Search Results - "Signal Transduction drug effects"

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action

Authors: Wilhelmsen, Kevin Deshpande, Aditi Tronnes, Sarah et al.

Source: Wilhelmsen, K, Deshpande, A, Tronnes, S, Mahanta, M, Banicki, M, Cochran, M, Cowdin, S, Fortney, K, Hartman, G, Hughes, R E, Montgomery, R, Portillo, C P, Rubin, P, Salazar, T, Wang, Y, Yan, S, Morgan, B A, Duisembekova, A, Riou, R, Marleaux, M, Hochheiser, I V, Buthmann, H, Ferber, D, Torp, J, Wang, W, Cranston, M, McKee, C M, Mawhinney, T J, McKay, E C, Eroglu, F K, Kümmerle-Deschner, J, Weber, A N R, Py, B F, Geyer, M & Coll, R C 2025, 'Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action', Journal of Experimental Medicine, vol. 222, no. 11, e20242403. https://doi.org/10.1084/jem.20242403

Subject Terms: animals, interleukin-1beta/metabolism, mice, HEK293 Cells, peritonitis/drug therapy, signal transduction/drug effects, NLR family, pyrin domain-containing 3 protein/antagonists & inhibitors, inflammasomes/metabolism, name=SDG 3 - Good Health and Well-being, mutation, humans, drug discovery

File Description: application/pdf

Access URL: https://pure.qub.ac.uk/en/publications/c6b357f8-36c1-4b33-9e72-36a8577362e5

Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations

Authors: Hsuan-Chia Chang Chung-Ying Tsai Cheng-Lung Hsu et al.

Source: Nat Metab
Nature metabolism, vol. 7, no. 5, pp. 918-927

Subject Terms: Humans, Asparagine/deficiency, Asparagine/metabolism, Asparaginase/therapeutic use, Asparaginase/pharmacology, Reactive Oxygen Species/metabolism, Nasopharyngeal Carcinoma/drug therapy, Nasopharyngeal Carcinoma/immunology, Nasopharyngeal Carcinoma/metabolism, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, CD8-Positive T-Lymphocytes/drug effects, Signal Transduction/drug effects, T-Lymphocytes/immunology, T-Lymphocytes/metabolism, T-Lymphocytes/drug effects, Nasopharyngeal Neoplasms/drug therapy, Nasopharyngeal Neoplasms/immunology, Nasopharyngeal Neoplasms/metabolism, Brief Communication

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Access URL: https://pubmed.ncbi.nlm.nih.gov/40045118
https://serval.unil.ch/resource/serval:BIB_CA5792C804FD.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_CA5792C804FD
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_CA5792C804FD8

Sodium butyrate attenuates experimental neonatal necrotizing enterocolitis by suppressing TLR4-mediated NLRP3 inflammasome-dependent pyroptosis

Authors: Gao, Yanan Yang, Liting Wu, Hongya et al.

Source: Food & Function. 16:3508-3524

Subject Terms: Pyroptosis/drug effects, Male, Inflammasomes, Intestinal inflammation, Network pharmacologies, Butyric Acid/administration & dosage, NLR Family, Pyrin Domain-Containing 3 Protein/genetics, Inflammasome, Cell Line, Food science, Rats, Sprague-Dawley, Signalling pathways, Tlr4 protein, rat, Enterocolitis, Necrotizing, Signal Transduction/drug effects, Sciences des denrées alimentaires, NLR Family, Pyrin Domain-Containing 3 Protein, Pyroptosis, Inflammasomes/metabolism, Animals, Humans, Enterocolitis, Necrotizing/genetics, Intestinal barriers, Premature infants, Inflammasomes/drug effects, Butyric Acid/pharmacology, NF-kappa B, Enterocolitis, Necrotizing/metabolism, Sodium butyrate, Enterocolitis, Necrotizing/drug therapy, Life sciences, Rats, Toll-Like Receptor 4, Molecular Docking Simulation, Disease Models, Animal, Toll-Like Receptor 4/metabolism, Animals, Newborn, NF-kappa B/metabolism, Rat model, Sciences du vivant, Neonatal rat, Butyric Acid, Nlrp3 protein, rat, NLR Family, Pyrin Domain-Containing 3 Protein/metabolism, Toll-Like Receptor 4/genetics, Protective effects, Food Science, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/40223745
https://hdl.handle.net/2268/332375
https://doi.org/10.1039/d4fo03517h

Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease

Authors: Rachel M. Barker Alfie Chambers Patrick G. Kehoe et al.

Source: Clin Sci (Lond)

Subject Terms: Male, Neoplasms, Hormone-Dependent, Breast Neoplasms, tau Proteins, Hormone-Dependent/metabolism, Phosphatidylinositol 3-Kinases, tau Proteins/metabolism, Breast Neoplasms/drug therapy, Alzheimer Disease, Signal Transduction/drug effects, Neoplasms, Proto-Oncogene Proteins c-akt/metabolism, Animals, Humans, Alzheimer Disease/metabolism, Female, Gonadal Steroid Hormones/metabolism, Phosphatidylinositol 3-Kinases/metabolism, Gonadal Steroid Hormones, Proto-Oncogene Proteins c-akt, Neoplasms/metabolism, Cancer, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/39469929

Ruthenium Drug BOLD-100 Regulates BRAFMT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation

Authors: Daryl Griffin Robbie Carson Debbie Moss et al.

Source: Mol Cancer Res
Griffin, D, Carson, R, Moss, D, Sessler, T, Lavin, D, Tiwari, V, Karelia, S, Kennedy, R, Savage, K I, McDade, S, Carie, A, Pankovich, J, Bazett, M & Van Schaeybroeck, S 2024, 'Ruthenium drug BOLD-100 regulates BRAFMT colorectal cancer cell apoptosis through AhR/ROS/ATR signaling axis modulation', Molecular Cancer Research, vol. 22, no. 12, pp. 1088-1101. https://doi.org/10.1158/1541-7786.MCR-24-0151

Subject Terms: Proto-Oncogene Proteins B-raf, Ataxia Telangiectasia Mutated Proteins/metabolism, name=Oncology, name=Cancer Research, colorectal cancer, Apoptosis, Ataxia Telangiectasia Mutated Proteins, Cancer Genes and Networks, Cell Line, ruthenium drug, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects, Cell Line, Tumor, Proto-Oncogene Proteins B-raf/genetics, Receptors, Basic Helix-Loop-Helix Transcription Factors, Humans, name=SDG 3 - Good Health and Well-being, Tumor, cell apoptosis, Apoptosis/drug effects, Colorectal Neoplasms/drug therapy, 3. Good health, Receptors, Aryl Hydrocarbon, Aryl Hydrocarbon/metabolism, BOLD-100, BRAFMT, Colorectal Neoplasms, Reactive Oxygen Species, Signal Transduction

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Access URL: https://pubmed.ncbi.nlm.nih.gov/39083088
https://pure.qub.ac.uk/en/publications/357b4c8d-d077-4033-8c9a-433d6c961788

Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2

Authors: Sha Chen Qian Wang Diane Bakker et al.

Contributors: Sha Chen Qian Wang Diane Bakker et al.

