Suchergebnisse - "Sertoli Cells"

The insecticide chlorpyrifos leads to genotoxic effects by triggering oxidative stress and apoptosis in Sertoli cells.

Autoren: Aydin Y Kurtel H Cakir E et al.

Quelle: Toxicology and industrial health [Toxicol Ind Health] 2025 Dec; Vol. 41 (12), pp. 550-562. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: England NLM ID: 8602702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0393 (Electronic) Linking ISSN: 07482337 NLM ISO Abbreviation: Toxicol Ind Health Subsets: MEDLINE

MeSH-Schlagworte: Chlorpyrifos*/toxicity , Sertoli Cells*/drug effects , Sertoli Cells*/metabolism , Oxidative Stress*/drug effects , Apoptosis*/drug effects , Insecticides*/toxicity , DNA Damage*/drug effects, Male ; Animals ; Cell Survival/drug effects ; Cell Line ; Mice ; Malondialdehyde/metabolism

Cytotoxicity of methamphetamine exposure on Sertoli cells: a pilot study with implications for male infertility.

Autoren: Fisher D Zabida O Abdul-Rasool S et al.

Quelle: Drug and chemical toxicology [Drug Chem Toxicol] 2025 Nov; Vol. 48 (6), pp. 1317-1327. Date of Electronic Publication: 2025 Mar 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Methamphetamine*/toxicity , Methamphetamine*/administration & dosage , Sertoli Cells*/drug effects , Sertoli Cells*/pathology , Sertoli Cells*/metabolism , Infertility, Male*/chemically induced , Central Nervous System Stimulants*/toxicity , Central Nervous System Stimulants*/administration & dosage, Male ; Pilot Projects ; Cell Survival/drug effects ; Animals ; Blood-Testis Barrier/drug effects ; Blood-Testis Barrier/metabolism ; Dose-Response Relationship, Drug ; Cell Proliferation/drug effects ; Humans ; Cell Line ; Spermatogenesis/drug effects

In vitro effects of environmentally relevant concentrations of nonylphenol and selected pyrethroid metabolites on a mouse sertoli cell line (TM4).

Autoren: Matjomane NK Repsold L Patrick SM et al.

Quelle: Toxicology mechanisms and methods [Toxicol Mech Methods] 2025 Nov; Vol. 35 (9), pp. 1289-1298. Date of Electronic Publication: 2025 Jul 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6524 (Electronic) Linking ISSN: 15376516 NLM ISO Abbreviation: Toxicol Mech Methods Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/drug effects , Sertoli Cells*/metabolism , Sertoli Cells*/pathology , Phenols*/toxicity , Phenols*/metabolism , Pyrethrins*/toxicity , Pyrethrins*/metabolism , Endocrine Disruptors*/toxicity , Endocrine Disruptors*/metabolism , Environmental Pollutants*/toxicity, Animals ; Mice ; Male ; Cell Survival/drug effects ; Reactive Oxygen Species/metabolism ; Oxidative Stress/drug effects ; Cell Line ; Dose-Response Relationship, Drug

1α,25(OH) 2 D 3 alleviates perfluorooctane sulfonic acid-induced oxidative injury through the Nrf2-ARE pathway via VDR in Sertoli cells.

Autoren: Liang Y Huo H Wei W et al.

Quelle: Journal of endocrinological investigation [J Endocrinol Invest] 2025 Oct; Vol. 48 (10), pp. 2413-2426. Date of Electronic Publication: 2025 Jul 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/drug effects , Sertoli Cells*/metabolism , Sertoli Cells*/pathology , Fluorocarbons*/toxicity , Alkanesulfonic Acids*/toxicity , NF-E2-Related Factor 2*/metabolism , Oxidative Stress*/drug effects , Receptors, Calcitriol*/metabolism , Calcitriol*/pharmacology, Animals ; Male ; Mice ; Signal Transduction/drug effects ; Reactive Oxygen Species/metabolism ; Cell Survival/drug effects

Selenium nanoparticles attenuates silver nanoparticles toxicity in mice Sertoli cells via modulation of SOD and Kindlin-2.

Autoren: Safaei S Azarnia M Amini E et al.

