Search Results - "Signal Transduction"

A new mechanism of light signals involved in the virulence of Botrytis cinerea: regulating photomorphogenesis and N-vanillylnonanamide biosynthesis.

Authors: Li G Zhang Z Chen Y et al.

Source: Science China. Life sciences [Sci China Life Sci] 2025 Dec; Vol. 68 (12), pp. 3682-3695. Date of Electronic Publication: 2025 Sep 11.

Publication Type: Journal Article

Journal Info: Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE

MeSH Terms: Botrytis*/pathogenicity , Botrytis*/metabolism , Botrytis*/genetics , Botrytis*/radiation effects , Botrytis*/growth & development , Light* , Amides*/metabolism , Light Signal Transduction*, Gene Expression Regulation, Fungal/radiation effects ; Fungal Proteins/metabolism ; Fungal Proteins/genetics ; Virulence/radiation effects ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Signal Transduction ; Morphogenesis/radiation effects ; Benzaldehydes/metabolism

SCR Organism: Botrytis cinerea

TANDEM ZINC-FINGER/PLUS3: a multifaceted integrator of light signaling.

Authors: Feng Z Zioutopoulou A Xu T et al.

Source: Trends in plant science [Trends Plant Sci] 2025 Jun; Vol. 30 (6), pp. 654-664. Date of Electronic Publication: 2024 Dec 18.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science, Ltd Country of Publication: England NLM ID: 9890299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4372 (Electronic) Linking ISSN: 13601385 NLM ISO Abbreviation: Trends Plant Sci Subsets: MEDLINE

MeSH Terms: Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Light Signal Transduction* , Transcription Factors*/metabolism , Transcription Factors*/genetics, Zinc Fingers ; Arabidopsis/metabolism ; Arabidopsis/genetics ; Gene Expression Regulation, Plant ; Signal Transduction ; Light ; Phytochrome A/metabolism

Phytochrome B-mediated light signalling enhances rice resistance to saline-alkaline and sheath blight by regulating multiple downstream transcription factors.

Authors: Chen H Zhou T Wu X et al.

Source: Plant biotechnology journal [Plant Biotechnol J] 2025 May; Vol. 23 (5), pp. 1476-1490. Date of Electronic Publication: 2025 Jan 31.

Publication Type: Journal Article

Journal Info: Publisher: Wiley on behalf of the Society for Experimental Biology, Association of Applied Biologists Country of Publication: England NLM ID: 101201889 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-7652 (Electronic) Linking ISSN: 14677644 NLM ISO Abbreviation: Plant Biotechnol J Subsets: MEDLINE

MeSH Terms: Oryza*/genetics , Oryza*/microbiology , Oryza*/metabolism , Oryza*/physiology , Phytochrome B*/metabolism , Phytochrome B*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Plant Diseases*/microbiology , Light Signal Transduction*/physiology, Plant Proteins/metabolism ; Plant Proteins/genetics ; Gene Expression Regulation, Plant ; Disease Resistance/genetics ; Signal Transduction

The E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC 1 and transcription factors ELONGATED HYPOCOTYL 5 and ROOT HAIR DEFECTIVE6 integrate light signaling and root hair development.

Authors: Zhang T Zhu J Liu Y et al.

Source: Plant physiology [Plant Physiol] 2025 Feb 07; Vol. 197 (2).

Publication Type: Journal Article

Journal Info: Publisher: American Society of Plant Biologists Country of Publication: United States NLM ID: 0401224 Publication Model: Print Cited Medium: Internet ISSN: 1532-2548 (Electronic) Linking ISSN: 00320889 NLM ISO Abbreviation: Plant Physiol Subsets: MEDLINE

MeSH Terms: Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Arabidopsis*/genetics , Arabidopsis*/growth & development , Arabidopsis*/metabolism , Arabidopsis*/radiation effects , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Plant Roots*/growth & development , Plant Roots*/genetics , Plant Roots*/metabolism , Basic-Leucine Zipper Transcription Factors*/metabolism , Basic-Leucine Zipper Transcription Factors*/genetics , Light Signal Transduction* , Nuclear Proteins*/metabolism , Nuclear Proteins*/genetics, Gene Expression Regulation, Plant ; Signal Transduction ; Light ; Basic Helix-Loop-Helix Transcription Factors

Nitrogen at the crossroads of light: integration of light signalling and plant nitrogen metabolism.

