Suchergebnisse - "STAT1 Transcription Factor metabolism"

Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens

Autoren: Di Liberto, Giovanni Egervari, Kristof Levente Vogrig, Alberto et al.

Quelle: Acta Neuropathol
Acta neuropathologica 149(1), 35 (2025). doi:10.1007/s00401-025-02882-7
Acta neuropathologica, vol. 149, no. 1, pp. 35

Schlagwörter: Male, CD8-Positive T-Lymphocytes, Autoantigens, Neurons / pathology, Neuroinflammation, pathology [Brain], pathology [Neurons], Encephalitis / metabolism, Humans, Encephalitis/pathology, Encephalitis/immunology, Encephalitis/metabolism, Female, Middle Aged, Neurons/pathology, Neurons/immunology, Neurons/metabolism, Hashimoto Disease/pathology, Hashimoto Disease/immunology, Adult, STAT1 Transcription Factor/metabolism, Synapses/pathology, Synapses/immunology, Synapses/metabolism, Aged, Autoantigens/immunology, Brain/pathology, Brain/immunology, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/pathology, Young Adult, Neurodegeneration, Phagocytes, Resident memory T cells, Synapses, pathology [Encephalitis], Neurons, Neurons / metabolism, Brain / immunology, Brain / pathology, Brain, CD8-Positive T-Lymphocytes / immunology, STAT1 Transcription Factor, Hashimoto Disease / pathology, metabolism [Neurons], STAT1 Transcription Factor / metabolism, Encephalitis, immunology [Brain], pathology [Synapses], immunology [Autoantigens], Encephalitis / immunology, Hashimoto Disease, 616.07, Autoantigens / immunology, Hashimoto Disease / immunology, pathology [Hashimoto Disease], Synapses / immunology, ddc:610, immunology [Encephalitis], immunology [Synapses], Original Paper, Synapses / pathology, immunology [CD8-Positive T-Lymphocytes], metabolism [Synapses], Neurons / immunology, Synapses / metabolism, Encephalitis / pathology, pathology [CD8-Positive T-Lymphocytes], immunology [Hashimoto Disease], CD8-Positive T-Lymphocytes / pathology, metabolism [STAT1 Transcription Factor], metabolism [Encephalitis], immunology [Neurons]

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40278930
https://pub.dzne.de/record/278073
https://serval.unil.ch/resource/serval:BIB_2BE75AE22CA6.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_2BE75AE22CA6
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_2BE75AE22CA66

Radiation‐Enhanced AF1q Moves Center Stage as a Key Driver to Favorable Tumor Stage in Rectal Cancer Patients

Autoren: Gruber, Elisabeth S. Oberhuber, Georg Gurnhofer, Elisabeth et al.

Quelle: Cancer Med
Cancer Medicine, Vol 14, Iss 5, Pp n/a-n/a (2025)

Schlagwörter: Male, Adult, STAT1 Transcription Factor Metabolism, Rectal Neoplasms Metabolism, Indoleamine-Pyrrole 2,3,-Dioxygenase Metabolism, Biomarkers, Tumor, Rectal Neoplasms Genetics, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, STAT1 Transcription Factor Genetics, B7-H1 Antigen Metabolism, RC254-282, Neoplasm Staging, Aged, B7-H1 Antigen Genetics, Aged, 80 and over, Indoleamine-Pyrrole 2,3,-Dioxygenase Genetics, Rectal Neoplasms, Biomarkers, Tumor Metabolism, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Prognosis, Rectal Neoplasms Pathology, STAT1 Transcription Factor, Rectal Neoplasms Radiotherapy, Female, Research Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40062505
https://doaj.org/article/dcb10b802ba34d61bfa1fb37e969a92d

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Autoren: Grootaert, Mandy O.J. Pasut, Alessandra Raman, Jana et al.

Quelle: Cardiovasc Diabetol
Cardiovascular Diabetology, Vol 24, Iss 1, Pp 1-16 (2025)
Cardiovascular Diabetology

Schlagwörter: Male, Cardiac & Cardiovascular Systems, Endothelial cells, PERICYTES, Left, Sodium Chloride, MOUSE, Inbred C57BL, Ventricular Function, Left, Mice, Ventricular Function, Pericytes/metabolism pathology, 1102 Cardiorespiratory Medicine and Haematology, Coronary Vessels/physiopathology metabolism pathology, Dietary/adverse effects, Coronary Vessels, Diastolic/physiopathology metabolism pathology etiology genetics, PRESERVED EJECTION FRACTION, Smooth muscle cells, Diastolic dysfunction, Single-Cell Analysis, 3201 Cardiovascular medicine and haematology, Life Sciences & Biomedicine, Receptor, Signal Transduction, PATHOPHYSIOLOGY, Mice, Transgenic, Platelet-Derived Growth Factor beta/metabolism genetics, Vascular Remodeling, Receptor, Platelet-Derived Growth Factor beta, Endocrinology & Metabolism, Paracrine Communication, Diseases of the circulatory (Cardiovascular) system, Animals, Heart Failure, Heart Failure, Diastolic, Science & Technology, Animal, Research, Endothelial Cells, Stroke Volume, HFpEF, Actins, Mice, Inbred C57BL, MICE, Endothelial Cells/metabolism pathology, Disease Models, Animal, Cardiovascular System & Hematology, RC666-701, Disease Models, STAT1 Transcription Factor/metabolism genetics, Cardiovascular System & Cardiology, Pericytes

