Výsledky vyhľadávania - "Statistical Methods in Clinical Trials and Drug Development"

Recurrent Gleason Score 6 Prostate Cancer After Radiotherapy or Ablation: Should We Observe Them All? Results from a Large Multicenter Salvage Radical Prostatectomy Consortium

Autori: Giancarlo Marra Giorgio Calleris Francesca Conte a ďalší

Zdroj: European Urology Focus. 10:461-468

Predmety: Male, Ablation Techniques, Pulmonary and Respiratory Medicine, Statistics and Probability, Biopsy, Urology, External beam radiotherapy, GUIDELINES, DIAGNOSIS, DISEASE, Metastasis, Advancements in Prostate Cancer Research, Recurrence, TOMOGRAPHY, Salvage radical prostatectomy, Health Sciences, FOS: Mathematics, Humans, Metastatic Prostate Cancer, Gleason score 6, Prostate cancer, Internal medicine, Retrospective Studies, Aged, Cancer, RISK, Salvage Therapy, Prostatectomy, Science & Technology, Prostate Cancer, 3202 Clinical sciences, Prostatic Neoplasms, Prostate Cancer Research and Treatment, 1103 Clinical Sciences, Urology & Nephrology, Middle Aged, 3. Good health, Radiation therapy, Oncology, Physical Sciences, PATTERNS, BIOPSY, Medicine, Neoplasm Grading, Neoplasm Recurrence, Local, Life Sciences & Biomedicine, Statistical Methods in Clinical Trials and Drug Development, Mathematics

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37704503
https://www.eu-focus.europeanurology.com/action/showPdf?pii=S2405-4569(23)00194-3
https://doi.org/10.1016/j.euf.2023.08.007
https://lirias.kuleuven.be/handle/20.500.12942/731690
https://doi.org/10.1016/j.euf.2023.08.007
https://hdl.handle.net/2318/2035372
https://doi.org/10.1016/j.euf.2023.08.007

Gaussian Copula Regression Modeling for Marker Classification Metrics with Competing Risk Outcomes

Autori: Alejandro Román Vásquez Gabriel Escarela Hortensia Reyes-Cervantes a ďalší

Zdroj: International Journal of Mathematics and Mathematical Sciences, Vol 2024 (2024)

Predmety: Statistics and Probability, Statistics, Covariate, Logistic regression, Receiver operating characteristic, Regularization and Variable Selection Methods, Accelerated failure time model, 01 natural sciences, 3. Good health, FOS: Economics and business, 03 medical and health sciences, 0302 clinical medicine, Methods for Handling Missing Data in Statistical Analysis, Parametric statistics, Physical Sciences, QA1-939, FOS: Mathematics, Logit, Copula (linguistics), Econometrics, 0101 mathematics, Covariance Estimation, Mathematics, Statistical Methods in Clinical Trials and Drug Development, Censoring (clinical trials)

Popis súboru: text/xhtml

Prístupová URL adresa: https://doaj.org/article/fbca68d841ef4108881960d85597cfe3

Influence of reduced centrifugation time on clinical chemistry analytes and literature review

Autori: Piraya Tantisaranon Kanyarat Dumkengkhachornwong Areerat Hnoonual

Zdroj: Türk Biyokimya Dergisi, Vol 48, Iss 4, Pp 376-387 (2023)

Predmety: Statistics and Probability, Physiology, Social Sciences, Centrifugation, QD415-436, clinical chemistry analyte, Biochemistry, Decision Sciences, Analyte, Health Sciences, FOS: Mathematics, centrifugation time, plasma, turnaround time, Laboratory Quality Management, Chromatography, relative centrifugal force, Physics, Laboratory Medicine and Testing Procedures, 6. Clean water, 3. Good health, Chemistry, Separator (oil production), Methods for Evidence Synthesis in Research, FOS: Biological sciences, Physical Sciences, Medicine, Thermodynamics, Statistics, Probability and Uncertainty, Statistical Methods in Clinical Trials and Drug Development, Mathematics

Prístupová URL adresa: https://doaj.org/article/6db6320f9d0b4fb1b55dc7dd023fc890

Consensus on safety management of novel hormonal therapy for advanced prostate cancer

