Search Results - "Reverse dosimetry"

Turtles as models for the maternal transfer of organic pollutants across reptile species, chemicals, and matrices

Authors: Peter Vermeiren Lilah De Marchi Sandrine Charles et al.

Source: Ecotoxicology and Environmental Safety, Vol 307, Iss , Pp 119365- (2025)

Subject Terms: Internal bioaccumulation, Molecular properties, Predictive Bayesian regression modelling, Cross-species extrapolation, Marine turtles, Reverse dosimetry, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651325017105; https://doaj.org/toc/0147-6513

Access URL: https://doaj.org/article/a374ca8afa7f4004890914202048bb5f

Risk based ranking of prioritized pesticides: where the exposome meets comparative toxicogenomics

Authors: Beibei Gao Xu Yang Jiawei Duan et al.

Source: Environment International, Vol 205, Iss , Pp 109882- (2025)

Subject Terms: ESIEHR framework, Indoor environment, Human biomonitoring, Reverse dosimetry evaluation system, Pesticides, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412025006336; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/96444307c446464ea1c8590ef2e60328

Mono-n-hexyl phthalate: exposure estimation and assessment of health risks based on levels found in human urine samples

Authors: Ralph Pirow Ulrike Bernauer Annegret Blume et al.

Source: Arch Toxicol

Subject Terms: Adult, Male, 0301 basic medicine, Human biomonitoring data, Plasticizers/toxicity [MeSH], Female [MeSH], Phthalic Acids/urine [MeSH], Tolerable daily intake, Environmental Exposure/adverse effects [MeSH], Risk Assessment [MeSH], Adult [MeSH], Humans [MeSH], Animals [MeSH], Phthalic Acids/toxicity [MeSH], Environmental Pollutants/toxicity [MeSH], Di-n-hexyl phthalate, Male [MeSH], Germany [MeSH], Reverse dosimetry, Environmental Pollutants/urine [MeSH], Benchmark dose modelling, Child [MeSH], Mono-n-hexyl phthalate, Pregnancy [MeSH], Environmental Exposure/analysis [MeSH], Regulatory Toxicology, Phthalic Acids, Environmental Exposure, Risk Assessment, 01 natural sciences, 03 medical and health sciences, Plasticizers, Pregnancy, Germany, Humans, Animals, Female, Environmental Pollutants, Child, 0105 earth and related environmental sciences

Access URL: https://pubmed.ncbi.nlm.nih.gov/39153032
https://repository.publisso.de/resource/frl:6503577

Uncertainties in the Extrapolation of In Vitro Data in Human Risk Assessment: A Case Study of qIVIVE for Imazalil Using the Monte Carlo Risk Assessment Platform

Authors: Anne Zwartsen Marco Zeilmaker Waldo J. de Boer et al.

Subject Terms: Biochemistry, Medicine, Pharmacology, Biotechnology, Immunology, Cancer, Mental Health, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, reverse dosimetry ), replacing animal experiments, replace animal experiments, human cell line, vitro test method, vitro nominal concentrations, vitro intracellular concentrations, vitro exposure durations, vivo exposure situations, various new extrapolations, mainly quantitative approach, hazard characterization leads, case study addresses, using available data, human risk assessment, vitro concentrations, hazard characterization, case study

Relation: https://figshare.com/articles/journal_contribution/Uncertainties_in_the_Extrapolation_of_In_Vitro_Data_in_Human_Risk_Assessment_A_Case_Study_of_qIVIVE_for_Imazalil_Using_the_Monte_Carlo_Risk_Assessment_Platform/29074224

Availability: https://doi.org/10.1021/acs.chemrestox.4c00287.s001
https://figshare.com/articles/journal_contribution/Uncertainties_in_the_Extrapolation_of_In_Vitro_Data_in_Human_Risk_Assessment_A_Case_Study_of_qIVIVE_for_Imazalil_Using_the_Monte_Carlo_Risk_Assessment_Platform/29074224

Biomonitoring-Based Risk Assessment of Pyrethroid Exposure in the U.S. Population: Application of High-Throughput and Physiologically Based Kinetic Models