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39920783
https://doaj.org/article/c8090c6f2cf9442c8a6b36581e9baeb7
https://cris.maastrichtuniversity.nl/en/publications/a8dd9bbd-323a-4f71-94f1-6ae0f09a713e
https://doi.org/10.1186/s12933-025-02623-w
https://lirias.kuleuven.be/handle/20.500.12942/760210
https://doi.org/10.1186/s12933-025-02623-w

Omics Investigations of Prostate Cancer Cells Exposed to Simulated Microgravity Conditions

Autoren: Schulz, Herbert Abdelfattah, Fatima Heinrich, Anna et al.

Quelle: Schulz, H, Abdelfattah, F, Heinrich, A, Melnik, D, Sandt, V, Krüger, M, Wehland, M, Hoffmann, P, Cortés-Sánchez, J L, Evert, M, Evert, K & Grimm, D 2025, 'Omics Investigations of Prostate Cancer Cells Exposed to Simulated Microgravity Conditions', Biomolecules, vol. 15, no. 2, 303. https://doi.org/10.3390/biom15020303

Schlagwörter: Cell Line, Tumor, DNA Methylation/genetics, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Humans, Male, Prostatic Neoplasms/genetics, STAT1 Transcription Factor/metabolism, Spheroids, Cellular/metabolism, Weightlessness Simulation, random positioning machine, prostate cancer, fibronectin, omics, cell culture, DNA methylation, simulated microgravity, gene expression

Verfügbarkeit: https://pure.au.dk/portal/en/publications/1f32a544-434d-4d20-857c-bffbf4a30c51
https://doi.org/10.3390/biom15020303
http://www.scopus.com/inward/record.url?scp=85218897056&partnerID=8YFLogxK

Severe Extrahematopoietic Manifestations in Complete STAT1 LOF after Successful Allogeneic HCT

Autoren: Frieß, Friederike Flaig, Michael Albert, Michael H. et al.

Quelle: J Clin Immunol

Schlagwörter: Male, STAT1 Transcription Factor, Correspondence, Female [MeSH], Male [MeSH], Humans [MeSH], STAT1 Transcription Factor/metabolism [MeSH], Hematopoietic Stem Cell Transplantation/methods [MeSH], STAT1 Transcription Factor/genetics [MeSH], Transplantation, Homologous [MeSH], Hematopoietic Stem Cell Transplantation, Humans, Transplantation, Homologous, Female

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39230758
https://repository.publisso.de/resource/frl:6499531

IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration

Autoren: Omrani, Omid Krepelova, Anna Rasa, Seyed Mohammad Mahdi et al.

Quelle: Nat Commun
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Schlagwörter: Intestines, Interferon-gamma, Mice, STAT1 Transcription Factor, Science, Homeostasis, Animals, Intestines/metabolism, STAT1 Transcription Factor/metabolism, STAT1 Transcription Factor/metabolism [MeSH], Interferon-gamma/metabolism, Interferon-gamma/metabolism [MeSH], Animals [MeSH], Intestinal Mucosa [MeSH], Mice [MeSH], Intestinal Mucosa, Intestines/metabolism [MeSH], Homeostasis [MeSH], Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37777550
https://doaj.org/article/8d8b248d97c8482fa9a842f1ea32364e
https://repository.publisso.de/resource/frl:6475556

IFN-γ Induces IL-15 Trans-Presentation by Epithelial Cells via IRF1

Autoren: Tae-Shin Kim Min-Seok Rha Eui-Cheol Shin et al.

Weitere Verfasser: Tae-Shin Kim Min-Seok Rha Eui-Cheol Shin et al.

