Search Results - "Substrate Specificity/drug effects"
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1
Authors: et al.
Contributors: et al.
Source: Nature
Subject Terms: Male, Nociception, 0301 basic medicine, Sensory Receptor Cells, Spiders/chemistry, Pain, Spider Venoms, Article, Substrate Specificity, Irritable Bowel Syndrome, 03 medical and health sciences, Nerve Fibers, Pain/chemically induced, Ganglia, Sensory, Irritable Bowel Syndrome/metabolism, Nociception/drug effects, Animals, Myelin Sheath, Myelin Sheath/metabolism, Ganglia, Sensory/cytology, 0303 health sciences, Spider Venoms/pharmacology, Oocytes/metabolism, Temperature, Nociceptors, Spiders, Nociceptors/drug effects, NAV1.1 Voltage-Gated Sodium Channel/chemistry, FoR multidisciplinary, Protein Structure, Tertiary, Multidisciplinary Sciences, NAV1.1 Voltage-Gated Sodium Channel, Disease Models, Animal, Hyperalgesia/chemically induced, Hyperalgesia, 1000 General, Oocytes, Science & Technology - Other Topics, Female, Stress, Mechanical, Sensory Receptor Cells/drug effects, Nerve Fibers/drug effects, Substrate Specificity/drug effects
Access URL: https://europepmc.org/articles/pmc4919188?pdf=render
https://pubmed.ncbi.nlm.nih.gov/27281198
https://digital.library.adelaide.edu.au/dspace/handle/2440/101733
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919188
https://www.nature.com/articles/nature17976.pdf
https://www.ncbi.nlm.nih.gov/pubmed/27281198
https://nature.com/articles/nature17976.epdf?referrer_access_token=avj5KASpApHH5YpcYnRUMdRgN0jAjWel9jnR3ZoTv0PnbDpLZvZyO7j9JLKLXaI2oNdGRrSC5_6q4OPzEVBy8hJFaHbwqwmlz7bx16EsmY6A05sUJ86PAr_bQy_yO0XPN_qBcHW3CkHievIjrhR6eGB_j9ZtuY2EOLtO1RhAzjrzB3AfeplAGlUmkYAyUcUOw8ErpecAO3oZpmHrfDDYTdcimNc1HBq0ZCWem4P6oGLzud4kNxS3O68OV5nxkNAm&tracking_referrer=www.theguardian.com
https://jhu.pure.elsevier.com/en/publications/selective-spider-toxins-reveal-a-role-for-the-nasubvsub11-channel
https://biblio.vub.ac.be/vubir/selective-spider-toxins-reveal-a-role-for-the-nav11-channel-in-mechanical-pain(fe3f9e35-f7f3-4ae0-87b8-976305e1d886).html -
2
Authors: et al.
Source: The Journal of Pharmacology and Experimental Therapeutics. 351:576-584
Subject Terms: Adult, Male, Microsomes - enzymology, Loperamide, Biomarkers - blood, Substrate Specificity, Beverages, Food-Drug Interactions, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Substrate Specificity - physiology, Microsomes, Substrate Specificity - drug effects, Cytochrome P-450 CYP3A, Humans, Prospective Studies, Food-Drug Interactions - physiology, Cross-Over Studies, Loperamide - administration & dosage, Middle Aged, 3. Good health, Cytochrome P-450 CYP3A - metabolism, 13. Climate action, Female, Loperamide - blood, Microsomes - drug effects, Biomarkers, Citrus paradisi, Forecasting
Access URL: https://europepmc.org/articles/pmc4244582?pdf=render
https://pubmed.ncbi.nlm.nih.gov/25253884
https://www.ncbi.nlm.nih.gov/pubmed/25253884
https://pubmed.ncbi.nlm.nih.gov/25253884/
https://jpet.aspetjournals.org/content/351/3/576
https://jpet.aspetjournals.org/content/351/3/576.full.pdf
http://europepmc.org/articles/PMC4244582 -
3
Authors: et al.
