Výsledky vyhledávání - "Single-chain variable fragment"

Identification of internalizing ScFvs for EGFR inhibition and apoptosis induction in cholangiocarcinoma cells

Autoři: Apinya Sayinta Jinchutha Duangdara Thitima Sumphanapai a další

Zdroj: Scientific Reports, Vol 15, Iss 1, Pp 1-15 (2025)

Témata: Cholangiocarcinoma, Single-chain variable fragment (scFv), EGFR tyrosine kinase, Antibodies internalization, Apoptosis, Medicine, Science

Popis souboru: electronic resource

Relation: https://doaj.org/toc/2045-2322

Přístupová URL adresa: https://doaj.org/article/3e6b95a77bc04432bc806317affbe978

Novel anti-VEGF scFv antibodies with superior in vitro and in vivo activities

Autoři: Gulcin Cakan-Akdogan Ozlem Erez Ceren Ozer a další

Zdroj: Scientific Reports, Vol 15, Iss 1, Pp 1-11 (2025)

Témata: VEGF, Single chain variable fragment, Angiogenesis, HUVEC, Zebrafish, Medicine, Science

Popis souboru: electronic resource

Relation: https://doaj.org/toc/2045-2322

Přístupová URL adresa: https://doaj.org/article/50b76c5984f247f09de5add3c80cc8c1

Design of a prodrug bispecific antibody masked by a functional molecule for lymphocyte activation for cancer therapy

Autoři: Daimei Miura Yuki Kato Masahiro Yasunaga a další

Zdroj: Journal of Biological Engineering, Vol 19, Iss 1, Pp 1-10 (2025)

Témata: Bispecific antibody, Prodrug, Co-stimulation, Single-chain variable fragment, Cancer therapy, Biology (General), QH301-705.5

Popis souboru: electronic resource

Relation: https://doaj.org/toc/1754-1611

Přístupová URL adresa: https://doaj.org/article/3c685bf25e5e42a88c6e3ef6122ab034

Novel scFv detection system targeting the glycoprotein of harbor porpoise rhabdovirus (HPRV) through computational and experimental validation

Autoři: Ika Agus Rini Mario Marweslie Misae Kiba a další

Zdroj: Heliyon, Vol 12, Iss 1, Pp e44276- (2026)

Témata: Marine virus, Detection system, In silico, single chain variable fragment, Science (General), Q1-390, Social sciences (General), H1-99

Popis souboru: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844025026805; https://doaj.org/toc/2405-8440

Přístupová URL adresa: https://doaj.org/article/58718ab6e73344f69f0b337abec81bdf

The Therapeutic Efficacy of MS473, a Fully Human Single-Chain Variable Fragment Targeting Staphylococcus aureus Toxic Shock Syndrome Toxin-1, in a D-Galactosamine-Sensitized Mouse Model of Lethal Shock

Autoři: Fatemeh Rahimi-Jamnani Hamid Reza Moradi Abolfazl Fateh a další

Zdroj: BMC Microbiology, Vol 25, Iss 1, Pp 1-11 (2025)

Témata: Staphylococcus aureus, Toxic shock syndrome, Superantigens, Toxic shock syndrome toxin-1, Single-chain variable fragment, Microbiology, QR1-502

Popis souboru: electronic resource

Relation: https://doaj.org/toc/1471-2180

Přístupová URL adresa: https://doaj.org/article/9055edeecf0849f3af1bb3b322829991

Chimeric single-chain variable fragment-human immunoglobulin G crystallizable fragment antibody against GD2 for neuroblastoma targeted immunotherapy

Autoři: Witida Laopajon Nuchjira Takheaw Kamonporn Kotemul a další

Zdroj: Explor Target Antitumor Ther
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 6, Pp 1145-1156 (2023)

Témata: 0301 basic medicine, Monoclonal antibody, disialoganglioside, Antibody-dependent cell-mediated cytotoxicity, Physiology, Molecular biology, Immunology, Mechanosensitive Ion Channels in Physiology and Disease, Fragment crystallizable region, Transfection, Biochemistry, Gene, neuroblastoma, 03 medical and health sciences, Neuroblastoma, Immunoglobulin Fab Fragments, 0302 clinical medicine, Single-chain variable fragment, single-chain variable fragment-fragment crystallization region fusion antibody, Immunoglobulin light chain, Health Sciences, Internal medicine, Biology, Antibody, Immunology and Microbiology, Recombinant DNA, FOS: Clinical medicine, HEK 293 cells, Life Sciences, RC31-1245, Complementarity determining region, 3. Good health, Immunotoxin Therapy for Cancer Treatment, Chemistry, Neurology, FOS: Biological sciences, Immunoglobulin G, Neuroblastoma Research and Treatment, Medicine, Original Article, targeted immunotherapy, Fusion protein, Receptor

