Search Results - "SAPONINS"

Hypoglycemic potential of American ginseng saponins: inhibition of α-amylase and improvement of insulin resistance.

Authors: Liang L Guo Y Yao X et al.

Source: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2025 Dec 15; Vol. 1267, pp. 124813. Date of Electronic Publication: 2025 Oct 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

MeSH Terms: Insulin Resistance* , Panax*/chemistry , alpha-Amylases*/antagonists & inhibitors , alpha-Amylases*/metabolism , Saponins*/pharmacology , Saponins*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry, Humans ; Hep G2 Cells ; Molecular Docking Simulation ; Chromatography, High Pressure Liquid ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Ginsenosides/pharmacology ; Ginsenosides/chemistry

Discovery of new dammarane saponins from Actinostemma lobatum: C-3 monoglucosylation governs α-glucosidase inhibition.

Authors: Li W Liu Z Li H et al.

Source: Fitoterapia [Fitoterapia] 2025 Dec; Vol. 187, pp. 106898. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

MeSH Terms: Saponins*/isolation & purification , Saponins*/pharmacology , Saponins*/chemistry , Glycoside Hydrolase Inhibitors*/isolation & purification , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Triterpenes*/isolation & purification , Triterpenes*/chemistry , Triterpenes*/pharmacology, Dammaranes ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; alpha-Glucosidases ; China

Panaxatriol saponins exert anti-renal fibrosis by suppressing TNF-α mediated inflammation and TGF-β1/Smad3 signaling pathway.

Authors: Yi S Li F Ma X et al.

Source: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2516774. Date of Electronic Publication: 2025 Jun 19.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH Terms: Ginsenosides*/pharmacology , Ginsenosides*/therapeutic use , Kidney*/pathology , Kidney*/drug effects , Saponins*/pharmacology , Saponins*/therapeutic use , Renal Insufficiency, Chronic*/pathology , Renal Insufficiency, Chronic*/drug therapy, Animals ; Fibrosis ; Rats, Sprague-Dawley ; Rats ; Smad3 Protein/metabolism ; Signal Transduction/drug effects ; Male ; Transforming Growth Factor beta1/metabolism ; Disease Models, Animal ; Tumor Necrosis Factor-alpha/metabolism ; Ureteral Obstruction/complications ; Molecular Docking Simulation ; Inflammation/drug therapy

Investigating the anti-atherosclerotic mechanisms of Panax notoginseng saponins through integrated cell experiments, online preparative high-performance liquid chromatography, network pharmacology, molecular docking, and molecular dynamics simulations.

Authors: Zhang W Zhou Y Cui Y et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Nov 28; Vol. 791, pp. 152927. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Saponins*/pharmacology , Saponins*/chemistry , Saponins*/isolation & purification , Panax notoginseng*/chemistry , Atherosclerosis*/drug therapy , Atherosclerosis*/metabolism , Atherosclerosis*/pathology, Molecular Dynamics Simulation ; Molecular Docking Simulation ; Mice ; Animals ; Network Pharmacology ; RAW 264.7 Cells ; Chromatography, High Pressure Liquid ; Signal Transduction/drug effects ; Foam Cells/drug effects ; Foam Cells/metabolism

Optimization of extraction and structural characterization of bioactive compounds from Musa balbisiana peel.

Authors: Hoang TNN Luu TQH Anh Nguyen V et al.

Source: Scientific reports [Sci Rep] 2025 Nov 20; Vol. 15 (1), pp. 41031. Date of Electronic Publication: 2025 Nov 20.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Saponins*/chemistry , Saponins*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/isolation & purification , Musa*/chemistry , Polyphenols*/chemistry , Polyphenols*/isolation & purification , Phytochemicals*/chemistry , Phytochemicals*/isolation & purification, Fruit/chemistry ; Oleanolic Acid/chemistry ; Oleanolic Acid/isolation & purification ; Spectroscopy, Fourier Transform Infrared ; Microwaves ; Spectrum Analysis, Raman

Advances in Camellia oleifera seed meal Saponins: Extraction, analysis, bioactivity, and application.

Authors: Zhang J Liu J Wang J et al.

Source: Food chemistry [Food Chem] 2025 Nov 15; Vol. 492 (Pt 1), pp. 145277. Date of Electronic Publication: 2025 Jun 24.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Saponins*/isolation & purification , Saponins*/chemistry , Saponins*/pharmacology , Seeds*/chemistry , Camellia*/chemistry , Plant Extracts*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/pharmacology, Humans ; Antioxidants/isolation & purification ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Animals

Comprehensive Identification and Abscisic Acid-Responsive Expression Profiling of NAC Transcription Factor in Triterpenoid Saponin in Hedera helix .

Authors: Deng X Zheng F Xu Z et al.

Source: Biomolecules [Biomolecules] 2025 Nov 06; Vol. 15 (11). Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

MeSH Terms: Abscisic Acid*/pharmacology , Abscisic Acid*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , Saponins*/metabolism , Saponins*/genetics , Plant Proteins*/genetics , Plant Proteins*/metabolism , Triterpenes*/metabolism, Gene Expression Regulation, Plant/drug effects ; Gene Expression Profiling ; Plant Leaves/metabolism ; Plant Leaves/genetics ; Promoter Regions, Genetic ; Transcriptome

Two new saponins from the rhizomes of Paris yunnanensis Franch.