Source: Mol Biol Cell
Timmerman, I, Hoogenboezem, M, Bennett, A M, Geerts, D, Hordijk, P L & Van Buul, J D 2012, 'The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation', Molecular Biology of the Cell, vol. 23, no. 21, pp. 4212-4225. https://doi.org/10.1091/mbc.E12-01-0038Subject Terms: Adherens Junctions/drug effects, 0301 basic medicine, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Cadherins/metabolism, Phosphotyrosine/metabolism, Substrate Specificity, 03 medical and health sciences, Antigens, CD, rhoA GTP-Binding Protein/metabolism, Chlorocebus aethiops, Electric Impedance, Human Umbilical Vein Endothelial Cells, Animals, Humans, Gene Silencing, Antigens, Phosphorylation, Phosphotyrosine, cdc42 GTP-Binding Protein, cdc42 GTP-Binding Protein/metabolism, Non-Receptor Type 11/metabolism, beta Catenin, Gene Silencing/drug effects, 0303 health sciences, CD/metabolism, Thrombin, Phosphorylation/drug effects, Endothelial Cells, Articles, Adherens Junctions, rac1 GTP-Binding Protein/metabolism, Cadherins, beta Catenin/metabolism, Enzyme Activation, HEK293 Cells, COS Cells, Enzyme Activation/drug effects, Protein Tyrosine Phosphatase, Thrombin/pharmacology, Endothelial Cells/cytology, Substrate Specificity/drug effects
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4
Authors: et al.
Contributors: et al.
Source: Bioresource Technology. 123:636-645
Subject Terms: Laccase/metabolism, Yarrowia/enzymology, 0106 biological sciences, 0301 basic medicine, Evolution, Molecular Sequence Data, Oryza/chemistry, Cellulase/metabolism, Peptides/chemistry, Metals/pharmacology, 01 natural sciences, Substrate Specificity, Phenols/isolation & purification, Evolution, Molecular, 03 medical and health sciences, Yarrowia/isolation & purification, Cellulase, Phenols, Waste Products/analysis, Amino Acid Sequence, Enzyme Inhibitors, Hydrolysis/drug effects, Phylogeny, Enzyme Inhibitors/pharmacology, Ions, Waste Products, Hydrolysis, Laccase, Molecular, Reproducibility of Results, Oryza, Carbohydrate Metabolism/drug effects, Enzyme Activation, Kinetics, Environmental/drug effects, Biodegradation, Environmental, Metals, Biodegradation, Carbohydrate Metabolism, Enzyme Activation/drug effects, Peptides, Laccase/isolation & purification, Substrate Specificity/drug effects
Access URL: https://pubmed.ncbi.nlm.nih.gov/22960123
https://www.sciencedirect.com/science/article/pii/S0960852412011133
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158378
https://www.ncbi.nlm.nih.gov/pubmed/22960123
https://orbit.dtu.dk/en/publications/enhanced-enzymatic-hydrolysis-of-rice-straw-by-removal-of-phenolic-compounds-using-a-novel-laccase-from-yeast-yarrowia-lipolytica(43fc26b3-8183-49cd-8426-de6df47133dd).html
https://pubmed.ncbi.nlm.nih.gov/22960123/
https://orbit.dtu.dk/en/publications/enhanced-enzymatic-hydrolysis-of-rice-straw-by-removal-of-phenoli -
5
Authors: et al.
