Search Results - "SAM Domain and HD Domain-Containing Protein 1"

SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.

Authors: Yaxian L Xiaodong W Futao M et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Oct; Vol. 327 (Pt 1), pp. 147188. Date of Electronic Publication: 2025 Aug 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Macrophages*/metabolism , Macrophages*/pathology , TOR Serine-Threonine Kinases*/metabolism , Colitis, Ulcerative*/metabolism , Colitis, Ulcerative*/pathology , Colitis, Ulcerative*/genetics , Autophagy*/genetics , SAM Domain and HD Domain-Containing Protein 1*/deficiency , SAM Domain and HD Domain-Containing Protein 1*/genetics , SAM Domain and HD Domain-Containing Protein 1*/metabolism , Lysosomes*/metabolism , Homeostasis* , Cathepsin D*/metabolism , Microphthalmia-Associated Transcription Factor*/metabolism, Animals ; Mice ; Inflammation/pathology ; Inflammation/metabolism ; Inflammation/genetics ; Signal Transduction ; Humans ; Mice, Knockout

Confirmation of BIK and SAMHD1 as Prostate Cancer Susceptibility Genes.

Authors: Pavlovich CP Wei J Gielzak M et al.

Source: The Prostate [Prostate] 2025 Dec; Vol. 85 (16), pp. 1556-1561. Date of Electronic Publication: 2025 Aug 18.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8101368 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0045 (Electronic) Linking ISSN: 02704137 NLM ISO Abbreviation: Prostate Subsets: MEDLINE

MeSH Terms: Prostatic Neoplasms*/genetics , Genetic Predisposition to Disease*/genetics , SAM Domain and HD Domain-Containing Protein 1*/genetics , Mitochondrial Proteins*/genetics, Humans ; Male ; Middle Aged ; Aged ; Case-Control Studies

Continuous assay for the dNTP triphosphohydrolase of activated SAMHD1.

Authors: Eskandari R Groom DP Tamura R et al.

Source: Analytical biochemistry [Anal Biochem] 2026 Jan; Vol. 708, pp. 115966. Date of Electronic Publication: 2025 Sep 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/metabolism , SAM Domain and HD Domain-Containing Protein 1*/antagonists & inhibitors , Enzyme Assays*/methods, Humans ; Kinetics ; Phosphoric Monoester Hydrolases/metabolism

ssDNA and ssRNA Promote Phase Condensation of SAMHD1.

Authors: Smith BE Pohnerkar A Orris B et al.

Source: Biochemistry [Biochemistry] 2025 Sep 16; Vol. 64 (18), pp. 3886-3900. Date of Electronic Publication: 2025 Sep 06.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/chemistry , SAM Domain and HD Domain-Containing Protein 1*/metabolism , SAM Domain and HD Domain-Containing Protein 1*/genetics , DNA, Single-Stranded*/metabolism , DNA, Single-Stranded*/chemistry , RNA*/metabolism , RNA*/chemistry, Humans ; Guanosine Triphosphate/metabolism

The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA.

Authors: Rabinowitz J Vila IK Luchsinger C et al.

Source: The Journal of biological chemistry [J Biol Chem] 2025 Aug; Vol. 301 (8), pp. 110430. Date of Electronic Publication: 2025 Jun 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/genetics , SAM Domain and HD Domain-Containing Protein 1*/deficiency , SAM Domain and HD Domain-Containing Protein 1*/metabolism , Nucleotidyltransferases*/metabolism , Nucleotidyltransferases*/genetics , Monocytes*/metabolism , Interferon Type I*/metabolism , Interferon Type I*/genetics , DNA, Mitochondrial*/metabolism , DNA, Mitochondrial*/genetics, Humans ; Signal Transduction ; Autoimmune Diseases of the Nervous System/genetics ; Autoimmune Diseases of the Nervous System/metabolism ; Nervous System Malformations/genetics ; Nervous System Malformations/metabolism ; Interferon-Induced Helicase, IFIH1/metabolism ; Interferon-Induced Helicase, IFIH1/genetics

SCR Disease Name: Aicardi-Goutieres syndrome

SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway.

