Suchergebnisse - "Spheroids, Cellular"

Immune cell infiltration of patient derived glioblastoma cell spheroids in acoustic levitation in bulk acoustic wave devices.

Autoren: Mousset X Kuermanbayi S Dupuis C et al.

Quelle: Lab on a chip [Lab Chip] 2025 Dec 02; Vol. 25 (24), pp. 6635-6649. Date of Electronic Publication: 2025 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE

MeSH-Schlagworte: Glioblastoma*/pathology , Glioblastoma*/immunology , Spheroids, Cellular*/pathology , Spheroids, Cellular*/immunology , Lab-On-A-Chip Devices* , Sound* , Acoustics* , Microfluidic Analytical Techniques*/instrumentation, Humans ; Cell Line, Tumor ; Cell Culture Techniques/instrumentation ; Equipment Design

Comparative analysis of 3D and 2D cell-culturing methods in hair follicle spheroid morphogenesis and drug responsiveness.

Autoren: Tan JJY Thuya WL Zhu H et al.

Quelle: Biomaterials advances [Biomater Adv] 2025 Dec; Vol. 177, pp. 214423. Date of Electronic Publication: 2025 Jul 21.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE

MeSH-Schlagworte: Hair Follicle*/cytology , Hair Follicle*/drug effects , Hair Follicle*/growth & development , Hair Follicle*/metabolism , Spheroids, Cellular*/cytology , Spheroids, Cellular*/drug effects , Spheroids, Cellular*/metabolism , Cell Culture Techniques*/methods , Cell Culture Techniques, Three Dimensional*/methods, Animals ; Morphogenesis/drug effects ; Minoxidil/pharmacology ; Keratinocytes/cytology ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Cells, Cultured ; Humans

Telomerase inhibitors - TMPyP4, BIBR 1532 and imetelstat - alter the adhesion potential of breast cancer MCF7 and MDA-MB-231 cells that leads to impaired ability to form spheroids.

Autoren: Kopczyński P Romaniuk-Drapała A Rygiel K et al.

Quelle: Cell adhesion & migration [Cell Adh Migr] 2025 Dec; Vol. 19 (1), pp. 2571328. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101469464 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-6926 (Electronic) Linking ISSN: 19336918 NLM ISO Abbreviation: Cell Adh Migr Subsets: MEDLINE

MeSH-Schlagworte: Telomerase*/antagonists & inhibitors , Telomerase*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/drug therapy , Spheroids, Cellular*/drug effects , Spheroids, Cellular*/pathology , Aminobenzoates*/pharmacology , Pyridines*/pharmacology , Enzyme Inhibitors*/pharmacology, Humans ; Cell Adhesion/drug effects ; Female ; MCF-7 Cells ; Molecular Docking Simulation ; G-Quadruplexes/drug effects ; Cell Line, Tumor ; MDA-MB-231 Cells ; Naphthalenes ; Oligonucleotides ; Porphyrins

Human Mesenchymal Stem Cell-Derived Skeletal Muscle Cell Spheroids for Treating Dexamethasone-Induced Sarcopenia.

Autoren: Yum Y Yoon J Nam YH et al.

Quelle: Tissue engineering and regenerative medicine [Tissue Eng Regen Med] 2025 Dec; Vol. 22 (8), pp. 1159-1172. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer International Publishing co-published with Korean Tissue Engineering and Regenerative Medicine Country of Publication: Korea (South) NLM ID: 101699923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-5469 (Electronic) Linking ISSN: 17382696 NLM ISO Abbreviation: Tissue Eng Regen Med Subsets: MEDLINE

MeSH-Schlagworte: Dexamethasone*/adverse effects , Sarcopenia*/therapy , Sarcopenia*/chemically induced , Sarcopenia*/pathology , Sarcopenia*/physiopathology , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Spheroids, Cellular*/transplantation , Spheroids, Cellular*/cytology , Spheroids, Cellular*/metabolism , Muscle, Skeletal*/pathology , Mesenchymal Stem Cell Transplantation*, Animals ; Humans ; Rats ; Male ; Rats, Sprague-Dawley ; Disease Models, Animal

Transmission electron microscopic analysis of pancreatic ductal adenocarcinoma cell spheres formed in 3D cultures.