Authors: Zheng SX Wang MC Tian YY et al.

Source: Natural product research [Nat Prod Res] 2025 Nov; Vol. 39 (21), pp. 6153-6160. Date of Electronic Publication: 2024 Jul 04.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

MeSH Terms: Saponins*/chemistry , Saponins*/pharmacology , Saponins*/isolation & purification , Rhizome*/chemistry , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/isolation & purification , Melanthiaceae*/chemistry, Mice ; RAW 264.7 Cells ; Animals ; Molecular Structure ; Nitric Oxide/biosynthesis ; Lipopolysaccharides/pharmacology

Dietary supplementary with soya saponins alleviates the poor intestinal health of broilers challenged with coccidia via reshaping the structure of the intestinal microbiota.

Authors: Li P Han S Shi W et al.

Source: Poultry science [Poult Sci] 2025 Nov; Vol. 104 (11), pp. 105886. Date of Electronic Publication: 2025 Sep 22.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult Sci Subsets: MEDLINE

MeSH Terms: Chickens*/physiology , Gastrointestinal Microbiome*/drug effects , Coccidiosis*/veterinary , Coccidiosis*/parasitology , Coccidiosis*/immunology , Poultry Diseases*/parasitology , Poultry Diseases*/microbiology , Saponins*/administration & dosage , Saponins*/metabolism , Glycine max*/chemistry , Intestines*/drug effects , Intestines*/microbiology, Animals ; Diet/veterinary ; Male ; Animal Feed/analysis ; Dietary Supplements/analysis ; Random Allocation ; Eimeria/physiology

Purification of steroidal saponins from dioscoreae hypoglaucae rhizoma by macroporous resin and evaluation of their anti-inflammatory effect.

Authors: Qin Z Du Y Zhong Y et al.

Source: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2025 Nov 01; Vol. 1265, pp. 124769. Date of Electronic Publication: 2025 Aug 14.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

MeSH Terms: Saponins*/pharmacology , Saponins*/isolation & purification , Saponins*/chemistry , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/isolation & purification , Anti-Inflammatory Agents*/chemistry , Rhizome*/chemistry , Dioscorea*/chemistry , Steroids*/pharmacology , Steroids*/isolation & purification , Steroids*/chemistry, Mice ; Animals ; RAW 264.7 Cells ; Chromatography, High Pressure Liquid/methods ; Plant Extracts/chemistry ; Plant Extracts/pharmacology

Discovery of a previously undescribed immunopotentiator: identification and immune-stimulating activity of saponins from Hylomecon japonica (Thunb.) Prantl & Kündig.

Authors: Shi P Zhao J Niu J et al.

Source: Phytochemistry [Phytochemistry] 2025 Nov; Vol. 239, pp. 114601. Date of Electronic Publication: 2025 Jun 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE

MeSH Terms: Saponins*/pharmacology , Saponins*/chemistry , Saponins*/isolation & purification , Immunologic Factors*/pharmacology , Immunologic Factors*/chemistry , Immunologic Factors*/isolation & purification, Animals ; Mice ; Molecular Structure ; Dendritic Cells/drug effects ; Cytokines ; Cell Proliferation/drug effects

Research Progress and Prospects of Saponins in the Treatment of NAFLD: A Narrative Review.

Authors: Xue S Wang Q Guo X et al.

Source: Molecules (Basel, Switzerland) [Molecules] 2025 Oct 31; Vol. 30 (21). Date of Electronic Publication: 2025 Oct 31.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH Terms: Saponins*/therapeutic use , Saponins*/pharmacology , Saponins*/chemistry , Non-alcoholic Fatty Liver Disease*/drug therapy , Non-alcoholic Fatty Liver Disease*/metabolism , Non-alcoholic Fatty Liver Disease*/pathology, Humans ; Animals ; Lipid Metabolism/drug effects ; Gastrointestinal Microbiome/drug effects ; Oxidative Stress/drug effects ; Autophagy/drug effects ; Reactive Oxygen Species/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Liver/drug effects ; Liver/metabolism ; Liver/pathology

Antiradical and Antioxidant Activity and Stimulation of Pancreatic Lipase by Extracts Obtained from Saponin-Rich Raw Materials: Experimental and In Silico Study.

Authors: Sroka Z Kapusta K Suchańska K et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 22; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Lipase*/metabolism , Lipase*/chemistry , Saponins*/chemistry , Saponins*/pharmacology , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Antioxidants*/pharmacology , Antioxidants*/chemistry , Pancreas*/enzymology, Panax/chemistry ; Aesculus/chemistry ; Animals ; Seeds/chemistry ; Free Radical Scavengers/pharmacology ; Free Radical Scavengers/chemistry ; Molecular Docking Simulation ; Computer Simulation ; Trigonella/chemistry

The Perspectives of Combining Antibiotics with Saponins-Herbal Excipients.

