Výsledky vyhľadávania - "Sulfonamides administration & dosage"

Encorafenib, Cetuximab, and mFOLFOX6 in BRAF -Mutated Colorectal Cancer

Autori: Elena Elez Takayuki Yoshino Lin Shen a ďalší

Zdroj: N Engl J Med
Elez, E, BREAKWATER Trial Investigators & Poulsen, L Ø 2025, 'Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer', The New England Journal of Medicine, vol. 392, no. 24, pp. 2425-2437. https://doi.org/10.1056/NEJMoa2501912

Predmety: Adult, Male, Organoplatinum Compounds, Leucovorin, Cetuximab/adverse effects, Article, Young Adult, Carbamates/administration & dosage, Neoplasm Metastasis/drug therapy, Humans, Proto-Oncogene Proteins B-raf/antagonists & inhibitors, Treatments in Oncology, Aged, Aged, 80 and over, Sulfonamides/administration & dosage, Gastroenterology, Colorectal Neoplasms/drug therapy, Antineoplastic Combined Chemotherapy Protocols/administration & dosage, Middle Aged, Hematology/Oncology, Progression-Free Survival, Treatment Outcome, Mutation, Female, Fluorouracil, Gastrointestinal Tract Cancer

Prístupová URL adresa: http://www.scopus.com/inward/record.url?scp=105009834683&partnerID=8YFLogxK
https://doi.org/10.1056/NEJMoa2501912
https://pmc.ncbi.nlm.nih.gov/articles/PMC12197837/pdf/nihms-2071508.pdf
https://vbn.aau.dk/da/publications/78e1b9c2-1743-44a4-8c52-05389d9e3026

REACT: a randomized trial to assess the efficacy and safety of clazosentan for preventing clinical deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Autori: Stephan A. Mayer Nicolas Bruder Giuseppe Citerio a ďalší

Prispievatelia: Stephan A. Mayer Nicolas Bruder Giuseppe Citerio a ďalší

Zdroj: Journal of Neurosurgery. :1-12

Predmety: Male, Vasospasm, Intracranial/diagnostic imaging, Pyridines, Tetrazoles, cerebral ischemia, Brain Ischemia, Dioxanes, 0302 clinical medicine, Vasospasm, Intracranial, Pyridines/administration & dosage, Prospective Studies, Human health sciences, clazosentan, Vasospasm, Intracranial/prevention & control, Pyridines/therapeutic use, Sulfonamides, Subarachnoid Hemorrhage/diagnostic imaging, Anesthesia & intensive care, Middle Aged, Brain Ischemia/etiology, 3. Good health, Dioxanes/therapeutic use, Treatment Outcome, Neurology, Tetrazoles/therapeutic use, endothelin-1, Vasospasm, Intracranial/etiology, Dioxanes/adverse effects, Female, Tetrazoles/adverse effects, Adult, Anesthésie & soins intensifs, subarachnoid hemorrhage, vascular disorders, Sciences de la santé humaine, 03 medical and health sciences, Double-Blind Method, Neurologie, Humans, Pyrimidines/administration & dosage, Pyridines/adverse effects, aneurysm, cerebral vasospasm, Aged, Sulfonamides/administration & dosage, Pyrimidines/adverse effects, Pyrimidines/therapeutic use, Sulfonamides/adverse effects, Sulfonamides/therapeutic use, Subarachnoid Hemorrhage, Vasospasm, Intracranial/drug therapy, Pyrimidines, Subarachnoid Hemorrhage/complications, Surgery, Neurology (clinical), Brain Ischemia/prevention & control

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39126720

First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial: 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial

Autori: Fürstenau, Moritz Kater, Arnon P Robrecht, Sandra a ďalší

Prispievatelia: Fürstenau, Moritz Kater, Arnon P Robrecht, Sandra a ďalší

Zdroj: Fürstenau, M, Kater, A P, Robrecht, S, von Tresckow, J, Zhang, C, Gregor, M, Thornton, P, Staber, P B, Tadmor, T, Lindström, V, Juliusson, G, Janssens, A, Levin, M-D, da Cunha-Bang, C, Schneider, C, Goldschmidt, N, Vandenberghe, E, Rossi, D, Benz, R, Nösslinger, T, Heintel, D, Poulsen, C B, Christiansen, I, Frederiksen, H, Enggaard, L, Posthuma, E F M, Issa, D E, Visser, H P J, Bellido, M, Kutsch, N, Dürig, J, Stehle, A, Vöhringer, M, Böttcher, S, Schulte, C, Simon, F, Fink, A-M, Fischer, K, Holmes, E E, Kreuzer, K-A, Ritgen, M, Brüggemann, M, Tausch, E, Stilgenbauer, S, Hallek, M, Niemann, C U & Eichhorst, B 2024, 'First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial', The Lancet Oncology, vol. 25, no. 6, pp. 744-759. https://doi.org/10.1016/S1470-2045(24)00196-7
Fuerstenau, M, Kater, A P, Robrecht, S, von Tresckow, J, Zhang, C, Gregor, M, Thornton, P, Staber, P B, Tadmor, T, Lindstroem, V, Juliusson, G, Janssens, A, Levin, M-D, Cunha-Bang, C, Schneider, C, Goldschmidt, N, Vandenberghe, E, Rossi, D, Benz, R, Noesslinger, T, Heintel, D, Poulsen, C B, Christiansen, I, Frederiksen, H, Enggaard, L, Posthuma, E F M, Issa, D E, Visser, H P J, Bellido, M, Kutsch, N, Duerig, J, Stehle, A, Voehringer, M, Boettcher, S, Schulte, C, Simon, F, Fink, A-M, Fischer, K, Holmes, E E, Kreuzer, K-A, Ritgen, M, Brueggemann, M, Tausch, E, Stilgenbauer, S, Hallek, M, Niemann, C U & Eichhorst, B 2024, ' First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13) : 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial ', Lancet Oncology, vol. 25, no. 6, pp. 744-759 . https://doi.org/10.1016/S1470-2045(24)00196-7

