Suchergebnisse - "Sordelli C"

Management of dengue myocarditis with impending cardiac arrest in a patient with double valve replacement using VA ECMO-case report.

Autoren: Bansal, Vipul Gupta, Vivek Aslam, Naved et al.

Quelle: International Journal of Artificial Organs; Nov2025, Vol. 48 Issue 11, p858-863, 6p

Omega-3 Supplementation in Coronary Artery Bypass Graft Patients: Impact on ICU Stay and Hospital Stay—A Systematic Review and Meta-Analysis.

Autoren: Ouagueni, Asma Shi, Zumin Shraim, Mujahed et al.

Quelle: Nutrients. Oct2024, Vol. 16 Issue 19, p3298. 18p.

Necrotising myositis caused by Clostridium clostridioforme and Clostridium difficile in an alpaca following grain overload.

Autoren: Po, Eleonora Sawran, Ami Ward, Rob et al.

Quelle: Veterinary Record Case Reports. Mar2024, Vol. 12 Issue 1, p1-8. 8p.

Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.

Autoren: University of Cyprus AVVA Pharmaceuticals Ltd. Athanasios Athanasiou, Cardiothoracic Surgeon (CTS), MD, MSc, MSc, MPA, PhD(cand.)

Weitere Verfasser: University of Cyprus AVVA Pharmaceuticals Ltd. Athanasios Athanasiou, Cardiothoracic Surgeon (CTS), MD, MSc, MSc, MPA, PhD(cand.)

