Suchergebnisse - "Syk Kinase"

Spleen tyrosine kinase signaling in myeloid cells promotes macrophage infiltration, glomerulosclerosis, and interstitial fibrosis in diabetic kidney disease.

Autoren: Chia XX Ozols E Nikolic-Paterson DJ et al.

Quelle: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2025 Dec 01; Vol. 329 (6), pp. F872-F882. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1466 (Electronic) Linking ISSN: 15221466 NLM ISO Abbreviation: Am J Physiol Renal Physiol Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/metabolism , Syk Kinase*/genetics , Syk Kinase*/deficiency , Diabetic Nephropathies*/pathology , Diabetic Nephropathies*/enzymology , Diabetic Nephropathies*/genetics , Macrophages*/pathology , Macrophages*/enzymology , Myeloid Cells*/enzymology , Myeloid Cells*/pathology, Animals ; Humans ; Fibrosis ; Signal Transduction ; Male ; Diabetes Mellitus, Experimental/enzymology ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Experimental/complications ; Mice, Knockout ; Mice ; Antigens, Differentiation, Myelomonocytic/metabolism ; Mice, Inbred C57BL ; Kidney/pathology ; Kidney/enzymology ; Female ; Middle Aged ; Antigens, CD/metabolism

A novel immunocompetent transgenic mouse model of DHF reveals Syk-mediated Th2-polarized cytokine storm as a key driver of vascular leakage.

Autoren: Wang Y Yang W Yang Y et al.

Quelle: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2531178. Date of Electronic Publication: 2025 Jul 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/genetics , Syk Kinase*/metabolism , Syk Kinase*/immunology , Cytokines*/immunology , Cytokines*/metabolism , Th2 Cells*/immunology , Severe Dengue*/immunology , Severe Dengue*/virology , Severe Dengue*/pathology , Severe Dengue*/genetics , Cytokine Release Syndrome*/immunology , Cytokine Release Syndrome*/virology, Animals ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Mice, Inbred C57BL ; Humans ; Dengue Virus/immunology ; Dengue Virus/physiology ; Capillary Permeability ; Female

SYK overexpression enhances microtubule instability in an MDA-MB-231-derived paclitaxel-resistant cell line.

Autoren: Kuo HH Huang CW Chiang WR et al.

Quelle: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2025 Dec; Vol. 1872 (8), pp. 120059. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE

MeSH-Schlagworte: Paclitaxel*/pharmacology , Drug Resistance, Neoplasm*/drug effects , Drug Resistance, Neoplasm*/genetics , Microtubules*/metabolism , Microtubules*/drug effects , Syk Kinase*/genetics , Syk Kinase*/metabolism , Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/genetics , Triple Negative Breast Neoplasms*/metabolism, Humans ; Cell Line, Tumor ; Female ; Cell Proliferation/drug effects ; Antineoplastic Agents, Phytogenic/pharmacology ; Spindle Apparatus/drug effects ; Spindle Apparatus/metabolism

A Drug Screening Targeting Upregulation of Syk Gene Identifies Neochlorogenic Acid and L-Arabinitol Capable of Inducing the M2 Phenotype of Microglia in Alzheimer's Disease.

Autoren: Hu D Li X Li Y et al.

Quelle: Chembiochem : a European journal of chemical biology [Chembiochem] 2025 Nov 27; Vol. 26 (23), pp. e202500515. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/genetics , Syk Kinase*/metabolism , Syk Kinase*/antagonists & inhibitors , Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Up-Regulation*/drug effects , Microglia*/drug effects , Microglia*/metabolism , Microglia*/pathology, Animals ; Phagocytosis/drug effects ; Amyloid beta-Peptides/metabolism ; Humans ; Drug Evaluation, Preclinical ; Mice ; Phenotype

TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk.

Autoren: Veleeparambil M Wang C Kessler PM et al.

Quelle: MBio [mBio] 2025 Nov 12; Vol. 16 (11), pp. e0027625. Date of Electronic Publication: 2025 Sep 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/metabolism , Syk Kinase*/genetics , Toll-Like Receptor 9*/metabolism , Toll-Like Receptor 9*/genetics , ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Signal Transduction* , Tyrosine*/metabolism, Phosphorylation ; Animals ; Humans ; Mice ; src-Family Kinases/metabolism ; src-Family Kinases/genetics ; Ligands

Phosphorylation at Y317 on Syk negatively regulates both ITAM- and hemITAM-mediated signaling and function in platelets.