Source: Basic Res Cardiol
Basic research in cardiology, Vol. 119, no.5, p. 751-772 (2024)

Subject Terms: Male, 0301 basic medicine, Sodium-Hydrogen Exchangers, Heart failure, Mice, Inbred C57BL [MeSH], Original Contribution, NHE1, Nitric Oxide/metabolism [MeSH], Male [MeSH], Sodium-Hydrogen Exchanger 1/metabolism [MeSH], Sodium-Hydrogen Exchangers/metabolism [MeSH], Myocytes, Cardiac/metabolism [MeSH], Sodium-Glucose Transporter 2/metabolism [MeSH], Signal Transduction/drug effects [MeSH], Myocytes, Cardiac/drug effects [MeSH], SGLT2 inhibitors, Disease Models, Animal [MeSH], Sodium-Hydrogen Exchanger 1/genetics [MeSH], Heart Failure/metabolism [MeSH], Heart Failure/drug therapy [MeSH], Benzhydryl Compounds/pharmacology [MeSH], Glucosides/pharmacology [MeSH], Nitric oxide, Animals [MeSH], Heart Failure/prevention, Myocytes, Cardiac/pathology [MeSH], Mice, Knockout [MeSH], Oxidative stress, Mice [MeSH], Sodium-Glucose Transporter 2 Inhibitors/pharmacology [MeSH], Heart Failure/pathology [MeSH], Sodium-Glucose Transporter 2/genetics [MeSH], Diastolic dysfunction, Sodium-Hydrogen Exchangers/genetics [MeSH], Nitric Oxide, EVENTS, Mice, 03 medical and health sciences, ENHANCEMENT, 0302 clinical medicine, Glucosides, Sodium-Glucose Transporter 2, CARDIAC NA+/H+ EXCHANGER, Animals, Myocytes, Cardiac, Benzhydryl Compounds, Sodium-Glucose Transporter 2 Inhibitors, Heart Failure, Mice, Knockout, Sodium-Hydrogen Exchanger 1, 3. Good health, HYPERTROPHY, MODEL, Mice, Inbred C57BL, Disease Models, Animal, TARGET, PRESERVED EJECTION FRACTION, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/39046464
https://cris.maastrichtuniversity.nl/en/publications/bed657b0-166a-4852-8c1d-20b87ac85f54
https://doi.org/10.1007/s00395-024-01067-9
https://pure.amsterdamumc.nl/en/publications/6aa89832-401d-4526-b37b-084e4f7422d7
https://doi.org/10.1007/s00395-024-01067-9
https://hdl.handle.net/2078.1/299692
https://repository.publisso.de/resource/frl:6523694

Perinatal nicotine-induced neurotoxicity and behavioral alterations in newborn mice are associated with oxidative stress, inflammation and downregulated Nrf2/HO-1 signaling: protective role of Anethum graveolens

Authors: Maodaa, Saleh Ajarem, Jamaan S Alruhaimi, Reem S et al.

Source: Journal of Molecular Histology. 56

Subject Terms: Inflammation, Nicotine, Smoking, Membrane Proteins, Inflammation - metabolism - drug therapy, Antioxidants, Nicotine - toxicity - adverse effects, Neurotoxicity Syndromes - etiology - metabolism, Heme Oxygenase-1 - metabolism, Mice, Behavior, Animal - drug effects, Plant Extracts - pharmacology, Animals, Newborn, Oxidative Stress - drug effects, Oxidative stress, Pregnancy, Prenatal Exposure Delayed Effects, Signal Transduction - drug effects, NF-E2-Related Factor 2 - metabolism, Animals, Female, Dill

Access URL: https://e-space.mmu.ac.uk/640389/

Targeting Oestrogen Receptor Signalling in Breast Cancer Therapy

Authors: Howell, Sacha J Howell, Anthony

Source: Advances in Experimental Medicine and Biology ISBN: 9783031708749
Howell, S J & Howell, A 2025, Targeting Oestrogen Receptor Signalling in Breast Cancer Therapy. in A Guide to Breast Cancer Research : From Cellular Heterogeneity and Molecular Mechanisms to Therapy. Advances in Experimental Medicine and Biology, vol. 1464, Springer Nature, pp. 449-474. https://doi.org/10.1007/978-3-031-70875-6_22