Quelle: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2025 Oct; Vol. 91, pp. 127720. Date of Electronic Publication: 2025 Aug 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Gustav Fisher Country of Publication: Germany NLM ID: 9508274 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3252 (Electronic) Linking ISSN: 0946672X NLM ISO Abbreviation: J Trace Elem Med Biol Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/drug effects , Sertoli Cells*/metabolism , Selenium*/pharmacology , Selenium*/chemistry , Metal Nanoparticles*/chemistry , Metal Nanoparticles*/toxicity , Superoxide Dismutase*/metabolism , Superoxide Dismutase*/genetics , Silver*/toxicity , Silver*/chemistry , Muscle Proteins*/metabolism, Animals ; Male ; Mice ; Reactive Oxygen Species/metabolism ; Cell Survival/drug effects ; Oxidative Stress/drug effects ; Malondialdehyde/metabolism ; Cytoskeletal Proteins

Gut microbiota-metabolite crosstalk mediates icariin's protection against obesity-induced spermatogenic dysfunction through NF-κB/AMH axis in Sertoli cells.

Autoren: Huang Q Ji L Meng Z et al.

Quelle: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Dec; Vol. 149, pp. 157490. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH-Schlagworte: Flavonoids*/pharmacology , Gastrointestinal Microbiome*/drug effects , Obesity*/complications , NF-kappa B*/metabolism , Sertoli Cells*/drug effects , Sertoli Cells*/metabolism , Anti-Mullerian Hormone*/metabolism , Spermatogenesis*/drug effects, Male ; Animals ; Diet, High-Fat/adverse effects ; Mice ; Mice, Inbred C57BL ; Infertility, Male/drug therapy ; Infertility, Male/etiology ; Anti-Inflammatory Agents/pharmacology ; Signal Transduction/drug effects ; Testis/drug effects

Mumps virus infection triggers early pro-inflammatory responses and impairs Leydig and Sertoli cell function in an ex vivo human testis model.

Autoren: Franklin L Kuassivi ON Satie AP et al.

Quelle: Human reproduction (Oxford, England) [Hum Reprod] 2025 Dec 01; Vol. 40 (12), pp. 2231-2246.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print Cited Medium: Internet ISSN: 1460-2350 (Electronic) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE

MeSH-Schlagworte: Leydig Cells*/virology , Leydig Cells*/metabolism , Leydig Cells*/pathology , Sertoli Cells*/virology , Sertoli Cells*/metabolism , Sertoli Cells*/pathology , Mumps virus*/physiology , Mumps*/immunology , Mumps*/virology , Testis*/virology , Testis*/pathology , Testis*/metabolism , Testis*/immunology, Humans ; Male ; Adult ; Middle Aged ; Virus Replication ; Aged ; Immunity, Innate ; Testosterone/metabolism ; Inhibins/metabolism ; Orchitis/virology ; Inflammation

RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility.

Autoren: He C Cui Y Chen W et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e17491. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/metabolism , Sertoli Cells*/cytology , DNA Methylation*/genetics , Cellular Reprogramming*/genetics , Spermatogonia*/metabolism , Fertility*/genetics , Infertility, Male*/genetics , Infertility, Male*/metabolism , Adult Germline Stem Cells*/metabolism, Male ; Humans ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; Azoospermia/genetics

Nrf2/Bach1 axis regulates redox homeostasis and energy metabolism to optimize Sertoli cell-mediated efferocytosis.

Autoren: Wu D Zhang K Tan J et al.

Quelle: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2025 Dec 01; Vol. 610, pp. 112661. Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: North Holland Publishing Country of Publication: Ireland NLM ID: 7500844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8057 (Electronic) Linking ISSN: 03037207 NLM ISO Abbreviation: Mol Cell Endocrinol Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/metabolism , NF-E2-Related Factor 2*/metabolism , Energy Metabolism* , Basic-Leucine Zipper Transcription Factors*/metabolism , Basic-Leucine Zipper Transcription Factors*/genetics , Homeostasis* , Phagocytosis*, Male ; Animals ; Oxidation-Reduction ; Mice ; Mice, Inbred C57BL ; Oxidative Stress ; Ferroptosis/genetics ; Signal Transduction ; Efferocytosis

Single-cell, spatial and bulk transcriptome data analysis revealed LINC00467-mediated Sertoli cell ferroptosis is a potential therapeutic target and biomarker for azoospermia.