Predmety: Male, Medizin, Piperidines/administration & dosage, Rituximab/administration & dosage, Cyclophosphamide/administration & dosage, Vidarabine/analogs & derivatives, Piperidines, Monoclonal, Antineoplastic Combined Chemotherapy Protocols, Chronic, Sulfonamides, Leukemia, Ibrutinib, Heterocyclic/administration & dosage, Middle Aged, Lymphocytic, Progression-Free Survival, 3. Good health, Bendamustine, Humanized/administration & dosage, Female, Immunotherapy, Cancers, Rituximab, Vidarabine, Antibodies, Monoclonal, Humanized/administration & dosage, Adult, Guidelines, B-Cell/drug therapy, Antibodies, Monoclonal, Humanized, Antibodies, Bridged Bicyclo Compounds, Obinutuzumab, Humans, Pyrimidines/administration & dosage, Cyclophosphamide, Aged, Sulfonamides/administration & dosage, Acalabrutinib, Adenine, Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy, Pyrazoles/administration & dosage, Bridged Bicyclo Compounds, Heterocyclic, Leukemia, Lymphocytic, Chronic, B-Cell, Bridged Bicyclo Compounds, Heterocyclic/administration & dosage, Pyrimidines, Pyrazoles, Chlorambucil, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Adenine/analogs & derivatives, Cll, Follow-Up Studies

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38821083
https://vbn.aau.dk/ws/files/718022411/F_rstenau_et_al._2024_._First-line_venetoclax_combinations_versus_chemoimmunotherapy_in_fit_patients_with_chronic_lymphocytic_leukaemia_GAIA-CLL13_-_4-year_follow-up_from_a_multicentre_open-label_randomised_phase_3_trial.pdf
https://vbn.aau.dk/da/publications/94b2c096-a230-4cfb-b1cb-3f1e21048b8d
https://doi.org/10.1016/S1470-2045(24)00196-7
http://www.scopus.com/inward/record.url?scp=85194085374&partnerID=8YFLogxK
https://research.rug.nl/en/publications/54e23617-72a7-4e84-a971-484f9776d6b5
https://doi.org/10.1016/S1470-2045(24)00196-7
https://hdl.handle.net/11370/54e23617-72a7-4e84-a971-484f9776d6b5
https://pure.amsterdamumc.nl/en/publications/6c072122-c40d-4938-b051-ee450f59a5c9
https://doi.org/10.1016/S1470-2045(24)00196-7
http://hdl.handle.net/10138/576618
https://curis.ku.dk/ws/files/460526731/1-s2.0-S1470204524001967-main.pdf
https://portal.findresearcher.sdu.dk/da/publications/cdc040d1-38d0-4dd9-b810-60b242058f6d
https://doi.org/10.1016/S1470-2045(24)00196-7
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85194085374
https://doi.org/10.1016/s1470-2045(24)00196-7
https://www.ncbi.nlm.nih.gov/pubmed/38821083

Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial

Autori: McIlroy, Graham Gaskell, Charlotte Jackson, Aimee a ďalší

Zdroj: BMC Cancer
BMC Cancer, Vol 25, Iss 1, Pp 1-11 (2025)
McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, A J & McMullin, M F 2025, 'Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial', BMC Cancer, vol. 25, no. 1, 56. https://doi.org/10.1186/s12885-024-13383-3

Predmety: Fedratinib, Myelofibrosis, Study Protocol, male, middle aged, sulfonamides/administration & dosage, humans, RC254-282, Janus Kinase 2/genetics, polyethylene glycols/administration & dosage, adult, benzenesulfonamides, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Bayes Theorem, antineoplastic combined Chemotherapy Protocols/therapeutic use, Ropeginterferon alfa-2b, interferon alpha-2/administration & dosage, primary myelofibrosis/drug therapy, Phase II, recombinant proteins/administration & dosage, pyrrolidines/therapeutic use, Clinical trial, aged, female, interferon-alpha/administration & dosage, JAK2 inhibition

Popis súboru: application/pdf

Prístupová URL adresa: https://doaj.org/article/602bbf7f2cd5496e88df64c1884057e4
https://ora.ox.ac.uk/objects/uuid:2376e00f-3446-4371-827d-263f496c8528
https://doi.org/10.1186/s12885-024-13383-3
https://pure.qub.ac.uk/en/publications/96bfd95a-66ba-4f63-8b5a-31999c7f8b9f

