Search Results - "SOMATOMEDIN"

Genome-wide identification and characterization of IGF/IGFR/IGFBP gene families in spotted sea bass and their expression profiles in response to environmental stress.

Authors: Zhang C Yang X Zhang Y et al.

Source: Comparative biochemistry and physiology. Part D, Genomics & proteomics [Comp Biochem Physiol Part D Genomics Proteomics] 2025 Dec; Vol. 56, pp. 101575. Date of Electronic Publication: 2025 Jul 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101270611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0407 (Electronic) Linking ISSN: 1744117X NLM ISO Abbreviation: Comp Biochem Physiol Part D Genomics Proteomics Subsets: MEDLINE

MeSH Terms: Bass*/genetics , Bass*/physiology , Bass*/metabolism , Insulin-Like Growth Factor Binding Proteins*/genetics , Insulin-Like Growth Factor Binding Proteins*/metabolism , Stress, Physiological*/genetics , Fish Proteins*/genetics , Fish Proteins*/metabolism , Somatomedins*/genetics , Somatomedins*/metabolism , Receptors, Somatomedin*/genetics , Receptors, Somatomedin*/metabolism, Animals ; Phylogeny ; Multigene Family

Conditional ablation of Insr and Igf1r using Esr2-Cre leads to abnormal ovarian follicle development and infertility in mice†.

Authors: Sekulovski N Whorton AE Shi M et al.

Source: Biology of reproduction [Biol Reprod] 2025 Nov 14; Vol. 113 (5), pp. 1196-1208.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0207224 Publication Model: Print Cited Medium: Internet ISSN: 1529-7268 (Electronic) Linking ISSN: 00063363 NLM ISO Abbreviation: Biol Reprod Subsets: MEDLINE

MeSH Terms: Receptor, Insulin*/genetics , Receptor, Insulin*/metabolism , Ovarian Follicle*/growth & development , Ovarian Follicle*/metabolism , Receptor, IGF Type 1*/genetics , Receptor, IGF Type 1*/metabolism , Infertility, Female*/genetics , Infertility, Female*/metabolism , Estrogen Receptor beta*/genetics , Estrogen Receptor beta*/metabolism , Receptors, Somatomedin*/genetics , Receptors, Somatomedin*/metabolism, Animals ; Female ; Mice ; Mice, Knockout ; Integrases/genetics ; Integrases/metabolism ; Signal Transduction

Protective effects of propafenone, propranolol, and amiodarone against isoproterenol-induced lethal arrhythmias in IGF1R deficiency mice.

Authors: Sun Z Chen Y Li J et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Sep 08; Vol. 778, pp. 152416. Date of Electronic Publication: 2025 Jul 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Arrhythmias, Cardiac*/chemically induced , Arrhythmias, Cardiac*/drug therapy , Arrhythmias, Cardiac*/prevention & control , Arrhythmias, Cardiac*/mortality , Amiodarone*/pharmacology , Amiodarone*/therapeutic use , Propranolol*/pharmacology , Propranolol*/therapeutic use , Propafenone*/pharmacology , Propafenone*/therapeutic use , Receptor, IGF Type 1*/deficiency , Receptor, IGF Type 1*/genetics , Anti-Arrhythmia Agents*/pharmacology , Anti-Arrhythmia Agents*/therapeutic use , Receptors, Somatomedin*/deficiency , Receptors, Somatomedin*/genetics, Animals ; Isoproterenol ; Mice ; Male ; Mice, Knockout ; Mice, Inbred C57BL

Regulation and function of insulin and insulin-like growth factor receptor signalling.

Authors: Choi E Duan C Bai XC

Source: Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2025 Jul; Vol. 26 (7), pp. 558-580. Date of Electronic Publication: 2025 Feb 10.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0080 (Electronic) Linking ISSN: 14710072 NLM ISO Abbreviation: Nat Rev Mol Cell Biol Subsets: MEDLINE

MeSH Terms: Signal Transduction*/physiology , Insulin*/metabolism , Receptor, Insulin*/metabolism , Receptor, Insulin*/chemistry , Receptors, Somatomedin*/metabolism , Receptors, Somatomedin*/chemistry, Humans ; Animals ; Receptor, IGF Type 1/metabolism ; Ligands

HER2-positive neuroendocrine breast carcinoma: a case study uncovers CCND1 , FGF19 , and IGF1R amplifications as new molecular drivers.

Authors: Zordan M Fiorio E Maffeis V et al.

Source: Pathologica [Pathologica] 2025 Sep; Vol. 117 (4), pp. 348-356.

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: Pacini Editore SpA Country of Publication: Italy NLM ID: 0401123 Publication Model: Print Cited Medium: Internet ISSN: 1591-951X (Electronic) Linking ISSN: 00312983 NLM ISO Abbreviation: Pathologica Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Carcinoma, Neuroendocrine*/genetics , Carcinoma, Neuroendocrine*/pathology , Carcinoma, Neuroendocrine*/therapy , Receptor, ErbB-2*/genetics , Receptor, ErbB-2*/metabolism , Cyclin D1*/genetics , Fibroblast Growth Factors*/genetics , Receptor, IGF Type 1*/genetics , Biomarkers, Tumor*/genetics , Receptors, Somatomedin*/genetics, Humans ; Female ; Gene Amplification ; Middle Aged

Distinguishing Genetic Alterations Versus (Epi)Mutations in Silver-Russell Syndrome and Focus on the IGF1R Gene.