Subject Terms: Selective Estrogen Receptor Modulators, Antineoplastic Agents, Hormonal/therapeutic use, Antineoplastic Agents, Hormonal, Aromatase Inhibitors, Antineoplastic Agents, Breast Neoplasms, Breast Neoplasms/drug therapy, Estrogen Receptor Antagonists/therapeutic use, Receptors, Estrogen, Signal Transduction/drug effects, Selective Estrogen Receptor Modulators/therapeutic use, Receptors, Humans, Animals, Female, Estrogen/metabolism, Receptors, Estrogen/metabolism, Hormonal/therapeutic use, Molecular Targeted Therapy/methods, Aromatase Inhibitors/therapeutic use, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/39821038
https://research.manchester.ac.uk/en/publications/79ac5dd8-2fdd-4734-bc60-6c0a12c34d02
https://doi.org/10.1007/978-3-031-70875-6_22

Triggering Toll-Like Receptor 5 Signaling During Pneumococcal Superinfection Prevents the Selection of Antibiotic Resistance

Authors: Costa, Charlotte Sirard, Jean-Claude Gibson, Paddy et al.

Contributors: Costa, Charlotte Sirard, Jean-Claude Gibson, Paddy et al.

Source: J Infect Dis
The Journal of infectious diseases, vol. 230, no. 5, pp. e1126-e1135
The Journal of Infectious Diseases

Subject Terms: infection dynamics, 0301 basic medicine, 0303 health sciences, antibiotic resistance, Amoxicillin, Models, Theoretical, Toll-like receptor 5, Pneumococcal Infections, Anti-Bacterial Agents, 3. Good health, modelling, [SDV] Life Sciences [q-bio], Toll-Like Receptor 5, 03 medical and health sciences, Streptococcus pneumoniae, Superinfection, Drug Resistance, Bacterial, Major Article, Humans, Animals, airways, Superinfection/microbiology, Superinfection/drug therapy, Streptococcus pneumoniae/drug effects, Toll-Like Receptor 5/metabolism, Toll-Like Receptor 5/agonists, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Signal Transduction/drug effects, Flagellin, Pneumococcal Infections/drug therapy, Pneumococcal Infections/microbiology, Pneumococcal Infections/immunology, Pneumococcal Infections/prevention & control, Amoxicillin/pharmacology, Amoxicillin/administration & dosage, flagellin, innate immunity, Signal Transduction

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Access URL: https://pubmed.ncbi.nlm.nih.gov/38716762
https://inserm.hal.science/inserm-04605101v1/document
https://inserm.hal.science/inserm-04605101v1
https://doi.org/10.1093/infdis/jiae239
https://serval.unil.ch/resource/serval:BIB_DBC6497572C4.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_DBC6497572C40
https://serval.unil.ch/notice/serval:BIB_DBC6497572C4

Targeting ferroptosis for treating kidney disease

Authors: Eikan Mishima

Source: Clin Exp Nephrol

Subject Terms: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Invited Review Article, Reperfusion Injury, Iron, Iron/metabolism [MeSH], Humans [MeSH], Ischemia reperfusion injury, Cell death, Kidney Diseases/physiopathology [MeSH], Reperfusion Injury [MeSH], Animals [MeSH], Lipid radicals, Ferroptosis/drug effects [MeSH], Kidney Diseases/drug therapy [MeSH], Oxidative stress, Kidney Diseases/pathology [MeSH], Warfarin, Signal Transduction/drug effects [MeSH], Lipid peroxidation, Kidney Diseases/metabolism [MeSH], Ferroptosis, Humans, Animals, Kidney Diseases, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/38644406
https://repository.publisso.de/resource/frl:6490223

Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor

Authors: Supriya A. Gaitonde Charlotte Avet Mario de la Fuente Revenga et al.