Source: Biochemical Journal. 431:267-275
Subject Terms: Male, 0301 basic medicine, Insulin/pharmacology, Mutation/genetics, Phosphofructokinase-2, Mice, Transgenic, Protein Serine-Threonine Kinases, Biochimie, biophysique & biologie moléculaire, Cell Line, Mice, 03 medical and health sciences, Myocytes, Cardiac/drug effects/enzymology, Animals, Humans, Insulin, Myocytes, Cardiac, Rats, Wistar, Protein Kinase Inhibitors, Organ Specificity/drug effects, 0303 health sciences, Binding Sites, Myocardium, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Proto-Oncogene Proteins c-akt/antagonists & inhibitors/deficiency/metabolism, Protein-Serine-Threonine Kinases/metabolism, Myocardium/cytology/enzymology, Life sciences, Rats, 3. Good health, Enzyme Activation, Phosphofructokinase-2/metabolism, Organ Specificity, Protein Kinase Inhibitors/pharmacology, Mutation, Sciences du vivant, Enzyme Activation/drug effects, Cattle, Proto-Oncogene Proteins c-akt, Substrate Specificity/drug effects, Biochemistry, biophysics & molecular biology
Access URL: https://hal.archives-ouvertes.fr/hal-00521560/file/PEER_stage2_10.1042%252FBJ20101089.pdf
https://pubmed.ncbi.nlm.nih.gov/20687898
http://www.tara.tcd.ie/bitstream/2262/45583/1/PEER_stage2_10.1042%252FBJ20101089.pdf
https://www.ncbi.nlm.nih.gov/pubmed/20687898
https://portlandpress.com/biochemj/article/431/2/267/45301/Heart-6phosphofructo2kinase-activation-by-insulin
https://dial.uclouvain.be/pr/boreal/object/boreal:34995
https://orbi.uliege.be/handle/2268/78031
https://europepmc.org/abstract/MED/20687898
https://hdl.handle.net/2268/78031
https://doi.org/10.1042/BJ20101089 -
6
Authors: et al.
Contributors: et al.
Source: Journal of Biotechnology. 147:7-16
Subject Terms: Electrophoresis, 0301 basic medicine, Mutation/genetics, Sodium Chloride/pharmacology, Thermolysin, Thermolysin/genetics, Sodium Chloride, Mutagenesis/genetics, Transformation, Substrate Specificity, Mutant Proteins/metabolism, Mutational combination, 03 medical and health sciences, Transformation, Genetic, Subcellular Fractions/metabolism, Activity–stability relationship, Enzyme Stability, Mutant Proteins/isolation & purification, Escherichia coli, Mutagenesis/drug effects, Hydrolysis/drug effects, Thermolysin/isolation & purification, Site-directed mutagenesis, Genetic/drug effects, 0303 health sciences, Polyacrylamide Gel, Enzyme Stability/drug effects, Thermolysin/metabolism, Hydrolysis, Temperature, Caseins, Thermal stability, Subcellular Fractions/drug effects, Dipeptides, Acrylates/metabolism, Thermolysin/chemistry, Enzyme Activation, Kinetics, Dipeptides/metabolism, Acrylates, Mutagenesis, Mutation, Enzyme Activation/drug effects, Electrophoresis, Polyacrylamide Gel, Mutant Proteins, Caseins/metabolism, Substrate Specificity/drug effects, Subcellular Fractions
File Description: application/pdf
Access URL: https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/128776/1/j.jbiotec.2010.02.024.pdf
https://pubmed.ncbi.nlm.nih.gov/20214932
https://core.ac.uk/display/39257747
https://www.sciencedirect.com/science/article/pii/S0168165610001112
https://pubmed.ncbi.nlm.nih.gov/20214932/
https://www.ncbi.nlm.nih.gov/pubmed/20214932
http://ci.nii.ac.jp/naid/120002511254
https://europepmc.org/article/MED/20214932 -
7
Authors: et al.