Autori: Shufen Han Shinta Cheng Degang Ding a ďalší

Zdroj: UroPrecision. 1:53-71

Predmety: 0301 basic medicine, Pulmonary and Respiratory Medicine, Statistics and Probability, Cancer Research, Nursing, FOS: Health sciences, Lipid Metabolism in Cancer Pathogenesis, Adverse effect, 03 medical and health sciences, 0302 clinical medicine, Advancements in Prostate Cancer Research, Biochemistry, Genetics and Molecular Biology, Health Sciences, FOS: Mathematics, Metastatic Prostate Cancer, Intensive care medicine, Internal medicine, Cancer, Prostate cancer, Quality of life (healthcare), Prostate Cancer, Life Sciences, 3. Good health, Oncology, Physical Sciences, Hormone Therapy, Medicine, Statistical Methods in Clinical Trials and Drug Development, Mathematics, Hormonal therapy

What is a Randomization Test?

Autori: Yao Zhang Qingyuan Zhao

Zdroj: Journal of the American Statistical Association. 118:2928-2942

Predmety: Statistics and Probability, FOS: Computer and information sciences, Test (biology), Regularization and Variable Selection Methods, Randomization, 01 natural sciences, Methodology (stat.ME), Health Sciences, 0502 economics and business, FOS: Mathematics, Psychology, 0101 mathematics, Integration of Traditional Medicine and Modern Science, Biology, Internal medicine, Statistics - Methodology, 05 social sciences, Paleontology, Computer science, FOS: Psychology, 62G10, 62B15, Complementary and alternative medicine, Randomized controlled trial, Physical Sciences, Medicine, Restricted randomization, Statistical Methods in Clinical Trials and Drug Development, Mathematics

Prístupová URL adresa: http://arxiv.org/abs/2203.10980

On The Use of Analysis of Variance under Unequal group variances

Autori: Adekunle Omotayo Abidoye Egburonu O. D

Zdroj: East Asian Journal of Multidisciplinary Research. 2:1079-1084

Predmety: Statistics and Probability, Variance inflation factor, Variance decomposition of forecast errors, One-way analysis of variance, FOS: Economics and business, Statistical hypothesis testing, Variance (accounting), Artificial Intelligence, Accounting, FOS: Mathematics, Levene's test, Business, Econometrics, Inductive Modeling in Scientific Research, Analysis of variance, Statistic, Multiple Testing, Chromatography, Homogeneity (statistics), Sample (material), 4. Education, Statistics, 16. Peace & justice, Chemistry, Test statistic, Computer Science, Physical Sciences, F-test of equality of variances, Multicollinearity, Regression analysis, Mathematics, Statistical Methods in Clinical Trials and Drug Development, Detection and Handling of Multicollinearity in Regression Analysis

One-compartment stochastic pharmacokinetic model

Autori: Ricardo Cano Macias José Alfredo Jiménez Moscoso Jorge Mauricio Ruiz Vera

Zdroj: Universitas Scientiarum, Vol 28, Iss 1, Pp 23-41 (2023)

Predmety: Statistics and Probability, Science (General), Laplace transform, Computational Mechanics, Poaceae, Mathematical analysis, Q1-390, Engineering, Variance (accounting), pk model, Accounting, FOS: Mathematics, Pharmacokinetics, Business, Pharmacokinetic/Pharmacodynamic Modeling, Biology, Mathematical Modeling of Cancer Growth and Treatment, Pharmacology, itô's lemma, Ecology, Mathematical optimization, Applied mathematics, Thermophoresis and Thermodiffusion Studies, Lemma (botany), Modeling and Simulation, FOS: Biological sciences, Physical Sciences, Medicine, analytic solutions, stochastic differential equations, Mathematics, Statistical Methods in Clinical Trials and Drug Development

Prístupová URL adresa: https://doaj.org/article/d53b8a1964b74fe88702c1c3f53bf939

A commentary on establishing a local centre of excellence for research and training in pharmacometrics: Lessons from the pharmacometrics Africa–Uganda chapter