Source: Mol Psychiatry

Subject Terms: 0301 basic medicine, Serotonin, 0303 health sciences, Aripiprazole, Olanzapine/pharmacology [MeSH], Receptor, Serotonin, 5-HT2A/drug effects [MeSH], Haloperidol/pharmacology [MeSH], 14/5, Schizophrenia/drug therapy [MeSH], 96/10, Antipsychotic Agents/pharmacology [MeSH], 13/109, Signal Transduction/drug effects [MeSH], Clozapine/pharmacology [MeSH], Aripiprazole/pharmacology [MeSH], Serotonin 5-HT2 Receptor Agonists/pharmacology [MeSH], Serotonin/metabolism [MeSH], 82/80, Risperidone/pharmacology [MeSH], Humans [MeSH], 631/154, Receptor, Serotonin, 5-HT2A/metabolism [MeSH], 692/699/476/1799, Article, 96/106, 14/35, HEK293 Cells [MeSH], Schizophrenia/metabolism [MeSH], 13/95, 14/33, 631/1647, article, Risperidone, 03 medical and health sciences, HEK293 Cells, Olanzapine, Schizophrenia, Humans, Haloperidol, Receptor, Serotonin, 5-HT2A, Clozapine, Serotonin 5-HT2 Receptor Agonists, Antipsychotic Agents, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/38561467
https://repository.publisso.de/resource/frl:6522659

Inhibition of Sodium/Hydrogen Exchanger‐1 in the Right Ventricle and Lung Dysfunction Induced by Experimental Pulmonary Arterial Hypertension in Rats

Authors: Giuseppina Milano Melanie Reinero Julien Puyal et al.

Source: J Am Heart Assoc
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 14, Iss 6 (2025)
Journal of the American Heart Association, vol. 14, no. 6, pp. e036859

Subject Terms: Male, autophagy, Pulmonary Arterial Hypertension, Sodium-Hydrogen Exchanger 1, Indoles, Hypertrophy, Right Ventricular, Ventricular Dysfunction, Right, Heart Ventricles, Hypertension, Pulmonary, Sugen5416/hypoxia, right ventricle, Guanidines, sodium/hydrogen exchanger type 1, Rats, Rats, Sprague-Dawley, Disease Models, Animal, Animals, Sodium-Hydrogen Exchanger 1/metabolism, Sodium-Hydrogen Exchanger 1/antagonists & inhibitors, Ventricular Dysfunction, Right/physiopathology, Ventricular Dysfunction, Right/metabolism, Ventricular Dysfunction, Right/prevention & control, Pulmonary Arterial Hypertension/physiopathology, Pulmonary Arterial Hypertension/drug therapy, Pulmonary Arterial Hypertension/metabolism, Lung/drug effects, Lung/metabolism, Lung/physiopathology, Ventricular Function, Right/drug effects, Hypertrophy, Right Ventricular/physiopathology, Hypertrophy, Right Ventricular/metabolism, Hypertrophy, Right Ventricular/prevention & control, Hypertrophy, Right Ventricular/etiology, Hypertension, Pulmonary/physiopathology, Hypertension, Pulmonary/metabolism, Hypertension, Pulmonary/chemically induced, Hypertension, Pulmonary/drug therapy, Hypertension, Pulmonary/prevention & control, Pyrroles/pharmacology, Pulmonary Artery/drug effects, Pulmonary Artery/physiopathology, Pulmonary Artery/metabolism, Pulmonary Artery/pathology, Signal Transduction/drug effects, Heart Ventricles/physiopathology, Heart Ventricles/metabolism, Heart Ventricles/drug effects, Heart Ventricles/pathology, pulmonary arterial hypertension, RC666-701, Ventricular Function, Right, Diseases of the circulatory (Cardiovascular) system, Pyrroles, Lung, Original Research

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40055146
https://doaj.org/article/53dd231a80d44b44a7c45dedc0ffb46f
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_78B8931539371
https://serval.unil.ch/notice/serval:BIB_78B893153937
https://serval.unil.ch/resource/serval:BIB_78B893153937.P001/REF.pdf

Palmitate potentiates the SMAD3-PAI-1 pathway by reducing nuclear GDF15 levels

Authors: Montori-Grau, Marta Barroso, Emma Jurado-Aguilar, Javier et al.

