Suchergebnisse - "Serine Endopeptidases"

TMPRSS11E-mediated TFR1 cleavage influences IFN-γR2 internalization and the macrophage innate response.

Autoren: Wang T Chen Z Jiang Y et al.

Quelle: Communications biology [Commun Biol] 2025 Dec 03; Vol. 8 (1), pp. 1741. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Transferrin*/metabolism , Receptors, Transferrin*/genetics , Immunity, Innate* , Receptors, Interferon*/metabolism , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Macrophages*/immunology , Macrophages*/metabolism , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Macrophages, Alveolar*/metabolism , Macrophages, Alveolar*/immunology , Antigens, CD*/metabolism, Humans ; Animals ; Interferon gamma Receptor ; Mice ; Iron/metabolism ; THP-1 Cells ; Cell Differentiation ; Interferon-gamma

Anti-FAP CAR-NK cells as a novel targeted therapy against cervical cancer and cancer-associated fibroblasts.

Autoren: Polten R Kutle I Stalp JL et al.

Quelle: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2556714. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

MeSH-Schlagworte: Uterine Cervical Neoplasms*/therapy , Uterine Cervical Neoplasms*/immunology , Uterine Cervical Neoplasms*/pathology , Killer Cells, Natural*/immunology , Killer Cells, Natural*/transplantation , Killer Cells, Natural*/metabolism , Serine Endopeptidases*/immunology , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Cancer-Associated Fibroblasts*/immunology , Cancer-Associated Fibroblasts*/metabolism , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/genetics , Membrane Proteins*/immunology , Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/metabolism , Gelatinases*/immunology , Gelatinases*/antagonists & inhibitors , Gelatinases*/metabolism , Gelatinases*/genetics , Immunotherapy, Adoptive*/methods, Humans ; Female ; Tumor Microenvironment/immunology ; Endopeptidases ; Cell Line, Tumor ; Coculture Techniques

Molecular, Structural and Functional Characterization of Antheraea mylitta Expressed Cocoonase: An Integrative Approach.

Autoren: Tiwari NP Pandey JP Pandey DM

Quelle: The protein journal [Protein J] 2025 Dec; Vol. 44 (6), pp. 789-807. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 101212092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8355 (Electronic) Linking ISSN: 15723887 NLM ISO Abbreviation: Protein J Subsets: MEDLINE

MeSH-Schlagworte: Moths*/enzymology , Moths*/genetics , Insect Proteins*/genetics , Insect Proteins*/chemistry , Insect Proteins*/metabolism , Serine Endopeptidases*/chemistry , Serine Endopeptidases*/genetics , Serine Endopeptidases*/metabolism, Animals ; Phylogeny ; Amino Acid Sequence ; Cloning, Molecular ; Recombinant Proteins/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Gene Expression

High-Grade Early-Onset Prostate Cancer: Assessment of TMPRSS2::ERG -Negative Tumors Suggests Low Frequency of Germline Alterations and a Pathogenic Role for HOXB13.

Autoren: Maharjan D Siegmund S Michalova K et al.

Quelle: The American journal of surgical pathology [Am J Surg Pathol] 2025 Dec 01; Vol. 49 (12), pp. 1279-1287. Date of Electronic Publication: 2025 Aug 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 7707904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-0979 (Electronic) Linking ISSN: 01475185 NLM ISO Abbreviation: Am J Surg Pathol Subsets: MEDLINE

MeSH-Schlagworte: Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/chemistry , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/analysis , Germ-Line Mutation* , Homeodomain Proteins*/genetics , Serine Endopeptidases*/genetics , Serine Endopeptidases*/analysis, Humans ; Male ; Middle Aged ; Transcriptional Regulator ERG/analysis ; Transcriptional Regulator ERG/genetics ; Neoplasm Grading ; Age of Onset ; Genetic Predisposition to Disease ; Immunohistochemistry ; Adult ; Mismatch Repair Endonuclease PMS2/analysis

GH replacement therapy in adults stimulates fibroblast activation protein-α activity.

Autoren: Bæk A Pedersen AKN Billeskov TB et al.