Autoren: Elzoheiry MA Dangelmaier CA Vajipayajula DN et al.

Quelle: Blood advances [Blood Adv] 2025 Nov 11; Vol. 9 (21), pp. 5626-5637.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/metabolism , Syk Kinase*/genetics , Syk Kinase*/chemistry , Blood Platelets*/metabolism , Signal Transduction* , Immunoreceptor Tyrosine-Based Activation Motif*, Animals ; Phosphorylation ; Mice ; Humans ; Lectins, C-Type/metabolism

Targeting SYK with miR-512-3p provides therapeutic potential in myocardial fibrosis.

Autoren: Li W Yang W Hou F et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 28; Vol. 15 (1), pp. 37622. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/genetics , Syk Kinase*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism , Myocardium*/pathology , Myocardium*/metabolism , Cardiomyopathies*/genetics , Cardiomyopathies*/pathology , Cardiomyopathies*/metabolism, Animals ; Fibrosis ; Mice ; Male ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Disease Models, Animal ; Isoproterenol ; Cell Proliferation ; Signal Transduction ; Mice, Inbred C57BL ; Cell Line

Novel SYK Variant Causes Enhanced SYK Autophosphorylation and PI3K Activation in an Antibody-Deficient Patient.

Autoren: Edwards ESJ Chatelier J Snell GI et al.

Quelle: Journal of clinical immunology [J Clin Immunol] 2025 Oct 20; Vol. 45 (1), pp. 147. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 8102137 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2592 (Electronic) Linking ISSN: 02719142 NLM ISO Abbreviation: J Clin Immunol Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/genetics , Syk Kinase*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , Agammaglobulinemia*/genetics , Immunologic Deficiency Syndromes*/genetics, Humans ; Female ; Phosphorylation ; Adult ; B-Lymphocytes/immunology ; Mutation, Missense ; Signal Transduction

Integrative machine learning and structure-based drug repurposing for identifying potent inhibitors of human SYK activity against cancer.

Autoren: Iqbal MW Sun X Sasidharan RS et al.

Quelle: Life sciences [Life Sci] 2025 Oct 01; Vol. 378, pp. 123814. Date of Electronic Publication: 2025 Jun 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/antagonists & inhibitors , Syk Kinase*/metabolism , Syk Kinase*/chemistry , Machine Learning* , Drug Repositioning*/methods , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Neoplasms*/drug therapy , Neoplasms*/enzymology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Structure-Activity Relationship

Spleen Tyrosine Kinase Exacerbates Anti-Citrullinated Protein/Peptide Antibody-Mediated Osteoclast Bone Resorption via Promotion of Vav3 Phosphorylation.

Autoren: Wang T Zhu L Pan Y et al.

Quelle: Cell biology international [Cell Biol Int] 2025 Nov; Vol. 49 (11), pp. 1464-1474. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Chichester Country of Publication: England NLM ID: 9307129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8355 (Electronic) Linking ISSN: 10656995 NLM ISO Abbreviation: Cell Biol Int Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/metabolism , Osteoclasts*/metabolism , Bone Resorption*/metabolism , Bone Resorption*/pathology , Bone Resorption*/immunology , Proto-Oncogene Proteins c-vav*/metabolism, Animals ; Phosphorylation ; Mice ; Cell Differentiation ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/immunology ; Mice, Inbred C57BL ; Autoantibodies/immunology ; Male

The spleen tyrosine kinase inhibitor entospletinib resolves inflammation to promote repair following acute kidney injury.

Autoren: Elias EE Lau A Belay SG et al.

Quelle: JCI insight [JCI Insight] 2025 Aug 22; Vol. 10 (16). Date of Electronic Publication: 2025 Aug 22 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/antagonists & inhibitors , Syk Kinase*/metabolism , Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/pathology , Acute Kidney Injury*/complications , Inflammation*/drug therapy , Inflammation*/pathology , Reperfusion Injury*/drug therapy , Reperfusion Injury*/pathology , Reperfusion Injury*/complications , Protein Kinase Inhibitors*/pharmacology , Pyrimidines*/pharmacology, Animals ; Mice ; Male ; Kidney/pathology ; Kidney/drug effects ; Mice, Inbred C57BL ; Disease Models, Animal ; Macrophages/drug effects ; Tyrosine Kinase Inhibitors

SYK identified by bioinformatics analysis promotes the proliferation of multiple myeloma.

