Search Results - "System"

Central nervous system mechanisms of salt-sensitive hypertension.

Authors: Feng Earley Y Pan S Verma H et al.

Source: Physiological reviews [Physiol Rev] 2025 Oct 01; Vol. 105 (4), pp. 1989-2032. Date of Electronic Publication: 2025 May 02.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0231714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1210 (Electronic) Linking ISSN: 00319333 NLM ISO Abbreviation: Physiol Rev Subsets: MEDLINE

MeSH Terms: Hypertension*/physiopathology , Hypertension*/metabolism , Hypertension*/etiology , Sodium Chloride, Dietary*/adverse effects , Central Nervous System*/physiopathology , Central Nervous System*/metabolism , Blood Pressure*, Humans ; Animals ; Renin-Angiotensin System/physiology

Endocrine and metabolic drivers of sebum dysregulation: Mechanisms and therapeutic strategies.

Authors: Li J Mao B Tang X et al.

Source: Life sciences [Life Sci] 2025 Dec 15; Vol. 383, pp. 124044. Date of Electronic Publication: 2025 Oct 26.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

MeSH Terms: Sebum*/metabolism , Endocrine System*/metabolism, Humans ; Animals ; Inflammation/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Skin/metabolism ; Skin/microbiology ; Signal Transduction ; Sebaceous Glands/metabolism ; Pituitary-Adrenal System/metabolism

The role of immune mechanisms in hypertension and advances in immunomodulatory research.

Authors: Chen X Sun L Xuan K et al.

Source: Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2025 Dec; Vol. 47 (1), pp. 2535328. Date of Electronic Publication: 2025 Jul 28.

Publication Type: Journal Article; Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9305929 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6006 (Electronic) Linking ISSN: 10641963 NLM ISO Abbreviation: Clin Exp Hypertens Subsets: MEDLINE

MeSH Terms: Hypertension*/immunology , Hypertension*/physiopathology , Immune System* , Immunomodulation*, Humans ; Animals ; Blood Pressure/immunology ; Sympathetic Nervous System/immunology ; Sympathetic Nervous System/physiopathology ; Inflammation/immunology

Gut Microbiota and Central Nervous System Tumors: A Comprehensive Systematic Review and Meta-Analysis of Microbiome-CNS Interactions.

Authors: Nowacka A Śniegocki M Bożiłow D et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 04; Vol. 26 (21). Date of Electronic Publication: 2025 Nov 04.

Publication Type: Journal Article; Meta-Analysis; Systematic Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Central Nervous System Neoplasms*/microbiology , Central Nervous System Neoplasms*/metabolism , Gastrointestinal Microbiome*, Humans ; Central Nervous System

Autonomic Neuropathies.

Authors: Cook GA Kissel JT Dimachkie MM

Source: Neurologic clinics [Neurol Clin] 2025 Nov; Vol. 43 (4), pp. 851-872. Date of Electronic Publication: 2025 Jul 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Saunders Country of Publication: United States NLM ID: 8219232 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9875 (Electronic) Linking ISSN: 07338619 NLM ISO Abbreviation: Neurol Clin Subsets: MEDLINE

MeSH Terms: Autonomic Nervous System Diseases*/diagnosis , Autonomic Nervous System Diseases*/therapy , Autonomic Nervous System Diseases*/etiology , Autonomic Nervous System Diseases*/physiopathology, Humans ; Autonomic Nervous System/physiopathology

Neurological Manifestations of SARS-CoV-2.

Authors: Miftahof J Bernauer B Tan CS

Source: Viruses [Viruses] 2025 Oct 28; Vol. 17 (11). Date of Electronic Publication: 2025 Oct 28.

Publication Type: Journal Article; Review; Systematic Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH Terms: COVID-19*/complications , COVID-19*/pathology , COVID-19*/virology , SARS-CoV-2*/pathogenicity , Nervous System Diseases*/virology , Nervous System Diseases*/pathology , Nervous System Diseases*/etiology, Humans ; Animals ; Disease Models, Animal ; Brain/virology ; Brain/pathology ; Central Nervous System/virology ; Central Nervous System/pathology

Functional Roles of the Complement Immune System in Cardiac Inflammation and Hypertrophy.