Autoren: Bo H Zhu F Zhao X et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 01; Vol. 240, pp. 650-662. Date of Electronic Publication: 2025 Aug 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/genetics , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Sertoli Cells*/metabolism , Sertoli Cells*/pathology , Azoospermia*/genetics , Azoospermia*/pathology , Azoospermia*/metabolism, Male ; Humans ; Single-Cell Analysis ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Biomarkers/metabolism ; Gene Expression Profiling ; Spermatogenesis/genetics ; Transcriptome ; Adult ; Sperm Retrieval

SCR Disease Name: Azoospermia, Nonobstructive

Characterization of Human Sertoli Cells Infected With Monkeypox Virus.

Autoren: Sun Y Liu L Wang Z et al.

Quelle: Journal of medical virology [J Med Virol] 2025 Nov; Vol. 97 (11), pp. e70661.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/virology , Monkeypox virus*/physiology, Humans ; Male ; Virus Replication ; Viral Load ; Gene Expression Profiling

L-citrulline protects testicular Sertoli cell function by mitigating DNA damage via the gut-testis axis of sheep fed a high-concentrate diet.

Autoren: Shan L Guo X Hu Y et al.

Quelle: NPJ biofilms and microbiomes [NPJ Biofilms Microbiomes] 2025 Oct 30; Vol. 11 (1), pp. 202. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101666944 Publication Model: Electronic Cited Medium: Internet ISSN: 2055-5008 (Electronic) Linking ISSN: 20555008 NLM ISO Abbreviation: NPJ Biofilms Microbiomes Subsets: MEDLINE

MeSH-Schlagworte: DNA Damage*/drug effects , Sertoli Cells*/drug effects , Sertoli Cells*/metabolism , Sertoli Cells*/physiology , Gastrointestinal Microbiome*/drug effects , Citrulline*/metabolism , Citrulline*/pharmacology , Testis*/drug effects , Diet*/adverse effects, Male ; Animals ; Sheep ; Fecal Microbiota Transplantation ; Blood-Testis Barrier/drug effects ; Metabolomics ; Infertility, Male ; Dysbiosis

ATG5-dependent autophagy in Sertoli cells protects against cadmium-disrupted blood-testis barrier via perturbing CXCL2/CXCR2 axis.

Autoren: Li H Hu YF Wang XR et al.

Quelle: Cell biology and toxicology [Cell Biol Toxicol] 2025 Oct 24; Vol. 41 (1), pp. 143. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/metabolism , Sertoli Cells*/drug effects , Receptors, Interleukin-8B*/metabolism , Autophagy*/drug effects , Blood-Testis Barrier*/drug effects , Blood-Testis Barrier*/metabolism , Blood-Testis Barrier*/pathology , Autophagy-Related Protein 5*/metabolism , Autophagy-Related Protein 5*/genetics , Cadmium*/toxicity , Chemokine CXCL2*/metabolism, Male ; Animals ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Spermatogenesis/drug effects ; Signal Transduction/drug effects

Assessment of microplastic toxicity on blood-testis barrier using 3D cell spheroids.

Autoren: Liu Y Du C Li H et al.

Quelle: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Oct 01; Vol. 304, pp. 119062. Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH-Schlagworte: Microplastics*/toxicity , Blood-Testis Barrier*/drug effects , Sertoli Cells*/drug effects , Water Pollutants, Chemical*/toxicity, Male ; Spheroids, Cellular/drug effects ; Animals ; Polystyrenes/toxicity ; Humans

Melatonin enhances the function of porcine immature Sertoli cells by inhibiting the HMGCS1-estradiol pathway.

Autoren: Du ZQ Mou Q Yang YW et al.

Quelle: Theriogenology [Theriogenology] 2025 Oct 01; Vol. 245, pp. 117502. Date of Electronic Publication: 2025 May 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/drug effects , Sertoli Cells*/physiology , Melatonin*/pharmacology , Estradiol*/metabolism , Hydroxymethylglutaryl-CoA Synthase*/metabolism , Hydroxymethylglutaryl-CoA Synthase*/genetics, Animals ; Swine/physiology ; Male ; Signal Transduction/drug effects ; Gene Expression Regulation/drug effects

Effects of Aging on Mammalian Spermatogenesis From a Cellular Perspective.