REACT: a randomized trial to assess the efficacy and safety of clazosentan for preventing clinical deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

Autori: Mayer, Stephan A Bruder, Nicolas Citerio, Giuseppe a ďalší

Prispievatelia: Mayer, Stephan A Bruder, Nicolas Citerio, Giuseppe a ďalší

Zdroj: Journal of Neurosurgery, 142 (1), 98 - 109 (2025-01-01)

Predmety: aneurysm, cerebral ischemia, cerebral vasospasm, clazosentan, endothelin-1, subarachnoid hemorrhage, vascular disorders, Pyridines, Dioxanes, Pyrimidines, Sulfonamides, Tetrazoles, Humans, Male, Middle Aged, Female, Double-Blind Method, Aged, Prospective Studies, Treatment Outcome, Adult, Vasospasm, Intracranial/etiology, Vasospasm, Intracranial/prevention & control, Vasospasm, Intracranial/drug therapy, Vasospasm, Intracranial/diagnostic imaging, Subarachnoid Hemorrhage/complications, Subarachnoid Hemorrhage/diagnostic imaging, Pyridines/therapeutic use, Pyridines/adverse effects, Pyridines/administration & dosage, Dioxanes/therapeutic use, Dioxanes/adverse effects, Pyrimidines/therapeutic use, Pyrimidines/adverse effects, Pyrimidines/administration & dosage, Brain Ischemia/prevention & control, Brain Ischemia/etiology, Sulfonamides/therapeutic use, Sulfonamides/adverse effects, Sulfonamides/administration & dosage, Tetrazoles/therapeutic use, Tetrazoles/adverse effects, Brain Ischemia, Vasospasm, Intracranial, Surgery, Neurology (clinical), Human health sciences, Neurology, Anesthesia & intensive care, Sciences de la santé humaine, Neurologie, Anesthésie & soins intensifs

Relation: https://thejns.org/view/journals/j-neurosurg/aop/article-10.3171-2024.4.JNS232191/article-10.3171-2024.4.JNS232191.xml; urn:issn:0022-3085; urn:issn:1933-0693

Prístupová URL adresa: https://orbi.uliege.be/handle/2268/328394

Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia

Autori: Feehan, KT Bridgewater, HE Stenkiewicz-Witeska, J a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Feehan, K T, Bridgewater, H E, Stenkiewicz-Witeska, J, De maeyer, R P H, Ferguson, J, Mack, M, Brown, J, Ercoli, G, Mawer, C M, Akbar, A N, Glanville, J R W, Jalali, P, Bracken, O V, Nicolaou, A, Kendall, A C, Sugimoto, M A & Gilroy, D W 2024, 'Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia', Nature Communications, vol. 15, no. 1, 4326. https://doi.org/10.1038/s41467-024-48138-y

Predmety: Male, 0301 basic medicine, T-Lymphocytes, Inbred C57BL, Mice, Receptors, Lymphocytes, Lung, Pneumonia, Pneumococcal/immunology, Phagocytes, Sulfonamides, 0303 health sciences, Prostaglandin E, Streptococcus pneumoniae/physiology, Inflammation/immunology, Lymphocytes/cytology, CD, 3. Good health, Streptococcus pneumoniae, Lung/immunology, Alveolar/cytology, Quinolines, Pneumococcal, Female, Integrin alpha Chains, Macrophages, Alveolar/cytology, Dinoprostone/antagonists & inhibitors, T-Lymphocytes/cytology, Phagocytes/cytology, Science, Quinolines/administration & dosage, Alveolar, Article, Dinoprostone, 03 medical and health sciences, Macrophages, Alveolar, Animals, Antigens, Inflammation, Sulfonamides/administration & dosage, Animal, Macrophages, Macrophages/cytology, Pneumonia, Pneumonia, Pneumococcal, Fibrosis, Mice, Inbred C57BL, Prostaglandins/biosynthesis, Disease Models, Prostaglandins, EP4 Subtype, Pneumococcal/immunology, Transcriptome

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38773113
https://doaj.org/article/2c3602528dd144b09810421a90f86c86
https://ora.ox.ac.uk/objects/uuid:b2036724-ee75-401f-a515-7e36ac0387ae
https://doi.org/10.1038/s41467-024-48138-y
https://discovery-pp.ucl.ac.uk/id/eprint/10193030/

Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet

Autori: Gueneau de Mussy, P. Sidharta, P.N. Wuerzner, G. a ďalší

Zdroj: Clin Pharmacol Ther
Clinical pharmacology and therapeutics, vol. 109, no. 3, pp. 746-753