Autoren: Deng J Li P Li S et al.

Quelle: Expert review of hematology [Expert Rev Hematol] 2025 Jul; Vol. 18 (7), pp. 569-583. Date of Electronic Publication: 2025 May 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4094 (Electronic) Linking ISSN: 17474094 NLM ISO Abbreviation: Expert Rev Hematol Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/genetics , Syk Kinase*/metabolism , Syk Kinase*/antagonists & inhibitors , Multiple Myeloma*/genetics , Multiple Myeloma*/pathology , Multiple Myeloma*/metabolism , Multiple Myeloma*/drug therapy , Computational Biology*/methods, Humans ; Animals ; Cell Proliferation/drug effects ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Apoptosis/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Interaction Maps

Resveratrol suppresses OSCC invasion and migration by regulating macrophage polarization via Syk signaling pathway.

Autoren: Li W Qi Y Li Y et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Sep 29; Vol. 16, pp. 1660851. Date of Electronic Publication: 2025 Sep 29 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Resveratrol*/pharmacology , Syk Kinase*/metabolism , Mouth Neoplasms*/pathology , Mouth Neoplasms*/drug therapy , Mouth Neoplasms*/metabolism , Mouth Neoplasms*/immunology , Tumor-Associated Macrophages*/drug effects , Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/metabolism , Carcinoma, Squamous Cell*/pathology , Carcinoma, Squamous Cell*/drug therapy , Carcinoma, Squamous Cell*/metabolism , Macrophages*/drug effects , Macrophages*/immunology , Squamous Cell Carcinoma of Head and Neck*/pathology , Squamous Cell Carcinoma of Head and Neck*/drug therapy , Squamous Cell Carcinoma of Head and Neck*/metabolism, Humans ; Cell Movement/drug effects ; Signal Transduction/drug effects ; Neoplasm Invasiveness ; Cell Line, Tumor ; Cell Polarity/drug effects ; Macrophage Activation/drug effects

S100A9 promotes inflammasome-dependent autoinflammation by blocking the degradation of SYK tyrosine kinase.

Autoren: Wolf J Kusche Y Eroglu FK et al.

Quelle: Journal of leukocyte biology [J Leukoc Biol] 2025 Sep 01; Vol. 117 (9).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/metabolism , Inflammasomes*/metabolism , Inflammasomes*/immunology , Calgranulin B*/metabolism , Calgranulin B*/genetics , Inflammation*/pathology , Inflammation*/metabolism , Inflammation*/immunology, NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Humans ; Monocytes/metabolism ; Monocytes/immunology ; Proteolysis ; Animals ; Mice ; Signal Transduction

Hypoxia suppressed the Siglec-5 signaling in TAMs via modulating the balance of SHP2/SYK activation in hepatocellular carcinoma.

Autoren: Luo S Mao J Zhang L et al.

Quelle: Scientific reports [Sci Rep] 2025 Aug 26; Vol. 15 (1), pp. 31409. Date of Electronic Publication: 2025 Aug 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Syk Kinase*/metabolism , Hypoxia*/metabolism , Antigens, CD*/metabolism , Antigens, CD*/genetics , Antigens, Differentiation, Myelomonocytic*/metabolism , Antigens, Differentiation, Myelomonocytic*/genetics , Tumor-Associated Macrophages*/metabolism , Antigens, Differentiation, B-Lymphocyte*/metabolism, Humans ; Animals ; Signal Transduction ; Hep G2 Cells ; Mice ; Cell Proliferation ; Cell Movement ; Mice, Nude ; Cell Hypoxia

HSF1 in macrophages suppressed the progression of asthma via modulating SIRPα/SHP2-Dectin-1/ SYK mediated ROS and inflammatory responses.

Autoren: Liu X Zhang Y Wu H et al.