Quelle: European journal of endocrinology [Eur J Endocrinol] 2025 Nov 26; Vol. 193 (6), pp. 659-666.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 9423848 Publication Model: Print Cited Medium: Internet ISSN: 1479-683X (Electronic) Linking ISSN: 08044643 NLM ISO Abbreviation: Eur J Endocrinol Subsets: MEDLINE

MeSH-Schlagworte: Human Growth Hormone*/deficiency , Human Growth Hormone*/therapeutic use , Serine Endopeptidases*/blood , Serine Endopeptidases*/metabolism , Gelatinases*/blood , Gelatinases*/metabolism , Membrane Proteins*/blood , Membrane Proteins*/metabolism , Hormone Replacement Therapy* , Hypopituitarism*/drug therapy , Hypopituitarism*/blood, Humans ; Adult ; Male ; Female ; Middle Aged ; Fibroblast Growth Factors/blood ; Endopeptidases ; Biomarkers/blood ; Collagen/metabolism ; Procollagen/blood ; Young Adult

Beyond Natriuretic Peptides: Corin and Furin As Phenotype-Specific Biomarkers and Therapeutic Gatekeepers in Heart Failure.

Autoren: Patel DV Patel S Acharya S et al.

Quelle: Current heart failure reports [Curr Heart Fail Rep] 2025 Nov 20; Vol. 22 (1), pp. 41. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Current Science Country of Publication: United States NLM ID: 101196487 Publication Model: Electronic Cited Medium: Internet ISSN: 1546-9549 (Electronic) Linking ISSN: 15469530 NLM ISO Abbreviation: Curr Heart Fail Rep Subsets: MEDLINE

MeSH-Schlagworte: Heart Failure*/metabolism , Heart Failure*/blood , Heart Failure*/drug therapy , Heart Failure*/therapy , Furin*/metabolism , Furin*/blood , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/blood , Natriuretic Peptides*, Humans ; Biomarkers/metabolism ; Biomarkers/blood ; Phenotype

Prolyl endopeptidase is a multifunctional host factor required for FMDV infection.

Autoren: Ma K Hao R Liu T et al.

Quelle: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2025 Nov 19; Vol. 82 (1), pp. 408. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Foot-and-Mouth Disease Virus*/physiology , Foot-and-Mouth Disease Virus*/pathogenicity , Foot-and-Mouth Disease*/virology , Foot-and-Mouth Disease*/genetics , Foot-and-Mouth Disease*/metabolism , Prolyl Oligopeptidases*/metabolism , Prolyl Oligopeptidases*/genetics , Host-Pathogen Interactions* , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics, Animals ; Mice ; DEAD Box Protein 58/genetics ; DEAD Box Protein 58/metabolism ; Interferon-Induced Helicase, IFIH1/genetics ; Interferon-Induced Helicase, IFIH1/metabolism ; Virus Replication ; RNA-Binding Proteins/metabolism ; RNA-Binding Proteins/genetics ; Humans

Fibroblast Activation Protein Alpha (FAP) Expression Is Associated with Disease Recurrence and Poor Response to Tyrosine Kinase Inhibitors in Advanced Clear Cell Renal Cell Carcinoma.

Autoren: Riaza Montes M Suárez B Solano-Iturri JD et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 17; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Renal Cell*/drug therapy , Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/metabolism , Carcinoma, Renal Cell*/mortality , Gelatinases*/metabolism , Gelatinases*/genetics , Kidney Neoplasms*/drug therapy , Kidney Neoplasms*/metabolism , Kidney Neoplasms*/pathology , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Neoplasm Recurrence, Local*/metabolism , Neoplasm Recurrence, Local*/pathology , Neoplasm Recurrence, Local*/drug therapy, Humans ; Male ; Female ; Middle Aged ; Aged ; Endopeptidases ; Prognosis ; Adult ; Biomarkers, Tumor/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Aged, 80 and over ; Disease-Free Survival ; Tyrosine Kinase Inhibitors

Early postnatal reelin treatment suppresses epileptic spasms in a rat model of cortical malformation.