Contributors: Montori-Grau, Marta Barroso, Emma Jurado-Aguilar, Javier et al.

Source: Cell Mol Life Sci
Cellular and molecular life sciences, vol. 82, no. 1, pp. 43

Subject Terms: Male, Growth Differentiation Factor 15, Muscle Fibers, Skeletal, PAI-1, Palmitates, Palmitate, Diet, High-Fat, SMAD3, Cell Line, Mice, Oleate, Plasminogen Activator Inhibitor 1, Animals, Humans, Smad3 Protein, Muscle, Skeletal, Mice, Knockout, Cell Nucleus, Insulin resistance, [SDV] Life Sciences [q-bio], Mice, Inbred C57BL, GDF15, Smad3 Protein/metabolism, Growth Differentiation Factor 15/metabolism, Growth Differentiation Factor 15/genetics, Signal Transduction/drug effects, Plasminogen Activator Inhibitor 1/metabolism, Plasminogen Activator Inhibitor 1/genetics, Muscle Fibers, Skeletal/metabolism, Muscle Fibers, Skeletal/drug effects, Palmitates/pharmacology, Cell Nucleus/metabolism, Cell Nucleus/drug effects, Muscle, Skeletal/metabolism, Diet, High-Fat/adverse effects, Muscle, Original Article, Signal Transduction

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39825925
https://serval.unil.ch/resource/serval:BIB_138E6565B2A4.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_138E6565B2A4
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_138E6565B2A46
https://hal.inrae.fr/hal-05176146v1
https://doi.org/10.1007/s00018-024-05571-y
https://hal.inrae.fr/hal-05176146v1/document

Exploring the antiproliferative effect of PI3K/Akt/mTOR pathway and CDK4/6 inhibitors in human papillomavirus‑positive and ‑negative head and neck squamous cell carcinoma cell lines

Authors: Verhees, Femke Demers, Imke Legemaate, Dion et al.

Source: Int J Oncol

Subject Terms: Head and Neck Neoplasms/drug therapy virology metabolism, cell survival, Cell Line, Cell Proliferation/drug effects, Papillomavirus Infections/drug therapy virology, Signal Transduction/drug effects, Phosphoinositide-3 Kinase Inhibitors/pharmacology, Thiazoles/pharmacology, Proto-Oncogene Proteins c-akt/metabolism, Humans, Piperazines/pharmacology, human papillomavirus, Pyridines/pharmacology, Tumor, Apoptosis/drug effects, apoptosis, Human Papillomavirus Viruses, cell line, Articles, Cyclin-Dependent Kinase 6/antagonists & inhibitors, TOR Serine-Threonine Kinases/metabolism antagonists & inhibitors, Aminopyridines/pharmacology, Protein Kinase Inhibitors/pharmacology therapeutic use, Squamous Cell Carcinoma of Head and Neck/drug therapy virology metabolism pathology, cell cycle, head and neck cancer, Cyclin-Dependent Kinase 4/antagonists & inhibitors metabolism, Phosphatidylinositol 3-Kinases/metabolism, Purines/pharmacology, Cell Survival/drug effects

OX40 in the Pathogenesis of Atopic Dermatitis—A New Therapeutic Target

Authors: Michael Croft Ehsanollah Esfandiari Camilla Chong et al.

