Suchergebnisse - "Substrate affinity"

Exploring redox modulation of plant UDP-glucose pyrophosphorylase

Autoren: Decker, Daniel Aubert, Juliette Wilczynska, Malgorzata et al.

Quelle: International Journal of Molecular Sciences. 24(10)

Schlagwörter: carbohydrate metabolism, glutathione, hydrogen peroxide, protein structure, redox regulation, substrate affinity, UDP-glucose pyrophosphorylase

Dateibeschreibung: electronic

Zugangs-URL: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-209182
https://doi.org/10.3390/ijms24108914

Mutational Analysis and Application of a Multidomain GH157 Family Endo-β-1,3-glucanase from Bacteroides sp. M27

Autoren: Yunfan Wei Shaoqin Luo Xiasen Wei et al.

Schlagwörter: Biophysics, Biochemistry, Medicine, Microbiology, Genetics, Biotechnology, Evolutionary Biology, Inorganic Chemistry, Computational Biology, Chemical Sciences not elsewhere classified, substrate affinity experiments, soluble oligosaccharide production, calculated mutation energy, generate two mutants, effectively hydrolyze curdlan, homology analysis indicated, two potential carbohydrate, 157 family β, potential applications, gh157 family, curdlan ), structural analysis, mutational analysis, yielding β, two cbms, two c, synergistic hydrolysis, specific activity, provides insight, multidomain enzyme

Verfügbarkeit: https://doi.org/10.1021/acs.jafc.5c07576.s001
https://figshare.com/articles/journal_contribution/Mutational_Analysis_and_Application_of_a_Multidomain_GH157_Family_Endo-_-1_3-glucanase_from_Bacteroides_sp_M27/29468991

Structural Adaptations of Bacterial Grx3 to Temperature: Pro29 Is Essential for Cold Adaptation in Sphingomonas sp. Grx3

Autoren: Luyen Vu ChangWoo Lee

Schlagwörter: Biophysics, Biochemistry, Microbiology, Molecular Biology, Biotechnology, Evolutionary Biology, Inorganic Chemistry, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, varying thermal habitats, least stable mutant, enhancing substrate affinity, escherichia coli grx3, investigated cold adaptation, reciprocal f29p substitution, glu31 salt bridge, salt bridge, cold adaptation, p29y substitution, although glu31, critical adaptation, bridge due, α1 loop, structural adaptations, sphingomonas <, spgrx3 wild, spgrx3 failed, spgrx3 ), significantly enhanced

Relation: https://figshare.com/articles/journal_contribution/Structural_Adaptations_of_Bacterial_Grx3_to_Temperature_Pro29_Is_Essential_for_Cold_Adaptation_in_i_Sphingomonas_i_sp_Grx3/29149554

Verfügbarkeit: https://doi.org/10.1021/acsomega.5c03414.s001
https://figshare.com/articles/journal_contribution/Structural_Adaptations_of_Bacterial_Grx3_to_Temperature_Pro29_Is_Essential_for_Cold_Adaptation_in_i_Sphingomonas_i_sp_Grx3/29149554

Mitigating Uricase Immunogenicity through Zwitterionic Peptide Fusion for Enhanced Gout Therapy

Autoren: Zhun Bao Qingsi Li Zhaoyu Zhou et al.

Schlagwörter: Biochemistry, Physiology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Information Systems not elsewhere classified, zwitterionic peptide fusion, repeated vpkeg sequences, promising protein drug, longest zwitterionic peptide, longer zwitterionic peptides, fusing zwitterionic peptides, blood circulation time, rat gout models, mitigating uricase immunogenicity, treating gout, varying lengths, therapeutic efficacy, synthetic biology, successfully mitigated, substrate affinity, significantly limited, results show, negligible cytotoxicity, likely due, kidney functions, immunogenicity uricase

Relation: https://figshare.com/articles/journal_contribution/Mitigating_Uricase_Immunogenicity_through_Zwitterionic_Peptide_Fusion_for_Enhanced_Gout_Therapy/29083658

Verfügbarkeit: https://doi.org/10.1021/acs.langmuir.5c00829.s001
https://figshare.com/articles/journal_contribution/Mitigating_Uricase_Immunogenicity_through_Zwitterionic_Peptide_Fusion_for_Enhanced_Gout_Therapy/29083658

A Novel Perspective on the Instability of Mainstream Partial Nitrification: The Niche Differentiation of Nitrifying Guilds

Autoren: Xiaochuan Ran Tong Wang Mingda Zhou et al.