Authors: Yang H Cheung P-HH Wu L

Source: MBio [mBio] 2025 Jul 09; Vol. 16 (7), pp. e0042525. Date of Electronic Publication: 2025 May 28.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/metabolism , SAM Domain and HD Domain-Containing Protein 1*/genetics , Apoptosis* , HIV-1*/physiology , Mitochondria*/metabolism , Monocytes*/virology , Monocytes*/metabolism, Humans ; THP-1 Cells ; HIV Infections/virology ; HIV Infections/metabolism ; U937 Cells ; Membrane Potential, Mitochondrial

Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts.

Authors: Larrous P Garnier C Morel M et al.

Source: Journal of virology [J Virol] 2025 May 20; Vol. 99 (5), pp. e0019825. Date of Electronic Publication: 2025 Apr 22.

Publication Type: Journal Article

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/metabolism , SAM Domain and HD Domain-Containing Protein 1*/genetics , SAM Domain and HD Domain-Containing Protein 1*/antagonists & inhibitors , Viral Regulatory and Accessory Proteins*/genetics , Viral Regulatory and Accessory Proteins*/metabolism , Simian Immunodeficiency Virus*/genetics , Simian Immunodeficiency Virus*/metabolism , Gene Products, vpr*/genetics , Gene Products, vpr*/metabolism, Animals ; Humans ; Evolution, Molecular ; Chlorocebus aethiops ; HIV-2/genetics ; HIV-2/metabolism ; HEK293 Cells

SAMHD1 deficiency enhances macrophage-mediated clearance of Salmonella Typhimurium via NF-κB activation in zebrafish.

Authors: Martínez-López A Tyrkalska SD Martínez-Morcillo FJ et al.

Source: Frontiers in immunology [Front Immunol] 2025 Apr 25; Vol. 16, pp. 1509725. Date of Electronic Publication: 2025 Apr 25 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Zebrafish*/immunology , Zebrafish*/microbiology , Zebrafish*/genetics , SAM Domain and HD Domain-Containing Protein 1*/genetics , SAM Domain and HD Domain-Containing Protein 1*/deficiency , SAM Domain and HD Domain-Containing Protein 1*/immunology , NF-kappa B*/metabolism , NF-kappa B*/immunology , Macrophages*/immunology , Macrophages*/metabolism , Macrophages*/microbiology , Salmonella typhimurium*/immunology , Zebrafish Proteins*/genetics , Salmonella Infections*/immunology, Animals ; Immunity, Innate ; Interferon Type I/metabolism ; Interferon Type I/immunology

Prognostic and predictive implications of sterile alpha motif and HD domain-containing protein 1 (SAMHD1) expression in breast cancer.

Authors: Kouvaraki M Zerdes I Sifakis EG et al.

Source: International journal of cancer [Int J Cancer] 2025 Apr 15; Vol. 156 (8), pp. 1621-1633. Date of Electronic Publication: 2024 Dec 27.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/genetics , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Breast Neoplasms*/mortality , SAM Domain and HD Domain-Containing Protein 1*/genetics , SAM Domain and HD Domain-Containing Protein 1*/metabolism , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism, Humans ; Female ; Prognosis ; Middle Aged ; Capecitabine/therapeutic use ; Gene Expression Regulation, Neoplastic ; Adult ; Aged ; Disease-Free Survival

Moyamoya syndrome in a patient with Aicardi-Goutières syndrome associated with a SAMHD1 mutation: a case report.

Authors: Le Floch K Barillon J Bonanno MC et al.

Source: Pediatric radiology [Pediatr Radiol] 2025 Jun; Vol. 55 (7), pp. 1537-1541. Date of Electronic Publication: 2025 May 29.

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0365332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1998 (Electronic) Linking ISSN: 03010449 NLM ISO Abbreviation: Pediatr Radiol Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/genetics , Moyamoya Disease*/diagnostic imaging , Moyamoya Disease*/genetics , Moyamoya Disease*/complications , Autoimmune Diseases of the Nervous System*/genetics , Autoimmune Diseases of the Nervous System*/complications , Autoimmune Diseases of the Nervous System*/diagnostic imaging , Nervous System Malformations*/genetics , Nervous System Malformations*/diagnostic imaging , Nervous System Malformations*/complications , Magnetic Resonance Imaging*/methods, Humans ; Mutation ; Diagnosis, Differential ; Female ; Male ; Child, Preschool

SCR Disease Name: Aicardi-Goutieres syndrome

dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction.