Source: Biochemistry. 48:1712-1722
Subject Terms: Models, Molecular, 0301 basic medicine, Mutant Proteins: metabolism, Escherichia coli: enzymology, Fatty Acid Synthetase Complex: metabolism, Crystallography, X-Ray, Substrate Specificity, Thiolester Hydrolases: metabolism, Hydrolysis: drug effects, Models, Escherichia coli Proteins: chemistry, Catalytic Domain, Hydroxybenzoates, Site-Directed, Amino Acids: metabolism, Amino Acids, Thiolester Hydrolases: chemistry, 0303 health sciences, Crystallography, Escherichia coli Proteins, Hydrolysis, Temperature, Hydrogen-Ion Concentration, 3. Good health, Mutant Proteins: chemistry, Ribosomes: metabolism, Protein Structure, Escherichia coli: drug effects, Enterobactin, Quaternary, 03 medical and health sciences, Escherichia coli, Escherichia coli Proteins: metabolism, Protein Structure, Quaternary, Hydroxybenzoic Acids: pharmacology, Molecular, Substrate Specificity: drug effects, Protein Structure, Tertiary, Kinetics, Mutagenesis, X-Ray, Mutagenesis, Site-Directed, Ribosomes: drug effects, Mutant Proteins, Thiolester Hydrolases, Fatty Acid Synthases, Enterobactin: biosynthesis, Hydrogen-Ion Concentration: drug effects, Ribosomes, Tertiary
Access URL: https://pubmed.ncbi.nlm.nih.gov/19193103
https://www.ncbi.nlm.nih.gov/pubmed/19193103
https://jhu.pure.elsevier.com/en/publications/preferential-hydrolysis-of-aberrant-intermediates-by-the-type-ii-
http://repository.ust.hk/ir/Record/1783.1-30828
https://core.ac.uk/display/34026367
https://pubs.acs.org/doi/10.1021/bi802165x
https://europepmc.org/abstract/MED/19193103 -
8
Authors: et al.
Source: Biochemical and biophysical research communications 366, 994-1000 (2008). doi:10.1016/j.bbrc.2007.12.061
Subject Terms: 0301 basic medicine, Enzyme Inhibitors: pharmacology, Protein Folding, Protein Conformation, Adenosine Diphosphate: pharmacology, Magnesium: pharmacology, Substrate Specificity, Adenosine Triphosphate: biosynthesis, 03 medical and health sciences, Adenosine Diphosphate: chemistry, Adenosine Triphosphate, X-Ray Diffraction, Enzyme Stability, Scattering, Small Angle, Humans, Magnesium, Sulfhydryl Compounds, Enzyme Inhibitors, Phosphoglycerate Kinase: antagonists & inhibitors, Protein Conformation: drug effects, 0303 health sciences, Phosphoglycerate Kinase: chemistry, Adenosine Diphosphate: metabolism, glycerate 1,3-biphosphate, Sulfhydryl Compounds: metabolism, Diphosphoglyceric Acids: metabolism, Stereoisomerism, Diphosphoglyceric Acids, Substrate Specificity: drug effects, Adenosine Diphosphate, Kinetics, Phosphoglycerate Kinase, Enzyme Stability: drug effects, Phosphoglycerate Kinase: metabolism, Protein Binding
Access URL: https://pubmed.ncbi.nlm.nih.gov/18096512
https://europepmc.org/abstract/MED/18096512
https://www.ncbi.nlm.nih.gov/pubmed/18096512
https://www.sciencedirect.com/science/article/pii/S0006291X07026885
https://hal.archives-ouvertes.fr/hal-00257625
http://www.sciencedirect.com/science/article/pii/S0006291X07026885
https://dumas.ccsd.cnrs.fr/IBMM/hal-00257625v1
https://bib-pubdb1.desy.de/record/86749 -
9
Authors: et al.
Source: FEBS Letters. 280:147-151
Subject Terms: S-Adenosyl-methionine, S-Adenosylmethionine, Site-Specific DNA-Methyltransferase (Adenine-Specific), Enzyme Stability/drug effects, Hot Temperature, Ultraviolet Rays, Sinefungin, Methyltransferases/metabolism, Methyltransferases, Binding, S-Adenosylmethionine/metabolism, Binding, Competitive, Substrate Specificity, Cross-Linking Reagents/metabolism, Enzyme Activation, Dam methylase, Cross-Linking Reagents, Competitive, Endopeptidases/pharmacology, Proteolysis, Endopeptidases, Enzyme Stability, Substrate Specificity/drug effects, Photocrosslinking
Access URL: https://pubmed.ncbi.nlm.nih.gov/2009958
https://www.sciencedirect.com/science/article/pii/001457939180224Q
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2891%2980224-Q
http://www.sciencedirect.com/science/article/pii/001457939180224Q
https://www.ncbi.nlm.nih.gov/pubmed/2009958
https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2891%2980224-Q -
10
Authors: et al.