Authors: Vimercati A Tannorella P Guzzetti S et al.

Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2025 Mar 17; Vol. 110 (4), pp. e932-e944.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE

MeSH Terms: Silver-Russell Syndrome*/genetics , Silver-Russell Syndrome*/diagnosis , Receptor, IGF Type 1*/genetics , Mutation* , Receptors, Somatomedin*/genetics, Humans ; Male ; Female ; Child ; Child, Preschool ; Genomic Imprinting ; Insulin-Like Growth Factor II/genetics ; Adolescent ; Infant ; HMGA2 Protein/genetics ; DNA-Binding Proteins/genetics

Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1.

Authors: Yu D Jain S Wangzhou A et al.

Source: Nature [Nature] 2025 Oct; Vol. 646 (8085), pp. 676-686. Date of Electronic Publication: 2025 Aug 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH Terms: Insulin-Like Growth Factor I*/metabolism , Insulin-Like Growth Factor I*/deficiency , Insulin-Like Growth Factor I*/genetics , Microglia*/metabolism , Microglia*/cytology , Neurogenesis* , GABAergic Neurons*/cytology , GABAergic Neurons*/metabolism , Brain*/cytology , Brain*/embryology, Humans ; Cell Proliferation ; Receptor, IGF Type 1/metabolism ; Organoids/cytology ; Organoids/metabolism ; Female ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Male ; Receptors, Somatomedin/metabolism

Mitigation effect of grape seed extract against cadmium-induced hormonal toxicity in common carp (Cyprinus carpio).

Authors: Korkmaz, Nuh Erdoğan, Kenan Örün, Gül Nihal et al.

Source: BMC Veterinary Research. 7/1/2025, Vol. 21 Issue 1, p1-10. 10p.

Subjects: Somatomedin C, Grape seed extract, Poisons, Heavy metal toxicology, Carp

Picropodophyllin induces ferroptosis via blockage of AKT/NRF2/SLC7A11 and AKT/NRF2/SLC40A1 axes in hepatocellular carcinoma as a natural IGF1R inhibitor.

Authors: Zheng J Liu Y Zhu F et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Jul 25; Vol. 143, pp. 156840. Date of Electronic Publication: 2025 May 10.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Podophyllotoxin*/analogs & derivatives , Podophyllotoxin*/pharmacology, Humans ; Animals ; Receptor, IGF Type 1/antagonists & inhibitors ; Receptor, IGF Type 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Mice ; Signal Transduction/drug effects ; Mice, Nude ; Amino Acid Transport System y+/metabolism ; Cell Line, Tumor ; Male ; Mice, Inbred BALB C ; Xenograft Model Antitumor Assays ; Receptors, Somatomedin/antagonists & inhibitors ; Molecular Docking Simulation ; Female

The effects of monochromatic LED light from one to 14 days of age on the growth, muscle development, and blood parameters of goslings.

Authors: Xue, J. J. Huang, X. F. Liu, Z. L. et al.

Source: South African Journal of Animal Science. 2025, Vol. 55 Issue 3, p140-145. 6p.

Subjects: Green light, Somatomedin C, Monochromatic light, Blue light, Leg muscles

Persistent Stimulation of Sex-related Hormones in the Uterus is Associated with Differences in the Igf/Akt Signaling Pathway and Uterine Damage.

Authors: Min Jee Oh Yun Dong Choi Sang Hwan Kim

Source: Indian Journal of Animal Research. Apr2025, Vol. 59 Issue 4, p574-580. 7p.

Subjects: Somatomedin, Protein kinase B, Chorionic gonadotropins, Blood proteins, Estrus synchronization, Endometrium

THE IMPACT OF SUPPLEMENTING BROILER CHICKENS WITH TRIBULUS TERRESTRIS POWDER ON GENE EXPRESSION OF GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR 1.

Alternate Title: كمكمل غذائي مستدام على التعبير الجيني T. terrestris تأثير إضافة مسحوق نبات في دجاج اللحم IGF و 1 GH لهرمونات

Authors: MOHAMMED, ALI A. AL-ASSAF, IBTISAM N. MOHAMMED, GHASSAN F.

Source: Assiut Veterinary Medical Journal. Apr2025, Vol. 71 Issue 185, p302-313. 12p.

Subjects: Somatomedin C, Lauric acid, Palmitic acid, Tribulus terrestris, Broiler chickens

Association between insulin-associated gene polymorphisms and new-onset diabetes mellitus in statin-treated patients.

Authors: Park M Kim JS Park YA et al.