Autoren: Li T Xu W Yin L et al.

Quelle: Molecular reproduction and development [Mol Reprod Dev] 2025 Oct; Vol. 92 (10), pp. e70061.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8903333 Publication Model: Print Cited Medium: Internet ISSN: 1098-2795 (Electronic) Linking ISSN: 1040452X NLM ISO Abbreviation: Mol Reprod Dev Subsets: MEDLINE

MeSH-Schlagworte: Spermatogenesis*/physiology , Aging*/physiology , Aging*/pathology , Aging*/metabolism , Sertoli Cells*/metabolism , Sertoli Cells*/cytology , Sertoli Cells*/pathology , Leydig Cells*/metabolism , Leydig Cells*/cytology , Leydig Cells*/pathology , Spermatozoa*/metabolism, Male ; Animals ; Humans ; Mammals ; Testis

Size-Dependent Effects of Phyllanthus niruri Nanoemulsions on Blood-Testis Barrier Integrity and Cellular Responses in TM4 Sertoli Cells.

Autoren: Sadaqa E Mudhakir D

Quelle: IEEE transactions on nanobioscience [IEEE Trans Nanobioscience] 2025 Oct; Vol. 24 (4), pp. 454-464.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 101152869 Publication Model: Print Cited Medium: Internet ISSN: 1558-2639 (Electronic) Linking ISSN: 15361241 NLM ISO Abbreviation: IEEE Trans Nanobioscience Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/drug effects , Sertoli Cells*/cytology , Blood-Testis Barrier*/drug effects , Phyllanthus*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/toxicity , Plant Extracts*/pharmacology, Male ; Emulsions/chemistry ; Emulsions/toxicity ; Animals ; Mice ; Cell Line ; Particle Size ; Cell Survival/drug effects ; DNA Damage/drug effects

Bisphenol S disrupts human sertoli cell function through NR1H3 degradation: Mechanistic insights from integrated bulk and single-cell transcriptomics.

Autoren: Lu Z Xue P Lu D et al.

Quelle: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Nov 15; Vol. 307, pp. 119418. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH-Schlagworte: Sertoli Cells*/drug effects , Phenols*/toxicity , Sulfones*/toxicity , Transcriptome*/drug effects , Environmental Pollutants*/toxicity, Humans ; Male ; Cell Survival/drug effects ; Cell Proliferation/drug effects ; Single-Cell Analysis ; Molecular Docking Simulation ; Bisphenol S Compounds

Structural and functional insights into spermatogenesis and Sertoli cell plasticity in adult common carp (Cyprinus carpio).

Autoren: Arias Vigoya AA Oliveira MA Butzge AJ et al.

Quelle: Theriogenology [Theriogenology] 2025 Nov; Vol. 247, pp. 117574. Date of Electronic Publication: 2025 Jul 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE

MeSH-Schlagworte: Spermatogenesis*/physiology , Sertoli Cells*/physiology , Carps*/growth & development , Carps*/physiology, Cell Plasticity/physiology ; Animals ; Seminiferous Epithelium/physiology ; Bromodeoxyuridine/chemistry ; Bromodeoxyuridine/metabolism ; Germ Cells/physiology ; Male ; Testis/anatomy & histology ; Testis/pathology ; Spermatogonia/physiology ; Meiosis/physiology

Aspirin inhibits the heat stress-induced apoptosis of bull primary Sertoli cells by enhancing the extracellular transport of misfolded proteins.

Autoren: Guo Y Jiang Z Zhang H et al.

Quelle: Theriogenology [Theriogenology] 2026 Jan 01; Vol. 249, pp. 117660. Date of Electronic Publication: 2025 Aug 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE

MeSH-Schlagworte: Apoptosis*/drug effects , Sertoli Cells*/drug effects , Aspirin*/pharmacology , Heat-Shock Response*/drug effects, Animals ; Male ; Cattle ; Protein Folding/drug effects ; Hot Temperature