Source: Am J Clin Dermatol

Subject Terms: ddc:610, T-Lymphocytes, OX40 Ligand, Review Article, Receptors, OX40, OX40 Ligand/metabolism [MeSH], Skin/immunology [MeSH], Receptors, OX40/antagonists, T-Lymphocytes/immunology [MeSH], T-Lymphocytes/metabolism [MeSH], Humans [MeSH], Severity of Illness Index [MeSH], Receptors, OX40/metabolism [MeSH], Treatment Outcome [MeSH], Dermatitis, Atopic/immunology [MeSH], Receptors, OX40/immunology [MeSH], Skin/pathology [MeSH], Signal Transduction/immunology [MeSH], Molecular Targeted Therapy [MeSH], OX40 Ligand/antagonists, Quality of Life [MeSH], Signal Transduction/drug effects [MeSH], Dermatitis, Atopic/drug therapy [MeSH], Severity of Illness Index, Dermatitis, Atopic, Treatment Outcome, Quality of Life, Humans, Molecular Targeted Therapy, Skin, Signal Transduction

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38236520
https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1131245
https://opus.bibliothek.uni-augsburg.de/opus4/files/113124/s40257-023-00838-9.pdf
https://doi.org/10.1007/s40257-023-00838-9
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/113124
https://repository.publisso.de/resource/frl:6490838

Multiple gene-drug prediction tool reveals Rosiglitazone based treatment pathway for non-segmental vitiligo

Authors: Zhao, Sijia Chen, Xi Dutta, Kuheli et al.

Source: Inflammation

Subject Terms: Melanins, 0301 basic medicine, Research, Vitiligo, Computational Biology, Receptor, Endothelin B, PPAR gamma, Rosiglitazone, 03 medical and health sciences, 0302 clinical medicine, Melanins/metabolism [MeSH], PPAR gamma/metabolism [MeSH], Melanocytes/metabolism [MeSH], PPAR gamma/agonists [MeSH], PPAR pathway, Rosiglitazone/pharmacology [MeSH], Melanins/biosynthesis [MeSH], PPAR gamma/genetics [MeSH], Zebrafish [MeSH], bioinformatics analysis, Vitiligo/drug therapy [MeSH], Vitiligo/genetics [MeSH], Signal Transduction/drug effects [MeSH], rosiglitazone, Rosiglitazone/therapeutic use [MeSH], Humans [MeSH], Animals [MeSH], Receptor, Endothelin B/genetics [MeSH], melanogenesis, Melanocytes/drug effects [MeSH], Receptor, Endothelin B/metabolism [MeSH], non-segmental vitiligo, Vitiligo/metabolism [MeSH], Computational Biology/methods [MeSH], Humans, Melanocytes, Animals, Zebrafish, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/38159176
https://repository.publisso.de/resource/frl:6495340

Synthesis, characterization, and anti-inflammatory potential of serotonin- and dopamine-conjugates of urolithin A

Authors: Maciej Korczak Martina Redl Piotr Roszkowski et al.

Source: Biomedicine & Pharmacotherapy. 189:118282

Subject Terms: Serotonin/chemistry, Inflammation, 106022 Mikrobiologie, Serotonin, 301209 Pharmazie, Caenorhabditis elegans/drug effects, Dopamine, Cytokines/metabolism, 301204 Pharmakognosie, Neurotransmitters, Postbiotic metabolite, Structure derivatization, Urolithin A, Mice, 301209 Pharmacy, Macrophages/drug effects, Signal Transduction/drug effects, Coumarins/pharmacology, NF-kappa B/metabolism, 106022 Microbiology, Animals, Anti-Inflammatory Agents/pharmacology, 301204 Pharmacognosy, Parkinson Disease/drug therapy, Dopamine/chemistry

Maternal lactoferrin supplementation prevents mitochondrial and redox homeostasis dysfunction, and improves antioxidant defenses through Nrf2 and UCP2 signaling after neonatal hypoxia-ischemia

Authors: Carvalho, Andrey Vinicios S Farias Sanches, Eduardo Ribeiro, Rafael T et al.

Source: ISSN: 0891-5849 ; Free radical biology & medicine, vol. 231 (2025) p. 68-79.

