Suchergebnisse - "SYSTEMS"

Antitoxin HigA orchestrates T3SS/T6SS expression in aquatic pathogen Edwardsiella piscicida.

Autoren: Li C Tian Y Wang Q et al.

Quelle: Microbiological research [Microbiol Res] 2025 Nov; Vol. 300, pp. 128281. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: G. Fischer Country of Publication: Germany NLM ID: 9437794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0623 (Electronic) Linking ISSN: 09445013 NLM ISO Abbreviation: Microbiol Res Subsets: MEDLINE

MeSH-Schlagworte: Edwardsiella*/genetics , Edwardsiella*/pathogenicity , Edwardsiella*/metabolism , Type VI Secretion Systems*/genetics , Type VI Secretion Systems*/metabolism , Type III Secretion Systems*/genetics , Type III Secretion Systems*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Antitoxins*/metabolism , Antitoxins*/genetics , Bacterial Toxins*/genetics , Bacterial Toxins*/metabolism, Animals ; Zebrafish/microbiology ; Enterobacteriaceae Infections/microbiology ; Gene Expression Regulation, Bacterial ; Virulence/genetics ; Fish Diseases/microbiology ; Toxin-Antitoxin Systems

SCR Organism: Edwardsiella piscicida

Hazard analysis of an Automated Lane Keeping System using Systems-Theoretic Process Analysis.

Autoren: Elizebeth MJ Khastgir S Jennings P

Quelle: Accident; analysis and prevention [Accid Anal Prev] 2025 Oct; Vol. 221, pp. 108171. Date of Electronic Publication: 2025 Aug 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 1254476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2057 (Electronic) Linking ISSN: 00014575 NLM ISO Abbreviation: Accid Anal Prev Subsets: MEDLINE

MeSH-Schlagworte: Systems Analysis* , Accidents, Traffic*/prevention & control , Automobile Driving* , Systems Theory* , Automation* , Automobiles*, Humans ; Algorithms ; Man-Machine Systems ; Software

Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition.

Autoren: Zhou X Diao R Li X et al.

Quelle: Nature [Nature] 2025 Nov; Vol. 647 (8091), pp. 1054-1062. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH-Schlagworte: CRISPR-Cas Systems*/genetics , CRISPR-Cas Systems*/immunology , CRISPR-Associated Protein 9*/metabolism , CRISPR-Associated Protein 9*/chemistry , CRISPR-Associated Protein 9*/genetics , Clustered Regularly Interspaced Short Palindromic Repeats*/genetics , Clustered Regularly Interspaced Short Palindromic Repeats*/immunology, Humans ; RNA, Guide, CRISPR-Cas Systems/genetics ; RNA, Guide, CRISPR-Cas Systems/metabolism ; Autoimmunity

From Data to Decision: A Comprehensive Review of Real-Time Analytics and Smart Technologies in the Surgical Suite.

Autoren: Watson JB Quintero-Peña C Moise AC et al.

Quelle: Methodist DeBakey cardiovascular journal [Methodist Debakey Cardiovasc J] 2025 Oct 07; Vol. 21 (5), pp. 5-15. Date of Electronic Publication: 2025 Oct 07 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Methodist DeBakey Heart & Vascular Center Country of Publication: United States NLM ID: 101508600 Publication Model: eCollection Cited Medium: Internet ISSN: 1947-6108 (Electronic) Linking ISSN: 19476108 NLM ISO Abbreviation: Methodist Debakey Cardiovasc J Subsets: MEDLINE

MeSH-Schlagworte: Monitoring, Intraoperative*/methods , Operating Rooms* , Decision Support Systems, Clinical* , Decision Support Techniques* , Operating Room Information Systems* , Surgery, Computer-Assisted*/instrumentation, Humans ; Predictive Value of Tests ; Clinical Decision-Making ; Workflow ; Systems Integration

A systematic survey of type I secretion systems and their substrate proteins in Salmonella .

Autoren: Yu M Chen Y Cao X et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2533414. Date of Electronic Publication: 2025 Jul 15.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Salmonella*/genetics , Salmonella*/metabolism , Salmonella*/pathogenicity , Type I Secretion Systems*/genetics , Type I Secretion Systems*/metabolism, Multigene Family ; Gene Expression Regulation, Bacterial ; Evolution, Molecular ; Genome, Bacterial ; Type III Secretion Systems/genetics ; Genomic Islands ; Virulence Factors/genetics

Programmable targeted RNA degradation via dCas13d-directed chaperone-mediated autophagy (dCasCMA).

Autoren: Wen HP Yu C Bi S et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10738. Date of Electronic Publication: 2025 Nov 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Chaperone-Mediated Autophagy*/genetics , RNA Stability*/genetics , CRISPR-Cas Systems*/genetics, Humans ; Animals ; RNA, Guide, CRISPR-Cas Systems/genetics ; RNA, Guide, CRISPR-Cas Systems/metabolism ; Mice ; HEK293 Cells ; Autophagy

Conditional guide RNA deactivation by mRNA and small molecule triggers in Saccharomyces cerevisiae.