Quelle: The Journal of Immunology. 208:338-346

Schlagwörter: Signal Transduction / physiology, Transcriptional Activation, 0301 basic medicine, Interleukin-15 / metabolism, Interferon-beta / immunology, Interferon-alpha / immunology, Transcriptional Activation / genetics, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Cell Line, Interferon-gamma, 03 medical and health sciences, Cell Line, Tumor, Receptors, Up-Regulation / genetics, Killer Cells, Humans, Interleukin-15, 0303 health sciences, Tumor, Lymphocyte Activation / immunology, Interferon Regulatory Factor-1 / metabolism, Receptors, Interleukin-15, Interferon Regulatory Factor-3 / metabolism, CD8-Positive T-Lymphocytes / immunology, Interferon-alpha, Epithelial Cells, Interferon-beta, Up-Regulation, 3. Good health, Killer Cells, Natural, Natural / immunology, STAT1 Transcription Factor, A549 Cells, Interferon-gamma / immunology, STAT1 Transcription Factor / metabolism, Interferon Regulatory Factor-3, Epithelial Cells / metabolism, HeLa Cells, Interferon Regulatory Factor-1, Signal Transduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/34893528

Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse

Autoren: Gabriele Koepf Sylvia Torres-Odio Jana Key et al.

Quelle: Neurogenetics

Schlagwörter: 0301 basic medicine, ddc:610, 0303 health sciences, RNA-Binding Proteins, STAT1 Transcription Factor/immunology [MeSH], Ataxia, DNA, Mitochondrial/genetics [MeSH], cGAS-STING, MTRNR1, STAT1 Transcription Factor/metabolism [MeSH], Up-Regulation [MeSH], Release of mtDNA and mtRNA, Cytosol/metabolism [MeSH], Mitochondria/genetics [MeSH], Original Article, Immunity, Innate/immunology [MeSH], HSP40 Heat-Shock Proteins/metabolism [MeSH], Mitochondria/immunology [MeSH], RNA-Binding Proteins/immunology [MeSH], HSP40 Heat-Shock Proteins/immunology [MeSH], Mitochondrial amino acid tRNA synthetases, Nucleic Acids/immunology [MeSH], POLG, Nucleic Acids/metabolism [MeSH], Leukodystrophy, Animals [MeSH], Cytosol/immunology [MeSH], PRLTS3, TWINKLE, Mice [MeSH], RNA-Binding Proteins/genetics [MeSH], DNA, Mitochondrial/immunology [MeSH], HSP40 Heat-Shock Proteins, DNA, Mitochondrial, Immunity, Innate, Mitochondria, Up-Regulation, Mice, 03 medical and health sciences, Cytosol, STAT1 Transcription Factor, Nucleic Acids, Animals

Dateibeschreibung: application/octet-stream

Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s10048-021-00657-2.pdf
https://pubmed.ncbi.nlm.nih.gov/34345994
https://link.springer.com/content/pdf/10.1007/s10048-021-00657-2.pdf
https://link.springer.com/article/10.1007/s10048-021-00657-2
https://paperity.org/p/267003950/increased-presence-of-nuclear-dnaja3-and-upregulation-of-cytosolic-stat1-and-of-nucleic
https://pubmed.ncbi.nlm.nih.gov/34345994/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426249
https://repository.publisso.de/resource/frl:6446355
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62600

IFNalpha activates dormant haematopoietic stem cells in vivo.

Autoren: Essers, M.A. Offner, S. Blanco-Bose, W.E. et al.

Schlagwörter: Animals, Antigens, Ly/metabolism, Cell Count, Cell Cycle/drug effects, Cell Proliferation/drug effects, Fluorouracil/pharmacology, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/drug effects, Interferon-alpha/pharmacology, Membrane Proteins/deficiency, Membrane Proteins/metabolism, Mice, Inbred C57BL, Phosphorylation/drug effects, Receptor, Interferon alpha-beta/deficiency, Interferon alpha-beta/metabolism, STAT1 Transcription Factor/deficiency, STAT1 Transcription Factor/metabolism, Signal Transduction/drug effects, Up-Regulation/drug effects

Relation: Nature; https://iris.unil.ch/handle/iris/188453; serval:BIB_8188D93E49A4; 000265182500046

Verfügbarkeit: https://iris.unil.ch/handle/iris/188453
https://doi.org/10.1038/nature07815

Definition of the immune evasion-replication interface of rabies virus P protein

Autoren: Zhan, Jingyu Harrison, Angela R. Portelli, Stephanie et al.

Quelle: Zhan, J, Harrison, A R, Portelli, S, Nguyen, T B, Kojima, I, Zheng, S, Yan, F, Masatani, T, Rawlinson, S M, Sethi, A, Ito, N, Ascher, D B, Moseley, G W & Gooley, P R 2021, 'Definition of the immune evasion-replication interface of rabies virus P protein', PLoS Pathogens, vol. 17, no. 7, e1009729. https://doi.org/10.1371/journal.ppat.1009729

Schlagwörter: Animals, COS Cells, Chlorocebus aethiops, HEK293 Cells, Humans, Immune Evasion/physiology, Molecular Chaperones/metabolism, Nucleocapsid Proteins/metabolism, Rabies/metabolism, Rabies virus/metabolism, STAT1 Transcription Factor/metabolism, Viral Structural Proteins/metabolism, Virus Replication/physiology

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/34237115; info:eu-repo/semantics/altIdentifier/pissn/1553-7366; info:eu-repo/semantics/altIdentifier/eissn/1553-7374

Verfügbarkeit: https://discovery.dundee.ac.uk/en/publications/ce976fce-0069-4ade-bbef-1d932c92ebf1
https://doi.org/10.1371/journal.ppat.1009729
https://discovery.dundee.ac.uk/ws/files/73209356/journal.ppat.1009729.pdf

A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus

Autoren: Menon, M Blair, PA Isenberg, DA et al.