Autoren: Shichi Y Fujiwara M Gomi F et al.

Quelle: Medical molecular morphology [Med Mol Morphol] 2025 Dec; Vol. 58 (4), pp. 298-306. Date of Electronic Publication: 2025 Apr 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Japan NLM ID: 101239023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-1499 (Electronic) Linking ISSN: 18601499 NLM ISO Abbreviation: Med Mol Morphol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Pancreatic Ductal*/ultrastructure , Carcinoma, Pancreatic Ductal*/pathology , Spheroids, Cellular*/ultrastructure , Spheroids, Cellular*/pathology , Pancreatic Neoplasms*/ultrastructure , Pancreatic Neoplasms*/pathology, Humans ; Cell Line, Tumor ; Microscopy, Electron, Transmission ; Cell Culture Techniques/methods ; Cell Culture Techniques, Three Dimensional

High-throughput combination screening of Pidnarulex and other G-quadruplex ligands in multi-cell type tumor spheroids.

Autoren: Dexheimer TS Coussens NP Silvers T et al.

Quelle: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2025 Dec; Vol. 37, pp. 100284. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/drug effects , Spheroids, Cellular*/metabolism , G-Quadruplexes*/drug effects , High-Throughput Screening Assays*/methods , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/genetics, Humans ; Ligands ; Cell Line, Tumor ; Drug Screening Assays, Antitumor/methods ; Cell Survival/drug effects ; Antineoplastic Agents/pharmacology ; Drug Synergism ; DNA Damage/drug effects ; Tumor Microenvironment/drug effects

3D-cultured DFAT spheroid-derived exosomes promote aged wound healing via modulation of the NF-κB/Serpine1 pathway.

Autoren: Ma X Wei W Zeng H et al.

Quelle: Tissue & cell [Tissue Cell] 2025 Dec; Vol. 97, pp. 103049. Date of Electronic Publication: 2025 Jul 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE

MeSH-Schlagworte: Wound Healing* , Exosomes*/metabolism , NF-kappa B*/metabolism , Signal Transduction* , Spheroids, Cellular*/metabolism , Spheroids, Cellular*/cytology , Adipose Tissue*/cytology , Adipose Tissue*/metabolism , Aging* , Cell Culture Techniques, Three Dimensional*, Humans ; Animals ; Mice ; Cellular Senescence ; Fibroblasts/metabolism ; Cell Proliferation ; Cell Movement

A customizable micropatterned platform for osteosarcoma spheroid generation, imaging, and drug screening.

Autoren: Lipreri MV Totaro MT Raimondi I et al.

Quelle: Biomaterials advances [Biomater Adv] 2025 Dec; Vol. 177, pp. 214419. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/drug effects , Spheroids, Cellular*/pathology , Osteosarcoma*/pathology , Osteosarcoma*/drug therapy , Osteosarcoma*/diagnostic imaging , Antineoplastic Agents*/pharmacology , Bone Neoplasms*/drug therapy , Bone Neoplasms*/pathology , Cell Culture Techniques*/methods , Cell Culture Techniques*/instrumentation, Humans ; Drug Screening Assays, Antitumor/methods ; Drug Screening Assays, Antitumor/instrumentation ; Cell Line, Tumor ; Cell Survival/drug effects ; Printing, Three-Dimensional

Sustained growth factor release driven cellular therapy indicates enhanced potential for regeneration upon mechanical injury.

Autoren: Tsigkos IA Tsimbouri PM Salmeron-Sanchez M et al.