Predmety: Adult, Endothelin Receptor Antagonists, Male, Sulfonamides, Cross-Over Studies, Research, Glycopeptides, Administration, Oral, Natriuresis, Sodium, Dietary, Middle Aged, Water-Electrolyte Balance, Healthy Volunteers, Uric Acid, 3. Good health, 03 medical and health sciences, Pyrimidines, 0302 clinical medicine, Body Water, Double-Blind Method, Homeostasis, Humans, Aldosterone, Switzerland, Aldosterone/blood, Body Water/metabolism, Endothelin Receptor Antagonists/administration & dosage, Endothelin Receptor Antagonists/adverse effects, Glycopeptides/blood, Natriuresis/drug effects, Pyrimidines/administration & dosage, Pyrimidines/adverse effects, Sodium, Dietary/adverse effects, Sulfonamides/administration & dosage, Sulfonamides/adverse effects, Uric Acid/blood, Water-Electrolyte Balance/drug effects, Weight Gain/drug effects, Young Adult

Popis súboru: application/pdf

Prístupová URL adresa: https://ascpt.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpt.2043
https://pubmed.ncbi.nlm.nih.gov/32897570
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984323
https://serval.unil.ch/en/notice/serval:BIB_1BE20415C0D5
https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2043
https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2043
https://serval.unil.ch/notice/serval:BIB_1BE20415C0D5
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_1BE20415C0D58
https://serval.unil.ch/resource/serval:BIB_1BE20415C0D5.P001/REF.pdf

Impact of enhanced compliance initiatives on the efficacy of rosuvastatin in reducing low density lipoprotein cholesterol levels in patients with primary hypercholesterolaemia.

Autori: Riesen, W.F. Noll, G. Dariolo, R. a ďalší

Prispievatelia: Riesen, W.F. Noll, G. Dariolo, R. a ďalší

Predmety: Aged, Female, Fluorobenzenes/administration & dosage, Fluorobenzenes/therapeutic use, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Hypercholesterolemia/drug therapy, Lipoproteins, LDL/drug effects, Male, Middle Aged, Patient Compliance, Pyrimidines/administration & dosage, Pyrimidines/therapeutic use, Rosuvastatin Calcium, Sulfonamides/administration & dosage, Sulfonamides/therapeutic use, Switzerland, Treatment Outcome

Popis súboru: application/pdf

Relation: Swiss Medical Weekly; https://iris.unil.ch/handle/iris/235385; serval:BIB_F0C3708131E2; 000257973200002

Dostupnosť: https://iris.unil.ch/handle/iris/235385

Assessment of the efficacy of different statins in murine collagen-induced arthritis

Autori: Palmer, G. Chobaz, V. Talabot-Ayer, D. a ďalší

Predmety: Animals Arthritis, Experimental/*drug therapy/physiopathology Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Fluorobenzenes/administration & dosage/therapeutic use Heptanoic Acids/administration & dosage/therapeutic use Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/*therapeutic use Lipids/blood Lymph Nodes/drug effects/pathology Male Mice Mice, Inbred DBA Nuclear Proteins/genetics/metabolism Pyrimidines/administration & dosage/therapeutic use Pyrroles/administration & dosage/therapeutic use RNA, Messenger/metabolism Reverse Transcriptase Polymerase Chain Reaction Simvastatin/administration & dosage/therapeutic use Sulfonamides/administration & dosage/therapeutic use Trans-Activators/genetics/metabolism Treatment Outcome

Relation: Arthritis & rheumatism; https://iris.unil.ch/handle/iris/229261; serval:BIB_C6A41203BC4A; 000225750200038

Dostupnosť: https://iris.unil.ch/handle/iris/229261
https://doi.org/10.1002/art.20673

An exploratory study investigating the metabolic activity and local cytokine profile in patients with melanoma treated with pazopanib and paclitaxel.

Autori: Thurneysen, S. Cheng, P.F. Nagel, H.W. a ďalší

Predmety: Administration, Oral, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Cytokines/metabolism, Drug Administration Schedule, Female, Humans, Infusions, Intravenous, Male, Melanoma/drug therapy, Melanoma/metabolism, Paclitaxel/administration & dosage, Pyrimidines/administration & dosage, Skin Neoplasms/drug therapy, Skin Neoplasms/metabolism, Sulfonamides/administration & dosage, Treatment Outcome, Up-Regulation

Relation: British Journal of Dermatology; https://iris.unil.ch/handle/iris/196600; serval:BIB_B287A12518AD; 000386465300033

Dostupnosť: https://iris.unil.ch/handle/iris/196600
https://doi.org/10.1111/bjd.14727

Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide.

Autori: Biollaz, J. Munafo, A. Buclin, T. a ďalší

Predmety: Administration, Topical, Adult, Carbonic Anhydrase Inhibitors/pharmacokinetics, Double-Blind Method, Half-Life, Humans, Male, Prospective Studies, Sulfonamides/administration & dosage, Sulfonamides/adverse effects, Thiophenes/administration & dosage, Thiophenes/adverse effects

Relation: European Journal of Clinical Pharmacology; https://iris.unil.ch/handle/iris/183424; serval:BIB_9C877F5F9C94; A1995QE32900013; 7720769