Authors: Sathee L R S Barman D et al.

Source: Journal of experimental botany [J Exp Bot] 2025 Feb 07; Vol. 76 (3), pp. 803-818.

Publication Type: Journal Article; Review

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9882906 Publication Model: Print Cited Medium: Internet ISSN: 1460-2431 (Electronic) Linking ISSN: 00220957 NLM ISO Abbreviation: J Exp Bot Subsets: MEDLINE

MeSH Terms: Nitrogen*/metabolism , Plants*/metabolism , Plants*/radiation effects , Light* , Light Signal Transduction*, Signal Transduction ; Gene Expression Regulation, Plant

Lighting the path: how light signaling regulates stomatal movement and plant immunity.

Authors: Singh N Giri MK Chattopadhyay D

Source: Journal of experimental botany [J Exp Bot] 2025 Feb 07; Vol. 76 (3), pp. 769-786.

Publication Type: Journal Article; Review

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9882906 Publication Model: Print Cited Medium: Internet ISSN: 1460-2431 (Electronic) Linking ISSN: 00220957 NLM ISO Abbreviation: J Exp Bot Subsets: MEDLINE

MeSH Terms: Plant Stomata*/physiology , Plant Stomata*/radiation effects , Plant Stomata*/immunology , Plant Immunity*/radiation effects , Light Signal Transduction*, Light ; Signal Transduction

Light signal regulates endoreduplication and tomato fruit expansion through the SlPIF1a-SlTLFP8-SlCDKB2 module.

Authors: Zhang J Xu J Wang X et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jan 28; Vol. 122 (4), pp. e2404445122. Date of Electronic Publication: 2025 Jan 23.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Solanum lycopersicum*/genetics , Solanum lycopersicum*/growth & development , Solanum lycopersicum*/metabolism , Solanum lycopersicum*/radiation effects , Plant Proteins*/metabolism , Plant Proteins*/genetics , Fruit*/growth & development , Fruit*/genetics , Fruit*/metabolism , Fruit*/radiation effects , Endoreduplication*/radiation effects , Light Signal Transduction* , F-Box Proteins*/metabolism , F-Box Proteins*/genetics , Cyclin-Dependent Kinases*/metabolism , Cyclin-Dependent Kinases*/genetics, Gene Expression Regulation, Plant ; Light ; Ubiquitination ; Signal Transduction

Light signal transduction in plants: insights from phytochrome nuclear translocation and photobody formation.

Authors: Chang G Xiang F Fan Y et al.

Source: The New phytologist [New Phytol] 2025 Dec; Vol. 248 (5), pp. 2221-2235. Date of Electronic Publication: 2025 Sep 12.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley on behalf of New Phytologist Trust Country of Publication: England NLM ID: 9882884 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8137 (Electronic) Linking ISSN: 0028646X NLM ISO Abbreviation: New Phytol Subsets: MEDLINE

MeSH Terms: Phytochrome*/metabolism , Cell Nucleus*/metabolism , Cell Nucleus*/radiation effects , Light Signal Transduction*/radiation effects , Plants*/metabolism , Plants*/radiation effects , Light* , Signal Transduction*/radiation effects, Active Transport, Cell Nucleus/radiation effects

BBX32 integrates ethylene and light signaling to delay apical hook opening and optimize seedling soil emergence.