Autoren: Xi C Chiu S Voje WE et al.

Quelle: New biotechnology [N Biotechnol] 2025 Nov 25; Vol. 89, pp. 105-118. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101465345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4347 (Electronic) Linking ISSN: 18716784 NLM ISO Abbreviation: N Biotechnol Subsets: MEDLINE

MeSH-Schlagworte: Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/metabolism , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , RNA, Guide, CRISPR-Cas Systems*/genetics , RNA, Guide, CRISPR-Cas Systems*/metabolism, CRISPR-Cas Systems/genetics ; Gene Expression Regulation, Fungal

A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release.

Autoren: Elsharkasy OM Hegeman CV Driedonks TAP et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 10309. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: CRISPR-Cas Systems*/genetics , Extracellular Vesicles*/metabolism , Aptamers, Nucleotide*/metabolism , Aptamers, Nucleotide*/genetics , Gene Editing*/methods, Humans ; Ultraviolet Rays ; RNA, Guide, CRISPR-Cas Systems/genetics ; RNA, Guide, CRISPR-Cas Systems/metabolism ; CRISPR-Associated Protein 9/metabolism ; CRISPR-Associated Protein 9/genetics ; HEK293 Cells

Engineered hypercompact Fanzor-ωRNA system with enhanced genome editing activity.

Autoren: Zhao G Liu Y Zhang G et al.

Quelle: Molecular cell [Mol Cell] 2025 Nov 20; Vol. 85 (22), pp. 4138-4151.e4. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH-Schlagworte: Gene Editing*/methods , RNA, Guide, CRISPR-Cas Systems*/genetics , RNA, Guide, CRISPR-Cas Systems*/metabolism , Genome, Human*, Humans ; HEK293 Cells ; Animals ; Dependovirus/genetics ; CRISPR-Cas Systems ; Mice

Emerging insights into the type I secretion system: a key player in Salmonella virulence and host-pathogen interactions.

Autoren: Li S Liu H Qiu J

Quelle: MBio [mBio] 2025 Nov 12; Vol. 16 (11), pp. e0165525. Date of Electronic Publication: 2025 Sep 22.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH-Schlagworte: Host-Pathogen Interactions* , Salmonella*/pathogenicity , Salmonella*/genetics , Type I Secretion Systems*/metabolism , Type I Secretion Systems*/genetics, Humans ; Virulence ; Animals ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Salmonella Infections/microbiology ; Type III Secretion Systems/metabolism ; Virulence Factors/metabolism ; Virulence Factors/genetics

[Imported: Cross-Sectoral Image Data Integration - DICOM Link Exchange (DLX) DIN/TS 19455. A Review].

Transliterierter Titel: Eingespielt: sektorenübergreifende Bilddatenintegration – DICOM Link Exchange (DLX) DIN/TS 19455. Ein Überblick.

Autoren: Kämmerer M Engelmann U Eßeling R et al.

Quelle: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin [Rofo] 2025 Nov; Vol. 197 (11), pp. 1279-1283. Date of Electronic Publication: 2025 Mar 17.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Thieme Country of Publication: Germany NLM ID: 7507497 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-9010 (Electronic) Linking ISSN: 14389010 NLM ISO Abbreviation: Rofo Subsets: MEDLINE

MeSH-Schlagworte: Radiology Information Systems*/standards , Radiology Information Systems*/organization & administration, Germany ; Humans ; Systems Integration ; Societies, Medical ; User-Computer Interface

Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons.

Autoren: Jin S Zhu Z Li Y et al.

Quelle: Cell [Cell] 2025 Oct 30; Vol. 188 (22), pp. 6283-6300.e22. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH-Schlagworte: CRISPR-Cas Systems*/genetics , DNA Transposable Elements*/genetics , Evolution, Molecular* , RNA*/metabolism, RNA, Guide, CRISPR-Cas Systems/metabolism ; RNA, Guide, CRISPR-Cas Systems/genetics ; Cryoelectron Microscopy ; Clustered Regularly Interspaced Short Palindromic Repeats ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics

Development of programmable RNA imaging with RNA-guided GFP via click chemistry.

Autoren: Nakamura J Shiraishi M Yamamoto J et al.

Quelle: Nucleic acids research [Nucleic Acids Res] 2025 Oct 28; Vol. 53 (20).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH-Schlagworte: Click Chemistry*/methods , Green Fluorescent Proteins*/genetics , Green Fluorescent Proteins*/chemistry , Green Fluorescent Proteins*/metabolism , RNA, Guide, CRISPR-Cas Systems*/chemistry , RNA, Guide, CRISPR-Cas Systems*/genetics , RNA, Guide, CRISPR-Cas Systems*/metabolism , RNA* , Molecular Imaging*/methods, Humans ; CRISPR-Cas Systems ; Cyclooctanes/chemistry ; HEK293 Cells ; Azides/chemistry

An Intelligent and Visual Clinical Decision Support System for Medication Reconciliation at Admission in a Hospital Setting.