Quelle: The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.
Miloyan, B., Eaton, W.W. (2021). The Center for Epidemiologic Studies Depression (CES-D) Scale. In: Gu, D., Dupre, M.E. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham. https://doi.org/10.1007/978-3-030-22009-9_416
Siddaway AP, Wood AM, Taylor PJ. The Center for Epidemiologic Studies-Depression (CES-D) scale measures a continuum from well-being to depression: Testing two key predictions of positive clinical psychology. J Affect Disord. 2017 Apr 15;213:180-186. doi: 10.1016/j.jad.2017.02.015. Epub 2017 Feb 20.
Zhao YC, Wang CC, Yang JY, Li XY, Yanagita T, Xue CH, Zhang TT, Wang YM. N-3 PUFA Deficiency from Early Life to Adulthood Exacerbated Susceptibility to Reactive Oxygen Species-Induced Testicular Dysfunction in Adult Mice. J Agric Food Chem. 2023 May 10;71(18):6908-6919. doi: 10.1021/acs.jafc.2c07328. Epub 2023 Apr 25.
Madore C, Nadjar A, Delpech JC, Sere A, Aubert A, Portal C, Joffre C, Laye S. Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes. Brain Behav Immun. 2014 Oct;41:22-31. doi: 10.1016/j.bbi.2014.03.021. Epub 2014 Apr 13.
Cole GM, Ma QL, Frautschy SA. Omega-3 fatty acids and dementia. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):213-21. doi: 10.1016/j.plefa.2009.05.015. Epub 2009 Jun 12.
Delpech JC, Thomazeau A, Madore C, Bosch-Bouju C, Larrieu T, Lacabanne C, Remus-Borel J, Aubert A, Joffre C, Nadjar A, Laye S. Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment. Neuropsychopharmacology. 2015 Nov;40(12):2774-87. doi: 10.1038/npp.2015.127. Epub 2015 May 7.
Aid S, Vancassel S, Poumes-Ballihaut C, Chalon S, Guesnet P, Lavialle M. Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus. J Lipid Res. 2003 Aug;44(8):1545-51. doi: 10.1194/jlr.M300079-JLR200. Epub 2003 May 16.
Belkouch M, Hachem M, Elgot A, Lo Van A, Picq M, Guichardant M, Lagarde M, Bernoud-Hubac N. The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease. J Nutr Biochem. 2016 Dec;38:1-11. doi: 10.1016/j.jnutbio.2016.03.002. Epub 2016 Mar 24.
McNamara RK, Almeida DM. Omega-3 Polyunsaturated Fatty Acid Deficiency and Progressive Neuropathology in Psychiatric Disorders: A Review of Translational Evidence and Candidate Mechanisms. Harv Rev Psychiatry. 2019 Mar/Apr;27(2):94-107. doi: 10.1097/HRP.0000000000000199.
Palacios-Pelaez R, Lukiw WJ, Bazan NG. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Mol Neurobiol. 2010 Jun;41(2-3):367-74. doi: 10.1007/s12035-010-8139-z. Epub 2010 May 14.
Leyrolle Q, Decoeur F, Dejean C, Briere G, Leon S, Bakoyiannis I, Baroux E, Sterley TL, Bosch-Bouju C, Morel L, Amadieu C, Lecours C, St-Pierre MK, Bordeleau M, De Smedt-Peyrusse V, Sere A, Schwendimann L, Gregoire S, Bretillon L, Acar N, Joffre C, Ferreira G, Uricaru R, Thebault P, Gressens P, Tremblay ME, Laye S, Nadjar A. N-3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development. Glia. 2022 Jan;70(1):50-70. doi: 10.1002/glia.24088. Epub 2021 Sep 14.
Wang DD, Wu F, Zhang LY, Zhao YC, Wang CC, Xue CH, Yanagita T, Zhang TT, Wang YM. Effects of dietary n-3 PUFA levels in early life on susceptibility to high-fat-diet-induced metabolic syndrome in adult mice. J Nutr Biochem. 2021 Mar;89:108578. doi: 10.1016/j.jnutbio.2020.108578. Epub 2020 Dec 31.
Zou HY, Zhang HJ, Zhao YC, Li XY, Wang YM, Zhang TT, Xue CH. N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis. Mar Drugs. 2023 Jan 1;21(1):39. doi: 10.3390/md21010039.
Ramirez JL, Zahner GJ, Spaulding KA, et al. HHS Public Access. 2020;54:211-19.
Catry E, Neyrinck AM, Lobysheva I, Pachikian BD, Van Hul M, Cani PD, Dessy C, Delzenne NM. Nutritional depletion in n-3 PUFA in apoE knock-out mice: A new model of endothelial dysfunction associated with fatty liver disease. Mol Nutr Food Res. 2016 Oct;60(10):2198-2207. doi: 10.1002/mnfr.201500930. Epub 2016 Jun 1.
Danaei G, Ding EL, Mozaffarian D, Taylor B, Rehm J, Murray CJ, Ezzati M. The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Med. 2009 Apr 28;6(4):e1000058. doi: 10.1371/journal.pmed.1000058. Epub 2009 Apr 28.
Robertson RC, Seira Oriach C, Murphy K, Moloney GM, Cryan JF, Dinan TG, Ross RP, Stanton C. Deficiency of essential dietary n-3 PUFA disrupts the caecal microbiome and metabolome in mice. Br J Nutr. 2017 Dec;118(11):959-970. doi: 10.1017/S0007114517002999. Epub 2017 Nov 27.
Hutchins-Wiese HL, Picho K, Watkins BA, Li Y, Tannenbaum S, Claffey K, Kenny AM. High-dose eicosapentaenoic acid and docosahexaenoic acid supplementation reduces bone resorption in postmenopausal breast cancer survivors on aromatase inhibitors: a pilot study. Nutr Cancer. 2014;66(1):68-76. doi: 10.1080/01635581.2014.847964. Epub 2013 Nov 25.
Mocellin MC, de Quadros Camargo C, de Souza Fabre ME, et al. Fish oil effects on quality of life, body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy: a triple blind, randomized clinical trial. J Funct Foods 2017;31:113-22.
Takezaki T, Inoue M, Kataoka H, Ikeda S, Yoshida M, Ohashi Y, Tajima K, Tominaga S. Diet and lung cancer risk from a 14-year population-based prospective study in Japan: with special reference to fish consumption. Nutr Cancer. 2003;45(2):160-7. doi: 10.1207/S15327914NC4502_04.
Patterson RE, Flatt SW, Newman VA, Natarajan L, Rock CL, Thomson CA, Caan BJ, Parker BA, Pierce JP. Marine fatty acid intake is associated with breast cancer prognosis. J Nutr. 2011 Feb;141(2):201-6. doi: 10.3945/jn.110.128777. Epub 2010 Dec 22.
Pan M, Zhao F, Xie B, Wu H, Zhang S, Ye C, Guan Z, Kang L, Zhang Y, Zhou X, Lei Y, Wang Q, Wang L, Yang F, Zhao C, Qu J, Zhou X. Dietary omega-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118. doi: 10.1073/pnas.2104689118.
Sala-Vila A, Diaz-Lopez A, Valls-Pedret C, Cofan M, Garcia-Layana A, Lamuela-Raventos RM, Castaner O, Zanon-Moreno V, Martinez-Gonzalez MA, Toledo E, Basora J, Salas-Salvado J, Corella D, Gomez-Gracia E, Fiol M, Estruch R, Lapetra J, Fito M, Aros F, Serra-Majem L, Pinto X, Ros E; Prevencion con Dieta Mediterranea (PREDIMED) Investigators. Dietary Marine omega-3 Fatty Acids and Incident Sight-Threatening Retinopathy in Middle-Aged and Older Individuals With Type 2 Diabetes: Prospective Investigation From the PREDIMED Trial. JAMA Ophthalmol. 2016 Oct 1;134(10):1142-1149. doi: 10.1001/jamaophthalmol.2016.2906.
Balic A, Vlasic D, Zuzul K, Marinovic B, Bukvic Mokos Z. Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases. Int J Mol Sci. 2020 Jan 23;21(3):741. doi: 10.3390/ijms21030741.
Kim HH, Cho S, Lee S, Kim KH, Cho KH, Eun HC, Chung JH. Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo. J Lipid Res. 2006 May;47(5):921-30. doi: 10.1194/jlr.M500420-JLR200. Epub 2006 Feb 7.
Giudetti AM, Cagnazzo R. Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. Prostaglandins Other Lipid Mediat. 2012 Dec;99(3-4):57-67. doi: 10.1016/j.prostaglandins.2012.09.006. Epub 2012 Oct 11.
Pastor N, Soler B, Mitmesser SH, Ferguson P, Lifschitz C. Infants fed docosahexaenoic acid- and arachidonic acid-supplemented formula have decreased incidence of bronchiolitis/bronchitis the first year of life. Clin Pediatr (Phila). 2006 Nov;45(9):850-5. doi: 10.1177/1073858406289801.
Duttaroy AK, Basak S. Maternal dietary fatty acids and their roles in human placental development. Prostaglandins Leukot Essent Fatty Acids. 2020 Apr;155:102080. doi: 10.1016/j.plefa.2020.102080. Epub 2020 Feb 21.
Lucas M, Asselin G, Merette C, Poulin MJ, Dodin S. Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. Menopause. 2009 Mar-Apr;16(2):357-66. doi: 10.1097/gme.0b013e3181865386.
Shek LP, Chong MF, Lim JY, Soh SE, Chong YS. Role of dietary long-chain polyunsaturated fatty acids in infant allergies and respiratory diseases. Clin Dev Immunol. 2012;2012:730568. doi: 10.1155/2012/730568. Epub 2012 Aug 28.
Stanhiser J, Jukic AMZ, McConnaughey DR, Steiner AZ. Omega-3 fatty acid supplementation and fecundability. Hum Reprod. 2022 May 3;37(5):1037-1046. doi: 10.1093/humrep/deac027.
Behboudi-Gandevani S, Hariri FZ, Moghaddam-Banaem L. The effect of omega 3 fatty acid supplementation on premenstrual syndrome and health-related quality of life: a randomized clinical trial. J Psychosom Obstet Gynaecol. 2018 Dec;39(4):266-272. doi: 10.1080/0167482X.2017.1348496. Epub 2017 Jul 14.
Donadio JV, Grande JP. The role of fish oil/omega-3 fatty acids in the treatment of IgA nephropathy. Semin Nephrol. 2004 May;24(3):225-43. doi: 10.1016/j.semnephrol.2004.01.004.
Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011 Nov;25(8):1725-34. doi: 10.1016/j.bbi.2011.07.229. Epub 2011 Jul 19.
Doaei S, Bourbour F, Teymoori Z, Jafari F, Kalantari N, Abbas Torki S, Ashoori N, Nemat Gorgani S, Gholamalizadeh M. The effect of omega-3 fatty acids supplementation on social and behavioral disorders of children with autism: a randomized clinical trial. Pediatr Endocrinol Diabetes Metab. 2021;27(1):12-18. doi: 10.5114/pedm.2020.101806.
Yehuda S, Rabinovitz-Shenkar S, Carasso RL. Effects of essential fatty acids in iron deficient and sleep-disturbed attention deficit hyperactivity disorder (ADHD) children. Eur J Clin Nutr. 2011 Oct;65(10):1167-9. doi: 10.1038/ejcn.2011.80. Epub 2011 May 18.
Grosso G, Micek A, Marventano S, Castellano S, Mistretta A, Pajak A, Galvano F. Dietary n-3 PUFA, fish consumption and depression: A systematic review and meta-analysis of observational studies. J Affect Disord. 2016 Nov 15;205:269-281. doi: 10.1016/j.jad.2016.08.011. Epub 2016 Aug 16.
Nemets H, Nemets B, Apter A, Bracha Z, Belmaker RH. Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry. 2006 Jun;163(6):1098-100. doi: 10.1176/ajp.2006.163.6.1098.
Minns LM, Kerling EH, Neely MR, Sullivan DK, Wampler JL, Harris CL, Berseth CL, Carlson SE. Toddler formula supplemented with docosahexaenoic acid (DHA) improves DHA status and respiratory health in a randomized, double-blind, controlled trial of US children less than 3 years of age. Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):287-93. doi: 10.1016/j.plefa.2010.02.009. Epub 2010 Mar 5.
Czumaj A, Sledzinski T. Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease. Nutrients. 2020 Jan 29;12(2):356. doi: 10.3390/nu12020356.
Muc M, Kreiner-Moller E, Larsen JM, Birch S, Brix S, Bisgaard H, Lauritzen L. Maternal fatty acid desaturase genotype correlates with infant immune responses at 6 months. Br J Nutr. 2015 Sep 28;114(6):891-8. doi: 10.1017/S0007114515002561. Epub 2015 Aug 18.
Bazinet RP, Laye S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014 Dec;15(12):771-85. doi: 10.1038/nrn3820. Epub 2014 Nov 12.
Madore C, Leyrolle Q, Lacabanne C, Benmamar-Badel A, Joffre C, Nadjar A, Laye S. Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota. Neural Plast. 2016;2016:3597209. doi: 10.1155/2016/3597209. Epub 2016 Oct 20.
AlAmmar WA, Albeesh FH, Ibrahim LM, Algindan YY, Yamani LZ, Khattab RY. Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: a systematic review. Nutr Neurosci. 2021 Jul;24(7):569-579. doi: 10.1080/1028415X.2019.1659560. Epub 2019 Aug 28.
Wei BZ, Li L, Dong CW, Tan CC; Alzheimer's Disease Neuroimaging Initiative; Xu W. The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers. Am J Clin Nutr. 2023 Jun;117(6):1096-1109. doi: 10.1016/j.ajcnut.2023.04.001. Epub 2023 Apr 5.
Riediger ND, Othman RA, Suh M, Moghadasian MH. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc. 2009 Apr;109(4):668-79. doi: 10.1016/j.jada.2008.12.022.
Dou Y, Wang Y, Chen Z, Yu X, Ma D. Effect of n-3 polyunsaturated fatty acid on bone health: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr. 2021 Nov 29;10(1):145-154. doi: 10.1002/fsn3.2655. eCollection 2022 Jan.
Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain. 2007 May;129(1-2):210-23. doi: 10.1016/j.pain.2007.01.020. Epub 2007 Mar 1.
Liput KP, Lepczynski A, Ogluszka M, Nawrocka A, Polawska E, Grzesiak A, Slaska B, Pareek CS, Czarnik U, Pierzchala M. Effects of Dietary n-3 and n-6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis. Int J Mol Sci. 2021 Jun 28;22(13):6965. doi: 10.3390/ijms22136965.
Sugawara E, Nikaido H. Properties of AdeABC and AdeIJK efflux systems of Acinetobacter baumannii compared with those of the AcrAB-TolC system of Escherichia coli. Antimicrob Agents Chemother. 2014 Dec;58(12):7250-7. doi: 10.1128/AAC.03728-14. Epub 2014 Sep 22.
Nienaber A, Ozturk M, Dolman R, Blaauw R, Zandberg LL, van Rensburg S, Britz M, Hayford FEA, Brombacher F, Loots DT, Smuts CM, Parihar SP, Malan L. n-3 long-chain PUFA promote antibacterial and inflammation-resolving effects in Mycobacterium tuberculosis-infected C3HeB/FeJ mice, dependent on fatty acid status. Br J Nutr. 2022 Feb 14;127(3):384-397. doi: 10.1017/S0007114521001124. Epub 2021 Apr 5.
Spooner MH, Jump DB. Omega-3 fatty acids and nonalcoholic fatty liver disease in adults and children: where do we stand? Curr Opin Clin Nutr Metab Care. 2019 Mar;22(2):103-110. doi: 10.1097/MCO.0000000000000539.
Siriwardhana N, Kalupahana NS, Moustaid-Moussa N. Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid and docosahexaenoic acid. Adv Food Nutr Res. 2012;65:211-22. doi: 10.1016/B978-0-12-416003-3.00013-5.
Chalon S. Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):259-69. doi: 10.1016/j.plefa.2006.07.005. Epub 2006 Sep 11.
Nordoy A, Marchioli R, Arnesen H, Videbaek J. n-3 polyunsaturated fatty acids and cardiovascular diseases. Lipids. 2001;36 Suppl:S127-9. doi: 10.1007/s11745-001-0695-7.
Landymore RW, Manku MS, Tan M, MacAulay MA, Sheridan B. Effects of low-dose marine oils on intimal hyperplasia in autologous vein grafts. J Thorac Cardiovasc Surg. 1989 Nov;98(5 Pt 1):788-91.
Pradelli L, Mayer K, Muscaritoli M, Heller AR. n-3 fatty acid-enriched parenteral nutrition regimens in elective surgical and ICU patients: a meta-analysis. Crit Care. 2012 Oct 4;16(5):R184. doi: 10.1186/cc11668.
Abeywardena MY, Head RJ. Longchain n-3 polyunsaturated fatty acids and blood vessel function. Cardiovasc Res. 2001 Dec;52(3):361-71. doi: 10.1016/s0008-6363(01)00406-0.
Jahangiri A, Leifert WR, Patten GS, McMurchie EJ. Termination of asynchronous contractile activity in rat atrial myocytes by n-3 polyunsaturated fatty acids. Mol Cell Biochem. 2000 Mar;206(1-2):33-41. doi: 10.1023/a:1007025007403.
Mozaffarian D, Psaty BM, Rimm EB, Lemaitre RN, Burke GL, Lyles MF, Lefkowitz D, Siscovick DS. Fish intake and risk of incident atrial fibrillation. Circulation. 2004 Jul 27;110(4):368-73. doi: 10.1161/01.CIR.0000138154.00779.A5. Epub 2004 Jul 19.
Thies F, Garry JM, Yaqoob P, Rerkasem K, Williams J, Shearman CP, Gallagher PJ, Calder PC, Grimble RF. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet. 2003 Feb 8;361(9356):477-85. doi: 10.1016/S0140-6736(03)12468-3.
Mozaffarian D. Fish, n-3 fatty acids, and cardiovascular haemodynamics. J Cardiovasc Med (Hagerstown). 2007 Sep;8 Suppl 1:S23-6. doi: 10.2459/01.JCM.0000289279.95427.e2.
Saremi A, Arora R. The utility of omega-3 fatty acids in cardiovascular disease. Am J Ther. 2009 Sep-Oct;16(5):421-36. doi: 10.1097/MJT.0b013e3180a5f0bb.