Authors: Hok KD Rich HE Shadid A et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 12; Vol. 26 (20). Date of Electronic Publication: 2025 Oct 12.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Cardiomegaly*/immunology , Cardiomegaly*/pathology , Cardiomegaly*/metabolism , Complement System Proteins*/immunology , Complement System Proteins*/metabolism , Inflammation*/immunology, Humans ; Animals ; Complement Activation/immunology ; Renin-Angiotensin System

ANN multi-layer perceptron for prediction of blood-brain barrier permeable compounds for central nervous system therapeutics.

Authors: Sharma A Selvam S Balaji PD et al.

Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2025 Oct; Vol. 43 (16), pp. 9011-9016. Date of Electronic Publication: 2024 Mar 18.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

MeSH Terms: Blood-Brain Barrier*/metabolism , Blood-Brain Barrier*/drug effects , Neural Networks, Computer* , Central Nervous System Agents*/chemistry , Central Nervous System Agents*/pharmacokinetics , Central Nervous System Agents*/pharmacology, Humans ; Permeability ; Algorithms ; Machine Learning ; Drug Discovery ; Central Nervous System/drug effects ; Multilayer Perceptrons

Increased sleep apnea-specific hypoxic burden is independently associated with cardiovascular autonomic dysfunction in obstructive sleep apnea: A large-scale study.

Authors: Li C Zhou Z Zhang X et al.

Source: Sleep medicine [Sleep Med] 2025 Dec; Vol. 136, pp. 106863. Date of Electronic Publication: 2025 Oct 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100898759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5506 (Electronic) Linking ISSN: 13899457 NLM ISO Abbreviation: Sleep Med Subsets: MEDLINE

MeSH Terms: Sleep Apnea, Obstructive*/physiopathology , Sleep Apnea, Obstructive*/complications , Hypoxia*/physiopathology , Hypoxia*/complications , Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/physiopathology , Autonomic Nervous System Diseases*/physiopathology , Autonomic Nervous System Diseases*/etiology, Humans ; Male ; Female ; Middle Aged ; Heart Rate/physiology ; Adult ; Polysomnography ; Autonomic Nervous System/physiopathology

Cutting-edge strategies for delivering drugs to the brain based on nanocarriers.

Authors: Shaw TK Shuvo SM Paul P et al.

Source: Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2025 Dec; Vol. 51 (12), pp. 1625-1638. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article; Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 7802620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5762 (Electronic) Linking ISSN: 03639045 NLM ISO Abbreviation: Drug Dev Ind Pharm Subsets: MEDLINE

MeSH Terms: Blood-Brain Barrier*/metabolism , Blood-Brain Barrier*/drug effects , Nanoparticles*/chemistry , Drug Delivery Systems*/methods , Drug Carriers*/chemistry , Central Nervous System Diseases*/drug therapy , Brain*/metabolism , Brain*/drug effects, Humans ; Animals ; Nanotechnology/methods ; Nanoparticle Drug Delivery System ; Neurodegenerative Diseases/drug therapy ; Gene Transfer Techniques

Autonomic neuropathy in diabetes.

Authors: Tannus LRM Cobas RA

Source: Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2025 Nov 28; Vol. 70 (special 1), pp. e250406. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article; Review

Journal Info: Publisher: Segmento Farma Editores Country of Publication: Brazil NLM ID: 101652058 Publication Model: Electronic Cited Medium: Internet ISSN: 2359-4292 (Electronic) Linking ISSN: 23593997 NLM ISO Abbreviation: Arch Endocrinol Metab Subsets: MEDLINE

MeSH Terms: Diabetic Neuropathies*/epidemiology , Diabetic Neuropathies*/physiopathology , Diabetic Neuropathies*/diagnosis , Diabetic Neuropathies*/therapy , Diabetic Neuropathies*/etiology , Autonomic Nervous System Diseases*/etiology , Autonomic Nervous System Diseases*/physiopathology , Autonomic Nervous System Diseases*/epidemiology, Humans ; Cardiovascular Diseases/etiology ; Autonomic Nervous System/physiopathology ; Quality of Life

Neuroendocrine-Immune Axis in Endometriosis: A Review on How the Nervous System Goes Beyond Pain Perception.