Authors: Ravindran N Rao KV Datta S

Source: The New phytologist [New Phytol] 2025 Oct; Vol. 248 (2), pp. 758-775. Date of Electronic Publication: 2025 May 28.

Publication Type: Journal Article

Journal Info: Publisher: Wiley on behalf of New Phytologist Trust Country of Publication: England NLM ID: 9882884 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8137 (Electronic) Linking ISSN: 0028646X NLM ISO Abbreviation: New Phytol Subsets: MEDLINE

MeSH Terms: Ethylenes*/metabolism , Ethylenes*/pharmacology , Seedlings*/radiation effects , Seedlings*/growth & development , Seedlings*/drug effects , Seedlings*/metabolism , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Arabidopsis*/radiation effects , Arabidopsis*/genetics , Arabidopsis*/growth & development , Arabidopsis*/metabolism , Arabidopsis*/drug effects , Light* , Soil* , Signal Transduction*/radiation effects , Signal Transduction*/drug effects , Light Signal Transduction*/radiation effects , Light Signal Transduction*/drug effects, Gene Expression Regulation, Plant/radiation effects ; Gene Expression Regulation, Plant/drug effects ; Etiolation/radiation effects ; Etiolation/drug effects ; Mutation/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Transcription Factors/metabolism

Serotonergic Regulation of Photic Signaling of Ascorbate in the Rat Thalamus.

Authors: Miyamoto H Hamada K

Source: Molecular neurobiology [Mol Neurobiol] 2025 Oct; Vol. 62 (10), pp. 13379-13389. Date of Electronic Publication: 2025 Jun 16.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Serotonin*/metabolism , Thalamus*/metabolism , Thalamus*/radiation effects , Ascorbic Acid*/metabolism , Signal Transduction* , Light Signal Transduction*/physiology , Light*, Animals ; Male ; Rats ; Circadian Rhythm/physiology ; Rats, Sprague-Dawley

G Protein: β-Arrestin Bias Confers Differential Regulation of Gα q Signaling by GPR17 Antagonists.

Authors: McDonald JK Abrol A Lumb C et al.

Source: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Dec 03; Vol. 16 (23), pp. 4479-4491. Date of Electronic Publication: 2025 Nov 12.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH Terms: Receptors, G-Protein-Coupled*/antagonists & inhibitors , Receptors, G-Protein-Coupled*/metabolism , Signal Transduction*/drug effects , Signal Transduction*/physiology , beta-Arrestins*/metabolism , GTP-Binding Protein alpha Subunits, Gq-G11*/metabolism, Humans ; Animals ; HEK293 Cells ; Mice ; beta-Arrestin 2/metabolism ; Nerve Tissue Proteins

Tannic acid prevents UVB-induced skin photoaging by regulating ferroptosis through NRF2/SLC7A11/GPX4 signaling.

Authors: Chen Z Ye L Zhu L et al.

Source: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2025 Dec; Vol. 273, pp. 113309. Date of Electronic Publication: 2025 Nov 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B Subsets: MEDLINE

MeSH Terms: Ultraviolet Rays*/adverse effects , NF-E2-Related Factor 2*/metabolism , Skin Aging*/drug effects , Skin Aging*/radiation effects , Ferroptosis*/drug effects , Ferroptosis*/radiation effects , Tannins*/pharmacology , Tannins*/chemistry , Signal Transduction*/drug effects , Signal Transduction*/radiation effects , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism, Animals ; Humans ; Mice ; Mice, Inbred BALB C ; Reactive Oxygen Species/metabolism ; Fibroblasts/metabolism ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/radiation effects ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Skin/radiation effects ; Skin/metabolism ; Skin/cytology ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Antioxidants ; Cell Line ; Polyphenols

Astaxanthin suppress ferroptosis through the Akt1-FoxO3a signaling pathway to alleviates brain injury after intracerebral hemorrhage.

Authors: Zhang J Hua Q Gao L et al.