Russo GL. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochem Pharmacol. 2009 Mar 15;77(6):937-46. doi: 10.1016/j.bcp.2008.10.020. Epub 2008 Oct 28.
Mori TA, Burke V, Puddey IB, Watts GF, O'Neal DN, Best JD, Beilin LJ. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr. 2000 May;71(5):1085-94. doi: 10.1093/ajcn/71.5.1085.
Kalstad AA, Myhre PL, Laake K, Tveit SH, Schmidt EB, Smith P, Nilsen DWT, Tveit A, Fagerland MW, Solheim S, Seljeflot I, Arnesen H; OMEMI Investigators. Effects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction: A Randomized, Controlled Trial. Circulation. 2021 Feb 9;143(6):528-539. doi: 10.1161/CIRCULATIONAHA.120.052209. Epub 2020 Nov 15.
Albert CM, Campos H, Stampfer MJ, Ridker PM, Manson JE, Willett WC, Ma J. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med. 2002 Apr 11;346(15):1113-8. doi: 10.1056/NEJMoa012918.
Siscovick DS, Raghunathan T, King I, Weinmann S, Bovbjerg VE, Kushi L, Cobb LA, Copass MK, Psaty BM, Lemaitre R, Retzlaff B, Knopp RH. Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. Am J Clin Nutr. 2000 Jan;71(1 Suppl):208S-12S. doi: 10.1093/ajcn/71.1.208S.
Lemaitre RN, King IB, Mozaffarian D, Kuller LH, Tracy RP, Siscovick DS. n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. Am J Clin Nutr. 2003 Feb;77(2):319-25. doi: 10.1093/ajcn/77.2.319.
Shahidi F, Ambigaipalan P. Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits. Annu Rev Food Sci Technol. 2018 Mar 25;9:345-381. doi: 10.1146/annurev-food-111317-095850.
Calder PC, Yaqoob P. Omega-3 polyunsaturated fatty acids and human health outcomes. Biofactors. 2009 May-Jun;35(3):266-72. doi: 10.1002/biof.42.
Bhatt DL, Steg PG, Brinton EA, Jacobson TA, Miller M, Tardif JC, Ketchum SB, Doyle RT Jr, Murphy SA, Soni PN, Braeckman RA, Juliano RA, Ballantyne CM; REDUCE-IT Investigators. Rationale and design of REDUCE-IT: Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial. Clin Cardiol. 2017 Mar;40(3):138-148. doi: 10.1002/clc.22692. Epub 2017 Mar 15.
AHA; ACC; National Heart, Lung, and Blood Institute; Smith SC Jr, Allen J, Blair SN, Bonow RO, Brass LM, Fonarow GC, Grundy SM, Hiratzka L, Jones D, Krumholz HM, Mosca L, Pearson T, Pfeffer MA, Taubert KA. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update endorsed by the National Heart, Lung, and Blood Institute. J Am Coll Cardiol. 2006 May 16;47(10):2130-9. doi: 10.1016/j.jacc.2006.04.026. No abstract available.
Lomivorotov VV, Efremov SM, Pokushalov EA, Romanov AB, Ponomarev DN, Cherniavsky AM, Shilova AN, Karaskov AM, Lomivorotov VN. Randomized trial of fish oil infusion to prevent atrial fibrillation after cardiac surgery: data from an implantable continuous cardiac monitor. J Cardiothorac Vasc Anesth. 2014 Oct;28(5):1278-84. doi: 10.1053/j.jvca.2014.02.019. Epub 2014 Jul 11.
Mayo Clinic Staff. Fish oil. Mayo Clinic Press. August 10, 2023. Accessed October 23, 2024. https://www.mayoclinic.org/drugs-supplements-fish-oil/art-20364810
Souza PR, Marques RM, Gomez EA, Colas RA, De Matteis R, Zak A, Patel M, Collier DJ, Dalli J. Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses: A Randomized Double-Blind Placebo-Controlled Study. Circ Res. 2020 Jan 3;126(1):75-90. doi: 10.1161/CIRCRESAHA.119.315506. Epub 2019 Dec 12.
Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002 Oct;56(8):365-79. doi: 10.1016/s0753-3322(02)00253-6.
Djuricic I, Calder PC. Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health. Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:383-406. doi: 10.1146/annurev-pharmtox-051921-090208.
von Schacky C, Fischer S, Weber PC. Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. J Clin Invest. 1985 Oct;76(4):1626-31. doi: 10.1172/JCI112147.
Biasi E. The effects of dietary choline. Neurosci Bull. 2011 Oct;27(5):330-42. doi: 10.1007/s12264-011-1523-5.
Zhang B, Zhen Y, Tao A, Bao Z, Zhang G. Polyunsaturated fatty acids for the prevention of atrial fibrillation after cardiac surgery: an updated meta-analysis of randomized controlled trials. J Cardiol. 2014 Jan;63(1):53-9. doi: 10.1016/j.jjcc.2013.06.014. Epub 2013 Aug 1.
Langlois PL, Hardy G, Manzanares W. Omega-3 polyunsaturated fatty acids in cardiac surgery patients: An updated systematic review and meta-analysis. Clin Nutr. 2017 Jun;36(3):737-746. doi: 10.1016/j.clnu.2016.05.013. Epub 2016 May 27.
Veljovic M, Mihajlovic I, Subota V, Antunovic M, Jevdjic J, Udovicic I, Popadic A, Vulovic T. Effect of pretreatment with omega-3 polyunsaturated fatty acids (PUfas) on hematological parameters and platelets aggregation in patients during elective coronary artery bypass grafting. Vojnosanit Pregl. 2013 Apr;70(4):396-402. doi: 10.2298/vsp1304396v.
Harker LA, Kelly AB, Hanson SR, Krupski W, Bass A, Osterud B, FitzGerald GA, Goodnight SH, Connor WE. Interruption of vascular thrombus formation and vascular lesion formation by dietary n-3 fatty acids in fish oil in nonhuman primates. Circulation. 1993 Mar;87(3):1017-29. doi: 10.1161/01.cir.87.3.1017.
Veljovic M, Popadic A, Vukic Z, Ilic R, Trifunovic Z, Antunovic M, Mandaric V, Tisma S, Markovic Z. Myocardial protection during elective coronary artery bypasses grafting by pretreatment with omega-3 polyunsaturated fatty acids. Vojnosanit Pregl. 2013 May;70(5):484-92. doi: 10.2298/vsp1305484v.
Stanger O, Aigner I, Schimetta W, Wonisch W. Antioxidant supplementation attenuates oxidative stress in patients undergoing coronary artery bypass graft surgery. Tohoku J Exp Med. 2014 Feb;232(2):145-54. doi: 10.1620/tjem.232.145.
Gholami M, Najafizadeh H, Teimouri H, Ardalan A, Pooria A, Tarrahi MJ. The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass graft surgery: a triple-blind clinical trial. J Complement Integr Med. 2019 Aug 21;16(4):/j/jcim.2019.16.issue-4/jcim-2018-0113/jcim-2018-0113.xml. doi: 10.1515/jcim-2018-0113.
Feguri GR, Lima PRL, Franco AC, Cruz FRH, Borges DC, Toledo LR, Segri NJ, Aguilar-Nascimento JE. Benefits of Fasting Abbreviation with Carbohydrates and Omega-3 Infusion During CABG: a Double-Blind Controlled Randomized Trial. Braz J Cardiovasc Surg. 2019 Mar-Apr;34(2):125-135. doi: 10.21470/1678-9741-2018-0336.
Mariscalco G, Sarzi Braga S, Banach M, Borsani P, Bruno VD, Napoleone M, Vitale C, Piffaretti G, Pedretti RF, Sala A. Preoperative n-3 polyunsatured fatty acids are associated with a decrease in the incidence of early atrial fibrillation following cardiac surgery. Angiology. 2010 Oct;61(7):643-50. doi: 10.1177/0003319710370962. Epub 2010 Jun 7.
Hagenfeldt L. Renal excretion of free fatty acids. Clin Chim Acta. 1971 May;32(3):471-4. doi: 10.1016/0009-8981(71)90450-5. No abstract available.
Dyerberg J, Madsen P, Moller JM, Aardestrup I, Schmidt EB. Bioavailability of marine n-3 fatty acid formulations. Prostaglandins Leukot Essent Fatty Acids. 2010 Sep;83(3):137-41. doi: 10.1016/j.plefa.2010.06.007.
Nelson GJ, Ackman RG. Absorption and transport of fat in mammals with emphasis on n-3 polyunsaturated fatty acids. Lipids. 1988 Nov;23(11):1005-14. doi: 10.1007/BF02535644.
Corsetto PA, Cremona A, Montorfano G, Jovenitti IE, Orsini F, Arosio P, Rizzo AM. Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. Cell Biochem Biophys. 2012 Sep;64(1):45-59. doi: 10.1007/s12013-012-9365-y.
Jump DB. The biochemistry of n-3 polyunsaturated fatty acids. J Biol Chem. 2002 Mar 15;277(11):8755-8. doi: 10.1074/jbc.R100062200. Epub 2001 Dec 17. No abstract available.
Valentine RC, Valentine DL. Omega-3 fatty acids in cellular membranes: a unified concept. Prog Lipid Res. 2004 Sep;43(5):383-402. doi: 10.1016/j.plipres.2004.05.004.
Mason RP, Libby P, Bhatt DL. Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1135-1147. doi: 10.1161/ATVBAHA.119.313286. Epub 2020 Mar 26.
Masson S, Wu JH, Simon C, Barlera S, Marchioli R, Mariani J, Macchia A, Lombardi F, Vago T, Aleksova A, Dreas L, Favaloro RR, Hershson AR, Puskas JD, Dozza L, Silletta MG, Tognoni G, Mozaffarian D, Latini R; OPERA Investigators. Circulating cardiac biomarkers and postoperative atrial fibrillation in the OPERA trial. Eur J Clin Invest. 2015 Feb;45(2):170-8. doi: 10.1111/eci.12393. Epub 2015 Jan 7.
Vasheghani Farahani A, Yousefi Azar A, Goodarzynejad HR, Khorrami E, Hosseinzadeh-Attar MJ, Oshnouei S, Alizadeh Ghavidel A, Golfeshan E, Ghourban Pour F. Fish oil supplementation for primary prevention of atrial fibrillation after coronary artery bypass graft surgery: A randomized clinical trial. Int J Surg. 2017 Jun;42:41-48. doi: 10.1016/j.ijsu.2017.04.025. Epub 2017 Apr 15.
Sorice M, Tritto FP, Sordelli C, Gregorio R, Piazza L. N-3 polyunsaturated fatty acids reduces post-operative atrial fibrillation incidence in patients undergoing "on-pump" coronary artery bypass graft surgery. Monaldi Arch Chest Dis. 2011 Jun;76(2):93-8. doi: 10.4081/monaldi.2011.196.
Calo L, Bianconi L, Colivicchi F, Lamberti F, Loricchio ML, de Ruvo E, Meo A, Pandozi C, Staibano M, Santini M. N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial. J Am Coll Cardiol. 2005 May 17;45(10):1723-8. doi: 10.1016/j.jacc.2005.02.079.
Charman A, Muriithi EW, Milne E, Wheatley DJ, Armstrong RA, Belcher PR. Fish oil before cardiac surgery: neutrophil activation is unaffected but myocardial damage is moderated. Prostaglandins Leukot Essent Fatty Acids. 2005 Apr;72(4):257-65. doi: 10.1016/j.plefa.2004.11.007.
Benedetto U, Melina G, di Bartolomeo R, Angeloni E, Sansone D, Falaschi G, Capuano F, Comito C, Roscitano A, Sinatra R. n-3 polyunsaturated fatty acids after coronary artery bypass grafting. Ann Thorac Surg. 2011 Apr;91(4):1169-75. doi: 10.1016/j.athoracsur.2010.11.068.
Castillo R, Rodrigo R, Perez F, Cereceda M, Asenjo R, Zamorano J, Navarrete R, Villalabeitia E, Sanz J, Baeza C, Aguayo R. Antioxidant therapy reduces oxidative and inflammatory tissue damage in patients subjected to cardiac surgery with extracorporeal circulation. Basic Clin Pharmacol Toxicol. 2011 Apr;108(4):256-62. doi: 10.1111/j.1742-7843.2010.00651.x. Epub 2010 Dec 8.
Rodrigo R, Korantzopoulos P, Cereceda M, Asenjo R, Zamorano J, Villalabeitia E, Baeza C, Aguayo R, Castillo R, Carrasco R, Gormaz JG. A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement. J Am Coll Cardiol. 2013 Oct 15;62(16):1457-65. doi: 10.1016/j.jacc.2013.07.014. Epub 2013 Jul 31.
Rodrigo R, Gutierrez R, Fernandez R, Guzman P. Ageing improves the antioxidant response against postoperative atrial fibrillation: a randomized controlled trial. Interact Cardiovasc Thorac Surg. 2012 Aug;15(2):209-14. doi: 10.1093/icvts/ivs154. Epub 2012 May 4.
National Institute of Health. Omega-3 fatty acids fact sheet for health professionals. NIH. 2023. https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/
Skuladottir GV, Heidarsdottir R, Arnar DO, Torfason B, Edvardsson V, Gottskalksson G, Palsson R, Indridason OS. Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery. Eur J Clin Invest. 2011 Sep;41(9):995-1003. doi: 10.1111/j.1365-2362.2011.02497.x. Epub 2011 Mar 17.
Akintoye E, Sethi P, Harris WS, Thompson PA, Marchioli R, Tavazzi L, Latini R, Pretorius M, Brown NJ, Libby P, Mozaffarian D. Fish Oil and Perioperative Bleeding. Circ Cardiovasc Qual Outcomes. 2018 Nov;11(11):e004584. doi: 10.1161/CIRCOUTCOMES.118.004584.
Berger MM, Delodder F, Liaudet L, Tozzi P, Schlaepfer J, Chiolero RL, Tappy L. Three short perioperative infusions of n-3 PUFAs reduce systemic inflammation induced by cardiopulmonary bypass surgery: a randomized controlled trial. Am J Clin Nutr. 2013 Feb;97(2):246-54. doi: 10.3945/ajcn.112.046573. Epub 2012 Dec 26.
Eritsland J, Arnesen H, Seljeflot I, Kierulf P. Long-term effects of n-3 polyunsaturated fatty acids on haemostatic variables and bleeding episodes in patients with coronary artery disease. Blood Coagul Fibrinolysis. 1995 Feb;6(1):17-22. doi: 10.1097/00001721-199502000-00003.
Gu J, Lundbye-Christensen S, Eschen RB, Andreasen A, Andreasen JJ. Marine n-3 fatty acids are incorporated into atrial tissue but do not correlate with postoperative atrial fibrillation in cardiac surgery. Vascul Pharmacol. 2016 Dec;87:70-75. doi: 10.1016/j.vph.2016.11.004. Epub 2016 Nov 17.
Mozaffarian D, Marchioli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, Latini R, Libby P, Lombardi F, O'Gara PT, Page RL, Tavazzi L, Tognoni G; OPERA Investigators. Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial. JAMA. 2012 Nov 21;308(19):2001-11. doi: 10.1001/jama.2012.28733.
Jackson JC, Mozaffarian D, Graves AJ, Brown NJ, Marchioli R, Kiehl AL, Ely EW. Fish Oil Supplementation Does Not Affect Cognitive Outcomes in Cardiac Surgery Patients in the Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) Trial. J Nutr. 2018 Mar 1;148(3):472-479. doi: 10.1093/jn/nxx002.
Sandesara CM, Chung MK, Van Wagoner DR, Barringer TA, Allen K, Ismail HM, Zimmerman B, Olshansky B. A Randomized, Placebo-Controlled Trial of Omega-3 Fatty Acids for Inhibition of Supraventricular Arrhythmias After Cardiac Surgery: The FISH Trial. J Am Heart Assoc. 2012 Jun;1(3):e000547. doi: 10.1161/JAHA.111.000547. Epub 2012 Jun 22.
Saravanan P, Bridgewater B, West AL, O'Neill SC, Calder PC, Davidson NC. Omega-3 fatty acid supplementation does not reduce risk of atrial fibrillation after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial. Circ Arrhythm Electrophysiol. 2010 Feb;3(1):46-53. doi: 10.1161/CIRCEP.109.899633. Epub 2009 Dec 30.
Akintoye E, Wu JH, Hou T, Song X, Yang J, Hammock B, Mozaffarian D. Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery. J Lipid Res. 2016 Mar;57(3):492-8. doi: 10.1194/jlr.P062398. Epub 2016 Jan 9.
Farquharson AL, Metcalf RG, Sanders P, Stuklis R, Edwards JR, Gibson RA, Cleland LG, Sullivan TR, James MJ, Young GD. Effect of dietary fish oil on atrial fibrillation after cardiac surgery. Am J Cardiol. 2011 Sep 15;108(6):851-6. doi: 10.1016/j.amjcard.2011.04.036. Epub 2011 Jul 15.
Heidarsdottir R, Arnar DO, Skuladottir GV, Torfason B, Edvardsson V, Gottskalksson G, Palsson R, Indridason OS. Does treatment with n-3 polyunsaturated fatty acids prevent atrial fibrillation after open heart surgery? Europace. 2010 Mar;12(3):356-63. doi: 10.1093/europace/eup429. Epub 2010 Jan 7.
Eritsland J, Arnesen H, Gronseth K, Fjeld NB, Abdelnoor M. Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol. 1996 Jan 1;77(1):31-6. doi: 10.1016/s0002-9149(97)89130-8.
Andreassen AK, Hartmann A, Offstad J, Geiran O, Kvernebo K, Simonsen S. Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients. J Am Coll Cardiol. 1997 May;29(6):1324-31. doi: 10.1016/s0735-1097(97)82757-x.
Rubanenko OA, Shchukin YV, Limareva LV, et al. Omega-3 polyunsaturated fatty acids: the role in prevention of atrial fibrillation in patients with coronary artery disease after coronary artery bypass graft surgery. Ration Pharmacother Cardiol 2022;18:12-19.
Kim HY. Analysis of variance (ANOVA) comparing means of more than two groups. Restor Dent Endod. 2014 Feb;39(1):74-7. doi: 10.5395/rde.2014.39.1.74. No abstract available.