Authors: Cheung P-HH Yang H Wu L

Source: Journal of virology [J Virol] 2025 May 20; Vol. 99 (5), pp. e0030225. Date of Electronic Publication: 2025 Apr 25.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/metabolism , Nucleotides*/metabolism, Humans ; Animals ; Immunity, Innate ; Virus Replication ; Host-Pathogen Interactions

New Phenotypes Associated With Pathogenic RNASEH2B and SAMHD1 Variants.

Authors: Abdel-Salam GMH Eid M El-Serafy MA et al.

Source: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2025 May; Vol. 85 (3), pp. e70019.

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 8401784 Publication Model: Print Cited Medium: Internet ISSN: 1873-474X (Electronic) Linking ISSN: 07365748 NLM ISO Abbreviation: Int J Dev Neurosci Subsets: MEDLINE

MeSH Terms: Autoimmune Diseases of the Nervous System*/genetics , Autoimmune Diseases of the Nervous System*/diagnostic imaging , Nervous System Malformations*/genetics , Nervous System Malformations*/diagnostic imaging , Ribonuclease H*/genetics , SAM Domain and HD Domain-Containing Protein 1*/genetics, Humans ; Mutation/genetics ; Phenotype

SCR Disease Name: Aicardi-Goutieres syndrome

Effect of NME2 and SAMHD1 genetic polymorphisms involved in Ara-C metabolism on the response to induction chemotherapy in adult acute myeloid leukemia.

Authors: Fouad LA Elsayed GM El-Gammal MM et al.

Source: Journal of the Egyptian National Cancer Institute [J Egypt Natl Canc Inst] 2025 Apr 28; Vol. 37 (1), pp. 14. Date of Electronic Publication: 2025 Apr 28.

Publication Type: Journal Article

Journal Info: Publisher: SpringerOpen Country of Publication: England NLM ID: 9424566 Publication Model: Electronic Cited Medium: Internet ISSN: 2589-0409 (Electronic) Linking ISSN: 11100362 NLM ISO Abbreviation: J Egypt Natl Canc Inst Subsets: MEDLINE

MeSH Terms: Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/mortality , Leukemia, Myeloid, Acute*/pathology , SAM Domain and HD Domain-Containing Protein 1*/genetics , Cytarabine*/metabolism , Cytarabine*/therapeutic use , Cytarabine*/administration & dosage , NM23 Nucleoside Diphosphate Kinases*/genetics, Humans ; Male ; Female ; Adult ; Middle Aged ; Induction Chemotherapy/methods ; Retrospective Studies ; Polymorphism, Single Nucleotide ; Young Adult ; Egypt ; Aged ; Genotype ; Adolescent

SAMHD1 dysfunction impairs DNA damage response and increases sensitivity to PARP inhibition in chronic lymphocytic leukemia.

Authors: Rodríguez-Sánchez A Quijada-Álamo M Pérez-Carretero C et al.

Source: Scientific reports [Sci Rep] 2025 Mar 26; Vol. 15 (1), pp. 10446. Date of Electronic Publication: 2025 Mar 26.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Leukemia, Lymphocytic, Chronic, B-Cell*/genetics , Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell*/metabolism , Leukemia, Lymphocytic, Chronic, B-Cell*/pathology , SAM Domain and HD Domain-Containing Protein 1*/genetics , SAM Domain and HD Domain-Containing Protein 1*/metabolism , DNA Damage* , Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology , Poly(ADP-ribose) Polymerase Inhibitors*/therapeutic use, Humans ; Mutation ; Female ; Male ; BRCA1 Protein/metabolism ; BRCA1 Protein/genetics ; Middle Aged ; Aged ; CRISPR-Cas Systems ; Cell Line, Tumor

Transition State Analysis of SAMHD1 from Primary ¹⁸ O, ³³ P, and Solvent Kinetic Isotope Effects.

Authors: Ghosh AK Groom DP Schramm VL

Source: Journal of the American Chemical Society [J Am Chem Soc] 2025 Mar 12; Vol. 147 (10), pp. 8852-8863. Date of Electronic Publication: 2025 Feb 27.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/chemistry , SAM Domain and HD Domain-Containing Protein 1*/metabolism , Deoxyadenine Nucleotides*/chemistry , Deoxyadenine Nucleotides*/metabolism, Kinetics ; Solvents/chemistry ; Oxygen Isotopes/chemistry ; Humans ; Hydrolysis

Inhibitors of SAMHD1 Obtained from Chemical Tethering to the Guanine Antiviral Acyclovir.