Quelle: Immunity
Menon, M, Blair, P A, Isenberg, D A & Mauri, C 2016, 'A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus', Immunity, vol. 44, no. 3, pp. 683-697. https://doi.org/10.1016/j.immuni.2016.02.012

Schlagwörter: Male, Cell Communication/drug effects, Antigens, CD/metabolism, Cell Communication, Rituximab/administration & dosage, 0302 clinical medicine, Antirheumatic Agents/administration & dosage, Immunology and Allergy, Homeostasis, Lupus Erythematosus, Systemic, Cells, Cultured, B-Lymphocytes, B-Lymphocytes, Regulatory, Cultured, CD/metabolism, Cell Differentiation, Middle Aged, Interleukin-10, 3. Good health, Infectious Diseases, STAT1 Transcription Factor, Antirheumatic Agents, Female, STAT1 Transcription Factor/metabolism, Rituximab, Regulatory/drug effects, Homeostasis/drug effects, Adult, STAT3 Transcription Factor, Cells, Immunology, Article, Dendritic Cells/drug effects, Interleukin-10/metabolism, Young Adult, Interferon-gamma, 03 medical and health sciences, Antigens, CD, Humans, Antigens, Interferon-gamma/metabolism, Aged, Lupus Erythematosus, Dendritic Cells, B-Lymphocytes, Regulatory/drug effects, STAT3 Transcription Factor/metabolism, Cell Differentiation/drug effects, Lupus Erythematosus, Systemic/drug therapy, Systemic/drug therapy, Transcriptional Activation/drug effects

Dateibeschreibung: application/pdf

Zugangs-URL: http://www.cell.com/article/S1074761316300504/pdf
https://pubmed.ncbi.nlm.nih.gov/26968426
https://research.manchester.ac.uk/en/publications/1d3ade0f-c5b6-4cc3-b03e-877898151a19
https://doi.org/10.1016/j.immuni.2016.02.012
https://core.ac.uk/display/82014876
https://discovery.ucl.ac.uk/id/eprint/1501016/
https://www.cell.com/immunity/fulltext/S1074-7613(16)30050-4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803914/
https://www.research.manchester.ac.uk/portal/files/159699156/1_s2.0_S1074761316300504_main.pdf
https://www.sciencedirect.com/science/article/pii/S1074761316300504
https://research.manchester.ac.uk/en/publications/1d3ade0f-c5b6-4cc3-b03e-877898151a19
https://doi.org/10.1016/j.immuni.2016.02.012
https://pure.manchester.ac.uk/ws/files/159699156/1_s2.0_S1074761316300504_main.pdf
https://discovery-pp.ucl.ac.uk/id/eprint/1501016/

Functional Characterization of MicroRNA-27a-3p Expression in Human Polycystic Ovary Syndrome

Autoren: Suk Ying Tsang Xiangdong Li Fei Sun et al.

Quelle: Endocrinology. 159:297-309

Schlagwörter: 0301 basic medicine, Granulosa cells - drug effects, Apoptosis, MicroRNAs - metabolism, Granulosa cell tumor - drug therapy, RNA interference, Smad5 protein - agonists, Polycystic ovary syndrome - pathology, Recombinant proteins - metabolism, STAT1 transcription factor - metabolism, Insulin, Cells, Cultured, Granulosa Cell Tumor, Gene expression regulation, 0303 health sciences, neoplastic - drug effects, Smad5 protein - antagonists & inhibitors, Insulin - pharmacology, STAT3 transcription factor - metabolism, Recombinant Proteins, Gene Expression Regulation, Neoplastic, STAT1 Transcription Factor, Hypoglycemic agents - pharmacology, Granulosa cells - metabolism, Smad5 protein - metabolism, STAT3 transcription factor - genetics, Female, RNA Interference, Granulosa cell tumor - metabolism, Polycystic Ovary Syndrome, Adult, tumor, STAT1 transcription factor - antagonists & inhibitors, Cells, Apoptosis - drug effects, ta3111, Recombinant proteins - chemistry, 03 medical and health sciences, Granulosa cells - pathology, STAT1 transcription factor - genetics, Cell Line, Tumor, Polycystic ovary syndrome - drug therapy, Humans, Hypoglycemic Agents, cultured, Cell Proliferation, Granulosa Cells, ta1182, Insulin resistance, Granulosa cell tumor - pathology, Polycystic ovary syndrome - metabolism, MicroRNAs, Smad5 protein - genetics, Gene Expression Regulation, Cell proliferation - drug effects, RNA, STAT3 transcription factor - antagonists & inhibitors, Insulin Resistance, Cell line, Gene expression regulation - drug effects, RNA - metabolism