Authors: Nan-Hung Hsieh Eric S. C. Kwok

Source: Toxics ; Volume 13 ; Issue 3 ; Pages: 216

Subject Terms: reverse dosimetry, bayesian, pyrethroids, urinary metabolites, exposure risk

Subject Geographic: agris

File Description: application/pdf

Relation: Agrochemicals and Food Toxicology; https://dx.doi.org/10.3390/toxics13030216

Availability: https://doi.org/10.3390/toxics13030216

Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict In Vivo Nrf2 Activation by EGCG and Its Colonic Metabolites in Humans

Authors: Liu, Chen van Mil, Jolijn Noorlander, Annelies et al.

Source: Journal of Agricultural and Food Chemistry. 70:14015-14031

Subject Terms: 0301 basic medicine, reverse dosimetry, 0303 health sciences, Colon, NF-E2-Related Factor 2, novel approach methodology, 01 natural sciences, Nrf2, Catechin, 0104 chemical sciences, microbial metabolism, Kinetics, 03 medical and health sciences, Gallic Acid, Humans, gallic acid, EGCG, pyrogallol, PBK model

Access URL: https://pubmed.ncbi.nlm.nih.gov/36262111

Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet

Authors: Aude Ratier Maribel Casas Regina Grazuleviciene et al.

Source: Environment International, Vol 186, Iss , Pp 108621- (2024)

Subject Terms: PBPK model, Reverse dosimetry, In utero, Longitudinal cohorts, Children, Human biomonitoring, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412024002071; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/3ab6f033a11d477c99d126fa86f7f776

A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling

Authors: Arthur de Carvalho e Silva George D. Loizou Kevin McNally et al.

Source: Front Toxicol
Frontiers in Toxicology, Vol 6 (2024)

Subject Terms: 0301 basic medicine, Markov chain Monte Carlo, reverse dosimetry, 0303 health sciences, 03 medical and health sciences, PBK, in silico, RA1190-1270, PFOA, Toxicology. Poisons, Toxicology, Bayesian, 3. Good health

Access URL: https://pubmed.ncbi.nlm.nih.gov/38577564
https://doaj.org/article/fd5a6987abd5448fb0bae9679c5000ab

Use of Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to PredictIn VivoAcute Toxicity of Tetrodotoxin in Rodents

Authors: Noorlander, Annelies Zhang, Mengying Van Ravenzwaay, Bennard et al.

Source: Toxicol Sci

Subject Terms: 0301 basic medicine, reverse dosimetry, 0303 health sciences, Dose-Response Relationship, Drug, new approach methodology, Rodentia, tetrodotoxin (TTX), Tetrodotoxin, Models, Biological, Rats, Kinetics, Mice, 03 medical and health sciences, physiologically based kinetic modeling, Emerging Technologies, Methods, and Models, neurotoxicity, Animals

Access URL: https://pubmed.ncbi.nlm.nih.gov/35218365
https://research.wur.nl/en/publications/use-of-physiologically-based-kinetic-modeling-facilitated-reverse-2
https://doi.org/10.1093/toxsci/kfac022

PBPK modeling to support risk assessment of pyrethroid exposure in French pregnant women

Authors: Thépaut, Elisa Bisson, Michèle Brochot, Céline et al.

Contributors: Thépaut, Elisa Bisson, Michèle Brochot, Céline et al.

Source: ISSN: 0013-9351.

Subject Terms: Pyrethroids, PBPK model, Biomonitoring, Mixtures, Reverse dosimetry, [SDV]Life Sciences [q-bio]

Availability: https://u-picardie.hal.science/hal-04510125
https://u-picardie.hal.science/hal-04510125v1/document
https://u-picardie.hal.science/hal-04510125v1/file/2024-008.pdf
https://doi.org/10.1016/j.envres.2024.118606

Estimating human exposure to pyrethroids' mixtures from biomonitoring data using physiologically based pharmacokinetic modeling

Authors: Quindroit, Paul Crepet, A. Brochot, C. et al.

Contributors: Quindroit, Paul Crepet, A. Brochot, C. et al.