Quelle: Biomaterials advances [Biomater Adv] 2025 Dec; Vol. 177, pp. 214389. Date of Electronic Publication: 2025 Jun 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/metabolism , Spheroids, Cellular*/physiology , Cell Culture Techniques*/methods , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/physiology , Mesenchymal Stem Cell Transplantation*/methods , Nerve Growth Factor*/pharmacology , Wounds and Injuries*/therapy, Cell Plasticity/drug effects ; Cell Plasticity/physiology ; Stem Cell Niche/physiology ; Wound Healing/physiology ; Regenerative Medicine/methods ; Hydrogels/chemistry ; Preservation, Biological/methods ; Polyethylene Glycols/chemistry ; Drug Delivery Systems/methods ; Drug Liberation ; Delayed-Action Preparations/pharmacology ; Humans

Injectable thermosensitive methylcellulose-carboxymethyl chitosan hydrogel for the delivery of human amniotic fluid mesenchymal stromal cell spheroids in cartilage regeneration.

Autoren: Zuliani CC da Cunha JB Correa RF et al.

Quelle: Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2025 Dec; Vol. 53 (1), pp. 453-467. Date of Electronic Publication: 2025 Oct 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE

MeSH-Schlagworte: Chitosan*/analogs & derivatives , Chitosan*/chemistry , Chitosan*/pharmacology , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Methylcellulose*/chemistry , Methylcellulose*/pharmacology , Hydrogels*/chemistry , Hydrogels*/pharmacology , Spheroids, Cellular*/cytology , Spheroids, Cellular*/transplantation , Spheroids, Cellular*/metabolism , Regeneration*/drug effects , Amniotic Fluid*/cytology , Cartilage*/physiology , Cartilage*/cytology , Temperature*, Humans ; Injections ; Cell Survival/drug effects

Assessment of cytotoxicity of some synthetic compounds against breast carcinoma spheroids with subsequent analysis of pro-apoptotic and gene expression.

Autoren: Mahmoud K Youssef EM Sroor FM et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 26; Vol. 15 (1), pp. 42543. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/drug effects , Spheroids, Cellular*/metabolism , Spheroids, Cellular*/pathology , Apoptosis*/drug effects , Apoptosis*/genetics , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/drug therapy , Antineoplastic Agents*/pharmacology , Gene Expression Regulation, Neoplastic*/drug effects, Humans ; Female ; MCF-7 Cells ; Drug Screening Assays, Antitumor ; Gene Expression Profiling ; Cell Survival/drug effects

β-lapachone impairs viability, migration, and epithelial-mesenchymal transition in mammary tumor spheroids.

Autoren: Coelho LL Vianna MM da Silva DM et al.

Quelle: BMC cancer [BMC Cancer] 2025 Nov 26; Vol. 25 (1), pp. 1826. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

MeSH-Schlagworte: Naphthoquinones*/pharmacology , Epithelial-Mesenchymal Transition*/drug effects , Spheroids, Cellular*/drug effects , Spheroids, Cellular*/pathology , Cell Movement*/drug effects , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism, Humans ; Female ; Cell Survival/drug effects ; MCF-7 Cells ; Cadherins/metabolism ; Vimentin/metabolism ; Tumor Cells, Cultured

Active foam dynamics of tissue spheroid fusion.

Autoren: Ongenae S Svitina H Belpaire TER et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 25; Vol. 16 (1), pp. 10467. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/cytology , Spheroids, Cellular*/drug effects , Spheroids, Cellular*/physiology , Spheroids, Cellular*/metabolism , Cell Fusion*, Humans ; Amides/pharmacology ; Pyridines/pharmacology ; Cell Movement/drug effects ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; rho-Associated Kinases/antagonists & inhibitors ; rho-Associated Kinases/metabolism ; Cytoskeleton/metabolism ; Cytoskeleton/drug effects ; Microscopy, Confocal ; Cells, Cultured

SpheroidSync as edge cutting transfer strategy for uniform and robust MCF7 spheroids in 3D culture.

Autoren: Mazloomi M Hamishehkar H Jahanban Esfahlan R

Quelle: Scientific reports [Sci Rep] 2025 Nov 21; Vol. 15 (1), pp. 41237. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/metabolism , Spheroids, Cellular*/pathology , Spheroids, Cellular*/cytology , Cell Culture Techniques, Three Dimensional*/methods , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Cell Culture Techniques*/methods, Humans ; MCF-7 Cells ; Cell Survival ; Female

Imaging Sensing of Cadmium-Induced Single Cancer Stem Cells in Tumor Spheroid Fabricated by 3D Bioprinting.