Autoren: Schofield R Lamy JB

Quelle: Studies in health technology and informatics [Stud Health Technol Inform] 2025 Oct 02; Vol. 332, pp. 103-107.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9214582 Publication Model: Print Cited Medium: Internet ISSN: 1879-8365 (Electronic) Linking ISSN: 09269630 NLM ISO Abbreviation: Stud Health Technol Inform Subsets: MEDLINE

MeSH-Schlagworte: Medication Reconciliation*/methods , Medication Reconciliation*/organization & administration , Decision Support Systems, Clinical*/organization & administration , Medication Errors*/prevention & control , Patient Admission*, Humans ; Medical Order Entry Systems/organization & administration ; User-Computer Interface ; Electronic Health Records/organization & administration

Efficacy of Novel Drug Delivery Systems for Insulin Administration and Technological Advances in Diabetes Mellitus: Review.

Autoren: Bakrey H Abdelaziz MAA Magbool FF et al.

Quelle: AAPS PharmSciTech [AAPS PharmSciTech] 2025 Dec 05; Vol. 27 (1), pp. 51. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE

MeSH-Schlagworte: Insulin*/administration & dosage , Drug Delivery Systems*/methods , Hypoglycemic Agents*/administration & dosage , Diabetes Mellitus*/drug therapy, Humans ; Insulin Infusion Systems ; Blood Glucose/drug effects ; Diabetes Mellitus, Type 2/drug therapy

High-fidelity AaCas12b ^Max enables the development of an engineered T cell therapy with enhanced safety and functional fitness.

Autoren: Sun J Liu K Sheng Y et al.

Quelle: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6101-6117. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH-Schlagworte: Gene Editing*/methods , CRISPR-Cas Systems* , CRISPR-Associated Protein 9*/genetics , CRISPR-Associated Protein 9*/metabolism , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism, Humans ; Animals ; Mice ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Cell Line, Tumor ; RNA, Guide, CRISPR-Cas Systems/genetics

Differential expression of genes in pre-blastoderm embryos of oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) microinjected with white locus CRISPR/Cas9 ribo nucleo protein (RNP) complex.

Autoren: Ashok K Ellango R Venkatesh R et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 333 (Pt 2), pp. 148735. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Tephritidae*/genetics , Tephritidae*/embryology , CRISPR-Cas Systems*/genetics , Ribonucleoproteins*/genetics , Gene Expression Regulation, Developmental* , CRISPR-Associated Protein 9*/genetics, Animals ; Microinjections ; Gene Editing ; Gene Expression Profiling ; Insect Proteins/genetics ; RNA, Guide, CRISPR-Cas Systems/genetics ; Transcriptome

SCR Organism: Bactrocera dorsalis

Biomaterial-based drug delivery: evaluating the safety profiles of liposomal Vyxeos.

Autoren: Liu Z Fu Z Liu Y et al.

Quelle: Drug delivery [Drug Deliv] 2025 Dec; Vol. 32 (1), pp. 2494781. Date of Electronic Publication: 2025 May 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9417471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0464 (Electronic) Linking ISSN: 10717544 NLM ISO Abbreviation: Drug Deliv Subsets: MEDLINE

MeSH-Schlagworte: Cytarabine*/administration & dosage , Cytarabine*/adverse effects , Daunorubicin*/administration & dosage , Daunorubicin*/adverse effects , Leukemia, Myeloid, Acute*/drug therapy , Drug Delivery Systems*/methods , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Antineoplastic Combined Chemotherapy Protocols*/administration & dosage, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Liposomes ; Aged ; Adult ; Adverse Drug Reaction Reporting Systems ; Young Adult ; Adolescent ; United States ; Aged, 80 and over

Engineered sgRNA captures single-stranded donor template and delivers at the DSB site to enhance HDR.

Autoren: Rahangdale S Vishwakarma A Chauhan R et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 332 (Pt 2), pp. 148614. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Gene Editing*/methods , RNA, Guide, CRISPR-Cas Systems*/genetics , DNA Breaks, Double-Stranded* , Recombinational DNA Repair* , DNA, Single-Stranded*/genetics, Saccharomyces cerevisiae/genetics ; CRISPR-Cas Systems/genetics ; Streptococcus pyogenes/genetics

Design principle of successful genome editing applications using CRISPR-based toolkits.

Autoren: Sharma J Biswas R Khare P

Quelle: Journal of applied genetics [J Appl Genet] 2025 Dec; Vol. 66 (4), pp. 1065-1077. Date of Electronic Publication: 2025 Jul 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: England NLM ID: 9514582 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3883 (Electronic) Linking ISSN: 12341983 NLM ISO Abbreviation: J Appl Genet Subsets: MEDLINE

MeSH-Schlagworte: Gene Editing*/methods , CRISPR-Cas Systems*/genetics , Clustered Regularly Interspaced Short Palindromic Repeats*/genetics, Streptococcus pyogenes/genetics ; Streptococcus pyogenes/enzymology ; Plasmids/genetics ; Genetic Engineering/methods ; RNA, Guide, CRISPR-Cas Systems/genetics ; Synthetic Biology/methods