Rosner BA. Fundamentals of Biostatistics. Thomson-Brooks/Cole; 2006.
He Z, Yang L, Tian J, Yang K, Wu J, Yao Y. Efficacy and safety of omega-3 fatty acids for the prevention of atrial fibrillation: a meta-analysis. Can J Cardiol. 2013 Feb;29(2):196-203. doi: 10.1016/j.cjca.2012.03.019. Epub 2012 Jun 7.
Costanzo S, di Niro V, Di Castelnuovo A, Gianfagna F, Donati MB, de Gaetano G, Iacoviello L. Prevention of postoperative atrial fibrillation in open heart surgery patients by preoperative supplementation of n-3 polyunsaturated fatty acids: an updated meta-analysis. J Thorac Cardiovasc Surg. 2013 Oct;146(4):906-11. doi: 10.1016/j.jtcvs.2013.03.015. Epub 2013 Apr 12.
Takagi H, Umemoto T. Preoperative n-3 Polyunsatured fatty acids do not reduce postoperative atrial fibrillation in cardiac surgery. Angiology. 2011 Apr;62(3):276-7; author reply 278-9. doi: 10.1177/0003319710389021. No abstract available.
Rinninella E, Costantini L. Polyunsaturated Fatty Acids as Prebiotics: Innovation or Confirmation? Foods. 2022 Jan 6;11(2):146. doi: 10.3390/foods11020146.
Costantini L, Molinari R, Farinon B, Merendino N. Impact of Omega-3 Fatty Acids on the Gut Microbiota. Int J Mol Sci. 2017 Dec 7;18(12):2645. doi: 10.3390/ijms18122645.
Shaikh SR, Edidin M. Polyunsaturated fatty acids and membrane organization: elucidating mechanisms to balance immunotherapy and susceptibility to infection. Chem Phys Lipids. 2008 May;153(1):24-33. doi: 10.1016/j.chemphyslip.2008.02.008. Epub 2008 Feb 23.
Hughes DA, Pinder AC. N-3 polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes and inhibit antigen-presentation in vitro. Clin Exp Immunol. 1997 Dec;110(3):516-23. doi: 10.1046/j.1365-2249.1997.4351455.x.
Asimakopoulos G, Smith PL, Ratnatunga CP, Taylor KM. Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass. Ann Thorac Surg. 1999 Sep;68(3):1107-15. doi: 10.1016/s0003-4975(99)00781-x.
Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? Br J Clin Pharmacol. 2013 Mar;75(3):645-62. doi: 10.1111/j.1365-2125.2012.04374.x.
Erkkila AT, Matthan NR, Herrington DM, Lichtenstein AH. Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. J Lipid Res. 2006 Dec;47(12):2814-9. doi: 10.1194/jlr.P600005-JLR200. Epub 2006 Sep 18.
Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 2006 Oct 18;296(15):1885-99. doi: 10.1001/jama.296.15.1885.
Jump DB, Depner CM, Tripathy S. Omega-3 fatty acid supplementation and cardiovascular disease. J Lipid Res. 2012 Dec;53(12):2525-45. doi: 10.1194/jlr.R027904. Epub 2012 Aug 17.
Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis. 2008 Mar;197(1):12-24. doi: 10.1016/j.atherosclerosis.2007.11.008. Epub 2007 Dec 26.
Jung UJ, Torrejon C, Tighe AP, Deckelbaum RJ. n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects. Am J Clin Nutr. 2008 Jun;87(6):2003S-9S. doi: 10.1093/ajcn/87.6.2003S.
Watanabe Y, Tatsuno I. Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future. Expert Rev Clin Pharmacol. 2017 Aug;10(8):865-873. doi: 10.1080/17512433.2017.1333902. Epub 2017 May 29.
Marchioli R, Barzi F, Bomba E, Chieffo C, Di Gregorio D, Di Mascio R, Franzosi MG, Geraci E, Levantesi G, Maggioni AP, Mantini L, Marfisi RM, Mastrogiuseppe G, Mininni N, Nicolosi GL, Santini M, Schweiger C, Tavazzi L, Tognoni G, Tucci C, Valagussa F; GISSI-Prevenzione Investigators. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation. 2002 Apr 23;105(16):1897-903. doi: 10.1161/01.cir.0000014682.14181.f2.
Leaf A. The electrophysiological basis for the antiarrhythmic actions of polyunsaturated fatty acids. Eur Heart J Suppl 2001;3:98-105.
Leaf A, Albert CM, Josephson M, Steinhaus D, Kluger J, Kang JX, Cox B, Zhang H, Schoenfeld D; Fatty Acid Antiarrhythmia Trial Investigators. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation. 2005 Nov 1;112(18):2762-8. doi: 10.1161/CIRCULATIONAHA.105.549527.
Leaf A, Kang JX, Xiao YF, Billman GE. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation. 2003 Jun 3;107(21):2646-52. doi: 10.1161/01.CIR.0000069566.78305.33. No abstract available.
Merendino N, Costantini L, Manzi L, Molinari R, D'Eliseo D, Velotti F. Dietary omega -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. Biomed Res Int. 2013;2013:310186. doi: 10.1155/2013/310186. Epub 2013 May 23.
Arnold LE, Young AS, Belury MA, Cole RM, Gracious B, Seidenfeld AM, Wolfson H, Fristad MA. Omega-3 Fatty Acid Plasma Levels Before and After Supplementation: Correlations with Mood and Clinical Outcomes in the Omega-3 and Therapy Studies. J Child Adolesc Psychopharmacol. 2017 Apr;27(3):223-233. doi: 10.1089/cap.2016.0123. Epub 2017 Feb 3.
Calder PC. Polyunsaturated fatty acids, inflammation, and immunity. Lipids. 2001 Sep;36(9):1007-24. doi: 10.1007/s11745-001-0812-7.
Miles EA, Calder PC. Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis. Br J Nutr. 2012 Jun;107 Suppl 2:S171-84. doi: 10.1017/S0007114512001560.
Calder PC. n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci (Lond). 2004 Jul;107(1):1-11. doi: 10.1042/CS20040119.
Zarate R, El Jaber-Vazdekis N, Tejera N, Perez JA, Rodriguez C. Significance of long chain polyunsaturated fatty acids in human health. Clin Transl Med. 2017 Dec;6(1):25. doi: 10.1186/s40169-017-0153-6. Epub 2017 Jul 27.
Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K; Japan EPA lipid intervention study (JELIS) Investigators. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007 Mar 31;369(9567):1090-8. doi: 10.1016/S0140-6736(07)60527-3.
Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, Elwood PC, Deadman NM. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet. 1989 Sep 30;2(8666):757-61. doi: 10.1016/s0140-6736(89)90828-3.
Nilsen DW, Albrektsen G, Landmark K, Moen S, Aarsland T, Woie L. Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. Am J Clin Nutr. 2001 Jul;74(1):50-6. doi: 10.1093/ajcn/74.1.50.
Heidt MC, Vician M, Stracke SK, Stadlbauer T, Grebe MT, Boening A, Vogt PR, Erdogan A. Beneficial effects of intravenously administered N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a prospective randomized study. Thorac Cardiovasc Surg. 2009 Aug;57(5):276-80. doi: 10.1055/s-0029-1185301. Epub 2009 Jul 23.
Kris-Etherton PM, Harris WS, Appel LJ; American Heart Association. Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002 Nov 19;106(21):2747-57. doi: 10.1161/01.cir.0000038493.65177.94. No abstract available.
Kris-Etherton PM, Griel AE, Psota TL, Gebauer SK, Zhang J, Etherton TD. Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption. Lipids. 2005 Dec;40(12):1193-200. doi: 10.1007/s11745-005-1485-y.
Mozaffarian D, Wu JH. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol. 2011 Nov 8;58(20):2047-67. doi: 10.1016/j.jacc.2011.06.063.
Hooper L, Thompson RL, Harrison RA, Summerbell CD, Moore H, Worthington HV, Durrington PN, Ness AR, Capps NE, Davey Smith G, Riemersma RA, Ebrahim SB. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD003177. doi: 10.1002/14651858.CD003177.pub2.
Krupa KN, Fritz K, Parmar M. Omega-3 Fatty Acids. 2024 Feb 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK564314/
Scientific Advisory Committee on Nutrition (SACN). Saturated fats and health. Published online 2019:443. https://www.gov.uk/government/publications/saturated-fats-and-health-sacn-report
EFSA. Scientific opinion on dietary reference values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. EFSA J 2016;8:1-107.
Cholewski M, Tomczykowa M, Tomczyk M. A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids. Nutrients. 2018 Nov 4;10(11):1662. doi: 10.3390/nu10111662.
Brouwer IA. Fish, Omega-3 Fatty Acids and Heart Disease. Woodhead Publishing Limited; 2008. doi: 10.1533/9781845694586.2.165.
Calder PC. Mechanisms of action of (n-3) fatty acids. J Nutr. 2012 Mar;142(3):592S-599S. doi: 10.3945/jn.111.155259. Epub 2012 Jan 25.
Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010 Jul 7;5(7):e11414. doi: 10.1371/journal.pone.0011414.
Levine M, Padayatty SJ, Espey MG. Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. Adv Nutr. 2011 Mar;2(2):78-88. doi: 10.3945/an.110.000109. Epub 2011 Mar 10.
Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3704-9. doi: 10.1073/pnas.93.8.3704.
Meier ML, Pierce KN. New therapies for the treatment of heart failure with preserved ejection fraction. Am J Health Syst Pharm. 2022 Aug 19;79(17):1424-1430. doi: 10.1093/ajhp/zxac129.
Solomon SD, Vaduganathan M, L Claggett B, Packer M, Zile M, Swedberg K, Rouleau J, A Pfeffer M, Desai A, Lund LH, Kober L, Anand I, Sweitzer N, Linssen G, Merkely B, Luis Arango J, Vinereanu D, Chen CH, Senni M, Sibulo A, Boytsov S, Shi V, Rizkala A, Lefkowitz M, McMurray JJV. Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure. Circulation. 2020 Feb 4;141(5):352-361. doi: 10.1161/CIRCULATIONAHA.119.044586. Epub 2019 Nov 17.
Hornig B, Arakawa N, Kohler C, Drexler H. Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure. Circulation. 1998 Feb 3;97(4):363-8. doi: 10.1161/01.cir.97.4.363.
Qin F, Yan C, Patel R, Liu W, Dong E. Vitamins C and E attenuate apoptosis, beta-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction. Free Radic Biol Med. 2006 May 15;40(10):1827-42. doi: 10.1016/j.freeradbiomed.2006.01.019. Epub 2006 Feb 8.
Shinke T, Shite J, Takaoka H, Hata K, Inoue N, Yoshikawa R, Matsumoto H, Masai H, Watanabe S, Ozawa T, Otake H, Matsumoto D, Hirata K, Yokoyama M. Vitamin C restores the contractile response to dobutamine and improves myocardial efficiency in patients with heart failure after anterior myocardial infarction. Am Heart J. 2007 Oct;154(4):645.e1-8. doi: 10.1016/j.ahj.2007.07.005.
Hemila H, Chalker E, de Man AME. Vitamin C May Improve Left Ventricular Ejection Fraction: A Meta-Analysis. Front Cardiovasc Med. 2022 Feb 25;9:789729. doi: 10.3389/fcvm.2022.789729. eCollection 2022.
Khan SA, Bhattacharjee S, Ghani MOA, Walden R, Chen QM. Vitamin C for Cardiac Protection during Percutaneous Coronary Intervention: A Systematic Review of Randomized Controlled Trials. Nutrients. 2020 Jul 23;12(8):2199. doi: 10.3390/nu12082199.
Valls N, Gormaz JG, Aguayo R, Gonzalez J, Brito R, Hasson D, Libuy M, Ramos C, Carrasco R, Prieto JC, Dussaillant G, Puentes A, Noriega V, Rodrigo R. Amelioration of persistent left ventricular function impairment through increased plasma ascorbate levels following myocardial infarction. Redox Rep. 2016 Mar;21(2):75-83. doi: 10.1179/1351000215Y.0000000018. Epub 2016 Feb 24.
Rodrigo R, Prieto JC, Aguayo R, Ramos C, Puentes A, Gajardo A, Panieri E, Rojas-Sole C, Lillo-Moya J, Saso L. Joint Cardioprotective Effect of Vitamin C and Other Antioxidants against Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention. Molecules. 2021 Sep 21;26(18):5702. doi: 10.3390/molecules26185702.
Malik A, Bagchi AK, Vinayak K, Akolkar G, Slezak J, Bello-Klein A, Jassal DS, Singal PK. Vitamin C: historical perspectives and heart failure. Heart Fail Rev. 2021 May;26(3):699-709. doi: 10.1007/s10741-020-10036-y. Epub 2020 Oct 8.
Keith M, Geranmayegan A, Sole MJ, Kurian R, Robinson A, Omran AS, Jeejeebhoy KN. Increased oxidative stress in patients with congestive heart failure. J Am Coll Cardiol. 1998 May;31(6):1352-6. doi: 10.1016/s0735-1097(98)00101-6.
de Lorgeril M, Salen P, Accominotti M, Cadau M, Steghens JP, Boucher F, de Leiris J. Dietary and blood antioxidants in patients with chronic heart failure. Insights into the potential importance of selenium in heart failure. Eur J Heart Fail. 2001 Dec;3(6):661-9. doi: 10.1016/s1388-9842(01)00179-9.
Munzel T, Camici GG, Maack C, Bonetti NR, Fuster V, Kovacic JC. Impact of Oxidative Stress on the Heart and Vasculature: Part 2 of a 3-Part Series. J Am Coll Cardiol. 2017 Jul 11;70(2):212-229. doi: 10.1016/j.jacc.2017.05.035.
Szyller J, Jagielski D, Bil-Lula I. Antioxidants in Arrhythmia Treatment-Still a Controversy? A Review of Selected Clinical and Laboratory Research. Antioxidants (Basel). 2022 Jun 2;11(6):1109. doi: 10.3390/antiox11061109.
Baker WL, Coleman CI. Meta-analysis of ascorbic acid for prevention of postoperative atrial fibrillation after cardiac surgery. Am J Health Syst Pharm. 2016 Dec 15;73(24):2056-2066. doi: 10.2146/ajhp160066. Epub 2016 Nov 2.
Korantzopoulos P, Kolettis T, Siogas K, Goudevenos J. Atrial fibrillation and electrical remodeling: the potential role of inflammation and oxidative stress. Med Sci Monit. 2003 Sep;9(9):RA225-9.
Hemila H, Suonsyrja T. Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2017 Feb 1;17(1):49. doi: 10.1186/s12872-017-0478-5.
Sacks GS. Randomized, prospective trial of antioxidant supplementation in critically iii surgical patients. Nutr Clin Pract 2003;18:264.
Emadi N, Nemati MH, Ghorbani M, Allahyari E. The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery. Braz J Cardiovasc Surg. 2019 Dec 1;34(5):517-524. doi: 10.21470/1678-9741-2018-0312.
Frei B, Stocker R, England L, Ames BN. Ascorbate: the most effective antioxidant in human blood plasma. Adv Exp Med Biol. 1990;264:155-63. doi: 10.1007/978-1-4684-5730-8_24.
Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6377-81. doi: 10.1073/pnas.86.16.6377.
Snezhkina AV, Kudryavtseva AV, Kardymon OL, Savvateeva MV, Melnikova NV, Krasnov GS, Dmitriev AA. ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells. Oxid Med Cell Longev. 2019 Aug 5;2019:6175804. doi: 10.1155/2019/6175804. eCollection 2019.
Landis RC, Brown JR, Fitzgerald D, Likosky DS, Shore-Lesserson L, Baker RA, Hammon JW. Attenuating the Systemic Inflammatory Response to Adult Cardiopulmonary Bypass: A Critical Review of the Evidence Base. J Extra Corpor Technol. 2014 Sep;46(3):197-211.
Giakoumidakis K, Baltopoulos GI, Charitos C, Patelarou E, Galanis P, Brokalaki H. Risk factors for prolonged stay in cardiac surgery intensive care units. Nurs Crit Care. 2011 Sep-Oct;16(5):243-51. doi: 10.1111/j.1478-5153.2010.00443.x.
Butler J, Rocker GM, Westaby S. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg. 1993 Feb;55(2):552-9. doi: 10.1016/0003-4975(93)91048-r.
Hall R. Identification of inflammatory mediators and their modulation by strategies for the management of the systemic inflammatory response during cardiac surgery. J Cardiothorac Vasc Anesth. 2013 Oct;27(5):983-1033. doi: 10.1053/j.jvca.2012.09.013. Epub 2012 Dec 29. No abstract available.
Langlois M, Duprez D, Delanghe J, De Buyzere M, Clement DL. Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis. Circulation. 2001 Apr 10;103(14):1863-8. doi: 10.1161/01.cir.103.14.1863.
Yokoyama T, Date C, Kokubo Y, Yoshiike N, Matsumura Y, Tanaka H. Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community. The Shibata study. Stroke. 2000 Oct;31(10):2287-94. doi: 10.1161/01.str.31.10.2287.
Kurl S, Tuomainen TP, Laukkanen JA, Nyyssonen K, Lakka T, Sivenius J, Salonen JT. Plasma vitamin C modifies the association between hypertension and risk of stroke. Stroke. 2002 Jun;33(6):1568-73. doi: 10.1161/01.str.0000017220.78722.d7.