Source: Journal of pharmacological sciences [J Pharmacol Sci] 2025 Dec; Vol. 159 (4), pp. 310-321. Date of Electronic Publication: 2025 Oct 17.

Publication Type: Journal Article

Journal Info: Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-8648 (Electronic) Linking ISSN: 13478613 NLM ISO Abbreviation: J Pharmacol Sci Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/genetics , Cerebral Hemorrhage*/complications , Cerebral Hemorrhage*/drug therapy , Signal Transduction*/drug effects , Signal Transduction*/genetics , Proto-Oncogene Proteins c-akt*/metabolism , Forkhead Box Protein O3*/metabolism , Forkhead Box Protein O3*/genetics , Brain Injuries*/etiology , Brain Injuries*/prevention & control , Brain Injuries*/drug therapy, Animals ; Xanthophylls/pharmacology ; Xanthophylls/therapeutic use ; Oxidative Stress/drug effects ; Male ; Rats ; Rats, Sprague-Dawley ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; PC12 Cells ; Disease Models, Animal ; Cell Survival/drug effects ; Up-Regulation/drug effects

Rosiridin reduces Idiopathic Pulmonary Fibrosis by inhibiting the STAT3/NFκB/SMAD3 signaling pathways.

Authors: Li Y Qi H Xu H et al.

Source: Journal of pharmacological sciences [J Pharmacol Sci] 2025 Dec; Vol. 159 (4), pp. 242-251. Date of Electronic Publication: 2025 Sep 19.

Publication Type: Journal Article

Journal Info: Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-8648 (Electronic) Linking ISSN: 13478613 NLM ISO Abbreviation: J Pharmacol Sci Subsets: MEDLINE

MeSH Terms: STAT3 Transcription Factor*/metabolism , Signal Transduction*/drug effects , Signal Transduction*/genetics , NF-kappa B*/metabolism , Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/pathology , Idiopathic Pulmonary Fibrosis*/metabolism , Idiopathic Pulmonary Fibrosis*/chemically induced , Smad3 Protein*/metabolism, Animals ; Oxidative Stress/drug effects ; Bleomycin ; Humans ; Male ; Mice, Inbred C57BL ; Apoptosis/drug effects ; Transforming Growth Factor beta1

Inhibiting the JAK-STAT3 pathway in nucleus accumbens astrocytes alleviates cocaine-induced motor hyperactivity.

Authors: Arnoux I Capano A Yakoubi R et al.

Source: Progress in neurobiology [Prog Neurobiol] 2025 Dec; Vol. 255, pp. 102852. Date of Electronic Publication: 2025 Nov 10.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0370121 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5118 (Electronic) Linking ISSN: 03010082 NLM ISO Abbreviation: Prog Neurobiol Subsets: MEDLINE

MeSH Terms: Astrocytes*/drug effects , Astrocytes*/metabolism , Nucleus Accumbens*/drug effects , Nucleus Accumbens*/metabolism , Cocaine*/pharmacology , STAT3 Transcription Factor*/metabolism , Signal Transduction*/drug effects , Signal Transduction*/physiology , Dopamine Uptake Inhibitors*/pharmacology , Janus Kinases*/metabolism , Hyperkinesis*/chemically induced , Hyperkinesis*/metabolism, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Cocaine-Related Disorders/metabolism

Systematic review: Effects of cholinergic signaling on cognition in human pharmacological studies.

Authors: Dan YR Christakou A Roelofs K

Source: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2025 Dec; Vol. 179, pp. 106408. Date of Electronic Publication: 2025 Oct 10.

Publication Type: Journal Article; Systematic Review; Review

Journal Info: Publisher: Pergamon Press Country of Publication: United States NLM ID: 7806090 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7528 (Electronic) Linking ISSN: 01497634 NLM ISO Abbreviation: Neurosci Biobehav Rev Subsets: MEDLINE

MeSH Terms: Cognition*/drug effects , Cognition*/physiology , Acetylcholine*/metabolism , Cholinergic Agents*/pharmacology , Brain*/drug effects , Brain*/physiology , Signal Transduction*/drug effects , Signal Transduction*/physiology, Humans ; Attention/drug effects ; Attention/physiology ; Animals

The neural circuits and signalling pathways of opioid use disorder.