Autoren: Kwon M Song JM

Quelle: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Nov 19; Vol. 17 (46), pp. 63147-63161. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/drug effects , Spheroids, Cellular*/metabolism , Spheroids, Cellular*/pathology , Cadmium*/toxicity , Cadmium*/pharmacology , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Bioprinting* , Printing, Three-Dimensional*, Humans ; Hep G2 Cells ; Hydrogels/chemistry

Collective Mechanical Memory Encoded by Long-Lasting Supracellular Cytoskeletal Structures in Multicellular Spheroids.

Autoren: Kim J Jeong H Jeon YW et al.

Quelle: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Nov 19; Vol. 17 (46), pp. 63089-63102. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/metabolism , Spheroids, Cellular*/pathology , Cytoskeleton*/metabolism , Cytoskeleton*/chemistry , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism, Humans ; Cell Line, Tumor ; Female ; Actins/metabolism ; Cell Movement ; Cell Adhesion ; Cell Communication

Droplet-based cell viability assay for analysis of spheroid formation, proliferation and high-resolution IC 50 profiling.

Autoren: Saupe M Wiedemeier S Moll F et al.

Quelle: Lab on a chip [Lab Chip] 2025 Nov 18; Vol. 25 (23), pp. 6138-6156. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/cytology , Spheroids, Cellular*/drug effects , Lab-On-A-Chip Devices* , Microfluidic Analytical Techniques*/instrumentation, Humans ; Cell Survival/drug effects ; HEK293 Cells ; Cell Proliferation/drug effects ; Inhibitory Concentration 50 ; Cell Culture Techniques/instrumentation

Fibroblast Growth Factor 2-engaged cell spheroid for stem cell therapy: role of Interleukin 8 in the immune-modulatory effectiveness in the critical limb ischemia model.

Autoren: Kim E Joo Y Kim JW et al.

Quelle: Stem cells translational medicine [Stem Cells Transl Med] 2025 Nov 14; Vol. 14 (11).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 101578022 Publication Model: Print Cited Medium: Internet ISSN: 2157-6580 (Electronic) Linking ISSN: 21576564 NLM ISO Abbreviation: Stem Cells Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Interleukin-8*/metabolism , Ischemia*/therapy , Ischemia*/immunology , Ischemia*/pathology , Spheroids, Cellular*/metabolism , Spheroids, Cellular*/cytology , Stem Cell Transplantation*/methods, Animals ; Humans ; Mice ; Disease Models, Animal ; Stem Cells/metabolism ; Stem Cells/cytology ; Male ; Mice, Inbred C57BL ; Macrophages/metabolism

Gap Junctional Communication Required for the Establishment of Long-Term Robust Ca ²⁺ Oscillations Across Human Neuronal Spheroids and Extended 2D Cultures.

Autoren: Kormann J Cöllen E Aksoy-Aksel A et al.

Quelle: Cells [Cells] 2025 Nov 06; Vol. 14 (21). Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH-Schlagworte: Gap Junctions*/metabolism , Neurons*/metabolism , Neurons*/cytology , Calcium Signaling* , Spheroids, Cellular*/metabolism , Spheroids, Cellular*/cytology , Cell Communication* , Calcium*/metabolism , Cell Culture Techniques*/methods, Humans ; Connexin 43/metabolism

c-Jun N-Terminal Kinase (JNK) Inhibitor IQ-1S as a Suppressor of Tumor Spheroid Growth.

Autoren: Afrimzon E Deutsch M Sobolev M et al.

Quelle: Molecules (Basel, Switzerland) [Molecules] 2025 Nov 03; Vol. 30 (21). Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH-Schlagworte: Spheroids, Cellular*/drug effects , Spheroids, Cellular*/pathology , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , JNK Mitogen-Activated Protein Kinases*/antagonists & inhibitors , JNK Mitogen-Activated Protein Kinases*/metabolism , Quinoxalines*/pharmacology , Quinoxalines*/chemistry , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Humans ; MCF-7 Cells ; Cell Proliferation/drug effects ; Female