Zugangs-URL: https://academic.oup.com/endo/article-pdf/159/1/297/23200752/en.2017-00219.pdf
https://pubmed.ncbi.nlm.nih.gov/29029022
https://www.ncbi.nlm.nih.gov/pubmed/29029022
https://europepmc.org/article/MED/29029022
https://academic.oup.com/endo/article/159/1/297/4210434
https://pubmed.ncbi.nlm.nih.gov/29029022/

Kr-POK (ZBTB7c) regulates cancer cell proliferation through glutamine metabolism

Autoren: Min-Young Kim Man-Wook Hur Bu-Nam Jeon et al.

Weitere Verfasser: Min-Young Kim Man-Wook Hur Bu-Nam Jeon et al.

Quelle: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1860:829-838

Schlagwörter: Male, 0301 basic medicine, Transcription, Genetic, Glutamine, Nude, Kr-POK (Zbtb7c), Mice, Nude, PIAS1, Cell Death/genetics, Cell Line, Mice, 03 medical and health sciences, Glutaminase, Neoplasms, Animals, Humans, Transcription Factors/metabolism, p-STAT1, RNA, Small Interfering, Inbred BALB C, Genetic/genetics, GLS1, Cell Proliferation, Mice, Inbred BALB C, 0303 health sciences, Glutaminase/metabolism, Cell Death, Intracellular Signaling Peptides and Proteins, Proteins, Neoplastic/genetics, Neoplasms/genetics, 3. Good health, Gene Expression Regulation, Neoplastic, HEK293 Cells, STAT1 Transcription Factor, Gene Expression Regulation, Small Interfering/genetics, RNA, Glutamine metabolism, STAT1 Transcription Factor/metabolism, Cell Proliferation/genetics, Glutamine/metabolism, Proteins/metabolism, Transcription, Neoplasms/metabolism, Transcription Factors

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/28571744
https://www.ncbi.nlm.nih.gov/pubmed/28571744
https://www.sciencedirect.com/science/article/abs/pii/S187493991730038X
http://www.sciencedirect.com/science/article/pii/S187493991730038X
https://pubmed.ncbi.nlm.nih.gov/28571744/
https://europepmc.org/abstract/MED/28571744

p-Coumaroyl Anthocyanin Mixture Isolated from Tuber Epidermis of Solanum tuberosum Attenuates Reactive Oxygen Species and Pro-inflammatory Mediators by Suppressing NF-κB and STAT1/3 Signaling in LPS-Induced RAW264.7 Macrophages

Autoren: Dae Sik Jang Yong Woo Ji Ji-Sun Shin et al.

Weitere Verfasser: Dae Sik Jang Yong Woo Ji Ji-Sun Shin et al.

Quelle: Biological & Pharmaceutical Bulletin. 40:1894-1902

Schlagwörter: Lipopolysaccharides, 0301 basic medicine, antioxidant, Anti-Inflammatory Agents, Nitric Oxide Synthase Type II, anthocyanin, Anthocyanins, Mice, Propionates / chemistry, Phosphorylation, anti-inflammatory, signal transducer and activator of transcription, 0303 health sciences, Nitric Oxide Synthase Type II / metabolism, NF-kappa B, Free Radical Scavengers / pharmacology, Propionates / pharmacology, Free Radical Scavengers, Free Radical Scavengers / chemistry, 3. Good health, Signal Transduction / drug effects, Plant Tubers, STAT1 Transcription Factor, Anthocyanins / chemistry, STAT1 Transcription Factor / metabolism, Cytokines, nuclear factor κB, Solanum tuberosum / chemistry, Coumaric Acids, Nitric Oxide / metabolism, STAT3 Transcription Factor / metabolism, Plant Extracts / chemistry, Anti-Inflammatory Agents / pharmacology, macrophage, Nitric Oxide, Lipopolysaccharides / pharmacology, Dinoprostone, NF-kappa B / metabolism, 03 medical and health sciences, Plant Extracts / pharmacology, Plant Tubers / chemistry, Animals, Anti-Inflammatory Agents / chemistry, Dinoprostone / metabolism, Phosphorylation / drug effects, Cyclooxygenase 2 / metabolism, Plant Extracts, Anthocyanins / pharmacology, Reactive Oxygen Species / metabolism, Cytokines / metabolism, RAW 264.7 Cells, Cyclooxygenase 2, Propionates, Reactive Oxygen Species