Authors: Mathis VP Ehrlich AT Darcq E

Source: Nature reviews. Neuroscience [Nat Rev Neurosci] 2025 Dec; Vol. 26 (12), pp. 778-797. Date of Electronic Publication: 2025 Oct 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962781 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0048 (Electronic) Linking ISSN: 1471003X NLM ISO Abbreviation: Nat Rev Neurosci Subsets: MEDLINE

MeSH Terms: Opioid-Related Disorders*/physiopathology , Opioid-Related Disorders*/metabolism , Signal Transduction*/physiology , Signal Transduction*/drug effects , Neural Pathways*/physiopathology , Neural Pathways*/metabolism , Neural Pathways*/drug effects , Brain*/physiopathology , Brain*/metabolism , Brain*/drug effects , Nerve Net*/physiopathology, Humans ; Animals ; Analgesics, Opioid/adverse effects ; Receptors, Opioid/metabolism

Mechanistic insights and therapeutic prospects of targeting the signal transducer and activator of transcription 3 signaling pathway in cerebrovascular diseases.

Authors: Wu JW Wang BX Sha XW et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117375. Date of Electronic Publication: 2025 Oct 05.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: STAT3 Transcription Factor*/metabolism , STAT3 Transcription Factor*/antagonists & inhibitors , STAT3 Transcription Factor*/genetics , Signal Transduction*/drug effects , Signal Transduction*/physiology , Cerebrovascular Disorders*/metabolism , Cerebrovascular Disorders*/drug therapy , Drug Delivery Systems*/methods, Humans ; Animals ; Molecular Targeted Therapy/methods

Ionic and signaling mechanisms involved in the excitation of entorhinal neurons by group I mGluRs.

Authors: Lei S Oraegbuna CS Boyle CA et al.

Source: Neuropharmacology [Neuropharmacology] 2025 Dec 01; Vol. 280, pp. 110683. Date of Electronic Publication: 2025 Sep 11.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH Terms: Entorhinal Cortex*/drug effects , Entorhinal Cortex*/cytology , Entorhinal Cortex*/physiology , Entorhinal Cortex*/metabolism , Receptors, Metabotropic Glutamate*/agonists , Receptors, Metabotropic Glutamate*/metabolism , Receptors, Metabotropic Glutamate*/physiology , Signal Transduction*/drug effects , Signal Transduction*/physiology , Pyramidal Cells*/drug effects , Pyramidal Cells*/physiology , Pyramidal Cells*/metabolism , Neurons*/drug effects , Neurons*/physiology, Animals ; Methoxyhydroxyphenylglycol/analogs & derivatives ; Methoxyhydroxyphenylglycol/pharmacology ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/metabolism ; TRPC Cation Channels/metabolism ; Receptor, Metabotropic Glutamate 5 ; Male ; Rats ; Phospholipase C beta/metabolism ; Calcium/metabolism ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Diglycerides/metabolism ; Protein Kinase C/metabolism ; Mice ; Excitatory Amino Acid Agonists/pharmacology ; Resorcinols

PatientProfiler: building patient-specific signaling models from proteogenomic data.

Authors: Lombardi V Di Rocco L Meo E et al.

Source: Molecular systems biology [Mol Syst Biol] 2025 Dec; Vol. 21 (12), pp. 1845-1865. Date of Electronic Publication: 2025 Oct 10.

Publication Type: Journal Article

Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE

MeSH Terms: Signal Transduction* , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Proteogenomics*/methods , Computational Biology*/methods, Humans ; Female ; Biomarkers, Tumor/genetics ; Prognosis ; Transcriptome