Jacques PF, Sulsky SI, Perrone GE, Jenner J, Schaefer EJ. Effect of vitamin C supplementation on lipoprotein cholesterol, apolipoprotein, and triglyceride concentrations. Ann Epidemiol. 1995 Jan;5(1):52-9. doi: 10.1016/1047-2797(94)00041-q.
Simon JA, Hudes ES. Relation of serum ascorbic acid to serum lipids and lipoproteins in US adults. J Am Coll Nutr. 1998 Jun;17(3):250-5. doi: 10.1080/07315724.1998.10718755.
Moran JP, Cohen L, Greene JM, Xu G, Feldman EB, Hames CG, Feldman DS. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr. 1993 Feb;57(2):213-7. doi: 10.1093/ajcn/57.2.213.
McCarron DA, Morris CD, Henry HJ, Stanton JL. Blood pressure and nutrient intake in the United States. Science. 1984 Jun 29;224(4656):1392-8. doi: 10.1126/science.6729459.
Carr AC, Shaw GM, Fowler AA, Natarajan R. Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock? Crit Care. 2015 Nov 27;19:418. doi: 10.1186/s13054-015-1131-2.
Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989 Apr 6;320(14):915-24. doi: 10.1056/NEJM198904063201407. No abstract available.
Armour J, Tyml K, Lidington D, Wilson JX. Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat. J Appl Physiol (1985). 2001 Mar;90(3):795-803. doi: 10.1152/jappl.2001.90.3.795.
Vahedi P, Rajabzadeh A, Soleimani A. An evaluation of the effects of ascorbic acid on the endothelium of coronary and aorta arteries in lead-intoxicated rabbits. SAGE Open Med. 2022 Jun 24;10:20503121221105330. doi: 10.1177/20503121221105330. eCollection 2022.
Solzbach U, Hornig B, Jeserich M, Just H. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation. 1997 Sep 2;96(5):1513-9. doi: 10.1161/01.cir.96.5.1513.
Madokoro Y, Kamikokuryo C, Niiyama S, Ito T, Hara S, Ichinose H, Kakihana Y. Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice. Front Pharmacol. 2022 Oct 6;13:929448. doi: 10.3389/fphar.2022.929448. eCollection 2022.
Vogiatzi G, Tousoulis D, Stefanadis C. The role of oxidative stress in atherosclerosis. Hellenic J Cardiol. 2009 Sep-Oct;50(5):402-9. No abstract available.
Batty M, Bennett MR, Yu E. The Role of Oxidative Stress in Atherosclerosis. Cells. 2022 Nov 30;11(23):3843. doi: 10.3390/cells11233843.
Chen Y, Luo X, Xu B, Bao X, Jia H, Yu B. Oxidative Stress-Mediated Programmed Cell Death: a Potential Therapy Target for Atherosclerosis. Cardiovasc Drugs Ther. 2024 Aug;38(4):819-832. doi: 10.1007/s10557-022-07414-z. Epub 2022 Dec 16.
Pacher P, Nivorozhkin A, Szabo C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. doi: 10.1124/pr.58.1.6.
Connor M. Allopurinol for pain relief: more than just crystal clearance? Br J Pharmacol. 2009 Jan;156(1):4-6. doi: 10.1111/j.1476-5381.2008.00065.x.
Cavarocchi NC, England MD, O'Brien JF, Solis E, Russo P, Schaff HV, Orszulak TA, Pluth JR, Kaye MP. Superoxide generation during cardiopulmonary bypass: is there a role for vitamin E? J Surg Res. 1986 Jun;40(6):519-27. doi: 10.1016/0022-4804(86)90093-4.
Lassnigg A, Punz A, Barker R, Keznickl P, Manhart N, Roth E, Hiesmayr M. Influence of intravenous vitamin E supplementation in cardiac surgery on oxidative stress: a double-blinded, randomized, controlled study. Br J Anaesth. 2003 Feb;90(2):148-54. doi: 10.1093/bja/aeg042.
Valle-Giner I, Marti-Bonmati E, Alegria-Toran A, Montero A, Morcillo EJ. Changes in alpha-tocopherol and retinol levels during cardiopulmonary bypass correlate with maximal arterial partial pressure of oxygen. Free Radic Res. 2007 Sep;41(9):1061-7. doi: 10.1080/10715760701466389.
Westhuyzen J, Cochrane AD, Tesar PJ, Mau T, Cross DB, Frenneaux MP, Khafagi FA, Fleming SJ. Effect of preoperative supplementation with alpha-tocopherol and ascorbic acid on myocardial injury in patients undergoing cardiac operations. J Thorac Cardiovasc Surg. 1997 May;113(5):942-8. doi: 10.1016/s0022-5223(97)70268-x.
Sisto T, Paajanen H, Metsa-Ketela T, Harmoinen A, Nordback I, Tarkka M. Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting. Ann Thorac Surg. 1995 Jun;59(6):1519-23. doi: 10.1016/0003-4975(95)00197-s.
Samadikhah J, Golzari SE, Sabermarouf B, Karimzadeh I, Tizro P, Mohammad Khanli H, Ghabili K. Efficacy of Combination Therapy of Statin and Vitamin C in Comparison with Statin in the Prevention of Post-CABG Atrial Fibrillation. Adv Pharm Bull. 2014;4(1):97-100. doi: 10.5681/apb.2014.015. Epub 2013 Dec 23.
Safaei N, Babaei H, Azarfarin R, Jodati AR, Yaghoubi A, Sheikhalizadeh MA. Comparative effect of grape seed extract (Vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery. Ann Card Anaesth. 2017 Jan-Mar;20(1):45-51. doi: 10.4103/0971-9784.197834.
Papoulidis P, Ananiadou O, Chalvatzoulis E, Ampatzidou F, Koutsogiannidis C, Karaiskos T, Madesis A, Drossos G. The role of ascorbic acid in the prevention of atrial fibrillation after elective on-pump myocardial revascularization surgery: a single-center experience--a pilot study. Interact Cardiovasc Thorac Surg. 2011 Feb;12(2):121-4. doi: 10.1510/icvts.2010.240473. Epub 2010 Nov 23.
Knodell RG, Tate MA, Akl BF, Wilson JW. Vitamin C prophylaxis for posttransfusion hepatitis: lack of effect in a controlled trial. Am J Clin Nutr. 1981 Jan;34(1):20-3. doi: 10.1093/ajcn/34.1.20.
Jouybar R, Kabgani H, Kamalipour H, et al. The perioperative effect of ascorbic acid on inflammatory response in coronary artery bypass graft surgery; a randomized controlled trial coronary artery bypass graft surgery. Iran Cardiovasc Res J 2012;6:13-17.
Gunes T, Bozok S, Kestelli M, Yurekli I, Ilhan G, Ozpak B, Bademci M, Ozcem B, Sahin A. alpha-tocopherol and ascorbic acid in early postoperative period of cardiopulmonary bypass. J Cardiovasc Med (Hagerstown). 2012 Nov;13(11):691-9. doi: 10.2459/JCM.0b013e328356a2dc.
Eslami M, Badkoubeh RS, Mousavi M, Radmehr H, Salehi M, Tavakoli N, Avadi MR. Oral ascorbic acid in combination with beta-blockers is more effective than beta-blockers alone in the prevention of atrial fibrillation after coronary artery bypass grafting. Tex Heart Inst J. 2007;34(3):268-74.
Dehghani MR, Majidi N, Rahmani A, Asgari B, Rezaei Y. Effect of oral vitamin C on atrial fibrillation development after isolated coronary artery bypass grafting surgery: A prospective randomized clinical trial. Cardiol J. 2014;21(5):492-9. doi: 10.5603/CJ.a2013.0154. Epub 2013 Dec 2.
Das D, Sen C, Goswami A. Effect of Vitamin C on adrenal suppression by etomidate induction in patients undergoing cardiac surgery: A randomized controlled trial. Ann Card Anaesth. 2016 Jul-Sep;19(3):410-7. doi: 10.4103/0971-9784.185522.
Colby JA, Chen WT, Baker WL, Coleman CI, Reinhart K, Kluger J, White CM. Effect of ascorbic acid on inflammatory markers after cardiothoracic surgery. Am J Health Syst Pharm. 2011 Sep 1;68(17):1632-9. doi: 10.2146/ajhp100703.
Carnes CA, Chung MK, Nakayama T, Nakayama H, Baliga RS, Piao S, Kanderian A, Pavia S, Hamlin RL, McCarthy PM, Bauer JA, Van Wagoner DR. Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circ Res. 2001 Sep 14;89(6):E32-8. doi: 10.1161/hh1801.097644.
Bjordahl PM, Helmer SD, Gosnell DJ, Wemmer GE, O'Hara WW, Milfeld DJ. Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients. Am J Surg. 2012 Dec;204(6):862-7; discussion 867. doi: 10.1016/j.amjsurg.2012.03.012. Epub 2012 Sep 28.
Antonic M. Effect of Ascorbic Acid on Postoperative Acute Kidney Injury in Coronary Artery Bypass Graft Patients: A Pilot Study. Heart Surg Forum. 2017 Oct 24;20(5):E214-E218. doi: 10.1532/hsf.1811.
Antonic M, Lipovec R, Gregorcic F, Juric P, Kosir G. Perioperative ascorbic acid supplementation does not reduce the incidence of postoperative atrial fibrillation in on-pump coronary artery bypass graft patients. J Cardiol. 2017 Jan;69(1):98-102. doi: 10.1016/j.jjcc.2016.01.010. Epub 2016 Feb 23.
Angdin M, Settergren G, Starkopf J, Zilmer M, Zilmer K, Vaage J. Protective effect of antioxidants on pulmonary endothelial function after cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2003 Jun;17(3):314-20. doi: 10.1016/s1053-0770(03)00053-3.
Hill A, Clasen KC, Wendt S, Majoros AG, Stoppe C, Adhikari NKJ, Heyland DK, Benstoem C. Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis. Nutrients. 2019 Sep 4;11(9):2103. doi: 10.3390/nu11092103.
Oktar GL, Sinci V, Kalaycioglu S, Soncul H, Gokgoz L, Halit V, Ersoz A. Biochemical and hemodynamic effects of ascorbic acid and alpha-tocopherol in coronary artery surgery. Scand J Clin Lab Invest. 2001;61(8):621-9. doi: 10.1080/003655101753267982.
Ballmer PE, Reinhart WH, Jordan P, Buhler E, Moser UK, Gey KF. Depletion of plasma vitamin C but not of vitamin E in response to cardiac operations. J Thorac Cardiovasc Surg. 1994 Aug;108(2):311-20.
Tai YH, Wu HL, Chu YH, Huang CH, Ho ST, Lin TC, Lu CC. Vitamin C supplementation attenuates oxidative stress and improves erythrocyte deformability in cardiac surgery with cardiopulmonary bypass. Chin J Physiol. 2022 Sep-Oct;65(5):241-249. doi: 10.4103/0304-4920.358234.
Rodemeister S, Duquesne M, Adolph M, Nohr D, Biesalski HK, Unertl K. Massive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation. Nutrition. 2014 Jun;30(6):673-8. doi: 10.1016/j.nut.2013.10.026. Epub 2013 Nov 6.
Carr AC, Vissers MC, Cook JS. The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life. Front Oncol. 2014 Oct 16;4:283. doi: 10.3389/fonc.2014.00283. eCollection 2014.
German Nutrition Society (DGE). New Reference Values for Vitamin C Intake. Ann Nutr Metab. 2015;67(1):13-20. doi: 10.1159/000434757. Epub 2015 Jul 22.
Hill A, Borgs C, Fitzner C, Stoppe C. Perioperative Vitamin C and E levels in Cardiac Surgery Patients and Their Clinical Significance. Nutrients. 2019 Sep 9;11(9):2157. doi: 10.3390/nu11092157.
Fukushima R, Yamazaki E. Vitamin C requirement in surgical patients. Curr Opin Clin Nutr Metab Care. 2010 Nov;13(6):669-76. doi: 10.1097/MCO.0b013e32833e05bc.
Rowe S, Carr AC. Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern? Nutrients. 2020 Jul 6;12(7):2008. doi: 10.3390/nu12072008.
Evans RM, Currie L, Campbell A. The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration. Br J Nutr. 1982 May;47(3):473-82. doi: 10.1079/bjn19820059.
Rumelin A, Jaehde U, Kerz T, Roth W, Kramer M, Fauth U. Early postoperative substitution procedure of the antioxidant ascorbic acid. J Nutr Biochem. 2005 Feb;16(2):104-8. doi: 10.1016/j.jnutbio.2004.10.005.
Carr AC, Rosengrave PC, Bayer S, Chambers S, Mehrtens J, Shaw GM. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care. 2017 Dec 11;21(1):300. doi: 10.1186/s13054-017-1891-y.
Ellinger S, Stehle P. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. Curr Opin Clin Nutr Metab Care. 2009 Nov;12(6):588-95. doi: 10.1097/MCO.0b013e328331a5b5.
Beattie AD, Sherlock S. Ascorbic acid deficiency in liver disease. Gut. 1976 Aug;17(8):571-5. doi: 10.1136/gut.17.8.571.
Ginter E. Chronic marginal vitamin C deficiency: biochemistry and pathophysiology. World Rev Nutr Diet. 1979;33:104-41. doi: 10.1159/000402551. No abstract available.
Ghalibaf MHE, Kianian F, Beigoli S, Behrouz S, Marefati N, Boskabady M, Boskabady MH. The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review. Inflammopharmacology. 2023 Apr;31(2):653-672. doi: 10.1007/s10787-023-01169-1. Epub 2023 Feb 27.
Otocka-Kmiecik A, Krol A. The Role of Vitamin C in Two Distinct Physiological States: Physical Activity and Sleep. Nutrients. 2020 Dec 21;12(12):3908. doi: 10.3390/nu12123908.
Tveden-Nyborg P. Vitamin C Deficiency in the Young Brain-Findings from Experimental Animal Models. Nutrients. 2021 May 15;13(5):1685. doi: 10.3390/nu13051685.
Nowak D. Vitamin C in Human Health and Disease. Nutrients. 2021 May 11;13(5):1595. doi: 10.3390/nu13051595.
Dosedel M, Jirkovsky E, Macakova K, Krcmova LK, Javorska L, Pourova J, Mercolini L, Remiao F, Novakova L, Mladenka P, On Behalf Of The Oemonom. Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination. Nutrients. 2021 Feb 13;13(2):615. doi: 10.3390/nu13020615.
Nyyssonen K, Parviainen MT, Salonen R, Tuomilehto J, Salonen JT. Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland. BMJ. 1997 Mar 1;314(7081):634-8. doi: 10.1136/bmj.314.7081.634.
Kristenson M, Zieden B, Kucinskiene Z, Elinder LS, Bergdahl B, Elwing B, Abaravicius A, Razinkoviene L, Calkauskas H, Olsson AG. Antioxidant state and mortality from coronary heart disease in Lithuanian and Swedish men: concomitant cross sectional study of men aged 50. BMJ. 1997 Mar 1;314(7081):629-33. doi: 10.1136/bmj.314.7081.629.
Al-Khudairy L, Flowers N, Wheelhouse R, Ghannam O, Hartley L, Stranges S, Rees K. Vitamin C supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2017 Mar 16;3(3):CD011114. doi: 10.1002/14651858.CD011114.pub2.
National Center for Biotechnology Information . PubChem Compound Summary for CID 54670067, Ascorbic Acid. Accessed Oct. 29 https://pubchem.ncbi.nlm.nih.gov/compound/Ascorbic-Acid, 2023.
Morelli MB, Gambardella J, Castellanos V, Trimarco V, Santulli G. Vitamin C and Cardiovascular Disease: An Update. Antioxidants (Basel). 2020 Dec 3;9(12):1227. doi: 10.3390/antiox9121227.
Naidu KA. Vitamin C in human health and disease is still a mystery? An overview. Nutr J. 2003 Aug 21;2:7. doi: 10.1186/1475-2891-2-7.
Mandl J, Szarka A, Banhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol. 2009 Aug;157(7):1097-110. doi: 10.1111/j.1476-5381.2009.00282.x. Epub 2009 Jun 5.
Paciolla C, Fortunato S, Dipierro N, Paradiso A, De Leonardis S, Mastropasqua L, de Pinto MC. Vitamin C in Plants: From Functions to Biofortification. Antioxidants (Basel). 2019 Oct 29;8(11):519. doi: 10.3390/antiox8110519.
Njus D, Kelley PM, Tu YJ, Schlegel HB. Ascorbic acid: The chemistry underlying its antioxidant properties. Free Radic Biol Med. 2020 Nov 1;159:37-43. doi: 10.1016/j.freeradbiomed.2020.07.013. Epub 2020 Jul 30.
May MJ, Vernoux T, Leaver C, et al. Glutathione homeostasis in plants: implications for environmental sensing and plant development. J Exp Bot 1998;49:649-667.
Zechmann B. Compartment-specific importance of glutathione during abiotic and biotic stress. Front Plant Sci. 2014 Oct 20;5:566. doi: 10.3389/fpls.2014.00566. eCollection 2014.
May JM, Harrison FE. Role of vitamin C in the function of the vascular endothelium. Antioxid Redox Signal. 2013 Dec 10;19(17):2068-83. doi: 10.1089/ars.2013.5205. Epub 2013 May 29.
Dingchao H, Zhiduan Q, Liye H, Xiaodong F. The protective effects of high-dose ascorbic acid on myocardium against reperfusion injury during and after cardiopulmonary bypass. Thorac Cardiovasc Surg. 1994 Oct;42(5):276-8. doi: 10.1055/s-2007-1016504.
Winkler BS, Orselli SM, Rex TS. The redox couple between glutathione and ascorbic acid: a chemical and physiological perspective. Free Radic Biol Med. 1994 Oct;17(4):333-49. doi: 10.1016/0891-5849(94)90019-1.
Rodrigo R, Guichard C, Charles R. Clinical pharmacology and therapeutic use of antioxidant vitamins. Fundam Clin Pharmacol. 2007 Apr;21(2):111-27. doi: 10.1111/j.1472-8206.2006.00466.x.