Dostupnosť: https://iris.unil.ch/handle/iris/183424

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer

Autori: Kopetz, S. Grothey, A. Yaeger, R. a ďalší

Prispievatelia: Kopetz, S. Grothey, A. Yaeger, R. a ďalší

Zdroj: RiUVic. Repositori institucional de la UVic-UCC
instname
Kopetz, S, Grothey, A, Yaeger, R, Van Cutsem, E, Desai, J, Yoshino, T, Wasan, H, Ciardiello, F, Loupakis, F, Hong, Y S, Steeghs, N, Guren, T K, Arkenau, H T, Garcia-Alfonso, P, Pfeiffer, P, Orlov, S, Lonardi, S, Elez, E, Kim, T W, Schellens, J H M, Guo, C, Krishnan, A, Dekervel, J, Morris, V, Ferrandiz, A C, Tarpgaard, L S, Braun, M, Gollerkeri, A, Keir, C, Maharry, K, Pickard, M, Christy-Bittel, J, Anderson, L, Sandor, V & Tabernero, J 2019, ' Encorafenib, binimetinib, and cetuximab in BRAF V600E–mutated colorectal cancer ', New England Journal of Medicine, vol. 381, no. 17, pp. 1632-1643 . https://doi.org/10.1056/NEJMoa1908075

Predmety: Male, IRINOTECAN, Cetuximab, Kaplan-Meier Estimate, TRAMETINIB, VEMURAFENIB, THERAPY, 0302 clinical medicine, Medicaments -- Assaigs clínics, Antineoplastic Combined Chemotherapy Protocols, 80 and over, Benzimidazoles/administration & dosage, Treatments in Oncology, 11 Medical and Health Sciences, Aged, 80 and over, Sulfonamides, COLON-CANCER, Colorectal Neoplasms/drug therapy, Middle Aged, DABRAFENIB, Intention to Treat Analysis, 3. Good health, Còlon -- Càncer, Disease Progression, Female, Colorectal Neoplasms, Life Sciences & Biomedicine, PROGRESSION-FREE SURVIVAL, Adult, Proto-Oncogene Proteins B-raf, Irinotecan/therapeutic use, INHIBITION, Irinotecan, 03 medical and health sciences, Medicine, General & Internal, Carbamates/administration & dosage, General & Internal Medicine, Proto-Oncogene Proteins B-raf/genetics, Humans, Cetuximab/administration & dosage, Aged, Colorectal Cancer, Sulfonamides/administration & dosage, Science & Technology, 42 Health sciences, MUTATIONS, Antineoplastic Combined Chemotherapy Protocols/adverse effects, 32 Biomedical and clinical sciences, Survival Analysis, Mutation, Benzimidazoles, Carbamates, Electrocorticography, ACQUIRED-RESISTANCE

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/31566309
https://pubmed.ncbi.nlm.nih.gov/31566309/
https://portal.findresearcher.sdu.dk/da/publications/encorafenib-binimetinib-and-cetuximab-in-braf-v600emutated-colore
https://mdanderson.elsevierpure.com/en/publications/encorafenib-binimetinib-and-cetuximab-in-braf-v600emutated-colore
https://www.nejm.org/doi/full/10.1056/NEJMoa1908075
https://www.ncbi.nlm.nih.gov/pubmed/31566309
https://www.nejm.org/doi/suppl/10.1056/NEJMoa1908075/suppl_file/nejmoa1908075_appendix.pdf
https://lirias.kuleuven.be/handle/123456789/642210
https://doi.org/10.1056/nejmoa1908075
https://findresearcher.sdu.dk:8443/ws/files/158747483/nejmoa1908075.pdf
https://discovery-pp.ucl.ac.uk/id/eprint/10086190/

Regression of liver fibrosis and hepatocellular carcinoma development after HCV eradication with oral antiviral agents

Autori: Hae Won Yoo Jun Yong Park Sang Gyune Kim a ďalší

Prispievatelia: Hae Won Yoo Jun Yong Park Sang Gyune Kim a ďalší

Zdroj: Sci Rep
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

Predmety: Liver Cirrhosis, Male, 0301 basic medicine, Time Factors, Pyrrolidines, Sustained Virologic Response, Administration, Oral, Antiviral Agents / adverse effects, Chronic / drug therapy, Carbamates / administration & dosage, Prospective Studies, 0303 health sciences, Hepatocellular / virology, Liver Neoplasms / diagnosis, Incidence, Liver Neoplasms, Imidazoles, Liver Neoplasms / epidemiology, Middle Aged, Hepatitis C, 3. Good health, Hepatocellular / diagnosis, Treatment Outcome, Administration, Combination, Imidazoles / administration & dosage, Medicine, Elasticity Imaging Techniques, Liver Cirrhosis / epidemiology, Drug Therapy, Combination, Female, Chronic / diagnosis, Liver Cirrhosis / diagnostic imaging, Oral, Liver Cirrhosis / drug therapy, Carcinoma, Hepatocellular, Seoul, Science, Antiviral Agents, Liver Cirrhosis / virology, Article, 03 medical and health sciences, Drug Therapy, Ribavirin / administration & dosage, Humans, Sulfonamides / administration & dosage, Retrospective Studies, Aged, Antiviral Agents / administration & dosage, Carcinoma, Liver Neoplasms / prevention & control, Chronic / virology, Pyrrolidines / administration & dosage, Hepatitis C, Chronic, Isoquinolines, Isoquinolines / administration & dosage, Hepatocellular / epidemiology, Interferons / administration & dosage, Liver Neoplasms / virology, Chronic / epidemiology, Carbamates, Interferons, Hepatocellular / prevention & control