Subject Terms: info:eu-repo/classification/ddc/618, Antioxidants, Bovine lactoferrin, Mitochondria, Neonatal hypoxia-ischemia, Neuroprotection, Oxidative stress, Animals, Lactoferrin / administration & dosage, Lactoferrin / pharmacology, NF-E2-Related Factor 2 / metabolism, NF-E2-Related Factor 2 / genetics, Female, Mitochondria / drug effects, Mitochondria / metabolism, Mitochondria / pathology, Uncoupling Protein 2 / metabolism, Uncoupling Protein 2 / genetics, Rats, Hypoxia-Ischemia, Brain / metabolism, Brain / pathology, Brain / drug therapy, Brain / diet therapy, Pregnancy, Oxidative Stress / drug effects, Wistar, Signal Transduction / drug effects, Newborn, Male

Relation: info:eu-repo/semantics/altIdentifier/pmid/40010517; unige:188896

Availability: https://archive-ouverte.unige.ch/unige:188896

Semiautomatic quantification of 3D Histone H3 phosphorylation signals during cell division in Arabidopsis root meristems

Authors: Kelemen, Adrienn Uyttewaal, Magalie Máthé, Csaba et al.

Contributors: Kelemen, Adrienn Uyttewaal, Magalie Máthé, Csaba et al.

Source: ISSN: 0028-646X.

Subject Terms: 3D image analysis, signal quantification, PP2A, histone phosphorylation, cell division, MESH: Arabidopsis Proteins / metabolism, MESH: Arabidopsis* / cytology, MESH: Mitosis / drug effects, MESH: Mutation / genetics, MESH: Phosphorylation / drug effects, MESH: Plant Roots* / cytology, MESH: Plant Roots* / metabolism, MESH: Signal Transduction* / drug effects, MESH: Arabidopsis* / drug effects, MESH: Arabidopsis* / metabolism, MESH: Cell Division* / drug effects, MESH: Histones* / metabolism, MESH: Imaging, Three-Dimensional* / methods, MESH: Meristem* / cytology, MESH: Meristem* / drug effects, MESH: Meristem* / metabolism, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/40619913; PUBMED: 40619913; WOS: 001523618500001

Availability: https://hal.inrae.fr/hal-05233351
https://hal.inrae.fr/hal-05233351v1/document
https://hal.inrae.fr/hal-05233351v1/file/2025_Kelemen-nph70365.pdf
https://doi.org/10.1111/nph.70365

Data Mining Approach to Melatonin Treatment in Alzheimer's Disease:New Gene Targets MMP2 and NR3C1

Authors: Zhang, Jingyi Tsui, Ka Chun Lee, Hoi Ying et al.

Source: Zhang, J, Tsui, K C, Lee, H Y, Aquili, L, Wong, K H, Kocabicak, E, Temel, Y, Lu, Z, Fung, M-L, Kalueff, A & Lim, L W 2025, 'Data Mining Approach to Melatonin Treatment in Alzheimer's Disease : New Gene Targets MMP2 and NR3C1', International Journal of Molecular Sciences, vol. 26, no. 1, 338. https://doi.org/10.3390/ijms26010338

Subject Terms: Alzheimer’s disease, GO enrichment, KEGG pathway, data mining, gene targets, melatonin, Alzheimer Disease/drug therapy genetics metabolism, Melatonin/pharmacology therapeutic use, Humans, Matrix Metalloproteinase 2/genetics metabolism, Protein Interaction Maps, Gene Regulatory Networks/drug effects, Gene Ontology, Signal Transduction/drug effects

Relation: info:eu-repo/semantics/altIdentifier/pissn/1661-6596; info:eu-repo/semantics/altIdentifier/eissn/1422-0067

Availability: https://cris.maastrichtuniversity.nl/en/publications/9cd8c225-f145-4aba-bbfc-5bb2927da6b5
https://doi.org/10.3390/ijms26010338
https://www.scopus.com/pages/publications/85214447375