Smooth, Vascular*/metabolism , Muscle, Smooth, Vascular*/pathology , Muscle, Smooth, Vascular*/drug effects , Pulmonary Artery*/pathology , Pulmonary Artery*/metabolism , Pulmonary Artery*/drug effects , Vascular Remodeling*/drug effects, Animals ; Mice, Knockout ; Mice ; Humans ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology

Adsorption properties of the pharmaceutical contaminant tamoxifen on calcined bone char.

Autoren: Bulduk İ Baydır AT Aşcıoğlu Ç

Quelle: Scientific reports [Sci Rep] 2025 Nov 06; Vol. 15 (1), pp. 38981. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/chemistry , Bone and Bones*/chemistry , Water Pollutants, Chemical*/chemistry , Water Pollutants, Chemical*/isolation & purification, Adsorption ; Kinetics ; Hydrogen-Ion Concentration ; Thermodynamics ; Temperature ; Water Purification/methods

Exploring Prima-1 ^MET as a single agent or in combination with tamoxifen in breast cancer cells in vitro.

Autoren: Alhammer AH Mudhafar SA Abdulfattah SY

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 05; Vol. 1006, pp. 178195. Date of Electronic Publication: 2025 Sep 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/pharmacology , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/drug therapy , Antineoplastic Combined Chemotherapy Protocols*/pharmacology , Antineoplastic Agents*/pharmacology , Breast Neoplasms*/pathology , Breast Neoplasms*/drug therapy, Humans ; Apoptosis/drug effects ; Cell Movement/drug effects ; Cell Survival/drug effects ; Female ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Cell Line, Tumor ; MCF-7 Cells ; Cyclin D1/metabolism ; Cyclin D1/genetics ; Drug Synergism ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Aza Compounds ; Quinuclidines ; Bridged Bicyclo Compounds, Heterocyclic

First real-world evidence from the Emilia-Romagna region suggests tamoxifen protects breast cancer patients from COVID-19.

Autoren: Bravaccini S Nicolini F Balzi W et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 05; Vol. 15 (1), pp. 38742. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/therapeutic use , COVID-19*/mortality , COVID-19*/epidemiology , COVID-19*/prevention & control , COVID-19*/complications , Breast Neoplasms*/drug therapy , Breast Neoplasms*/complications , Breast Neoplasms*/epidemiology , Antineoplastic Agents, Hormonal*/therapeutic use, Humans ; Female ; Italy/epidemiology ; Middle Aged ; Aged ; Hospitalization/statistics & numerical data ; SARS-CoV-2 ; Registries ; Aged, 80 and over ; Adult ; Aromatase Inhibitors/therapeutic use ; Male

Nano-curcumin attenuates tamoxifen resistance and malignant progression in ER-positive breast cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway.

Autoren: Zhang C Wang H Lei H et al.

Quelle: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2025 Nov; Vol. 254, pp. 106825. Date of Electronic Publication: 2025 Jul 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220 (Electronic) Linking ISSN: 09600760 NLM ISO Abbreviation: J Steroid Biochem Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Curcumin*/pharmacology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Drug Resistance, Neoplasm*/drug effects , Signal Transduction*/drug effects , Tamoxifen*/pharmacology, Humans ; TOR Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Female ; Animals ; Mice ; Receptors, Estrogen/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Proliferation/drug effects ; Nanoparticles/chemistry ; Cell Line, Tumor ; Mice, Nude ; Apoptosis/drug effects ; Mice, Inbred BALB C ; Disease Progression ; MCF-7 Cells