Authors: Chang L Shan J Li D et al.

Source: Biomolecules [Biomolecules] 2025 Oct 31; Vol. 15 (11). Date of Electronic Publication: 2025 Oct 31.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

MeSH Terms: Endometriosis*/immunology , Endometriosis*/metabolism , Endometriosis*/physiopathology , Endometriosis*/pathology , Neurosecretory Systems*/metabolism , Neurosecretory Systems*/immunology , Pain Perception* , Nervous System*/metabolism , Nervous System*/immunology, Humans ; Female ; Animals ; Immune System/metabolism

Nano-Based Vaccine Delivery Systems: Innovative Therapeutics Against Cancer and Neurological Disorders.

Authors: Ahmed S Gozal D Khalyfa A

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 23; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Neoplasms*/therapy , Neoplasms*/immunology , Nanoparticles*/chemistry , Nervous System Diseases*/therapy , Nervous System Diseases*/immunology , Nervous System Diseases*/drug therapy , Drug Delivery Systems*/methods , Cancer Vaccines*/administration & dosage , Cancer Vaccines*/immunology , Vaccines*/administration & dosage , Vaccines*/immunology, Humans ; Animals ; Adjuvants, Immunologic ; Nanoparticle Drug Delivery System

The psychobiotic revolution: comprehending the optimistic role of gut microbiota on gut-brain axis during neurological and Gastrointestinal (GI) disorders.

Authors: Mohiuddin M Asghar T Hameed H et al.

Source: World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2025 Oct 23; Vol. 41 (10), pp. 401. Date of Electronic Publication: 2025 Oct 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9012472 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-0972 (Electronic) Linking ISSN: 09593993 NLM ISO Abbreviation: World J Microbiol Biotechnol Subsets: MEDLINE

MeSH Terms: Gastrointestinal Microbiome*/physiology , Probiotics*/therapeutic use , Gastrointestinal Diseases*/microbiology , Gastrointestinal Diseases*/therapy , Brain* , Nervous System Diseases*/microbiology , Nervous System Diseases*/therapy , Brain-Gut Axis*, Humans ; Hypothalamo-Hypophyseal System ; COVID-19 ; Animals

IGFBP2-Ceramide Pathway Mediates Divergent Myelin Breakdown in the PNS and CNS Following Injury.

Authors: Ma S Fu X Lyu J et al.

Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Oct 22; Vol. 45 (43). Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article

Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

MeSH Terms: Insulin-Like Growth Factor Binding Protein 2*/metabolism , Insulin-Like Growth Factor Binding Protein 2*/genetics , Myelin Sheath*/metabolism , Myelin Sheath*/pathology , Ceramides*/metabolism , Central Nervous System*/metabolism , Central Nervous System*/injuries, Animals ; Mice ; Female ; Male ; Mice, Inbred C57BL ; Nerve Regeneration/physiology ; Signal Transduction/physiology ; Peripheral Nervous System/metabolism

Reconstitution of Human Cytochrome P450 Activity using a Leishmania Cell-Free Protein Expression System.

Authors: Johnston WA Thomson RES Alfaro-Palma J et al.

Source: ACS synthetic biology [ACS Synth Biol] 2025 Oct 17; Vol. 14 (10), pp. 4127-4133. Date of Electronic Publication: 2025 Sep 14.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-5063 (Electronic) Linking ISSN: 21615063 NLM ISO Abbreviation: ACS Synth Biol Subsets: MEDLINE

MeSH Terms: Leishmania*/metabolism , Leishmania*/genetics , Cytochrome P-450 CYP3A*/metabolism , Cytochrome P-450 CYP3A*/genetics , Cytochrome P-450 CYP2D6*/metabolism , Cytochrome P-450 CYP2D6*/genetics , Cytochrome P-450 Enzyme System*/metabolism , Cytochrome P-450 Enzyme System*/genetics, Humans ; Cell-Free System/metabolism ; NADPH-Ferrihemoprotein Reductase/metabolism ; NADPH-Ferrihemoprotein Reductase/genetics ; Arabidopsis/genetics

Exploring microglial replacement: From disease models to clinical translation.