Autori: Letisha Najjemba Aida Nakayiwa Kawuma Francis Williams Ojara a ďalší

Zdroj: Br J Clin Pharmacol

Predmety: Statistics and Probability, Medical education, Physiology, FOS: Political science, Immunology, FOS: Law, Immunogenicity of Biosimilar Therapeutics in Drug Development, Engineering ethics, Engineering, Health Sciences, FOS: Mathematics, Humans, Uganda, Pharmacokinetic/Pharmacodynamic Modeling, Political science, Immunology and Microbiology, FOS: Clinical medicine, Laboratory Medicine and Testing Procedures, Life Sciences, Mentorship, Computer science, Process (computing), 3. Good health, Operating system, FOS: Biological sciences, Pharmacology, Clinical, Physical Sciences, Commentary, Medicine, Excellence, Law, Statistical Methods in Clinical Trials and Drug Development, Mathematics

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37417585

Statistical Inference of the Class of Nonparametric Tests for the Panel Count and Current Status Data from the Perspective of the Saddlepoint Approximation

Autori: Abd El-Raheem M. Abd El-Raheem Mona Hosny Ehab F. Abd‐Elfattah

Zdroj: Journal of Mathematics, Vol 2023 (2023)

Predmety: Statistics and Probability, Artificial intelligence, Nonparametric statistics, Statistics, Mathematical optimization, Regularization and Variable Selection Methods, Applied mathematics, Computer science, 01 natural sciences, Statistical hypothesis testing, FOS: Economics and business, Methods for Handling Missing Data in Statistical Analysis, Inference, Physical Sciences, QA1-939, FOS: Mathematics, Poisson distribution, Econometrics, Statistical Methods, 0101 mathematics, Mathematics, Statistical Methods in Clinical Trials and Drug Development, Statistical inference, Count data

Popis súboru: text/xhtml

Prístupová URL adresa: https://doaj.org/article/703966dff939434f85ffccc4afdd9962

A proof of concept reinforcement learning based tool for non parametric population pharmacokinetics workflow optimization

Autori: Julian D. Otalvaro Walter M. Yamada A. M. Hernández a ďalší

Zdroj: J Pharmacokinet Pharmacodyn

Predmety: Statistics and Probability, Artificial intelligence, Population, Mathematical analysis, 7. Clean energy, Workflow, Database, 03 medical and health sciences, 0302 clinical medicine, Sociology, Artificial Intelligence, Biochemistry, Genetics and Molecular Biology, Reinforcement learning, Machine learning, FOS: Mathematics, Inductive Modeling in Scientific Research, Pharmacokinetic/Pharmacodynamic Modeling, Molecular Biology, Probability, Demography, Original Paper, 4. Education, Mathematical optimization, Statistics, Life Sciences, Inductive Modeling, Computer science, FOS: Sociology, 3. Good health, Stochasticity in Gene Regulatory Networks, Parametric statistics, Physical Sciences, Computer Science, Reinforcement, Psychology, State space, Algorithms, Statistical Methods in Clinical Trials and Drug Development, Mathematics, Discretization

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36478350

Method evaluation in the clinical laboratory

Autori: Tze Ping Loh Brian R. Cooke C. Markus a ďalší

Zdroj: Clinical Chemistry and Laboratory Medicine (CCLM). 61:751-758

Predmety: Statistics and Probability, Clinical Laboratory Guidelines, Physiology, Social Sciences, Research Methodology, Epistemology, Decision Sciences, 03 medical and health sciences, Engineering, 0302 clinical medicine, Health Sciences, FOS: Mathematics, Pathology, Humans, Medical laboratory, Good laboratory practice, Laboratory Quality Management, Clinical Laboratory Techniques, Laboratory Medicine and Testing Procedures, Linguistics, Clinical Laboratory Services, Terminology, Computer science, Quality assurance, External quality assessment, Management science, FOS: Philosophy, ethics and religion, 3. Good health, Philosophy, Methods for Evidence Synthesis in Research, FOS: Biological sciences, Physical Sciences, Quality (philosophy), FOS: Languages and literature, Medicine, Medical physics, Statistics, Probability and Uncertainty, Laboratories, Laboratories, Clinical, Statistical Methods in Clinical Trials and Drug Development, Mathematics