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38213540
https://doaj.org/article/34d65b7957394f8e82d8ec4a81ca6295

ScFv-h3D6 Prevents Bapineuzumab-Induced Hemorrhagic Events in the APP23 Mouse Model of Alzheimer’s Disease

Autoři: Silvia Lope-Piedrafita Gabriel Serra-Mir Paula Melón a další

Zdroj: Biomolecules, Vol 15, Iss 11, p 1602 (2025)

Témata: Alzheimer’s disease, amyloid-related imaging abnormalities, cerebral amyloid angiopathy, immunotherapy, magnetic resonance imaging, single-chain variable fragment, Microbiology, QR1-502

Popis souboru: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/11/1602; https://doaj.org/toc/2218-273X

Přístupová URL adresa: https://doaj.org/article/950f8b29acd842039b8f982213e203ee

The development and application of chimeric antigen receptor natural killer (CAR-NK) cells for cancer therapy: current state, challenges and emerging therapeutic advances

Autoři: Pin Yao Ya-Guang Liu Gang Huang a další

Zdroj: Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-27 (2024)

Témata: Chimeric antigen receptor (CAR), Single-chain variable fragment (scFv), Natural killer cells, Major histocompatibility complex (MHC), Tumor microenvironment (TME), Induced pluripotent stem cell (iPSC), Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Popis souboru: electronic resource

Relation: https://doaj.org/toc/2162-3619

Přístupová URL adresa: https://doaj.org/article/4442d43ba4af488c81033163b80f83cb

Immunoinformatics Design and Identification of B-Cell Epitopes from Vespa affinis PLA1 Allergen

Autoři: Sophida Sukprasert Siriporn Nonkhwao Thitijchaya Thanwiset a další

Zdroj: Toxins, Vol 17, Iss 8, p 373 (2025)

Témata: phospholipase A1, Vespa affinis, linear epitopes, polyclonal antibody, single-chain variable fragment antibody (scFv), Medicine

Popis souboru: electronic resource

Relation: https://www.mdpi.com/2072-6651/17/8/373; https://doaj.org/toc/2072-6651

Přístupová URL adresa: https://doaj.org/article/67bdeb24d1de405384801430afacaaca

Single-Chain Variable Fragments: Targeting Snake Venom Phospholipase A2 and Serine Protease

Autoři: Jia, Ying Garcia, Ariane Reyes, Elizabeth

Zdroj: School of Integrative Biological and Chemical Sciences Faculty Publications and Presentations

Témata: snakebite, PLA2, serine protease, peptide, immunogenicity, single-chain variable fragment, immunoglobulin G, Chemicals and Drugs

Popis souboru: application/pdf

Relation: https://scholarworks.utrgv.edu/ibcs_fac/84; https://scholarworks.utrgv.edu/context/ibcs_fac/article/1083/viewcontent/pdf.pdf

Dostupnost: https://scholarworks.utrgv.edu/ibcs_fac/84
https://doi.org/10.3390/toxins17020055
https://scholarworks.utrgv.edu/context/ibcs_fac/article/1083/viewcontent/pdf.pdf

The Design and Cell-Free Protein Synthesis of a Pembrolizumab Single-Chain Variable Fragment

Autoři: Landon E. Ebbert Tyler J. Free Mehran Soltani a další

Zdroj: Drugs and Drug Candidates ; Volume 4 ; Issue 1 ; Pages: 3

Témata: cell-free protein synthesis, pembrolizumab, Keytruda, single-chain variable fragment, scFv, cancer immunotherapy

Popis souboru: application/pdf

Relation: Biologics; https://dx.doi.org/10.3390/ddc4010003

Dostupnost: https://doi.org/10.3390/ddc4010003

CD7‐targeting pro‐apoptotic extracellular vesicles: A novel approach for T‐cell haematological malignancy therapy

Autoři: Bei Zhang Jianqiang Chen Jiming Chen a další

Zdroj: J Extracell Vesicles
Journal of Extracellular Vesicles, Vol 13, Iss 12, Pp n/a-n/a (2024)

Témata: 0301 basic medicine, 0303 health sciences, QH573-671, Bcl2 siRNA, Cytochromes c, Apoptosis, Antigens, CD7, anti‐CD7 single‐chain variable fragment, Endocytosis, Extracellular Vesicles, 03 medical and health sciences, cytochrome C, HEK293 Cells, Drug Delivery Systems, Proto-Oncogene Proteins c-bcl-2, Cell Line, Tumor, Hematologic Neoplasms, Humans, T‐cell malignancies, RNA, Small Interfering, extracellular vesicles, Cytology, Research Article, Single-Chain Antibodies

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39676736
https://doaj.org/article/8a4aaf2f345c4955834cf22b9d45ce49

Generation of bioluminescent enzyme immunoassay for ferritin by single-chain variable fragment and its NanoLuc luciferase fusion