Prístupová URL adresa: https://www.nature.com/articles/s41598-021-03272-1.pdf
https://pubmed.ncbi.nlm.nih.gov/34996920
https://doaj.org/article/2a378d125ae0426091933efb03db7a36

Daclatasvir/asunaprevir/beclabuvir, all‐oral, fixed‐dose combination for patients with chronic hepatitis C virus genotype 1

Autori: Jia‐Horng Kao Ming‐Lung Yu Cheng‐Yuan Peng a ďalší

Prispievatelia: Jia‐Horng Kao Ming‐Lung Yu Cheng‐Yuan Peng a ďalší

Zdroj: Journal of Gastroenterology and Hepatology. 32:1998-2005

Predmety: Adult, Male, 0301 basic medicine, Sulfonamides/administration & dosage, Asia, Indoles, Pyrrolidines, Genotype, Taiwan, Indoles/administration & dosage, Hepacivirus, NS5A, Russia, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Chronic/drug therapy, Republic of Korea, 80 and over, Humans, hepatitis, Benzazepines/administration & dosage, Aged, Aged, 80 and over, 0303 health sciences, treatment, Imidazoles, Chronic/virology, Benzazepines, Hepatitis C, Chronic, Middle Aged, Imidazoles/administration & dosage, Isoquinolines, Hepatitis C, Isoquinolines/administration & dosage, 3. Good health, Hepacivirus/genetics, Drug Combinations, Treatment Outcome, Female, Carbamates, Follow-Up Studies

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/28370350
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161709
https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.13796
https://researchoutput.ncku.edu.tw/zh/publications/daclatasvirasunaprevirbeclabuvir-all-oral-fixed-dose-combination-
https://www.ncbi.nlm.nih.gov/pubmed/28370350
https://scholars.lib.ntu.edu.tw/handle/123456789/581862
https://yonsei.pure.elsevier.com/en/publications/daclatasvirasunaprevirbeclabuvir-all-oral-fixed-dose-combination-

FUTURE-2: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion

Autori: Berger, Rolf M. F Haworth, Sheila G Bonnet, Damien a ďalší

Zdroj: International Journal of Cardiology, Vol. 202 (2016) pp. 52-8

Predmety: Adult, Endothelin Receptor Antagonists, Male, Time Factors, Administration, Oral, CHILDREN, Bosentan, Pediatric, Pulmonary arterial hypertension, Safety, DIAGNOSIS, Global Health, THERAPY, DISEASE, Biomarkers, Pharmacological, 03 medical and health sciences, 0302 clinical medicine, Humans, Familial Primary Pulmonary Hypertension, Endothelin Receptor Antagonists/administration & dosage/pharmacokinetics, Survival Rate/trends, Sulfonamides, ddc:618, Dose-Response Relationship, Drug, Biomarkers, Pharmacological/metabolism, ADULTS, Drug Tolerance, EFFICACY, ERA, 3. Good health, Survival Rate, Treatment Outcome, REGISTRY, SURVIVAL, Female, Familial Primary Pulmonary Hypertension/drug therapy/metabolism/mortality, Sulfonamides/administration & dosage/pharmacokinetics, Follow-Up Studies

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/26386921
https://pubmed.ncbi.nlm.nih.gov/26386921/
https://research.rug.nl/en/publications/future-2-results-from-an-open-label-long-term-safety-and-tolerabi
https://www.internationaljournalofcardiology.com/article/S0167-5273(15)30309-0/pdf
https://www.sciencedirect.com/science/article/pii/S0167527315303090
https://cris.unibo.it/handle/11585/534493
https://www.internationaljournalofcardiology.com/article/S0167-5273(15)30309-0/fulltext
https://archive-ouverte.unige.ch/unige:96702

Heritability of metoprolol and torsemide pharmacokinetics

Autori: Matthaei, Johannes Brockmöller, Jürgen Tzvetkov, Mladen a ďalší

Prispievatelia: Matthaei, Johannes Brockmöller, Jürgen Tzvetkov, Mladen a ďalší

Zdroj: Matthaei, J, Brockmöller, J, Tzvetkov, M, Sehrt, D, Sachse-Seeboth, C, Hjelmborg, J V B, Möller, S, Halekoh, U, Hofmann, U, Schwab, M & Kerb, R 2015, ' Heritability of metoprolol and torsemide pharmacokinetics ', Clinical Pharmacology and Therapeutics, vol. 98, no. 6, pp. 611-621 . https://doi.org/10.1002/cpt.258

Predmety: Adult, Male, 0301 basic medicine, Infusions, Heredity, Adolescent, Genotype, Twins, Organic Anion Transporters, Twins, Monozygotic/genetics, Twins, Dizygotic/genetics, Young Adult, 03 medical and health sciences, Cytochrome P-450 CYP2C9/genetics, Genetic, Biotransformation/genetics, Metoprolol/administration & dosage, Humans, Polymorphism, Infusions, Intravenous, Biotransformation, Cytochrome P-450 CYP2C9, Sulfonamides, 0303 health sciences, Sulfonamides/administration & dosage, Polymorphism, Genetic, Liver-Specific Organic Anion Transporter 1, Dizygotic/genetics, Middle Aged, Torsemide, 3. Good health, Organic Anion Transporters/genetics, Phenotype, Cytochrome P-450 CYP2D6, Pharmacogenetics, 13. Climate action, Area Under Curve, Female, Intravenous, Cytochrome P-450 CYP2D6/genetics, Monozygotic/genetics, Metoprolol