Authors: Makiej A Smułek W Kaczorek E

Source: Molecules (Basel, Switzerland) [Molecules] 2025 Oct 15; Vol. 30 (20). Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH Terms: Saponins*/pharmacology , Saponins*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/therapeutic use , Excipients*/chemistry , Excipients*/pharmacology, Humans ; Animals

New C-24 epimers of dammarane-type saponins from Gynostemma pentaphyllum and their absolute configurations.

Authors: Lu PX Li G Liang HZ et al.

Source: Fitoterapia [Fitoterapia] 2025 Oct; Vol. 186, pp. 106825. Date of Electronic Publication: 2025 Aug 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

MeSH Terms: Gynostemma*/chemistry , Saponins*/isolation & purification , Saponins*/chemistry , Saponins*/pharmacology , Triterpenes*/isolation & purification , Triterpenes*/chemistry , Triterpenes*/pharmacology, Dammaranes ; Molecular Structure ; Animals ; Rats ; PC12 Cells ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; China ; Plant Extracts

Target Screening and Validation of the Antitumor Effect of Saponin Extract From Holothuria leucospilota.

Authors: Xu F Liu G Zhao C et al.

Source: Chemistry & biodiversity [Chem Biodivers] 2025 Oct; Vol. 22 (10), pp. e03399. Date of Electronic Publication: 2025 Jun 16.

Publication Type: Journal Article

Journal Info: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH Terms: Saponins*/pharmacology , Saponins*/chemistry , Saponins*/isolation & purification , Holothuria*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/isolation & purification , Antineoplastic Agents, Phytogenic*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/isolation & purification, Humans ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Structure-Activity Relationship ; Molecular Structure

Two new triterpenoid saponins and two new goodyerosides isolated from the whole plant of Tournefortia sibirica .

Authors: Li J Jin L Jin M et al.

Source: Natural product research [Nat Prod Res] 2025 Oct; Vol. 39 (19), pp. 5524-5532. Date of Electronic Publication: 2024 Apr 24.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

MeSH Terms: Saponins*/chemistry , Saponins*/isolation & purification , Saponins*/pharmacology , Triterpenes*/chemistry , Triterpenes*/isolation & purification , Triterpenes*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/isolation & purification , Antineoplastic Agents, Phytogenic*/pharmacology, Humans ; Molecular Structure ; Oleanolic Acid/chemistry ; Oleanolic Acid/isolation & purification ; HeLa Cells ; Magnetic Resonance Spectroscopy ; Cell Line, Tumor

Massularosides A-D, new triterpenoid saponins from the stem bark of Massularia acuminata with an N-acetylglucosamine residue and their antifungal properties.

Authors: Bilongo CR Messi LM Atangana JF et al.

Source: Fitoterapia [Fitoterapia] 2025 Oct; Vol. 186, pp. 106866. Date of Electronic Publication: 2025 Sep 09.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

MeSH Terms: Saponins*/isolation & purification , Saponins*/pharmacology , Saponins*/chemistry , Antifungal Agents*/isolation & purification , Antifungal Agents*/pharmacology , Triterpenes*/isolation & purification , Triterpenes*/pharmacology , Triterpenes*/chemistry, Plant Bark/chemistry ; Molecular Structure ; Plant Stems/chemistry ; Microbial Sensitivity Tests ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology

Root-secreted saponins weaken soil disease suppression ability by shaping rhizosphere microbial communities in Panax notoginseng.

Authors: Liu Y Lu R Tian G et al.

Source: Microbiological research [Microbiol Res] 2025 Oct; Vol. 299, pp. 128263. Date of Electronic Publication: 2025 Jun 25.

Publication Type: Journal Article

Journal Info: Publisher: G. Fischer Country of Publication: Germany NLM ID: 9437794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0623 (Electronic) Linking ISSN: 09445013 NLM ISO Abbreviation: Microbiol Res Subsets: MEDLINE

MeSH Terms: Panax notoginseng*/microbiology , Panax notoginseng*/metabolism , Rhizosphere* , Plant Roots*/microbiology , Plant Roots*/metabolism , Plant Roots*/chemistry , Soil Microbiology* , Fusarium*/drug effects , Fusarium*/growth & development , Saponins*/pharmacology , Saponins*/metabolism , Plant Diseases*/microbiology , Plant Diseases*/prevention & control , Microbiota*/drug effects, Bacteria/classification ; Soil/chemistry

SCR Organism: Fusarium oxysporum

Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation.

Authors: Wang X Jiang H Wang H et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115682. Date of Electronic Publication: 2025 Oct 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Calpain*/genetics , Calpain*/metabolism , Calpain*/antagonists & inhibitors , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Microglia*/drug effects , Saponins*/therapeutic use , Saponins*/pharmacology , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/etiology , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/complications , Triterpenes*/therapeutic use , Triterpenes*/pharmacology , Diabetes Mellitus, Type 2*/drug therapy, Animals ; Mice, Inbred C57BL ; Mice ; Male ; Mice, Knockout ; Cell Line ; Signal Transduction/drug effects ; Neurons/drug effects ; Hippocampus/drug effects ; Hippocampus/pathology