Yussif NM. Vitamin C - an update on current uses and functions. Vitam C - an Updat Curr Uses Funct 2019;1:7-8.
Sadeghpour A, Alizadehasl A, Kyavar M, Sadeghi T, Moludi J, Gholizadeh F, Totonchi Z, Ghadrdoost B. Impact of vitamin C supplementation on post-cardiac surgery ICU and hospital length of stay. Anesth Pain Med. 2015 Feb 19;5(1):e25337. doi: 10.5812/aapm.25337. eCollection 2015 Feb.
Fernandes GS, Fernandez CD, Campos KE, Damasceno DC, Anselmo-Franci JA, Kempinas WD. Vitamin C partially attenuates male reproductive deficits in hyperglycemic rats. Reprod Biol Endocrinol. 2011 Jul 27;9:100. doi: 10.1186/1477-7827-9-100.
Sonmez M, Turk G, Yuce A. The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats. Theriogenology. 2005 Apr 15;63(7):2063-72. doi: 10.1016/j.theriogenology.2004.10.003. Epub 2004 Nov 18.
Holford P, Carr AC, Jovic TH, Ali SR, Whitaker IS, Marik PE, Smith AD. Vitamin C-An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19. Nutrients. 2020 Dec 7;12(12):3760. doi: 10.3390/nu12123760.
Paltiel O, Gordon L, Berg D, Israeli A. Effect of a computerized alert on the management of hypokalemia in hospitalized patients. Arch Intern Med. 2003 Jan 27;163(2):200-4. doi: 10.1001/archinte.163.2.200.
Geng J, Qian J, Si W, Cheng H, Ji F, Shen Z. The clinical benefits of perioperative antioxidant vitamin therapy in patients undergoing cardiac surgery: a meta-analysis. Interact Cardiovasc Thorac Surg. 2017 Dec 1;25(6):966-974. doi: 10.1093/icvts/ivx178.
Zhu YB, Zhang YP, Zhang J, Zhang YB. Evaluation of Vitamin C Supplementation on Kidney Function and Vascular Reactivity Following Renal Ischemic Injury in Mice. Kidney Blood Press Res. 2016;41(4):460-70. doi: 10.1159/000443447. Epub 2016 Jul 15.
Tanaka H, Matsuda T, Miyagantani Y, Yukioka T, Matsuda H, Shimazaki S. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch Surg. 2000 Mar;135(3):326-31. doi: 10.1001/archsurg.135.3.326.
Kahn SA, Beers RJ, Lentz CW. Resuscitation after severe burn injury using high-dose ascorbic acid: a retrospective review. J Burn Care Res. 2011 Jan-Feb;32(1):110-7. doi: 10.1097/BCR.0b013e318204b336.
Travica N, Ried K, Sali A, Scholey A, Hudson I, Pipingas A. Vitamin C Status and Cognitive Function: A Systematic Review. Nutrients. 2017 Aug 30;9(9):960. doi: 10.3390/nu9090960.
Eldridge CF, Bunge MB, Bunge RP, Wood PM. Differentiation of axon-related Schwann cells in vitro. I. Ascorbic acid regulates basal lamina assembly and myelin formation. J Cell Biol. 1987 Aug;105(2):1023-34. doi: 10.1083/jcb.105.2.1023.
Huang J, Agus DB, Winfree CJ, Kiss S, Mack WJ, McTaggart RA, Choudhri TF, Kim LJ, Mocco J, Pinsky DJ, Fox WD, Israel RJ, Boyd TA, Golde DW, Connolly ES Jr. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11720-4. doi: 10.1073/pnas.171325998.
Berger MM, Oudemans-van Straaten HM. Vitamin C supplementation in the critically ill patient. Curr Opin Clin Nutr Metab Care. 2015 Mar;18(2):193-201. doi: 10.1097/MCO.0000000000000148.
Oakes B, Bolia IK, Weber AE, Petrigliano FA. Vitamin C in orthopedic practices: Current concepts, novel ideas, and future perspectives. J Orthop Res. 2021 Apr;39(4):698-706. doi: 10.1002/jor.24947. Epub 2021 Jan 4.
Brzezinska O, Lukasik Z, Makowska J, Walczak K. Role of Vitamin C in Osteoporosis Development and Treatment-A Literature Review. Nutrients. 2020 Aug 10;12(8):2394. doi: 10.3390/nu12082394.
Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. Criteria and recommendations for vitamin C intake. JAMA. 1999 Apr 21;281(15):1415-23. doi: 10.1001/jama.281.15.1415.
Yamamoto T, Kinoshita M, Shinomiya N, Hiroi S, Sugasawa H, Matsushita Y, Majima T, Saitoh D, Seki S. Pretreatment with ascorbic acid prevents lethal gastrointestinal syndrome in mice receiving a massive amount of radiation. J Radiat Res. 2010;51(2):145-56. doi: 10.1269/jrr.09078. Epub 2009 Dec 4.
Al-Asmari AK, Khan AQ, Al-Qasim AM, Al-Yousef Y. Ascorbic acid attenuates antineoplastic drug 5-fluorouracil induced gastrointestinal toxicity in rats by modulating the expression of inflammatory mediators. Toxicol Rep. 2015 Jun 15;2:908-916. doi: 10.1016/j.toxrep.2015.06.006. eCollection 2015.
Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017 Aug 12;9(8):866. doi: 10.3390/nu9080866.
Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017 Nov 3;9(11):1211. doi: 10.3390/nu9111211.
Lim JC, Caballero Arredondo M, Braakhuis AJ, Donaldson PJ. Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract. Nutrients. 2020 Oct 14;12(10):3142. doi: 10.3390/nu12103142.
Grosso G, Bei R, Mistretta A, Marventano S, Calabrese G, Masuelli L, Giganti MG, Modesti A, Galvano F, Gazzolo D. Effects of vitamin C on health: a review of evidence. Front Biosci (Landmark Ed). 2013 Jun 1;18(3):1017-29. doi: 10.2741/4160.
Moser MA, Chun OK. Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies. Int J Mol Sci. 2016 Aug 12;17(8):1328. doi: 10.3390/ijms17081328.
Chambial S, Dwivedi S, Shukla KK, John PJ, Sharma P. Vitamin C in disease prevention and cure: an overview. Indian J Clin Biochem. 2013 Oct;28(4):314-28. doi: 10.1007/s12291-013-0375-3. Epub 2013 Sep 1.
Juraschek SP, Guallar E, Appel LJ, Miller ER 3rd. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012 May;95(5):1079-88. doi: 10.3945/ajcn.111.027995. Epub 2012 Apr 4.
Hill A, Wendt S, Benstoem C, Neubauer C, Meybohm P, Langlois P, Adhikari NK, Heyland DK, Stoppe C. Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach. Nutrients. 2018 Jul 27;10(8):974. doi: 10.3390/nu10080974.
Wilson JX. Evaluation of vitamin C for adjuvant sepsis therapy. Antioxid Redox Signal. 2013 Dec 10;19(17):2129-40. doi: 10.1089/ars.2013.5401. Epub 2013 Jun 25.
Tyml K. Vitamin C and Microvascular Dysfunction in Systemic Inflammation. Antioxidants (Basel). 2017 Jun 29;6(3):49. doi: 10.3390/antiox6030049.
Takahashi T, Lord B, Schulze PC, Fryer RM, Sarang SS, Gullans SR, Lee RT. Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes. Circulation. 2003 Apr 15;107(14):1912-6. doi: 10.1161/01.CIR.0000064899.53876.A3. Epub 2003 Mar 31.
Ashor AW, Siervo M, Lara J, Oggioni C, Mathers JC. Antioxidant vitamin supplementation reduces arterial stiffness in adults: a systematic review and meta-analysis of randomized controlled trials. J Nutr. 2014 Oct;144(10):1594-602. doi: 10.3945/jn.114.195826. Epub 2014 Aug 6.
Ashor AW, Lara J, Mathers JC, Siervo M. Effect of vitamin C on endothelial function in health and disease: a systematic review and meta-analysis of randomised controlled trials. Atherosclerosis. 2014 Jul;235(1):9-20. doi: 10.1016/j.atherosclerosis.2014.04.004. Epub 2014 Apr 18.
Hu X, Yuan L, Wang H, Li C, Cai J, Hu Y, Ma C. Efficacy and safety of vitamin C for atrial fibrillation after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials. Int J Surg. 2017 Jan;37:58-64. doi: 10.1016/j.ijsu.2016.12.009. Epub 2016 Dec 9.
Polymeropoulos E, Bagos P, Papadimitriou M, Rizos I, Patsouris E, Tauoumpoulis I. Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis. Adv Pharm Bull. 2016 Jun;6(2):243-50. doi: 10.15171/apb.2016.033. Epub 2016 Jun 30.
Tsao CS. An overview of ascorbic acid chemistry and biochemistry. In: Packer L, Fuchs JE, eds. Vitamin C in Health and Disease. Marcel Dekker Inc; 1997:25-58.
Zabet MH, Mohammadi M, Ramezani M, Khalili H. Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock. J Res Pharm Pract. 2016 Apr-Jun;5(2):94-100. doi: 10.4103/2279-042X.179569.
Spoelstra-de Man AME, Elbers PWG, Oudemans-van Straaten HM. Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury. Crit Care. 2018 Mar 20;22(1):70. doi: 10.1186/s13054-018-1996-y.
Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC. Vitamin C revisited. Crit Care. 2014 Aug 6;18(4):460. doi: 10.1186/s13054-014-0460-x.
Odgaard-Jensen J, Vist GE, Timmer A, Kunz R, Akl EA, Schunemann H, Briel M, Nordmann AJ, Pregno S, Oxman AD. Randomisation to protect against selection bias in healthcare trials. Cochrane Database Syst Rev. 2011 Apr 13;2011(4):MR000012. doi: 10.1002/14651858.MR000012.pub3.
Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995 Feb 1;273(5):408-12. doi: 10.1001/jama.273.5.408.
Day SJ, Altman DG. Statistics notes: blinding in clinical trials and other studies. BMJ. 2000 Aug 19-26;321(7259):504. doi: 10.1136/bmj.321.7259.504. No abstract available.
Kane SP. Sample Size Calculator. ClinCalc: https://clincalc.com/stats/samplesize.aspx. Updated July 24, 2019. Accessed August 4, 2021.
Rosner, Bernard (Bernard A.). (2011). Fundamentals of biostatistics. Boston :Brooks/Cole, Cengage Learning.
Hulley SB, Cummings SR, Browner WS, Grady D, Newman TB. Designing clinical research : an epidemiologic approach. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013. Appendix 6A, page 73. ISBN/ISSN: 9781608318049
Nielsen SJ, Karlsson M, Bjorklund E, Martinsson A, Hansson EC, Malm CJ, Pivodic A, Jeppsson A. Socioeconomic Factors, Secondary Prevention Medication, and Long-Term Survival After Coronary Artery Bypass Grafting: A Population-Based Cohort Study From the SWEDEHEART Registry. J Am Heart Assoc. 2020 Mar 3;9(5):e015491. doi: 10.1161/JAHA.119.015491. Epub 2020 Mar 2.
Farkouh ME, Domanski M, Dangas GD, Godoy LC, Mack MJ, Siami FS, Hamza TH, Shah B, Stefanini GG, Sidhu MS, Tanguay JF, Ramanathan K, Sharma SK, French J, Hueb W, Cohen DJ, Fuster V; FREEDOM Follow-On Study Investigators. Long-Term Survival Following Multivessel Revascularization in Patients With Diabetes: The FREEDOM Follow-On Study. J Am Coll Cardiol. 2019 Feb 19;73(6):629-638. doi: 10.1016/j.jacc.2018.11.001. Epub 2018 Nov 11.
Head SJ, Milojevic M, Daemen J, Ahn JM, Boersma E, Christiansen EH, Domanski MJ, Farkouh ME, Flather M, Fuster V, Hlatky MA, Holm NR, Hueb WA, Kamalesh M, Kim YH, Makikallio T, Mohr FW, Papageorgiou G, Park SJ, Rodriguez AE, Sabik JF 3rd, Stables RH, Stone GW, Serruys PW, Kappetein AP. Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data. Lancet. 2018 Mar 10;391(10124):939-948. doi: 10.1016/S0140-6736(18)30423-9. Epub 2018 Feb 23.
Xenogiannis I, Tajti P, Hall AB, Alaswad K, Rinfret S, Nicholson W, Karmpaliotis D, Mashayekhi K, Furkalo S, Cavalcante JL, Burke MN, Brilakis ES. Update on Cardiac Catheterization in Patients With Prior Coronary Artery Bypass Graft Surgery. JACC Cardiovasc Interv. 2019 Sep 9;12(17):1635-1649. doi: 10.1016/j.jcin.2019.04.051. Epub 2019 Aug 14.
Doenst T, Haverich A, Serruys P, Bonow RO, Kappetein P, Falk V, Velazquez E, Diegeler A, Sigusch H. PCI and CABG for Treating Stable Coronary Artery Disease: JACC Review Topic of the Week. J Am Coll Cardiol. 2019 Mar 5;73(8):964-976. doi: 10.1016/j.jacc.2018.11.053.
Bjorklund E, Nielsen SJ, Hansson EC, Karlsson M, Wallinder A, Martinsson A, Tygesen H, Romlin BS, Malm CJ, Pivodic A, Jeppsson A. Secondary prevention medications after coronary artery bypass grafting and long-term survival: a population-based longitudinal study from the SWEDEHEART registry. Eur Heart J. 2020 May 1;41(17):1653-1661. doi: 10.1093/eurheartj/ehz714.
Watson D, O'Connell Motherway M, Schoterman MH, van Neerven RJ, Nauta A, van Sinderen D. Selective carbohydrate utilization by lactobacilli and bifidobacteria. J Appl Microbiol. 2013 Apr;114(4):1132-46. doi: 10.1111/jam.12105. Epub 2013 Jan 11.
K. Tuohy, C. Ziemer, A. Klinder, Y. Knobel, B. Pool-Zobel and G. Gibson, "A Human Volunteer Study to Determine the Prebiotic Effects of Lactulose Powder on Human Colonic Microbiota.," Microbial Ecology in Health and Disease, vol. 14, no. 3, 2011.
Markowiak P, Slizewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017 Sep 15;9(9):1021. doi: 10.3390/nu9091021.
Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 2013 Apr 22;5(4):1417-35. doi: 10.3390/nu5041417.
Roberfroid M. Prebiotics: the concept revisited. J Nutr. 2007 Mar;137(3 Suppl 2):830S-7S. doi: 10.1093/jn/137.3.830S.
Cardelle-Cobas A, Corzo N, Olano A, Pelaez C, Requena T, Avila M. Galactooligosaccharides derived from lactose and lactulose: influence of structure on Lactobacillus, Streptococcus and Bifidobacterium growth. Int J Food Microbiol. 2011 Sep 1;149(1):81-7. doi: 10.1016/j.ijfoodmicro.2011.05.026. Epub 2011 Jun 12.
Musa MA, Kabir M, Hossain MI, Ahmed E, Siddique A, Rashid H, Mahfuz M, Mondal D, Ahmed T, Petri WA, Haque R. Measurement of intestinal permeability using lactulose and mannitol with conventional five hours and shortened two hours urine collection by two different methods: HPAE-PAD and LC-MSMS. PLoS One. 2019 Aug 8;14(8):e0220397. doi: 10.1371/journal.pone.0220397. eCollection 2019.
Nath A, Molnar MA, Csighy A, Koszegi K, Galambos I, Huszar KP, Koris A, Vatai G. Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels. Medicina (Kaunas). 2018 Dec 3;54(6):98. doi: 10.3390/medicina54060098.
Nath A, Haktanirlar G, Varga A, Molnar MA, Albert K, Galambos I, Koris A, Vatai G. Biological Activities of Lactose-Derived Prebiotics and Symbiotic with Probiotics on Gastrointestinal System. Medicina (Kaunas). 2018 Apr 17;54(2):18. doi: 10.3390/medicina54020018.
Zhai S, Zhu L, Qin S, Li L. Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice. Microbiologyopen. 2018 Dec;7(6):e00612. doi: 10.1002/mbo3.612. Epub 2018 Mar 24.
Bothe MK, Maathuis AJH, Bellmann S, van der Vossen JMBM, Berressem D, Koehler A, Schwejda-Guettes S, Gaigg B, Kuchinka-Koch A, Stover JF. Dose-Dependent Prebiotic Effect of Lactulose in a Computer-Controlled In Vitro Model of the Human Large Intestine. Nutrients. 2017 Jul 18;9(7):767. doi: 10.3390/nu9070767.
Ridola L, Faccioli J, Nardelli S, Gioia S, Riggio O. Hepatic Encephalopathy: Diagnosis and Management. J Transl Int Med. 2020 Dec 31;8(4):210-219. doi: 10.2478/jtim-2020-0034. eCollection 2020 Dec.
Pranami, D., Sharma, R., & Pathak, H. (2017). Lactulose: a prebiotic, laxative and detoxifying agent. Drugs & Therapy Perspectives, 33(5), 228-233.
Fuller S, Beck E, Salman H, Tapsell L. New Horizons for the Study of Dietary Fiber and Health: A Review. Plant Foods Hum Nutr. 2016 Mar;71(1):1-12. doi: 10.1007/s11130-016-0529-6.
Žilić, S., Dodig, D., Milašinović-Šeremešić, M., Kandić, V., Kostadinović, M., Prodanović, S., & Savić, Đ. (2011). Small grain cereals compared for dietary fibre and protein contents. Genetika, 43(2), 381-395. https://doi.org/10.2298/GENSR1102381Z
Mudgil D, Barak S. Composition, properties and health benefits of indigestible carbohydrate polymers as dietary fiber: a review. Int J Biol Macromol. 2013 Oct;61:1-6. doi: 10.1016/j.ijbiomac.2013.06.044. Epub 2013 Jul 2.
Modern enterosorbents and mechanisms of their action. Efferent therapy, 11(4), 3.
A review on enterosorbents and their application in clinical practice: Removal of toxic metals Author links open overlay panelSevda Fatullayeva , Dilgam Tagiyev, Nizami Zeynalov
Liu R, Dai L, Xu C, Wang K, Zheng C, Si C. Lignin-Based Micro- and Nanomaterials and their Composites in Biomedical Applications. ChemSusChem. 2020 Sep 7;13(17):4266-4283. doi: 10.1002/cssc.202000783. Epub 2020 Jun 25.