Schlagwörter: Cell Biology, Biotechnology, Ecology, Developmental Biology, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, restore system stabilization, nitrifying guilds short, microbial ecology perspective, various niche axes, mainstream pn systems, mainstream pn process, specific ecological niches, mainstream partial nitrification, partial nitrification, realized niches, novel perspective, ecological lens, niche differentiation, niche breadths, substrate affinity, standing challenge, review analyzes, oxidizing bacteria, optimized strategies, key approach, integrated solutions, factor approach, exogenous perturbations

Relation: https://figshare.com/articles/journal_contribution/A_Novel_Perspective_on_the_Instability_of_Mainstream_Partial_Nitrification_The_Niche_Differentiation_of_Nitrifying_Guilds/28887132

Verfügbarkeit: https://doi.org/10.1021/acs.est.5c01214.s001
https://figshare.com/articles/journal_contribution/A_Novel_Perspective_on_the_Instability_of_Mainstream_Partial_Nitrification_The_Niche_Differentiation_of_Nitrifying_Guilds/28887132

Protamine cleavage specificity of the avian pathogen Escherichia coli OmpT reveals two substrate-binding sites related to virulence

Autoren: Juanhua Liu Luyao Jiang Hang Wang et al.

Quelle: Front Vet Sci
Frontiers in Veterinary Science, Vol 11 (2024)

Schlagwörter: 0301 basic medicine, 0403 veterinary science, virulence, 03 medical and health sciences, avian pathogenic Escherichia coli, substrate-binding site, substrate affinity, Veterinary medicine, proteolytic activity, cleavage specificity, SF600-1100, Veterinary Science, 04 agricultural and veterinary sciences

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39301284
https://doaj.org/article/f37326ae490046bb9af6c0b24ee4bdcd

The Effects of SARS CoV-2 nsp13 Mutations on the Structure and Stability of Helicase in Chinese Isolates

Autoren: AKBULUT, Ekrem Malatya Turgut Özal University Institutional Repository

Weitere Verfasser: AKBULUT, Ekrem Malatya Turgut Özal University Institutional Repository

Quelle: European Journal of Biology, Vol 81, Iss 1, Pp 11-17 (2022)
Volume: 81, Issue: 1 11-17
European Journal of Biology

Schlagwörter: COVID19, QH301-705.5, substrate affinity, helicase, mutation, protein stability, SARS CoV-2 genome, Substrate affinity, Helicase, 3. Good health, covid19, sars cov-2 genome, Mutation, Protein stability, Biology (General)

Dateibeschreibung: application/pdf

Zugangs-URL: https://doaj.org/article/2a11f2d456764a54b51fe2e14be379b8
https://hdl.handle.net/20.500.12899/1174
https://doi.org/10.26650/eurjbiol.2022.1061858
https://dergipark.org.tr/tr/pub/iufsjb/issue/70878/1061858

Diversity and distribution of demersal deep-sea fishes on Gorringe bank

Autoren: Oliveira, Maria das Neves Tayana Santos Costa de

Schlagwörter: Gettysburg seamount, Ormonde seamount, Northeast Atlantic, Ichthyofauna, Image-based analyses, Community structure, Water Masses, Substrate affinity

Dateibeschreibung: application/pdf

Verfügbarkeit: http://hdl.handle.net/10773/40854

Stress-Induced Detoxification Enzymes in Rice Have Broad Substrate Affinity

Autoren: Vidya Niranjan Akshay Uttarkar Sujitha Dadi et al.

Quelle: ACS Omega
ACS Omega, Vol 6, Iss 4, Pp 3399-3410 (2021)

Schlagwörter: 0301 basic medicine, Chemical Sciences not elsewhere classified, substrate affinity, rice microarray studies, Biophysics, Plant Biology, ALDH, Stress-Induced Detoxification Enzymes, Biochemistry, Broad Substrate Affinity Reactive c, 03 medical and health sciences, cofactor binding, binding affinity, Genetics, silico analysis, Molecular Biology, QD1-999, 2. Zero hunger, 0303 health sciences, reactive substrates, phylogenetic relationship, RCC targets, Computational Biology, Cell Biology, rice-detoxifying protein structures, stress-specific cis, stress-responsive nature, simulation studies, carbonyl stress, Chemistry, Mental Health, Infectious Diseases, glutathione cofactor docking, study reports, nicotinamide adenine dinucleotide p, Several AKRs, stress-responsive transcription factors, detoxifying enzymes, crop improvement programs, Molecular simulations, ADH proteins, TF, Biotechnology, Biological Sciences not elsewhere classified