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/26344676
https://publikationen.uni-tuebingen.de/xmlui/handle/10900/71869
https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/cpt.258%4010.1002/%28ISSN%291532-6535%28CAT%29VirtualIssues%28VI%29ClinicalTrials
https://core.ac.uk/display/50708727
https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/71869
http://onlinelibrary.wiley.com/doi/10.1002/cpt.258/full
http://europepmc.org/abstract/MED/26344676
https://resolver.sub.uni-goettingen.de/purl?gro-2/35203
https://portal.findresearcher.sdu.dk/da/publications/09c139b8-a310-4344-b293-642eaed23ec0

c‐Met‐mediated reactivation of PI3K/AKT signaling contributes to insensitivity of BRAF(V600E) mutant thyroid cancer to BRAF inhibition

Autori: Hyung Kwon Byeon Yoon Woo Koh Won Shik Kim a ďalší

Prispievatelia: Hyung Kwon Byeon Yoon Woo Koh Won Shik Kim a ďalší

Zdroj: Molecular Carcinogenesis. 55:1678-1687

Predmety: 0301 basic medicine, Proto-Oncogene Proteins B-raf, Sulfonamides/administration & dosage, Indoles, Sulfonamides/pharmacology, molecular targeted therapy, Thyroid Neoplasms/metabolism, Drug Resistance, Indoles/administration & dosage, Cell Line, Sulfones/administration & dosage, Neoplastic/drug effects, Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, Signal Transduction/drug effects, Cell Line, Tumor, Proto-Oncogene Proteins c-akt/metabolism, Animals, Humans, Sulfones, Thyroid Neoplasms, Proto-Oncogene Proteins B-raf/genetics, 0303 health sciences, Sulfonamides, Tumor, Indoles/pharmacology, Proto-Oncogene Proteins c-met/metabolism, Drug Synergism, Proto-Oncogene Proteins c-met, Xenograft Model Antitumor Assays, Sulfones/pharmacology, Up-Regulation, 3. Good health, Gene Expression Regulation, Neoplastic, thyroid neoplasm/drug therapy, Gene Expression Regulation, Vemurafenib, Drug Resistance, Neoplasm, Mutation, Neoplasm, Thyroid Neoplasms/genetics, Phosphatidylinositol 3-Kinases/metabolism, Thyroid Neoplasms/drug therapy, Proto-Oncogene Proteins c-akt, Signal Transduction

Prístupová URL adresa: https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/148679/1/T013635.pdf
https://pubmed.ncbi.nlm.nih.gov/26456083
https://europepmc.org/article/MED/26456083
http://onlinelibrary.wiley.com/doi/10.1002/mc.22418/abstract
https://pubmed.ncbi.nlm.nih.gov/26456083/
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152431
https://yonsei.pure.elsevier.com/en/publications/c-met-mediated-reactivation-of-pi3kakt-signaling-contributes-to-i
https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.22418

High Sustained Virologic Response to Daclatasvir Plus Asunaprevir in Elderly and Cirrhotic Patients with Hepatitis C Virus Genotype 1b Without Baseline NS5A Polymorphisms

Autori: Joji Toyota Yoshiyuki Suzuki Patricia Mendez a ďalší

Prispievatelia: Joji Toyota Yoshiyuki Suzuki Patricia Mendez a ďalší

Zdroj: Adv Ther

Predmety: Liver Cirrhosis, Viral/genetics, Pyrrolidines, Drug Resistance, Hepacivirus, 0302 clinical medicine, Japan, Phosphoproteins/genetics, Chronic/drug therapy, Pharmacology (medical), Viral hepatitis, Original Research, Medicine(all), Sulfonamides, Imidazoles, Middle Aged, 16. Peace & justice, Hepatitis C, 3. Good health, Isoquinolines/administration & dosage, Combination, Infectious diseases, Drug Therapy, Combination, Antiviral Agents/administration & dosage, Asian Continental Ancestry Group, Adult, Chronic/complications, Genotype, Liver Cirrhosis/drug therapy, Antiviral Agents/therapeutic use, Imidazoles/therapeutic use, Antiviral Agents, 12. Responsible consumption, Daclatasvir, Young Adult, 03 medical and health sciences, Drug Therapy, Genetic, Asian People, Drug Resistance, Viral, Asunaprevir, Humans, Polymorphism, Isoquinolines/therapeutic use, Aged, Sulfonamides/administration & dosage, Polymorphism, Genetic, Sulfonamides/therapeutic use, Liver Cirrhosis/etiology, Hepatitis C, Chronic, Isoquinolines, Phosphoproteins, Hepacivirus/genetics, Viral Nonstructural Proteins/genetics, Carbamates, Imidazoles/administration & dosage