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36327459

Machine-Learning Assisted Screening of Correlated Covariates: Application to Clinical Data of Desipramine

Autori: Innocent G. Asiimwe Bonginkosi S'fiso Ndzamba Samer Mouksassi a ďalší

Zdroj: The AAPS Journal. 26

Predmety: Statistics and Probability, Artificial intelligence, Immunology, Population, Antidepressive Agents, Tricyclic, Immunogenicity of Biosimilar Therapeutics in Drug Development, Models, Biological, 01 natural sciences, Machine Learning, 03 medical and health sciences, 0302 clinical medicine, Machine learning, FOS: Mathematics, Humans, Computer Simulation, 0101 mathematics, Immunology and Microbiology, Multiple Testing, FOS: Clinical medicine, 4. Education, Statistics, Desipramine, Covariate, Life Sciences, Elastic net regularization, Computer science, Regression, Environmental health, Computational Theory and Mathematics, Physical Sciences, Computer Science, Medicine, Regression analysis, Algorithms, Statistical Methods in Clinical Trials and Drug Development, Mathematics, Computational Methods in Drug Discovery

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38816519

Estimating Simultaneous Confidence Intervals for Multiple Contrasts of Means of Normal Distribution with Known Coefficients of Variation

Autori: Kanyanatthanin Sodanin Sa‐Aat Niwitpong Suparat Niwitpong

Zdroj: Emerging Science Journal, Vol 6, Iss 4, Pp 705-716 (2022)

Predmety: normal distribution, Statistics and Probability, simultaneous confidence interval, Coefficient of variation, Population, Skew Distributions, Astrophysics, approach (mover), coefficient of variation, Coverage probability, Methods for Handling Missing Data in Statistical Analysis, Variance (accounting), Sociology, Skew Distributions and Applications in Statistics, Accounting, FOS: Mathematics, T1-995, Business, Technology (General), Demography, H1-99, Multiple Testing, Simulation Studies, method of variance estimates recovery, Physics, 4. Education, Confidence interval, Statistics, Mixed-Effects Models, central limit theorem approach (clt), FOS: Sociology, Social sciences (General), Monte Carlo method, Physical Sciences, Variation (astronomy), Multivariate Normality, Normal distribution, Mathematics, Statistical Methods in Clinical Trials and Drug Development

Prístupová URL adresa: https://doaj.org/article/d13341795cbc42c3925d51a96aaa1487

Bayesian Optimal Phase II Design for Randomized Clinical Trials

Autori: Yujie Zhao Bo Yang John Lee a ďalší

Zdroj: Statistics in Biopharmaceutical Research. 14:423-432

Predmety: Statistics and Probability, Economics and Econometrics, Artificial intelligence, Social Sciences, Organic chemistry, Experimental Design and Optimization Methods, Phase (matter), Management Science and Operations Research, Bayesian probability, 01 natural sciences, Decision Sciences, 03 medical and health sciences, 0302 clinical medicine, FOS: Mathematics, 0101 mathematics, Internal medicine, 4. Education, Statistics, Computer science, 3. Good health, Economics, Econometrics and Finance, Chemistry, Health Economics and Quality of Life Assessment, Randomized controlled trial, Physical Sciences, Medicine, Statistical Methods in Clinical Trials and Drug Development, Mathematics

Causal inference for time-to-event data with a cured subpopulation

Autori: Yi Wang Yuping Deng Xiao‐Hua Zhou

Zdroj: Biometrics. 80

Predmety: Statistics and Probability, Causal Inference, Artificial intelligence, Biometry, Methods for Causal Inference in Observational Studies, Regularization and Variable Selection Methods, 01 natural sciences, Disease-Free Survival, FOS: Economics and business, Inference, Observational study, 0502 economics and business, FOS: Mathematics, Humans, Computer Simulation, Identifiability, Intensive care medicine, Econometrics, 0101 mathematics, Internal medicine, Censoring (clinical trials), Models, Statistical, Mediation Analysis, Treatment Effects, Statistics, 05 social sciences, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Cure rate, Survival Analysis, Computer science, 3. Good health, Causality, Treatment Outcome, Physical Sciences, Medicine, Mathematics, Statistical Methods in Clinical Trials and Drug Development, Causal inference