Zugangs-URL: https://pubs.acs.org/doi/pdf/10.1021/acsomega.0c05961
https://pubmed.ncbi.nlm.nih.gov/33553958
https://doaj.org/article/c6ad334aa66043c198a278cd90af3681
https://pubs.acs.org/doi/10.1021/acsomega.0c05961
https://www.ncbi.nlm.nih.gov/pubmed/33553958
https://europepmc.org/article/MED/33553958
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860239/
https://pubmed.ncbi.nlm.nih.gov/33553958/

Substrate affinity is not crucial for Therapeutic L-Asparaginases : antileukemic activity of novel bacterial enzymes

Autoren: Ściuk, Anna Wątor, Kinga Staroń, Izabela et al.

Schlagwörter: L-asparaginase, substrate affinity, leukemia, cell proliferation, cell apoptosis

Relation: Molecules, T. 29, nr 10; https://ruj.uj.edu.pl/handle/item/344622

Verfügbarkeit: https://ruj.uj.edu.pl/handle/item/344622
https://doi.org/10.3390/molecules29102272
https://www.mdpi.com/1420-3049/29/10/2272

Influence of Two Hexose Transporters on Substrate Affinity and Pathogenicity in Magnaporthe oryzae

Autoren: Tinghong Huang Dekang Guo Xiao Luo et al.

Quelle: Microorganisms, Vol 12, Iss 4, p 681 (2024)

Schlagwörter: hexose transporters, pathogenicity, substrate affinity, Magnaporthe oryzae, Biology (General), QH301-705.5

Relation: https://www.mdpi.com/2076-2607/12/4/681; https://doaj.org/toc/2076-2607; https://doaj.org/article/5ad77081dbfa470da1156fa7140438cb

Verfügbarkeit: https://doi.org/10.3390/microorganisms12040681
https://doaj.org/article/5ad77081dbfa470da1156fa7140438cb

Analyzing the causes of method-to-method variability among Rubisco kinetic traits: from the first to the current measurements

Autoren: Concepción Iñiguez Ülo Niinemets Kristiina Mark et al.

Quelle: RIUMA. Repositorio Institucional de la Universidad de Málaga
Universidad de Málaga

Schlagwörter: 0301 basic medicine, 0303 health sciences, Rubisco, Ribulose-Bisphosphate Carboxylase, Turnover rate, Methodology, Substrate affinity, Enzimas - Análisis, Carbon Dioxide, Kinetics, 03 medical and health sciences, Phenotype, Carboxylation, Specificity factor, oxygenation, Photosynthesis, Enzimas - Cinética

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/34329386
https://hdl.handle.net/10630/34131
https://pubmed.ncbi.nlm.nih.gov/34329386/

Modification of Substrate Affinity of Nitrile Hydratase Based on Amino Acid Hotspot Mutation

Autoren: Baocheng CUI Jiao HUANG Jiaxin LI et al.

Quelle: Shipin gongye ke-ji, Vol 43, Iss 7, Pp 148-154 (2022)

Schlagwörter: nitrile hydratase, nicotinonitrile, virtual amino acid mutation, substrate affinity, Food processing and manufacture, TP368-456

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/1002-0306

Zugangs-URL: https://doaj.org/article/fc9b530d4ae74c2b93a184532c17f897

Tyr320 is a molecular determinant of the catalytic activity of β-glucosidase from Neosartorya fischeri

Autoren: Shanmugam, Ramasamy Kim, In Won Tiwari, Manish K. et al.

Quelle: International Journal of Biological Macromolecules. 151:609-617

Schlagwörter: 0301 basic medicine, 0303 health sciences, beta-Glucosidase, Substrate affinity, MD simulation, Molecular Dynamics Simulation, Catalysis, Recombinant Proteins, β-Glucosidase, Substrate Specificity, Molecular Docking Simulation, Catalytic efficiency, Kinetics, Structure-Activity Relationship, 03 medical and health sciences, Aspergillus, π-Sigma interaction, Catalytic Domain, Tyrosine, Amino Acid Sequence, Protein Binding

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/32061700
https://pubmed.ncbi.nlm.nih.gov/32061700/
https://www.sciencedirect.com/science/article/pii/S0141813019347130
https://www.ncbi.nlm.nih.gov/pubmed/32061700
https://pubag.nal.usda.gov/catalog/6841028