Autoři: He, Qiyi Yang, Li Lin, Mingxia a další

Zdroj: Analytical and Bioanalytical Chemistry. 414(23)

Témata: Biological Sciences, Digestive Diseases, Liver Disease, Enzyme-Linked Immunosorbent Assay, Ferritins, Immunoassay, Immunoenzyme Techniques, Luciferases, Peptide Library, Single-Chain Antibodies, Bioluminescent enzyme immunoassay, Single-chain variable fragment, Ferritin, NanoLuc luciferase, Biomarker, Chemical Sciences, Engineering, Analytical Chemistry, Biological sciences, Chemical sciences

Popis souboru: application/pdf

Přístupová URL adresa: https://escholarship.org/uc/item/38h5r6fn
https://escholarship.org/content/qt38h5r6fn/qt38h5r6fn.pdf

Enhanced therapeutic potential of antibody fragment via IEDDA-mediated site-specific albumin conjugation

Autoři: Eun Byeol Go Jae Hun Lee Jeong Haeng Cho a další

Zdroj: Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-12 (2024)

Témata: Single-chain variable fragment, Therapeutic antibody, Human serum albumin, Site-specific conjugation, Half-life extension, Biology (General), QH301-705.5

Popis souboru: electronic resource

Relation: https://doaj.org/toc/1754-1611

Přístupová URL adresa: https://doaj.org/article/f6190c0324714d5ab25c6d715ffe904d

In Silico characterization of single-chain variable fragment antibodies targeting Foot-and-Mouth disease virus

Autoři: Akter, Fatema Medhi, Manisha Katrapati, S.L. a další

Zdroj: 33(1):8-12

A Single-Chain Variable Fragment Antibody Alleviates Inflammation and Apoptosis of Neurons by Inhibiting Tau Aggregation

Autoři: Zongbao Wang Jingye Lin Peipei Chang a další

Zdroj: Biomolecules, Vol 15, Iss 6, p 872 (2025)

Témata: Alzheimer’s disease, extracellular Tau aggregates, single-chain variable fragment antibody, ROS, Microbiology, QR1-502

Popis souboru: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/6/872; https://doaj.org/toc/2218-273X

Přístupová URL adresa: https://doaj.org/article/da29423770d7405bb6c8ff03dd7f135a

Genetically surface-modified Escherichia coli outer membrane vesicles targeting MUC1 antigen in cancer cells

Autoři: Sedthawut Laotee Wanatchaporn Arunmanee

Zdroj: Biotechnology Reports, Vol 44, Iss , Pp e00854- (2024)

Témata: Outer membrane vesicles, Surface display system, Single-chain variable fragment, SpyTag/SpyCatcher system, Cell-specific delivery system, Biotechnology, TP248.13-248.65

Popis souboru: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2215017X24000274; https://doaj.org/toc/2215-017X

Přístupová URL adresa: https://doaj.org/article/c4c51ac0e39242baadd1960f592d0dc8

HIV-based virus-like particles: design and evaluation as a targeted therapy tool

Autoři: Travassos, Rafael José Cartaxo Melo, Rita RUN

Přispěvatelé: Travassos, Rafael José Cartaxo Melo, Rita RUN

Témata: Human Immunodeficiency Virus Type 1 (HIV-1)-Based Virus-Like-Particles, Human Ep- idermal Growth Factor Receptor 2 (HER2), Single-Chain Variable Fragment (scFv), Targeted Therapy, Domínio/Área Científica::Engenharia e Tecnologia::Outras Engenharias e Tecnologias

Popis souboru: application/pdf

Dostupnost: http://hdl.handle.net/10362/173481

scFv biofunctionalized nanoparticles to effective and safe targeting of CEA-expressing colorectal cancer cells

Autoři: Maria José Silveira Cláudia Martins Tânia Cruz a další

Zdroj: Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-17 (2023)

Témata: Cancer therapy, Carcinoembryonic antigen, Drug delivery, Nanomedicine, Single-chain variable fragment functionalization, Targeted therapies, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

Popis souboru: electronic resource

Relation: https://doaj.org/toc/1477-3155

Přístupová URL adresa: https://doaj.org/article/944965b549244896b8d04d9d5315af44

Production of Therapeutic Single-Chain Variable Fragments (ScFv) in Pichia pastoris

Autoři: Montoliu-Gaya, Laia Villegas, Sandra

Zdroj: Therapeutic Antibodies. Methods and Protocols. Gunnar Houen (red.). :151-167

Témata: Psychiatry, Psykiatri, Neurosciences, Neurovetenskaper, Alzheimer’s disease, Amyloid, Pichia pastoris, ScFv, Single-chain variable fragment, Therapeutic antibody

Přístupová URL adresa: https://gup.ub.gu.se/publication/313165