Source: ISSN: 1932-6203 ; PloS one, vol. 5, no. 5 (2010) e10575.
Subject Terms: info:eu-repo/classification/ddc/616, Adaptor Proteins, Signal Transducing/metabolism, Cell Line, Tumor, Enzyme Activation/drug effects, Eukaryotic Initiation Factor-2/metabolism, Hepacivirus/drug effects/*immunology, Hepatitis C/immunology/virology, Humans, Interferons/*biosynthesis, Kinetics, Models, Immunological, Phosphorylation/drug effects, Protein Biosynthesis, Protein Kinase Inhibitors/pharmacology, Substrate Specificity/drug effects, Time Factors, Transcription Factors/metabolism, Ubiquitin-Protein Ligases/metabolism, EIF-2 Kinase/antagonists & inhibitors/*metabolism
Relation: info:eu-repo/semantics/altIdentifier/pmid/20485506; unige:20602
Availability: https://archive-ouverte.unige.ch/unige:20602
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11
Contributors: et al.
Source: T200906171.pdf
Subject Terms: Amino Acid Substitution/drug effects, Cell Movement/drug effects, Fatty Acids/metabolism, Humans, Hydrolysis/drug effects, Immunoblotting, Kinetics, Lysophospholipids/pharmacology, Multienzyme Complexes/genetics, Multienzyme Complexes/metabolism, Mutant Proteins/genetics, Mutant Proteins/metabolism, Phosphodiesterase I/genetics, Phosphodiesterase I/metabolism, Phosphoric Diester Hydrolases, Point Mutation/genetics, Pyrophosphatases/genetics, Pyrophosphatases/metabolism, Substrate Specificity/drug effects, Histidine Residue, Artificial Substrate, Migration Response, Choline Oxidase, A2058 Human Melanoma Cell
Relation: LIPIDS IN HEALTH AND DISEASE; J02169; https://ir.ymlib.yonsei.ac.kr/handle/22282913/106060; T200906171; LIPIDS IN HEALTH AND DISEASE, Vol.8 : 4, 2009
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12
Authors: et al.
Source: PLoS One
PLoS ONE, Vol 8, Iss 1, p e53533 (2013)
Kristensen, J M, Larsen, S, Helge, J W, Dela, F & Wojtaszewski, J 2013, ' Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice ', P L o S One, vol. 8, no. 1, e53533 . https://doi.org/10.1371/journal.pone.0053533
Kristensen, J M, Larsen, S, Helge, J W, Dela, F & Wojtaszewski, J F P 2013, ' Two Weeks of Metformin Treatment Enhances Mitochondrial Respiration in Skeletal Muscle of AMPK Kinase Dead but Not Wild Type Mice ', P L o S One, vol. 8, no. 1, e53533 . https://doi.org/10.1371/journal.pone.0053533Subject Terms: 0301 basic medicine, Mitochondrial Proteins/metabolism, Science, ACTIVATED PROTEIN-KINASE SPRAGUE-DAWLEY RATS INSULIN-RESISTANCE GLUCOSE-UPTAKE COMPLEX-I EXERCISE EXPRESSION BIOGENESIS MECHANISM GLUT4, Blotting, Western, Cell Respiration, AMP-Activated Protein Kinases/metabolism, Pyruvate Dehydrogenase Complex, Pyruvate Dehydrogenase Complex/metabolism, Citrate (si)-Synthase, AMP-Activated Protein Kinases, Inbred C57BL, 3-Hydroxyacyl CoA Dehydrogenases/metabolism, Substrate Specificity, Cytochromes c/metabolism, Electron Transport, Mitochondrial Proteins, Mice, Phosphoserine, 03 medical and health sciences, Metformin/administration & dosage, Cell Respiration/drug effects, Animals, Phosphorylation, Muscle, Skeletal, Phosphoserine/metabolism, Skeletal/drug effects, 0303 health sciences, Blotting, Phosphorylation/drug effects, 3-Hydroxyacyl CoA Dehydrogenases, Cytochromes c, Mitochondria/drug effects, Metformin, Mitochondria, 3. Good health, Mice, Inbred C57BL, Muscle, Medicine, Female, Muscle, Skeletal/drug effects, Citrate (si)-Synthase/metabolism, Western, Electron Transport/drug effects, Substrate Specificity/drug effects, Research Article