Zugangs-URL: https://www.jstage.jst.go.jp/article/bpb/40/11/40_b17-00362/_pdf
https://pubmed.ncbi.nlm.nih.gov/29093336
https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/181761/1/T999201704.pdf
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181761
https://pubmed.ncbi.nlm.nih.gov/29093336/
https://doi.org/10.1248/bpb.b17-00362
http://www.ncbi.nlm.nih.gov/pubmed/29093336
https://www.ncbi.nlm.nih.gov/pubmed/29093336

The Dynamic Interface of Viruses with STATs

Autoren: Angela R. Harrison Gregory W. Moseley

Quelle: Journal of Virology. 94

Schlagwörter: 0301 basic medicine, 0303 health sciences, Signal Transduction/physiology, Gene Expression, STAT2 Transcription Factor, STAT4 Transcription Factor, STAT Transcription Factors/genetics, 3. Good health, STAT Transcription Factors, 03 medical and health sciences, STAT1 Transcription Factor, Host-Pathogen Interactions, Viruses, Cytokines, STAT1 Transcription Factor/metabolism, STAT6 Transcription Factor, STAT2 Transcription Factor/metabolism, Viruses/genetics, Immune Evasion, Signal Transduction

Zugangs-URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592203
https://pubmed.ncbi.nlm.nih.gov/32847860
https://pubmed.ncbi.nlm.nih.gov/32847860/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592203
https://europepmc.org/article/MED/32847860
https://research.monash.edu/en/publications/the-dynamic-interface-of-viruses-with-stats
https://www.ncbi.nlm.nih.gov/pubmed/32847860

Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen–glucose deprivation

Autoren: Kim, JY Yenari, MA Lee, JE et al.

Weitere Verfasser: Kim, JY Yenari, MA Lee, JE et al.

Quelle: Neuroscience. 286:272-280

Schlagwörter: 0301 basic medicine, I-kappa B Proteins/metabolism, STAT1 Transcription Factor/metabolism, MAP Kinase Signaling System, 1.1 Normal biological development and functioning, Biological Psychology, Primary Cell Culture, Transcription Factor AP-1/metabolism, Brain Ischemia, Mice, 70-kDa heat shock protein, 03 medical and health sciences, 0302 clinical medicine, Astrocytes/metabolism, Underpinning research, transcription factors, Genetics, Psychology, Animals, HSP70 Heat-Shock Proteins, Phosphorylation, JNK Mitogen-Activated Protein Kinases/metabolism, Mice, Inbred ICR, Neurology & Neurosurgery, Biomedical and Clinical Sciences, phosphorylation, Neurosciences, JNK Mitogen-Activated Protein Kinases, NF-kappa B, HSP70 Heat-Shock Proteins/metabolism, Brain Ischemia/metabolism, Encephalitis/metabolism, NF-kappa B/metabolism, Inbred ICR, 3. Good health, Oxygen, Transcription Factor AP-1, Glucose, STAT1 Transcription Factor, inflammation, Astrocytes, Biological psychology, Encephalitis, Cognitive Sciences, I-kappa B Proteins, ischemic injury, Heat-Shock Response, Biotechnology

Dateibeschreibung: application/pdf; 272~280

Zugangs-URL: https://europepmc.org/articles/pmc5957282?pdf=render
https://pubmed.ncbi.nlm.nih.gov/25485480
https://yonsei.pure.elsevier.com/en/publications/regulation-of-inflammatory-transcription-factors-by-heat-shock-pr
https://pubmed.ncbi.nlm.nih.gov/25485480/
https://europepmc.org/article/MED/25485480
https://escholarship.org/uc/item/8db0n00g.pdf
https://escholarship.org/content/qt8db0n00g/qt8db0n00g.pdf?t=ok31fa
https://khepri-node.dev.meta-infra.org/papers/regulation-of-inflammatory-transcription-factors/25485480
https://escholarship.org/uc/item/8db0n00g

Dual Modulation of Type I Interferon Response by Bluetongue Virus

Autoren: Doceul, Virginie Chauveau, Emilie Lara, Estelle et al.

Weitere Verfasser: Doceul, Virginie Chauveau, Emilie Lara, Estelle et al.