Authors: Egleston M Bhat S Howlader AH et al.

Source: Biochemistry [Biochemistry] 2025 Mar 04; Vol. 64 (5), pp. 1109-1120. Date of Electronic Publication: 2025 Feb 24.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/antagonists & inhibitors , SAM Domain and HD Domain-Containing Protein 1*/chemistry , SAM Domain and HD Domain-Containing Protein 1*/metabolism , Acyclovir*/chemistry , Acyclovir*/pharmacology , Acyclovir*/analogs & derivatives , Antiviral Agents*/chemistry , Antiviral Agents*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Humans ; Guanine/chemistry ; Allosteric Site

Nuclear Overexpression of SAMHD1 Induces M Phase Stalling in Hepatoma Cells and Suppresses HCC Progression by Interacting with the Cohesin Complex.

Authors: Shao J Wang W Li S et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Feb; Vol. 12 (6), pp. e2411988. Date of Electronic Publication: 2024 Dec 16.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , SAM Domain and HD Domain-Containing Protein 1*/metabolism , SAM Domain and HD Domain-Containing Protein 1*/genetics , Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/genetics , Chromosomal Proteins, Non-Histone*/metabolism , Chromosomal Proteins, Non-Histone*/genetics, Humans ; Animals ; Mice ; Disease Progression ; Male ; Cell Line, Tumor ; Female ; Mice, Knockout ; Cell Nucleus/metabolism ; Cell Proliferation

Deubiquitinase USP37 enhances the anti-HIV-2/SIV ability of the host restriction factor SAMHD1.

Authors: Cui W Wang H Gao Y et al.

Source: Journal of virology [J Virol] 2025 Jan 31; Vol. 99 (1), pp. e0185824. Date of Electronic Publication: 2024 Dec 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH Terms: Endopeptidases*/genetics , Endopeptidases*/metabolism , SAM Domain and HD Domain-Containing Protein 1*/genetics , SAM Domain and HD Domain-Containing Protein 1*/metabolism , HIV-2* , HIV Infections*/genetics , HIV Infections*/metabolism , Simian Acquired Immunodeficiency Syndrome*/genetics , Simian Acquired Immunodeficiency Syndrome*/metabolism, Humans ; Cells, Cultured ; Ubiquitin/metabolism ; Protein Binding ; Mutation ; Phosphorylation

SAMHD1 shapes deoxynucleotide triphosphate homeostasis by interconnecting the depletion and biosynthesis of different dNTPs.

Authors: McCown C Yu CH Ivanov DN

Source: Nature communications [Nat Commun] 2025 Jan 18; Vol. 16 (1), pp. 793. Date of Electronic Publication: 2025 Jan 18.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/metabolism , SAM Domain and HD Domain-Containing Protein 1*/genetics , SAM Domain and HD Domain-Containing Protein 1*/chemistry , Deoxyribonucleotides*/metabolism , Deoxyribonucleotides*/biosynthesis , Nucleotides*/metabolism, Humans ; Homeostasis ; HIV-1/physiology ; Allosteric Regulation ; Allosteric Site ; Substrate Specificity ; Protein Multimerization ; HEK293 Cells ; Hydrolysis

The avengers: SAMHD1 cooperates with MX2/MxB to defend against HIV-1.

Authors: Wan Z Zhong G Wang H

Source: MBio [mBio] 2024 Oct 16; Vol. 15 (10), pp. e0167524. Date of Electronic Publication: 2024 Sep 06.

Publication Type: Journal Article; Comment

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH Terms: SAM Domain and HD Domain-Containing Protein 1*/metabolism , SAM Domain and HD Domain-Containing Protein 1*/genetics , HIV-1*/physiology , HIV-1*/genetics , Myxovirus Resistance Proteins*/metabolism , Myxovirus Resistance Proteins*/genetics , HIV Infections*/virology , HIV Infections*/genetics , HIV Infections*/metabolism , Virus Replication*, Humans