Autoren: Lee M Kim EJ Yum MS

Quelle: Neuropharmacology [Neuropharmacology] 2025 Nov 15; Vol. 279, pp. 110637. Date of Electronic Publication: 2025 Aug 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Cell Adhesion Molecules, Neuronal*/therapeutic use , Cell Adhesion Molecules, Neuronal*/administration & dosage , Nerve Tissue Proteins*/therapeutic use , Nerve Tissue Proteins*/administration & dosage , Nerve Tissue Proteins*/pharmacology , Extracellular Matrix Proteins*/therapeutic use , Extracellular Matrix Proteins*/administration & dosage , Extracellular Matrix Proteins*/pharmacology , Serine Endopeptidases*/administration & dosage , Serine Endopeptidases*/therapeutic use , Malformations of Cortical Development*/drug therapy , Malformations of Cortical Development*/complications , Malformations of Cortical Development*/chemically induced , Epilepsy*/drug therapy, Animals ; Reelin Protein ; Disease Models, Animal ; Animals, Newborn ; Rats ; Rats, Sprague-Dawley ; Female ; Methylazoxymethanol Acetate/analogs & derivatives ; Methylazoxymethanol Acetate/toxicity ; Male ; Mice ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; N-Methylaspartate ; Disks Large Homolog 4 Protein/metabolism ; Pregnancy

An investigation of fucoidan as a potential inhibitor against DENV/NS3 proteases through molecular dynamics simulations and DFT studies.

Autoren: Ramalingam S Venkatraman A Muthumanickam S et al.

Quelle: Journal of molecular modeling [J Mol Model] 2025 Nov 06; Vol. 31 (12), pp. 321. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 9806569 Publication Model: Electronic Cited Medium: Internet ISSN: 0948-5023 (Electronic) Linking ISSN: 09485023 NLM ISO Abbreviation: J Mol Model Subsets: MEDLINE

MeSH-Schlagworte: Polysaccharides*/chemistry , Polysaccharides*/pharmacology , Molecular Dynamics Simulation* , Viral Nonstructural Proteins*/antagonists & inhibitors , Viral Nonstructural Proteins*/chemistry , Dengue Virus*/drug effects , Dengue Virus*/enzymology , Antiviral Agents*/chemistry , Antiviral Agents*/pharmacology , Protease Inhibitors*/chemistry , Protease Inhibitors*/pharmacology , Serine Endopeptidases*/chemistry , Serine Endopeptidases*/metabolism, Molecular Docking Simulation ; Density Functional Theory ; Catalytic Domain ; Viral Proteases

Factor VII-Activating Protease (FSAP) and Its Importance in Hemostasis-Part II: A Link Between FSAP, Blood Coagulation, and Fibrinolysis: A Narrative Review.

Autoren: Schachta I Żekanowska E Styczyński J et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 03; Vol. 26 (21). Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Fibrinolysis* , Hemostasis* , Blood Coagulation* , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/chemistry, Humans ; Animals ; Thrombin/metabolism

Dexamethasone enhances intestinal glucose absorption and TMPRSS2 expression with implications for hyperglycaemia and infection risk.

Autoren: Visvanathan R Houghton MJ Barber E et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 03; Vol. 15 (1), pp. 38329. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Dexamethasone*/pharmacology , Dexamethasone*/adverse effects , Glucose*/metabolism , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Hyperglycemia*/metabolism , Hyperglycemia*/chemically induced , Intestinal Absorption*/drug effects, Humans ; Animals ; Caco-2 Cells ; Mice ; Sodium-Glucose Transporter 1/metabolism ; Sodium-Glucose Transporter 1/genetics ; COVID-19/metabolism ; COVID-19/virology ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme 2/genetics ; SARS-CoV-2 ; Glucose Transporter Type 2/metabolism ; Glucose Transporter Type 2/genetics ; COVID-19 Drug Treatment ; Male

Effects of fibroblasts-derived exosomal FAP in regulating EMT in epithelial cells from chronic rhinosinusitis.