Popis súboru: 637~649

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007%2Fs12325-015-0221-5.pdf
https://pubmed.ncbi.nlm.nih.gov/26155891
https://www.ncbi.nlm.nih.gov/pubmed/26155891
https://link.springer.com/content/pdf/10.1007%2Fs12325-015-0221-5.pdf
https://paperity.org/p/73655591/high-sustained-virologic-response-to-daclatasvir-plus-asunaprevir-in-elderly-and
https://yonsei.pure.elsevier.com/en/publications/high-sustained-virologic-response-to-daclatasvir-plus-asunaprevir
https://rd.springer.com/article/10.1007/s12325-015-0221-5
https://mdanderson.elsevierpure.com/en/publications/high-sustained-virologic-response-to-daclatasvir-plus-asunaprevir

A phase I study on the combination of neoadjuvant radiotherapy plus pazopanib in patients with locally advanced soft tissue sarcoma of the extremities

Autori: Haas, R.L.M. Gelderblom, H. Sleijfer, S. a ďalší

Zdroj: Haas, R L M, Gelderblom, H, Sleijfer, S, van Boven, H H, Scholten, A, Dewit, L, Borst, G, van der Hage, J, Kerst, J M, Nout, R A, Hartgrink, H H, de Pree, I, Verhoef, C, Steeghs, N & van Coevorden, F 2015, ' A phase I study on the combination of neoadjuvant radiotherapy plus pazopanib in patients with locally advanced soft tissue sarcoma of the extremities ', Acta Oncologica, vol. 54, no. 8, pp. 1195-201 . https://doi.org/10.3109/0284186X.2015.1037404

Predmety: Adult, Male, Indazoles, Maximum Tolerated Dose, Angiogenesis Inhibitors, Soft Tissue Neoplasms, Chemoradiotherapy, Adjuvant/methods, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Angiogenesis Inhibitors/administration & dosage, Humans, Adjuvant/methods, Sarcoma/therapy, Pyrimidines/administration & dosage, Aged, Sulfonamides, Sulfonamides/administration & dosage, Manchester Cancer Research Centre, Neoadjuvant Therapy/methods, Extremities, Sarcoma, Chemoradiotherapy, Chemoradiotherapy, Adjuvant, Middle Aged, ResearchInstitutes_Networks_Beacons/mcrc, name=Manchester Cancer Research Centre, Neoadjuvant Therapy, 3. Good health, Pyrimidines, EMC MM-03-47-11, Female, EMC MM-03-86-01, Soft Tissue Neoplasms/therapy

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/25920360
https://research.manchester.ac.uk/en/publications/8d426a39-d863-4c88-8f38-2e442aadfee0
https://doi.org/10.3109/0284186X.2015.1037404
https://pure.eur.nl/en/publications/e015e207-1a5c-4578-beda-600aaf4a0b2e
https://doi.org/10.3109/0284186X.2015.1037404
https://www.research.manchester.ac.uk/portal/en/publications/a-phase-i-study-on-the-combination-of-neoadjuvant-radiotherapy-plus-pazopanib-in-patients-with-locally-advanced-soft-tissue-sarcoma-of-the-extremities(8d426a39-d863-4c88-8f38-2e442aadfee0).html
https://www.tandfonline.com/doi/full/10.3109/0284186X.2015.1037404
https://pubmed.ncbi.nlm.nih.gov/25920360/
https://europepmc.org/article/MED/25920360
https://repub.eur.nl/pub/82571
https://www.ncbi.nlm.nih.gov/pubmed/25920360
https://hdl.handle.net/1887/107931

LXR Agonist T0901317-Induced Hyperlipidemia Does Not Lead to Lipid Accumulation in the Rat Heart

Autori: Adrian Chabowski Jan Górski Piotr Zabielski a ďalší

Zdroj: Cellular Physiology and Biochemistry, Vol 35, Iss 3, Pp 1095-1106 (2015)

Predmety: Male, 0301 basic medicine, Hydrocarbons, Fluorinated, Hyperlipidemias - drug therapy, Physiology, Heart Ventricles, Hyperlipidemias, Hyperlipidemias - metabolism, QD415-436, Diet, High-Fat, Sulfonamides - administration & dosage, Liver X receptors, Biochemistry, Heart ventricles - pathology, 03 medical and health sciences, Myocardium - metabolism, QP1-981, Animals, Humans, high-fat, Fatty acids, Cardiac muscle, Liver X Receptors, Sulfonamides, 0303 health sciences, Myocardium, Heart ventricles - metabolism, Myocardium - pathology, Lipid Metabolism, Orphan Nuclear Receptors, Hydrocarbons, Diet, Rats, 3. Good health, fluorinated - administration & dosage, Cholesterol, Orphan nuclear receptors - biosynthesis, Lipid metabolism - drug effects, Diacylglycerol, Orphan nuclear receptors - agonists

Prístupová URL adresa: https://www.karger.com/Article/Pdf/373935
https://pubmed.ncbi.nlm.nih.gov/25659329
https://doaj.org/article/c61335d5129a47cfbbc21f2874b6f860
https://core.ac.uk/display/91615490
https://pubmed.ncbi.nlm.nih.gov/25659329/