Quelle: Journal of Virology. 88:10792-10802

Schlagwörter: MESH: Signal Transduction, 0301 basic medicine, [SDV]Life Sciences [q-bio], Bluetongue, MESH: Interferon Type I / genetics, 03 medical and health sciences, MESH: Bluetongue virus / physiology, MESH: Bluetongue / genetics, MESH: Janus Kinase 1 / genetics, MESH: Bluetongue / virology, Animals, Humans, MESH: Animals, MESH: STAT1 Transcription Factor / genetics, MESH: STAT1 Transcription Factor / metabolism, MESH: Humans, MESH: Interferon Type I / metabolism, MESH: Host-Pathogen Interactions, Janus Kinase 1, 3. Good health, [SDV] Life Sciences [q-bio], STAT1 Transcription Factor, Host-Pathogen Interactions, Interferon Type I, MESH: Bluetongue / metabolism, MESH: Janus Kinase 1 / metabolism, Bluetongue virus, Signal Transduction

Zugangs-URL: https://jvi.asm.org/content/jvi/88/18/10792.full.pdf
https://pubmed.ncbi.nlm.nih.gov/25008919
https://www.ncbi.nlm.nih.gov/pubmed/25008919
http://europepmc.org/articles/PMC4178850
https://pubmed.ncbi.nlm.nih.gov/25008919/
https://jvi.asm.org/content/88/18/10792

Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2

Autoren: Melanie Tran Atsushi Fukushima Troy L. Merry et al.

Quelle: Cell Metabolism. 20:85-102

Schlagwörter: Male, 0301 basic medicine, STAT3 Transcription Factor -- metabolism, Physiology, Signal Transduction -- drug effects, Inbred C57BL, 1307 Cell Biology, Non-Receptor Type 2 -- deficiency -- genetics -- metabolism, Mice, Insulin, Insulin-Like Growth Factor I, Cells, Cultured, Mice, Knockout, 2. Zero hunger, Insulin -- metabolism -- pharmacology, Protein Tyrosine Phosphatase, Non-Receptor Type 2, 0303 health sciences, Cultured, Type 2 diabetes, Sciences bio-médicales et agricoles, STAT1 Transcription Factor, Liver, Female, Glutathione Peroxidase -- deficiency -- genetics -- metabolism, Insulin-Like Growth Factor I -- metabolism, STAT3 Transcription Factor, Cells, Knockout, STAT1 Transcription Factor -- metabolism, Hepatic insulin resistance, Diet, High-Fat, Reactive Oxygen Species -- metabolism, Hepatocytes -- cytology -- metabolism, 03 medical and health sciences, 1312 Molecular Biology, Animals, Obesity, Molecular Biology, Glutathione Peroxidase, Growth Hormone -- metabolism, 1314 Physiology, Cell Biology, Diet, Obesity -- metabolism -- pathology, Mice, Inbred C57BL, High-Fat, Oxidative Stress, Growth Hormone, Hepatocytes, Protein Tyrosine Phosphatase, Hepatic oxidative stress, Reactive Oxygen Species, STAT5 Transcription Factor -- genetics -- metabolism, Liver -- enzymology -- metabolism

Dateibeschreibung: 1 full-text file(s): application/pdf

Zugangs-URL: http://www.cell.com/article/S1550413114002198/pdf
https://pubmed.ncbi.nlm.nih.gov/24954415
http://europepmc.org/articles/PMC4335267
https://research.monash.edu/en/publications/hepatic-oxidative-stress-promotes-insulin-stat-5-signaling-and-ob
https://findanexpert.unimelb.edu.au/scholarlywork/813741-hepatic-oxidative-stress-promotes-insulin-stat-5-signaling-and-obesity-by-inactivating-protein-tyrosine-phosphatase-n2
https://www.cell.com/article/S1550413114002198/pdf
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(14)00219-8
https://pubmed.ncbi.nlm.nih.gov/24954415/

Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell–mediated dendrite and synapse loss

Autoren: Mario Kreutzfeldt Andreas Bergthaler Ingmar Blümcke et al.

Weitere Verfasser: Mario Kreutzfeldt Andreas Bergthaler Ingmar Blümcke et al.

Quelle: J Exp Med
Journal of experimental medicine 210(10), 2087-2103 (2013). doi:10.1084/jem.20122143
Journal of Experimental Medicine, Vol. 210, No 10 (2013) pp. 2087-103
Kreutzfeldt, M, Bergthaler, A, Fernandez, M, Brück, W, Steinbach, K, Vorm, M, Coras, R, Blümcke, I, Bonilla, W V, Fleige, A, Forman, R, Müller, W, Becher, B, Misgeld, T, Kerschensteiner, M, Pinschewer, D D & Merkler, D 2013, 'Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss', Journal of Experimental Medicine, vol. 210, no. 10, pp. 2087-2103. https://doi.org/10.1084/jem.20122143
The Journal of experimental medicine
The Journal of Experimental Medicine