Autoren: Shen LF Fu ZM Chen HH

Quelle: Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2025 Nov-Dec; Vol. 91 (6), pp. 101703. Date of Electronic Publication: 2025 Sep 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: E.N.T. Brazilian Society Country of Publication: Brazil NLM ID: 101207337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1808-8686 (Electronic) Linking ISSN: 18088686 NLM ISO Abbreviation: Braz J Otorhinolaryngol Subsets: MEDLINE

MeSH-Schlagworte: Exosomes*/physiology , Exosomes*/metabolism , Epithelial-Mesenchymal Transition*/physiology , Fibroblasts*/metabolism , Fibroblasts*/physiology , Sinusitis*/pathology , Sinusitis*/metabolism , Epithelial Cells*/metabolism , Epithelial Cells*/physiology , Rhinitis*/pathology , Rhinitis*/metabolism , Nasal Polyps*/pathology , Nasal Polyps*/metabolism , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/physiology , Membrane Proteins*/metabolism , Membrane Proteins*/physiology , Gelatinases*/metabolism, Humans ; Chronic Disease ; Cell Movement ; Coculture Techniques ; Blotting, Western ; Cadherins/metabolism ; Microscopy, Confocal ; Cells, Cultured ; Endopeptidases ; Cell Communication/physiology ; Rhinosinusitis

The function of the HtrA protease in maintaining homeostasis of the human pathogen Helicobacter pylori.

Autoren: Zarzecka U Repetto O Ambroziak P et al.

Quelle: Microbial pathogenesis [Microb Pathog] 2025 Nov; Vol. 208, pp. 107979. Date of Electronic Publication: 2025 Aug 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH-Schlagworte: Helicobacter pylori*/enzymology , Helicobacter pylori*/genetics , Helicobacter pylori*/pathogenicity , Helicobacter pylori*/metabolism , Helicobacter pylori*/physiology , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Homeostasis* , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics, Humans ; Virulence Factors/metabolism ; Virulence Factors/genetics ; Proteome/analysis ; Gene Deletion ; Antigens, Bacterial/metabolism ; Virulence ; Bacterial Outer Membrane Proteins/metabolism ; Proteomics ; Cell Membrane/metabolism ; Helicobacter Infections/microbiology ; High-Temperature Requirement A Serine Peptidase 1 ; Proteolysis ; Serine Proteases

Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development.

Autoren: Dong G Mori D Matsuzaki T et al.

Quelle: Pharmacological research [Pharmacol Res] 2025 Nov; Vol. 221, pp. 107986. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

MeSH-Schlagworte: Cell Adhesion Molecules, Neuronal*/metabolism , Cell Adhesion Molecules, Neuronal*/genetics , Nerve Tissue Proteins*/metabolism , Nerve Tissue Proteins*/genetics , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Extracellular Matrix Proteins*/metabolism , Extracellular Matrix Proteins*/genetics , Actins*/metabolism , Microfilament Proteins*/metabolism , Microfilament Proteins*/genetics , Dendritic Spines*/metabolism, Reelin Protein ; Animals ; Phosphorylation ; Signal Transduction ; Mice ; Male ; Mice, Inbred C57BL ; Humans ; src-Family Kinases/metabolism ; Neurons/metabolism

FAP-α in soft tissue and bone sarcomas: A new potential diagnostic and therapeutic biomarker in the era of precision medicine.

Autoren: Bracigliano A Clemente O Peddio A et al.

Quelle: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2025 Nov; Vol. 215, pp. 104852. Date of Electronic Publication: 2025 Jul 14.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Netherlands NLM ID: 8916049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0461 (Electronic) Linking ISSN: 10408428 NLM ISO Abbreviation: Crit Rev Oncol Hematol Subsets: MEDLINE

MeSH-Schlagworte: Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/genetics , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Gelatinases*/metabolism , Gelatinases*/genetics , Sarcoma*/diagnosis , Sarcoma*/metabolism , Sarcoma*/therapy , Bone Neoplasms*/diagnosis , Bone Neoplasms*/metabolism , Bone Neoplasms*/therapy , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Soft Tissue Neoplasms*/diagnosis , Soft Tissue Neoplasms*/metabolism , Soft Tissue Neoplasms*/therapy , Osteosarcoma*/diagnosis , Osteosarcoma*/metabolism , Osteosarcoma*/therapy, Humans ; Precision Medicine/methods ; Endopeptidases ; Tumor Microenvironment ; Animals

FAP ⁺ fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus.