Quelle: Scientific reports [Sci Rep] 2025 Aug 13; Vol. 15 (1), pp. 29741. Date of Electronic Publication: 2025 Aug 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Asthma*/metabolism , Asthma*/pathology , Asthma*/immunology , Syk Kinase*/metabolism , Receptors, Immunologic*/metabolism , Macrophages*/metabolism , Macrophages*/immunology , Lectins, C-Type*/metabolism , Reactive Oxygen Species*/metabolism , Heat Shock Transcription Factors*/metabolism , Heat Shock Transcription Factors*/genetics, Animals ; Mice ; RAW 264.7 Cells ; Inflammation/metabolism ; Inflammation/pathology ; Mice, Inbred C57BL ; Disease Models, Animal ; Signal Transduction ; Lung/pathology ; Lung/metabolism ; Disease Progression ; Male

CD18 acts as an immune recognition molecule to induce the expressions of immune effectors through the Syk-ERK signaling pathway in oyster Crassostrea gigas.

Autoren: Guo Q Yang W Wang L et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Aug; Vol. 319 (Pt 1), pp. 145400. Date of Electronic Publication: 2025 Jun 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Crassostrea*/immunology , Crassostrea*/genetics , Crassostrea*/microbiology , Crassostrea*/metabolism , MAP Kinase Signaling System*/immunology , Syk Kinase*/metabolism , CD18 Antigens*/genetics , CD18 Antigens*/immunology , CD18 Antigens*/metabolism , CD18 Antigens*/chemistry, Animals ; Hemocytes/immunology ; Hemocytes/metabolism ; Vibrio/immunology ; Immunity, Innate ; Gene Expression Regulation ; Amino Acid Sequence

SCR Organism: Vibrio splendidus

ANGPTL4 promoted the cognitive impairment in vascular dementia via increasing integrin/p-Syk signalings induced mitochondrial autophagy and apoptosis in the hippocampus.

Autoren: Yao C Wang J

Quelle: Scientific reports [Sci Rep] 2025 Jul 13; Vol. 15 (1), pp. 25312. Date of Electronic Publication: 2025 Jul 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Dementia, Vascular*/metabolism , Dementia, Vascular*/pathology , Syk Kinase*/metabolism , Cognitive Dysfunction*/metabolism , Cognitive Dysfunction*/pathology , Cognitive Dysfunction*/etiology , Angiopoietin-Like Protein 4*/metabolism , Angiopoietin-Like Protein 4*/genetics , Mitochondria*/metabolism , Mitochondria*/pathology , Hippocampus*/metabolism , Hippocampus*/pathology , Apoptosis* , Autophagy*, Animals ; Rats ; Signal Transduction ; Male ; Rats, Sprague-Dawley ; Disease Models, Animal ; Membrane Proteins/metabolism ; Mitochondrial Proteins

TREM2 inhibits LPS-induced pyroptosis and inflammation by promoting mitophagy via SYK in BV2 cells.

Autoren: Jiang W Fan X Wu H et al.

Quelle: Neurotoxicology and teratology [Neurotoxicol Teratol] 2025 Jul-Aug; Vol. 110, pp. 107500. Date of Electronic Publication: 2025 May 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: United States NLM ID: 8709538 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9738 (Electronic) Linking ISSN: 08920362 NLM ISO Abbreviation: Neurotoxicol Teratol Subsets: MEDLINE

MeSH-Schlagworte: Membrane Glycoproteins*/metabolism , Syk Kinase*/metabolism , Pyroptosis*/drug effects , Receptors, Immunologic*/metabolism , Mitophagy*/drug effects , Microglia*/drug effects , Microglia*/metabolism , Inflammation*/chemically induced , Inflammation*/metabolism , Neuroinflammatory Diseases*/metabolism , Neuroinflammatory Diseases*/chemically induced, Animals ; Lipopolysaccharides/toxicity ; Lipopolysaccharides/pharmacology ; Mice ; Cell Line ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism

An electrostatic network with strong connectivity is a phospho-sensor for regulating affinity of Syk-receptor association.

Autoren: Hua DP Kinnun JJ Post CB

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jun 03; Vol. 122 (22), pp. e2421663122. Date of Electronic Publication: 2025 May 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Syk Kinase*/metabolism , Syk Kinase*/chemistry, Static Electricity ; Molecular Dynamics Simulation ; Phosphorylation ; Humans ; Protein Binding ; src Homology Domains ; Signal Transduction ; Thermodynamics