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38708764

The bioequivalence study design recommendations for immediate-release solid oral dosage forms in the international pharmaceutical regulators programme participating regulators and organisations: differences and commonalities

Autori: Eduardo Agostinho Freitas Fernandes Joy van Oudtshoorn Andrew Tam a ďalší

Zdroj: J Pharm Pharm Sci
Journal of Pharmacy & Pharmaceutical Sciences, Vol 27 (2024)

Predmety: Statistics and Probability, Science Archive, Immunology, Developmental Pharmacology in Pediatric Drug Use, Geometry, RM1-950, Guideline, Immunogenicity of Biosimilar Therapeutics in Drug Development, 01 natural sciences, 03 medical and health sciences, study design, Pharmacy and materia medica, 0302 clinical medicine, Health Sciences, FOS: Mathematics, Pathology, Humans, Drugs, Generic, Pharmacokinetics, IPRP, 0101 mathematics, Pharmacokinetic/Pharmacodynamic Modeling, Bioequivalence, Immunology and Microbiology, Pharmacology, Product (mathematics), bioequivalence, ICH, FOS: Clinical medicine, Physics, Life Sciences, Acoustics, immediate release, 16. Peace & justice, 3. Good health, RS1-441, Therapeutic Equivalency, Research Design, Harmonization, Physical Sciences, Pediatrics, Perinatology and Child Health, Medicine, Therapeutics. Pharmacology, Drug, Statistical Methods in Clinical Trials and Drug Development, Mathematics

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38577255
https://doaj.org/article/79b11805c0464d5e943c1517544011d9

Exploring the Kinh Vietnamese genomic database for the polymorphisms of the P450 genes towards precision public health

Autori: Diep Thi Hoang Tran Van Hiep Thảo Thi Phương Nguyễn a ďalší

Zdroj: Annals of Human Biology, Vol 49, Iss 2, Pp 152-155 (2022)

Predmety: CYP2C9, 0301 basic medicine, CYP3A5, Physiology, Cytochrome P450, Gene, Cytochrome P-450 Enzyme System, QP1-981, Cytochrome P-450 CYP3A, Biology (General), pharmacogenetics, Single-nucleotide polymorphism, 0303 health sciences, CYP2D6, Life Sciences, Genomics, FOS: Philosophy, ethics and religion, 3. Good health, Environmental health, Cytochrome P-450 CYP2D6, Drug Metabolism and Pharmacogenomics, khv, Physical Sciences, Medicine, Public Health, cyp450, Statistics and Probability, Pharmacology, Toxicology and Pharmaceutics, Genotype, QH301-705.5, Population, Vietnamese, 03 medical and health sciences, Asian People, Health Sciences, FOS: Mathematics, Genetics, Humans, CYP2C19, Biology, Cytochrome P-450 CYP2C9, Pharmacology, Transplantation, QM1-695, Linguistics, Kidney Transplantation, drug dosing, Cytochrome P-450 CYP2C19, Cytochrome P-450 CYP2B6, Philosophy, FOS: Biological sciences, Human anatomy, FOS: Languages and literature, next-generation sequencing, Statistical Methods in Clinical Trials and Drug Development, Mathematics

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/35289678
https://doaj.org/article/364593551ad140f79ce40ef8709e10e8

Two-Stage TMLE to reduce bias and improve efficiency in cluster randomized trials