Autoren: Ma J Huang Y Chen J et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 23; Vol. 16 (1), pp. 9387. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/genetics , Carcinoma, Renal Cell*/metabolism , Tumor Microenvironment*/genetics , Kidney Neoplasms*/pathology , Kidney Neoplasms*/genetics , Kidney Neoplasms*/metabolism , Fibroblasts*/metabolism , Fibroblasts*/pathology , Gelatinases*/metabolism , Gelatinases*/genetics , Thrombosis*/pathology , Thrombosis*/genetics , Thrombosis*/metabolism , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics, Humans ; Endopeptidases/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Male ; Female ; Prognosis ; Cell Line, Tumor ; Killer Cells, Natural/immunology ; Pericytes/metabolism ; Pericytes/pathology ; Single-Cell Analysis ; Gene Expression Regulation, Neoplastic ; Middle Aged ; Membrane Proteins

Hepatitis C virus NS3/4A protease cleaves SPG20, a key regulator of lipid droplet turnover, to promote lipid droplet formation.

Autoren: Matsui C Yuliandari P Deng L et al.

Quelle: Journal of virology [J Virol] 2025 Oct 23; Vol. 99 (10), pp. e0089025. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH-Schlagworte: Hepacivirus*/enzymology , Hepacivirus*/metabolism , Lipid Droplets*/metabolism , Lipid Droplets*/virology , Viral Nonstructural Proteins*/metabolism , Viral Nonstructural Proteins*/genetics , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics, Humans ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/genetics ; Hepatocytes/virology ; Hepatocytes/metabolism ; Proteolysis ; Hepatitis C/metabolism ; Hepatitis C/virology ; Virus Replication ; Cell Line ; Perilipin-2/metabolism ; Serine Proteases ; Nucleoside-Triphosphatase ; DEAD-box RNA Helicases ; Viral Proteases ; Repressor Proteins ; Cell Cycle Proteins

[Pathogenesis and mechanism of serine protease 23 in skin fibrosis of systemic sclerosis].

Autoren: Yuan X Li Z Xu D et al.

Quelle: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2025 Oct 18; Vol. 57 (5), pp. 903-910.

Publikationsart: English Abstract; Journal Article

Info zur Zeitschrift: Publisher: Beijing da xue Country of Publication: China NLM ID: 101125284 Publication Model: Print Cited Medium: Print ISSN: 1671-167X (Print) Linking ISSN: 1671167X NLM ISO Abbreviation: Beijing Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE

MeSH-Schlagworte: Scleroderma, Systemic*/pathology , Scleroderma, Systemic*/metabolism , Scleroderma, Systemic*/enzymology , Fibroblasts*/metabolism , Fibroblasts*/pathology , Skin*/pathology , Skin*/metabolism , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics, Humans ; Apoptosis ; Fibrosis ; Interleukin-6/metabolism ; Caspase 3/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Male ; Female ; Cells, Cultured ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Middle Aged ; Adult

Polyethylene microplastics trigger osteosarcoma progression via ITGA5/FAPα/LGMN cancer promoting complex: A novel environmental cancer promoting mechanism.

Autoren: Zhang W Huang S Liu K et al.

Quelle: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Oct 15; Vol. 305, pp. 119207. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH-Schlagworte: Osteosarcoma*/chemically induced , Osteosarcoma*/pathology , Osteosarcoma*/metabolism , Microplastics*/toxicity , Polyethylene*/toxicity , Bone Neoplasms*/chemically induced , Bone Neoplasms*/pathology , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics, Humans ; Animals ; Mice ; Cell Line, Tumor ; Disease Progression ; Membrane Proteins ; Endopeptidases