Ismailova, M. G., Yunuskhodjaeva, K. G., & Boyko, P. L. I. I. B. (2014). Physical-chemical and pharmacological research on new lignin enterosorbent. Journal of Pharmacy and Pharmacology, 2, 642-651.
Kumar R, Butreddy A, Kommineni N, Reddy PG, Bunekar N, Sarkar C, Dutt S, Mishra VK, Aadil KR, Mishra YK, Oupicky D, Kaushik A. Lignin: Drug/Gene Delivery and Tissue Engineering Applications. Int J Nanomedicine. 2021 Mar 26;16:2419-2441. doi: 10.2147/IJN.S303462. eCollection 2021.
Saravanan P, Davidson NC, Schmidt EB, Calder PC. Cardiovascular effects of marine omega-3 fatty acids. Lancet. 2010 Aug 14;376(9740):540-50. doi: 10.1016/S0140-6736(10)60445-X. Epub 2010 Jul 15.
Schmidt EB, Arnesen H, Christensen JH, Rasmussen LH, Kristensen SD, De Caterina R. Marine n-3 polyunsaturated fatty acids and coronary heart disease: Part II. clinical trials and recommendations. Thromb Res. 2005;115(4):257-62. doi: 10.1016/j.thromres.2004.09.007. No abstract available.
Arnesen H. n-3 fatty acids and revascularization procedures. Lipids. 2001;36 Suppl:S103-6. doi: 10.1007/s11745-001-0690-z.
Vijayakumar M, Vasudevan DM, Sundaram KR, Krishnan S, Vaidyanathan K, Nandakumar S, Chandrasekhar R, Mathew N. A randomized study of coconut oil versus sunflower oil on cardiovascular risk factors in patients with stable coronary heart disease. Indian Heart J. 2016 Jul-Aug;68(4):498-506. doi: 10.1016/j.ihj.2015.10.384. Epub 2016 Jan 13.
Raitt MH, Connor WE, Morris C, Kron J, Halperin B, Chugh SS, McClelland J, Cook J, MacMurdy K, Swenson R, Connor SL, Gerhard G, Kraemer DF, Oseran D, Marchant C, Calhoun D, Shnider R, McAnulty J. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA. 2005 Jun 15;293(23):2884-91. doi: 10.1001/jama.293.23.2884.
Nye ER, Ablett MB, Robertson MC, Ilsley CD, Sutherland WH. Effect of eicosapentaenoic acid on restenosis rate, clinical course and blood lipids in patients after percutaneous transluminal coronary angioplasty. Aust N Z J Med. 1990 Aug;20(4):549-52. doi: 10.1111/j.1445-5994.1990.tb01311.x.
Sacks FM, Stone PH, Gibson CM, Silverman DI, Rosner B, Pasternak RC. Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group. J Am Coll Cardiol. 1995 Jun;25(7):1492-8. doi: 10.1016/0735-1097(95)00095-l.
Danthiir V, Burns NR, Nettelbeck T, Wilson C, Wittert G. The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults. Nutr J. 2011 Oct 20;10:117. doi: 10.1186/1475-2891-10-117.
Doi M, Nosaka K, Miyoshi T, Iwamoto M, Kajiya M, Okawa K, Nakayama R, Takagi W, Takeda K, Hirohata S, Ito H. Early eicosapentaenoic acid treatment after percutaneous coronary intervention reduces acute inflammatory responses and ventricular arrhythmias in patients with acute myocardial infarction: a randomized, controlled study. Int J Cardiol. 2014 Oct 20;176(3):577-82. doi: 10.1016/j.ijcard.2014.08.055. Epub 2014 Aug 19.
Abdelhamid AS, Martin N, Bridges C, Brainard JS, Wang X, Brown TJ, Hanson S, Jimoh OF, Ajabnoor SM, Deane KH, Song F, Hooper L. Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018 Nov 27;11(11):CD012345. doi: 10.1002/14651858.CD012345.pub3.
Studer M, Briel M, Leimenstoll B, Glass TR, Bucher HC. Effect of different antilipidemic agents and diets on mortality: a systematic review. Arch Intern Med. 2005 Apr 11;165(7):725-30. doi: 10.1001/archinte.165.7.725.
Bucher HC, Hengstler P, Schindler C, Meier G. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med. 2002 Mar;112(4):298-304. doi: 10.1016/s0002-9343(01)01114-7.
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet. 1999 Aug 7;354(9177):447-55.
Lavie CJ, Milani RV, Mehra MR, Ventura HO. Omega-3 polyunsaturated fatty acids and cardiovascular diseases. J Am Coll Cardiol. 2009 Aug 11;54(7):585-94. doi: 10.1016/j.jacc.2009.02.084.
Lopez-Soldado I, Avella M, Botham KM. Differential influence of different dietary fatty acids on very low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants. Metabolism. 2009 Feb;58(2):186-95. doi: 10.1016/j.metabol.2008.09.012.
Deckelbaum RJ, Worgall TS, Seo T. n-3 fatty acids and gene expression. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1520S-1525S. doi: 10.1093/ajcn/83.6.1520S.
Botham KM, Zheng X, Napolitano M, Avella M, Cavallari C, Rivabene R, Bravo E. The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very-low-density lipoprotein by the liver: modulation by cellular oxidative state. Exp Biol Med (Maywood). 2003 Feb;228(2):143-51. doi: 10.1177/153537020322800203.
Mills SC, Windsor AC, Knight SC. The potential interactions between polyunsaturated fatty acids and colonic inflammatory processes. Clin Exp Immunol. 2005 Nov;142(2):216-28. doi: 10.1111/j.1365-2249.2005.02851.x.
Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR. Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Aging (Albany NY). 2017 Apr;9(4):1096-1129. doi: 10.18632/aging.101210.
Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S. doi: 10.1093/ajcn/83.6.1467S.
von Schacky C, Weber PC. Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. J Clin Invest. 1985 Dec;76(6):2446-50. doi: 10.1172/JCI112261.
Khair-el-Din TA, Sicher SC, Vazquez MA, Wright WJ, Lu CY. Docosahexaenoic acid, a major constituent of fetal serum and fish oil diets, inhibits IFN gamma-induced Ia-expression by murine macrophages in vitro. J Immunol. 1995 Feb 1;154(3):1296-306.
Kostoglou-Athanassiou I, Athanassiou L, Athanassiou P. The Effect of Omega-3 Fatty Acids on Rheumatoid Arthritis. Mediterr J Rheumatol. 2020 Jun 30;31(2):190-194. doi: 10.31138/mjr.31.2.190. eCollection 2020 Jun.
Cicero AF, Ertek S, Borghi C. Omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management. Curr Vasc Pharmacol. 2009 Jul;7(3):330-7. doi: 10.2174/157016109788340659.
Ando, K., Watanabe, T., Daidoji, H., Otaki, Y., Hashimoto, N., Kumagai, Y., ... & Kubota, I. (2015). Combination therapy of eicosapentaenoic acid and pitavastatin for coronary plaque regression evaluated by integrated backscatter intravascular ultrasonography: a randomized controlled trial. Circulation, 132(suppl_3), A12007-A12007. https://doi.org/10.1161/circ.132.suppl_3.12007
Mita T, Watada H, Ogihara T, Nomiyama T, Ogawa O, Kinoshita J, Shimizu T, Hirose T, Tanaka Y, Kawamori R. Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Atherosclerosis. 2007 Mar;191(1):162-7. doi: 10.1016/j.atherosclerosis.2006.03.005. Epub 2006 Apr 17.
Yoshiaki Shintani, Tomohiro Kawasaki, THE IMPACT OF A PURE-EPA OMEGA-3 FATTY ACID ON CORONARY PLAQUE STABILIZATION; A PLAQUE COMPONENT ANALYSIS WITH 64-SLICE MULTI-DETECTOR ROW COMPUTED TOMOGRAPHY, Journal of the American College of Cardiology, Volume 59, Issue 13, Supplement, 2012, Page E1731, ISSN 0735-1097, https://doi.org/10.1016/S0735-1097(12)61732-X. (https://www.sciencedirect.com/science/article/pii/S073510971261732X)
Wakita, Yoshinori, Yasushi Wakida, Takahumi Itou, and Rika Mizuno. "High Purity Eicosapentaenoic Acid in Addition to a Strong Statin Makes Regression of Coronary Plaque in Patients with Angina Pectoris." (2011): A8893-A8893. https://www.ahajournals.org/doi/10.1161/circ.124.suppl_21.A8893
Niki T, Wakatsuki T, Yamaguchi K, Taketani Y, Oeduka H, Kusunose K, Ise T, Iwase T, Yamada H, Soeki T, Sata M. Effects of the Addition of Eicosapentaenoic Acid to Strong Statin Therapy on Inflammatory Cytokines and Coronary Plaque Components Assessed by Integrated Backscatter Intravascular Ultrasound. Circ J. 2016;80(2):450-60. doi: 10.1253/circj.CJ-15-0813. Epub 2015 Dec 11.
Cawood AL, Ding R, Napper FL, Young RH, Williams JA, Ward MJ, Gudmundsen O, Vige R, Payne SP, Ye S, Shearman CP, Gallagher PJ, Grimble RF, Calder PC. Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability. Atherosclerosis. 2010 Sep;212(1):252-9. doi: 10.1016/j.atherosclerosis.2010.05.022. Epub 2010 May 20.
Nishio R, Shinke T, Otake H, Nakagawa M, Nagoshi R, Inoue T, Kozuki A, Hariki H, Osue T, Taniguchi Y, Iwasaki M, Hiranuma N, Konishi A, Kinutani H, Shite J, Hirata K. Stabilizing effect of combined eicosapentaenoic acid and statin therapy on coronary thin-cap fibroatheroma. Atherosclerosis. 2014 May;234(1):114-9. doi: 10.1016/j.atherosclerosis.2014.02.025. Epub 2014 Mar 5.
Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M. Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion. J Surg Res. 2012 Sep;177(1):e35-43. doi: 10.1016/j.jss.2012.04.010. Epub 2012 Apr 27.
Combination Eicosapentaenoic Acid and Statin Treatment Reversed Endothelial Dysfunction in HUVECs Exposed to Oxidized LDL R. Preston Mason, PhD ∙ Robert F. Jacob, PhD ∙ J. Jose Corbalan, PhD ∙ Tadeusz Malinski, PhD
Terano T, Shiina T, Tamura Y. Eicosapentaenoic acid suppressed the proliferation of vascular smooth muscle cells through modulation of various steps of growth signals. Lipids. 1996 Mar;31 Suppl:S301-4. doi: 10.1007/BF02637096.
McLennan PL. Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models. Lipids. 2001;36 Suppl:S111-4. doi: 10.1007/s11745-001-0692-x.
Mozaffarian D, Lemaitre RN, Kuller LH, Burke GL, Tracy RP, Siscovick DS; Cardiovascular Health Study. Cardiac benefits of fish consumption may depend on the type of fish meal consumed: the Cardiovascular Health Study. Circulation. 2003 Mar 18;107(10):1372-7. doi: 10.1161/01.cir.0000055315.79177.16.
Albert CM, Hennekens CH, O'Donnell CJ, Ajani UA, Carey VJ, Willett WC, Ruskin JN, Manson JE. Fish consumption and risk of sudden cardiac death. JAMA. 1998 Jan 7;279(1):23-8. doi: 10.1001/jama.279.1.23.
Siscovick DS, Raghunathan TE, King I, Weinmann S, Wicklund KG, Albright J, Bovbjerg V, Arbogast P, Smith H, Kushi LH, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA. 1995 Nov 1;274(17):1363-7. doi: 10.1001/jama.1995.03530170043030.
Kang JX, Leaf A. Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes. Eur J Pharmacol. 1996 Feb 15;297(1-2):97-106. doi: 10.1016/0014-2999(95)00701-6.
McLennan PL, Bridle TM, Abeywardena MY, Charnock JS. Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey. Am Heart J. 1992 Jun;123(6):1555-61. doi: 10.1016/0002-8703(92)90809-a.
Kang JX, Xiao YF, Leaf A. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3997-4001. doi: 10.1073/pnas.92.9.3997.
Murnaghan MF. Effect of fatty acids on the ventricular arrhythmia threshold in the isolated heart of the rabbit. Br J Pharmacol. 1981 Aug;73(4):909-15. doi: 10.1111/j.1476-5381.1981.tb08745.x.
Xiao YF, Gomez AM, Morgan JP, Lederer WJ, Leaf A. Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4182-7. doi: 10.1073/pnas.94.8.4182.
Xiao YF, Wright SN, Wang GK, Morgan JP, Leaf A. Fatty acids suppress voltage-gated Na+ currents in HEK293t cells transfected with the alpha-subunit of the human cardiac Na+ channel. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2680-5. doi: 10.1073/pnas.95.5.2680.
Billman GE, Kang JX, Leaf A. Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. Circulation. 1999 May 11;99(18):2452-7. doi: 10.1161/01.cir.99.18.2452.
Kang JX, Leaf A. Antiarrhythmic effects of polyunsaturated fatty acids. Recent studies. Circulation. 1996 Oct 1;94(7):1774-80. doi: 10.1161/01.cir.94.7.1774. No abstract available.
Leaf, A. (2001). The electrophysiological basis for the antiarrhythmic actions of polyunsaturated fatty acids. European heart journal supplements, 3(suppl_D), D98-D105. https://doi.org/10.1016/S1520-765X(01)90127-0
Jouven X, Charles MA, Desnos M, Ducimetiere P. Circulating nonesterified fatty acid level as a predictive risk factor for sudden death in the population. Circulation. 2001 Aug 14;104(7):756-61. doi: 10.1161/hc3201.094151.
Christensen JH. Omega-3 polyunsaturated Fatty acids and heart rate variability. Front Physiol. 2011 Nov 16;2:84. doi: 10.3389/fphys.2011.00084. eCollection 2011.
Thifault E, Cormier H, Bouchard-Mercier A, Rudkowska I, Paradis AM, Garneau V, Ouellette C, Lemieux S, Couture P, Vohl MC. Effects of age, sex, body mass index and APOE genotype on cardiovascular biomarker response to an n-3 polyunsaturated fatty acid supplementation. J Nutrigenet Nutrigenomics. 2013;6(2):73-82. doi: 10.1159/000350744. Epub 2013 May 8.
Harris WS. n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr. 1997 May;65(5 Suppl):1645S-1654S. doi: 10.1093/ajcn/65.5.1645S.
Nording ML, Yang J, Georgi K, Hegedus Karbowski C, German JB, Weiss RH, Hogg RJ, Trygg J, Hammock BD, Zivkovic AM. Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. PLoS One. 2013 Oct 24;8(10):e76575. doi: 10.1371/journal.pone.0076575. eCollection 2013.
Mozaffarian D, Stein PK, Prineas RJ, Siscovick DS. Dietary fish and omega-3 fatty acid consumption and heart rate variability in US adults. Circulation. 2008 Mar 4;117(9):1130-7. doi: 10.1161/CIRCULATIONAHA.107.732826. Epub 2008 Feb 19.
Fabian CJ, Kimler BF, Hursting SD. Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Res. 2015 May 4;17(1):62. doi: 10.1186/s13058-015-0571-6.
Bodkowski, R., Patkowska-Sokola, B., Filip-Psurska, B., Kempinska, K., Wietrzyk, J., Czyz, K., ... & Usydus, Z. (2014). Evaluation of the anti-proliferative activity of natural lipid preparations against tumor cell lines. J. Anim. Vet. Adv, 13(4), 257-266. DOI:10.3923/javaa.2014.257.266
Tsao, C.S. An overview of ascorbic acid chemistry and biochemistry. In Vitamin C in Health and Disease; Packer, L., Fuchs, J., Eds.; Marcel Dekker Inc.: New York, NY, USA, 1997; pp. 25-58.
Hamabe A, Takase B, Uehata A, Kurita A, Ohsuzu F, Tamai S. Impaired endothelium-dependent vasodilation in the brachial artery in variant angina pectoris and the effect of intravenous administration of vitamin C. Am J Cardiol. 2001 May 15;87(10):1154-9. doi: 10.1016/s0002-9149(01)01485-0.
Athanasiou A, Charalambous M, Anastasiou T, Aggeli K, Soteriades ES. Preoperative and postoperative administration of vitamin C in cardiac surgery patients - settings, dosages, duration, and clinical outcomes: a narrative review. Ann Med Surg (Lond). 2024 Apr 29;86(6):3591-3607. doi: 10.1097/MS9.0000000000002112. eCollection 2024 Jun.
Athanasiou A, Charalambous M, Anastasiou T, Soteriades ES. Pre- and post-operative administration of omega-3 polyunsaturated fatty acids in cardiac surgery patients. A narrative review. Ann Med Surg (Lond). 2025 Mar 18;87(4):2068-2092. doi: 10.1097/MS9.0000000000003061. eCollection 2025 Apr.
Ouagueni A, Shi Z, Shraim M, Al-Zoubi RM, Zarour A, Al-Ansari A, Bawadi H. Omega-3 Supplementation in Coronary Artery Bypass Graft Patients: Impact on ICU Stay and Hospital Stay-A Systematic Review and Meta-Analysis. Nutrients. 2024 Sep 29;16(19):3298. doi: 10.3390/nu16193298.
Howlett JG, Stebbins A, Petrie MC, Jhund PS, Castelvecchio S, Cherniavsky A, Sueta CA, Roy A, Pina IL, Wurm R, Drazner MH, Andersson B, Batlle C, Senni M, Chrzanowski L, Merkely B, Carson P, Desvigne-Nickens PM, Lee KL, Velazquez EJ, Al-Khalidi HR; STICH Trial Investigators. CABG Improves Outcomes in Patients With Ischemic Cardiomyopathy: 10-Year Follow-Up of the STICH Trial. JACC Heart Fail. 2019 Oct;7(10):878-887. doi: 10.1016/j.jchf.2019.04.018. Epub 2019 Sep 11.