Schlagwörter: 0301 basic medicine, immunology [T-Lymphocytes, Cytotoxic], metabolism [Lymphocytic Choriomeningitis], ddc:616.07, CD8-Positive T-Lymphocytes, 10263 Institute of Experimental Immunology, Mice, Lymphocytic choriomeningitis virus, Receptors, Interferon/genetics/metabolism, Phosphorylation, Child, genetics [Perforin], Receptors, Interferon, Neurons, Interferon-gamma/antagonists & inhibitors/metabolism, 0303 health sciences, immunology [Lymphocytic choriomeningitis virus], metabolism [Perforin], Neurons/immunology/metabolism/virology, immunology [Lymphocytic Choriomeningitis], 3. Good health, genetics [Receptors, Interferon], Protein Transport, Antigens, CD95, immunology [Dendrites], STAT1 Transcription Factor, Spinal Cord, metabolism [Neurons], 2723 Immunology and Allergy, metabolism [Interferon-gamma], STAT1 Transcription Factor/metabolism, Signal Transduction, Adult, metabolism [Spinal Cord], Lymphocytic Choriomeningitis/immunology/metabolism/prevention & control, virology [Neurons], Adolescent, metabolism [fas Receptor], prevention & control [Lymphocytic Choriomeningitis], Perforin/genetics/metabolism, 610 Medicine & health, Mice, Transgenic, pathology [Spinal Cord], 616.07, Lymphocytic Choriomeningitis, CD8-Positive T-Lymphocytes/immunology, antagonists & inhibitors [Interferon-gamma], Article, Dendrites/immunology, Synapses/immunology, Young Adult, Interferon-gamma, 03 medical and health sciences, genetics [fas Receptor], Animals, Humans, Lymphocytic choriomeningitis virus/immunology, ddc:610, fas Receptor, metabolism [Cell Nucleus], immunology [Spinal Cord], Spinal Cord/immunology/metabolism/pathology, Cell Nucleus, 2403 Immunology, immunology [Synapses], metabolism [Receptors, Interferon], Perforin, immunology [CD8-Positive T-Lymphocytes], Dendrites, T-Lymphocytes, Cytotoxic/immunology, interferon gamma receptor, Antigens, CD95/genetics/metabolism, metabolism [STAT1 Transcription Factor], Cell Nucleus/metabolism, Synapses, 570 Life sciences, biology, immunology [Neurons], T-Lymphocytes, Cytotoxic

Dateibeschreibung: application/pdf; 2087_002.pdf - application/pdf

Zugangs-URL: http://jem.rupress.org/content/jem/210/10/2087.full.pdf
http://jem.rupress.org/content/210/10/2087.full.pdf
https://pubmed.ncbi.nlm.nih.gov/23999498
https://pubmed.ncbi.nlm.nih.gov/23999498/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782053/
https://rupress.org/jem/article/210/10/2087/41409/Neuroprotective-intervention-by-interferon
https://archive-ouverte.unige.ch/unige:33447
https://europepmc.org/abstract/MED/23999498
https://mediatum.ub.tum.de/1328191
https://pub.dzne.de/record/137048
http://hdl.handle.net/10033/306168
https://archive-ouverte.unige.ch/unige:33447
https://resolver.sub.uni-goettingen.de/purl?gro-2/28728

Metallothioneins negatively regulate IL-27–induced type 1 regulatory T-cell differentiation

Autoren: Wu Chuan Pot Caroline Apetoh Lionel et al.

Quelle: Proceedings of the National Academy of Sciences, Vol. 110, No 19 (2013) pp. 7802-7
Proceedings of the National Academy of Sciences of the United States of America

Schlagwörter: STAT3 Transcription Factor, 0301 basic medicine, Encephalomyelitis, Autoimmune, Experimental, Cell Separation, ddc:616.07, 616.07, T-Lymphocytes, Regulatory, Interleukin-10/metabolism, Mice, 03 medical and health sciences, Animals, Humans, Phosphorylation, Metallothionein/metabolism, Cells, Cultured, Mice, Knockout, 0303 health sciences, T-Lymphocytes, Regulatory/immunology/metabolism, Interleukin-17, Cell Differentiation, Flow Cytometry, Interleukin-10, Mice, Inbred C57BL, Encephalomyelitis, Autoimmune, Experimental/immunology, STAT1 Transcription Factor, Interleukin-17/metabolism, Gene Expression Regulation, STAT3 Transcription Factor/metabolism, Metallothionein, STAT1 Transcription Factor/metabolism

Dateibeschreibung: application/pdf

Zugangs-URL: https://www.pnas.org/content/pnas/110/19/7802.full.pdf
https://pubmed.ncbi.nlm.nih.gov/23630250
https://www.pnas.org/content/pnas/110/19/7802.full.pdf
https://www.pubmedcentral.nih.gov/pmc/articles/PMC3651423/
https://www.pnas.org/content/110/19/7802.full.pdf
http://www.pnas.org/content/early/2013/04/23/1211776110.abstract.html
http://europepmc.org/articles/PMC3651423
https://www.pnas.org/content/110/19/7802
https://archive-ouverte.unige.ch/unige:33008