Source: European journal of clinical investigation [Eur J Clin Invest] 2025 Apr; Vol. 55 (4), pp. e14366. Date of Electronic Publication: 2024 Nov 30.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE

MeSH Terms: Hydroxymethylglutaryl-CoA Reductase Inhibitors*/adverse effects , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use , Diabetes Mellitus*/genetics , Diabetes Mellitus*/chemically induced , Insulin*/genetics, Humans ; Male ; Female ; Polymorphism, Single Nucleotide ; Middle Aged ; Retrospective Studies ; Aged ; Insulin Receptor Substrate Proteins/genetics ; Receptor, IGF Type 1/genetics ; Receptor, Insulin/genetics ; Antigens, CD/genetics ; Signal Transduction/genetics ; Insulin-Like Growth Factor I/genetics ; Receptors, Somatomedin/genetics ; Class I Phosphatidylinositol 3-Kinases/genetics ; Insulin-Like Growth Factor II ; Proto-Oncogene Proteins c-akt ; Class Ia Phosphatidylinositol 3-Kinase

A Blend of natural phytobiotics enhances growth performance, feed efficiency, and the immuno-health status of fingerlings of Nile tilapia (Oreochromis niloticus).

Authors: Mabrouk, Shreifa G. El-Nokrashy, Asmaa M. Ebied, Nahla A. et al.

Source: Open Veterinary Journal. 2025, Vol. 15 Issue 2, p746-764. 19p.

Subjects: Somatotropin receptors, Somatomedin, Tumor necrosis factors, Nile tilapia, Glutathione peroxidase, Digestive enzymes, Lysozymes

Зв’язок між концентрацією інсуліноподібного фактору росту і лептину та показниками ліпідного обміну в крові молочних корів за різних фізіологічних періодів.

Alternate Title: The relationship between the concentration of insulin-like growth factor, leptin and lipid metabolism indices in the blood of dairy cows during different physiological periods.

Authors: Сімонов, М. Р. Влізло, В. В. Пундяк, Т. О. et al.

Source: Scientific Messenger of Lviv National University of Verterinary Medicine & Biotechnologies Series: Veterinary Sciences. 2025, Vol. 27 Issue 117, p119-125. 7p.

Subjects: Somatomedin, Peptide hormones, Free fatty acids, Lipid metabolism, Cattle parturition, Leptin

Association between polymorphism within rabbit IGF1 gene and slaughter weight in Termond White rabbits.

Authors: MIGDAŁ, ANNA PAŁKA, SYLWIA EWA KMIECIK, MICHAŁ et al.

Source: Czech Journal of Animal Science. 2025, Vol. 70 Issue 1, p33-41. 9p.

Subjects: Somatomedin C, European rabbit, Genetic polymorphisms, Hindlimb, Polymerase chain reaction

Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R.

Authors: Shi L Ying H Dai Y et al.

Source: Human reproduction (Oxford, England) [Hum Reprod] 2025 Jan 01; Vol. 40 (1), pp. 119-137.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print Cited Medium: Internet ISSN: 1460-2350 (Electronic) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE

MeSH Terms: Follicular Fluid*/metabolism , Granulosa Cells*/metabolism , MicroRNAs*/metabolism , MicroRNAs*/genetics , Receptor, IGF Type 1*/metabolism , Receptor, IGF Type 1*/genetics , Endometriosis*/metabolism , Endometriosis*/pathology, Female ; Humans ; Animals ; Adult ; Rats ; Cross-Sectional Studies ; Up-Regulation ; Infertility, Female/metabolism ; Infertility, Female/genetics ; Infertility, Female/therapy ; Receptors, Somatomedin/metabolism ; Receptors, Somatomedin/genetics

A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism.

Authors: Juliana CA Chai J Arroyo P et al.

Source: The Journal of biological chemistry [J Biol Chem] 2023 Jun; Vol. 299 (6), pp. 104816. Date of Electronic Publication: 2023 May 11.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH Terms: Hyperinsulinism*/drug therapy , Receptors, Somatomedin*/agonists, Animals ; Child ; Humans ; Infant ; Mice ; Adenosine Triphosphate/metabolism ; Amino Acids/metabolism ; Glucose/metabolism ; Hypoglycemia/metabolism ; Insulin/metabolism ; Insulin Secretion ; Islets of Langerhans/metabolism ; Mutation ; Potassium Channels, Inwardly Rectifying/metabolism

Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors.

Authors: Ruiz-Viroga V de Ceglia M Morelli L et al.

Source: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2023 Apr 20; Vol. 123, pp. 110703. Date of Electronic Publication: 2022 Dec 21.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE

MeSH Terms: Brain-Derived Neurotrophic Factor*/metabolism , Memory Consolidation* , Pituitary Hormones*/metabolism , Receptor, trkB*/metabolism , Receptors, Somatomedin*/metabolism, Animals ; Male ; Rats ; Melanins

Characterization of the growth-related transcriptome in the Liver and Brain of mandarin fish (Siniperca chuatsi) through RNA-Seq analysis.

Authors: Ding, Weidong Cao, Liping Cao, Zheming et al.

Source: Journal of Applied Animal Research. Dec2024, Vol. 52 Issue 1, p1-13. 13p.

Subjects: Insulin-like growth factor-binding proteins, Somatomedin, Mitogen-activated protein kinases, RNA sequencing, Gene expression, Transforming growth factors-beta