Extracellular enzyme kinetics and thermodynamics along a climate gradient in southern California

Autoren: Baker, Nameer R Allison, Steven D

Schlagwörter: Climate Action, Climate gradient, Microbial decomposers, Extracellular enzymes, Substrate affinity, Temperature sensitivity, Environmental Sciences, Biological Sciences, Agricultural and Veterinary Sciences, Agronomy & Agriculture

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/2hg1p4wz
https://escholarship.org/content/qt2hg1p4wz/qt2hg1p4wz.pdf

Semi-rational design of the substrate-binding pocket of acyl-CoA dehydrogenase Tfu_1647 to improve catalytic activity for 6-carbon substrates.

Autoren: Liu, Lixia Zhou, Shenghu Deng, Yu

Quelle: J Biotechnol ; ISSN:1873-4863 ; Volume:409

Schlagwörter: Acyl-CoA dehydrogenases, Crystal structure, Semi-rational design, Substrate affinity, Substrate binding pocket

Relation: https://doi.org/10.1016/j.jbiotec.2025.10.007; https://pubmed.ncbi.nlm.nih.gov/41161642

Verfügbarkeit: https://doi.org/10.1016/j.jbiotec.2025.10.007
https://pubmed.ncbi.nlm.nih.gov/41161642

Investigation of changes in protein stability and substrate affinity of 3CL-protease of SARS-CoV-2 caused by mutations

Autoren: Ekrem Akbulut Malatya Turgut Özal University Institutional Repository

Weitere Verfasser: Ekrem Akbulut Malatya Turgut Özal University Institutional Repository

Quelle: Genet Mol Biol
Genetics and Molecular Biology, Vol 45, Iss 2 (2022)
Genetics and Molecular Biology v.45 n.2 2022
Genetics and Molecular Biology
Sociedade Brasileira de Genética (SBG)
instacron:SBG
Genetics and Molecular Biology, Volume: 45, Issue: 2, Article number: e20210404, Published: 29 APR 2022

Schlagwörter: 0301 basic medicine, 3CL-protease, substrate affinity, Substrate affinity, QH426-470, 3. Good health, Genomics and Bioinformatics, 03 medical and health sciences, Mutation analysis, protein stability, Protein stability, Genetics, SARS-CoV-2 genome, mutation analysis

Dateibeschreibung: application/pdf; text/html

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/35499274
https://doaj.org/article/88ba531608ea451fb96301816710b405
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000200801
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000200801&lng=en&tlng=en

Substrate-Binding Sites in Fungal Oligopeptide Transporters AreHighly Conserved Among Distant Groups of Yeasts and FilamentousFungi

Autoren: Becerra-Rodríguez, Carmen Devillers, Hugo Soares-Silva, Isabel et al.

Weitere Verfasser: Becerra-Rodríguez, Carmen Devillers, Hugo Soares-Silva, Isabel et al.

Schlagwörter: [SDV] Life Sciences [q-bio], peptides transporters, substrate affinity, Wine fermentations, yeast

Zugangs-URL: https://hal.inrae.fr/hal-04177015v1

Stress-Induced Detoxification Enzymes in Rice Have Broad Substrate Affinity

Autoren: Vidya Niranjan (383699) Akshay Uttarkar (8429202) Sujitha Dadi (10009102) et al.

Schlagwörter: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Biotechnology, Mental Health, Infectious Diseases, Plant Biology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, ALDH, glutathione cofactor docking, substrate affinity, study reports, detoxifying enzymes, carbonyl stress, phylogenetic relationship, stress-responsive transcription factors, ADH proteins, Molecular simulations, reactive substrates, Broad Substrate Affinity Reactive c., stress-specific cis, RCC targets, cofactor binding, rice-detoxifying protein structures, Several AKRs, binding affinity

Relation: https://figshare.com/articles/journal_contribution/Stress-Induced_Detoxification_Enzymes_in_Rice_Have_Broad_Substrate_Affinity/13614097

Verfügbarkeit: https://doi.org/10.1021/acsomega.0c05961.s001

Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation

Weitere Verfasser: Moriyama, Hideaki [Univ. of Nebraska, Lincoln, NE (United States)]

Quelle: BMC Research Notes; 8; 1

Dateibeschreibung: Medium: ED; Size: Article No. 784 (2015)

Zugangs-URL: http://www.osti.gov/scitech/servlets/purl/1241070