Autori: Laura B. Balzer Mark van der Laan James Ayieko a ďalší

Zdroj: Biostatistics
Biostatistics, vol 24, iss 2

Predmety: FOS: Computer and information sciences, Artificial intelligence, TMLE, Outcome Assessment, Multi-level models, Cluster (spacecraft), Oceanography, Estimator, Mathematical Sciences, Methods for Handling Missing Data in Statistical Analysis, Inference, Randomized experiment, Statistics - Machine Learning, Outcome Assessment, Health Care, Cluster randomized trials, Cluster Analysis, Precision Medicine, Group randomized trials, Randomized Controlled Trials as Topic, Multiple Testing, Statistics, Covariate, Geology, Programming language, Clustered data, Super Learner, Research Design, Randomized controlled trial, Physical Sciences, Medicine, Statistics and Probability, Methods for Causal Inference in Observational Studies, Statistics & Probability, Missing data, Clinical Trials and Supportive Activities, Outcome (game theory), Machine Learning (stat.ML), Statistics - Applications, Article, Methodology (stat.ME), FOS: Economics and business, Double robust, Bias, Clinical Research, Genetics, FOS: Mathematics, Humans, Computer Simulation, Applications (stat.AP), Econometrics, Statistics - Methodology, Probability, Selection bias, Covariate adjustment, Mathematical economics, Baseline (sea), FOS: Earth and related environmental sciences, Computer science, 8.4 Research design and methodologies (health services), Health Care, Data-adaptive, Good Health and Well Being, Surgery, Generic health relevance, Mathematics, Statistical Methods in Clinical Trials and Drug Development, Causal inference, Average treatment effect

Popis súboru: application/pdf

Prístupová URL adresa: https://academic.oup.com/biostatistics/advance-article-pdf/doi/10.1093/biostatistics/kxab043/41901265/kxab043.pdf
https://pubmed.ncbi.nlm.nih.gov/34939083
http://arxiv.org/abs/2106.15737
https://escholarship.org/content/qt9t9372s4/qt9t9372s4.pdf
https://escholarship.org/uc/item/9t9372s4

Deep historical borrowing framework to prospectively and simultaneously synthesize control information in confirmatory clinical trials with multiple endpoints

Autori: Tianyu Zhan Yiwang Zhou Ziqian Geng a ďalší

Zdroj: Journal of Biopharmaceutical Statistics. 32:90-106

Predmety: FOS: Computer and information sciences, Statistics and Probability, Economics and Econometrics, Artificial intelligence, Social Sciences, Control (management), Experimental Design and Optimization Methods, Management Science and Operations Research, 01 natural sciences, Confirmatory factor analysis, Structural equation modeling, Decision Sciences, Methodology (stat.ME), FOS: Economics and business, Machine learning, FOS: Mathematics, Humans, Psychology, Computer Simulation, Econometrics, 0101 mathematics, Data mining, Internal medicine, Statistics - Methodology, Probability, Multiple Testing, Bayes Theorem, Composite Endpoints, Computer science, Clinical trial, FOS: Psychology, Economics, Econometrics and Finance, Health Economics and Quality of Life Assessment, Research Design, Sample Size, Physical Sciences, Medicine, Statistical Methods in Clinical Trials and Drug Development, Mathematics, Matching Methods

Prístupová URL adresa: http://arxiv.org/pdf/2008.12774
https://pubmed.ncbi.nlm.nih.gov/34632951
http://arxiv.org/abs/2008.12774
https://www.tandfonline.com/doi/full/10.1080/10543406.2021.1975128

A Step-by-Step Process on Sample Size Determination for Medical Research

Autori: Mohamad Adam Bujang

Zdroj: Malays J Med Sci

Predmety: Statistics and Probability, Alternative medicine, Social Sciences, Research Methodology, Review Article, Sample size determination, Decision Sciences, 03 medical and health sciences, 0302 clinical medicine, 0504 sociology, FOS: Mathematics, Pathology, Chromatography, Sample (material), Statistics, 05 social sciences, Inter-Rater Reliability in Scientific Studies, Computer science, Process (computing), Chemistry, Operating system, Methods for Evidence Synthesis in Research, Sample Size, Physical Sciences, Protocol (science), Medicine, Statistics, Probability and Uncertainty, Statistical Methods in Clinical Trials and Drug Development, Mathematics

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/33958957
http://www.ncbi.nlm.nih.gov/pubmed/33958957
https://europepmc.org/article/MED/33958957
https://pubmed.ncbi.nlm.nih.gov/33958957/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075593/