Left Anterior Descending Artery to Right Coronary Artery Bifurcation Stenting with Culotte Technique in Acute Inferior Myocardial Infarction.

Alternate Title: Akut Alt Duvar Miyokard Enfarktüsünde Sol Ön İnen Koroner Arterden Sağ Koroner Artere Culotte Tekniği ile Bifurkasyon Stentleme İşlemi. (Turkish)

Autoren: Akçay, Murat Çınar, Ahmet Ulusoy, Aydın Can et al.

Quelle: Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi; Oct2025, Vol. 53 Issue 7, p536-540, 5p

A Case Report of Neisseria sicca Endocarditis in a Patient with Tissue Aortic Valve: Favorable Outcome Following Prompt Multidisciplinary Team Management.

Autoren: Jamil, Husam Ezzo, Talal Doumi, Aymen et al.

Quelle: British Journal of Hospital Medicine (17508460); Feb2025, Vol. 86 Issue 2, p1-6, 6p

Perivalvular Complication in Infective Endocarditis: An Integrated Imaging Approach in the Diagnostic Workup.

Autoren: Sordelli, Chiara Liguori, Carlo Fele, Nunzia et al.

Quelle: Journal of Cardiovascular Echography; Apr-Jun2025, Vol. 35 Issue 2, p108-115, 8p

Vaccination Timing Does Not Affect Growth Performance but Enhances Antibody Titers in Previously Vaccinated Calves.

Autoren: DeHaan, Erin R. Rusche, Warren C. Smith, Zachary K.

Quelle: Ruminants. Dec2024, Vol. 4 Issue 4, p476-490. 15p.

Crosstalk Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Atrial Fibrillation: Shared Mechanism, Diagnostic Integration, and Management Implications.

Autoren: Morawska, Agata Frankowski, Rafał Grabarczyk, Mikołaj et al.

Quelle: Life (2075-1729); Nov2025, Vol. 15 Issue 11, p1713, 29p

Revisiting echocardiographic features of prosthetic heart valves: the necessity of correct differentiation of mono-leaflet vs. bileaflet mechanical heart valves in a case report.

Autoren: Larti, Farnoosh Geraiely, Babak Asli, Samaneh Hasanpour et al.

Quelle: Journal of Cardiothoracic Surgery; 4/4/2024, Vol. 19 Issue 1, p1-4, 4p

Schlagwörter: PROSTHETIC heart valves, ECHOCARDIOGRAPHY, TRICUSPID valve, MITRAL valve insufficiency, TRICUSPID valve insufficiency

The mitral to aortic/pulmonary velocity-time integral ratio is a simple, feasible and accurate discriminator for echocardiographic evaluation of severe isolated mitral regurgitation.

Autoren: Nerlekar, Nitesh Ramkumar, Satish Maggiore, Paul et al.

Quelle: International Journal of Cardiovascular Imaging; Dec2024, Vol. 40 Issue 12, p2459-2467, 9p

Utility of the CHA²DS2-VASc score for predicting cerebral embolic events in patients with infective endocarditis.

Autoren: Mammadli, Anar Demirtola, Ayşe İrem İnan, Duygu

Quelle: Journal of Health Sciences & Medicine (JHSM); 2025, Vol. 8 Issue 4, p556-563, 8p

Schlagwörter: TRANSIENT ischemic attack, INFECTIVE endocarditis, ISCHEMIC stroke, DECISION making, ATRIAL fibrillation

Evaluation and Management of Mechanical Heart Valve Dysfunction and Thrombosis.

Autoren: Parizher, Gary Ali, Ambreen Cremer, Paul C.

Quelle: Current Cardiology Reports; Jul2024, Vol. 26 Issue 7, p747-755, 9p

Tricuspid repair in mitral regurgitation surgery: a systematic review and meta-analysis.

Autoren: Cardoso, João Lopes Ferraz Costa, Gonçalo Nuno Neves, Fátima et al.

Quelle: Journal of Cardiothoracic Surgery; 2/17/2023, Vol. 18 Issue 1, p1-9, 9p

Schlagwörter: MITRAL valve insufficiency, TRICUSPID valve surgery, MORTALITY, SURGERY, ODDS ratio, TRICUSPID valve

Author Index.

Quelle: European Heart Journal; Aug2012 Supplement 1, Vol. 33 Issue suppl_1, p1123-1196, 74p

Bi-Directional Relationship Between Bile Acids (BAs) and Gut Microbiota (GM): UDCA/TUDCA, Probiotics, and Dietary Interventions in Elderly People.

Autoren: Francini, Emanuele Badillo Pazmay, Gretta V. Fumarola, Stefania et al.

Quelle: International Journal of Molecular Sciences; Feb2025, Vol. 26 Issue 4, p1759, 18p

Schlagwörter: GUT microbiota, OLDER people, OLD age, BILE acids, CENTENARIANS

Malignant Edema in Some Sheep Flocks of Iran.

Autoren: Esmaeili, H. Joghataei, S. M. Lotfalizadeh, P. et al.

Quelle: Archives of Razi Institute; Jan/Feb2025, Vol. 80 Issue 1, p153-160, 8p

Schlagwörter: GAS gangrene, MEDICAL scientists, GRAM'S stain, SYMPTOMS, PROGNOSIS

A rare Serratia marcescens-associated acute endocarditis of a tricuspid valve in an intravenous drug user: A case report and literature review.

Autoren: Poruban, Tibor Hunavy, Mikulas Farkas, Daniel et al.

Quelle: Wiener Klinische Wochenschrift; Nov2023, Vol. 135 Issue 21/22, p631-636, 6p

Predictors of Improvement in Concomitant Tricuspid Regurgitation Following Transcatheter Edge-to-Edge Mitral Valve Repair.

Autoren: Gröger, Matthias Hirsch, Kai Felbel, Dominik et al.

Quelle: Journal of Clinical Medicine; Oct2023, Vol. 12 Issue 19, p6191, 11p

Schlagwörter: TRICUSPID valve insufficiency, MITRAL valve, MITRAL valve insufficiency, ODDS ratio, WOMEN patients

Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.

Autoren: Kelshiker, Mihir A Seligman, Henry Howard, James P et al.

Quelle: European Heart Journal; 4/21/2022, Vol. 43 Issue 16, p1582-1593, 12p

Schlagwörter: MAJOR adverse cardiovascular events, ACUTE coronary syndrome, MICROCIRCULATION disorders, HEART transplantation, MORTALITY