Authors: Zhou K Wang Y Xu Y et al.

Source: Brain, behavior, and immunity [Brain Behav Immun] 2025 Oct; Vol. 129, pp. 179-185. Date of Electronic Publication: 2025 Jun 09.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

MeSH Terms: Microglia*/physiology , Microglia*/transplantation , Central Nervous System Diseases*/therapy , Central Nervous System Diseases*/immunology, Humans ; Animals ; Translational Research, Biomedical ; Neuroinflammatory Diseases/therapy ; Disease Models, Animal ; Central Nervous System/immunology

mGluR5 promotes oxidative stress and central sensitization in chronic migraine through ERK-mediated phosphorylation of Drp1 to activate mitochondrial fission.

Authors: Wen H Wang H Zhong J et al.

Source: Neuroscience [Neuroscience] 2025 Oct 01; Vol. 584, pp. 166-179. Date of Electronic Publication: 2025 Aug 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

MeSH Terms: Oxidative Stress*/physiology , Oxidative Stress*/drug effects , Dynamins*/metabolism , Mitochondrial Dynamics*/physiology , Mitochondrial Dynamics*/drug effects , Receptor, Metabotropic Glutamate 5*/metabolism , Receptor, Metabotropic Glutamate 5*/antagonists & inhibitors , Migraine Disorders*/metabolism , Central Nervous System Sensitization*/physiology , Central Nervous System Sensitization*/drug effects, Animals ; Phosphorylation ; Male ; Hyperalgesia/metabolism ; Rats, Sprague-Dawley ; Mitochondria/metabolism ; MAP Kinase Signaling System/physiology ; Rats ; Chronic Disease

Relevance of the interactions between the complement and contact coagulation systems on renal pathology.

Authors: López-Lera A Corvillo F González-Sánchez L et al.

Source: Nefrologia [Nefrologia (Engl Ed)] 2025 Oct; Vol. 45 (8), pp. 501347. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier España, S.L.U Country of Publication: Spain NLM ID: 101778581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2013-2514 (Electronic) Linking ISSN: 20132514 NLM ISO Abbreviation: Nefrologia (Engl Ed) Subsets: MEDLINE

MeSH Terms: Complement System Proteins*/physiology , Kidney Diseases*/immunology , Blood Coagulation*/physiology, Humans ; Complement Activation ; Atypical Hemolytic Uremic Syndrome/immunology ; Kallikrein-Kinin System/physiology

Impact of autonomic dysfunction on cardiovascular outcomes among patients with ATTR cardiomyopathy: insights from the COMPASS-31.

Authors: Weinsaft A Teruya S Santos AM et al.

Source: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2025 Dec; Vol. 32 (4), pp. 314-323. Date of Electronic Publication: 2025 Jun 28.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9433802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-2818 (Electronic) Linking ISSN: 13506129 NLM ISO Abbreviation: Amyloid Subsets: MEDLINE

MeSH Terms: Cardiomyopathies*/physiopathology , Cardiomyopathies*/mortality , Cardiomyopathies*/genetics , Cardiomyopathies*/pathology , Amyloid Neuropathies, Familial*/physiopathology , Amyloid Neuropathies, Familial*/complications , Amyloid Neuropathies, Familial*/mortality , Amyloid Neuropathies, Familial*/pathology , Amyloid Neuropathies, Familial*/genetics , Autonomic Nervous System Diseases*/physiopathology, Humans ; Male ; Female ; Aged ; Quality of Life ; Middle Aged ; Prognosis ; Autonomic Nervous System/physiopathology ; Surveys and Questionnaires ; Registries ; Hospitalization ; Aged, 80 and over

SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related