File Description: application/pdf
Access URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0053533&type=printable
https://pubmed.ncbi.nlm.nih.gov/23341947
https://doaj.org/article/265ff3b51ed54a058260c1dd9026c6fd
https://core.ac.uk/display/50697936
https://dx.plos.org/10.1371/journal.pone.0053533
https://paperity.org/p/60994392/two-weeks-of-metformin-treatment-enhances-mitochondrial-respiration-in-skeletal-muscle-of
http://ui.adsabs.harvard.edu/abs/2013PLoSO...853533K/abstract
http://europepmc.org/articles/PMC3544921
https://static-curis.ku.dk/portal/files/123726982/Two_Weeks_of_Metformin_Treatment_Enhances_....pdf
https://curis.ku.dk/ws/files/123726982/Two_Weeks_of_Metformin_Treatment_Enhances_....pdf
https://portal.findresearcher.sdu.dk/da/publications/490befda-7ef7-4d41-89d6-1b18bb5dc383
https://portal.findresearcher.sdu.dk/da/publications/490befda-7ef7-4d41-89d6-1b18bb5dc383
https://doi.org/10.1371/journal.pone.0053533 -
13
Authors: et al.
Source: Arteriosclerosis, Thrombosis, and Vascular Biology
Subject Terms: Adolescent, Adult, Angiotensin I/metabolism, Angiotensin II/*metabolism/physiology, Angiotensin-Converting Enzyme Inhibitors/pharmacology, Captopril/pharmacology, Comparative Study, Coronary Vessels/drug effects/*enzymology/*metabolism, Extracellular Space/chemistry, Female, Humans, In Vitro, Isotonic Solutions, Male, Middle aged, Oligopeptides/pharmacology, Peptidyl-Dipeptidase A/*metabolism, Perfusion, Serine Endopeptidases/*metabolism, Serine Proteinase Inhibitors/pharmacology, Substrate Specificity/drug effects, Vasoconstriction/physiology
File Description: application/pdf
Relation: https://repub.eur.nl/pub/10104; urn:hdl:1765/10104
Availability: https://repub.eur.nl/pub/10104
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14
Authors:
Index Terms: Activity-stability relationship, Mutational combination, Site-directed mutagenesis, Thermal stability, Thermolysin, Acrylates/metabolism, Caseins/metabolism, Dipeptides/metabolism, Electrophoresis, Polyacrylamide Gel, Enzyme Activation/drug effects, Enzyme Stability/drug effects, Escherichia coli, Hydrolysis/drug effects, Kinetics, Mutagenesis/drug effects, Mutagenesis/genetics, Mutant Proteins/isolation & purification, Mutant Proteins/metabolism, Mutation/genetics, Sodium Chloride/pharmacology, Subcellular Fractions/drug effects, Subcellular Fractions/metabolism, Substrate Specificity/drug effects, Temperature, Thermolysin/chemistry, Thermolysin/genetics, Thermolysin/isolation & purification, Thermolysin/metabolism, Transformation, Genetic/drug effects, Journal Article., AM.
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