Subject Terms: PBPK model, Pyrethroids, Reverse dosimetry, Cumulative risk, Mixtures

File Description: application/octet-stream

Relation: Environ. Res.; http://hdl.handle.net/20.500.12210/90525

Availability: https://hdl.handle.net/20.500.12210/90525

Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

Authors: Zhao, Shensheng Wesseling, Sebastiaan Spenkelink, Bert et al.

Source: Arch Toxicol

Subject Terms: Male, 0301 basic medicine, 0303 health sciences, Quantitative in vitro to in vivo extrapolation (QIVIVE), Reverse dosimetry, Diazinon (DZN), GPI-Linked Proteins, Models, Biological, Rats, 3. Good health, Kinetics, 03 medical and health sciences, Organophosphorus Compounds, Liver, 13. Climate action, Diazinon, Acetylcholinesterase (AChE) inhibition, Physiologically based kinetic (PBK) modelling, Acetylcholinesterase, Microsomes, Liver, Animals, Humans, Toxic equivalency factor (TEF), Cholinesterase Inhibitors, Toxicokinetics and Metabolism

Access URL: https://link.springer.com/content/pdf/10.1007/s00204-021-03015-1.pdf
https://pubmed.ncbi.nlm.nih.gov/33715020
https://pubmed.ncbi.nlm.nih.gov/33715020/
https://link.springer.com/article/10.1007/s00204-021-03015-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113213
https://link.springer.com/content/pdf/10.1007/s00204-021-03015-1.pdf
https://www.narcis.nl/publication/RecordID/oai%3Alibrary.wur.nl%3Awurpubs%2F581660
http://pubmed.ncbi.nlm.nih.gov/33715020/
https://research.wur.nl/en/publications/physiologically-based-kinetic-modelling-based-prediction-of-in-vi
https://doi.org/10.1007/s00204-021-03015-1

Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry

Authors: Shensheng Zhao Isaac Omwenga Ivonne M.C.M. Rietjens et al.

Source: Arch Toxicol

Subject Terms: Male, 0301 basic medicine, Impact of Pesticides on Honey Bee Health, Health, Toxicology and Mutagenesis, Plant Science, Biochemistry, 01 natural sciences, Rats, Sprague-Dawley, Agricultural and Biological Sciences, Physiologically based kinetic (PBK) modeling, Organophosphate, Impact of Pesticides Use in Agriculture, Reverse dosimetry, Life Sciences, Organophosphates, 3. Good health, Chemistry, Physical Sciences, Microsomes, Liver, Acetylcholinesterase, Female, Aché, Biotechnology, Aquatic Ecotoxicology and Biomarkers of Pollution, Esterase, Models, Biological, 03 medical and health sciences, Species Specificity, In vitro, In vivo, Acetylcholinesterase (AChE) inhibition, Animals, Humans, Computer Simulation, Pesticides, Biology, Organophosphate pesticides (OPs), 0105 earth and related environmental sciences, Pharmacology, Dose-Response Relationship, Drug, Organothiophosphates, Microsome, Novel approach method (NAM), Agronomy, Rats, Pesticide, Enzyme, 13. Climate action, Insect Science, Environmental Science, Cholinesterase Inhibitors, Toxicokinetics and Metabolism

Access URL: https://link.springer.com/content/pdf/10.1007/s00204-021-03004-4.pdf
https://pubmed.ncbi.nlm.nih.gov/33651127
http://pubmed.ncbi.nlm.nih.gov/33651127/
http://www.ncbi.nlm.nih.gov/pubmed/33651127
https://link.springer.com/content/pdf/10.1007/s00204-021-03004-4.pdf
http://erepository.uonbi.ac.ke/handle/11295/154972
https://www.narcis.nl/publication/RecordID/oai%3Alibrary.wur.nl%3Awurpubs%2F580788
https://europepmc.org/article/MED/33651127
https://research.wur.nl/en/publications/prediction-of-dose-dependent-in-vivo-acetylcholinesterase-inhibit
https://doi.org/10.1007/s00204-021-03004-4

Prediction of the dose range for adverse neurological effects of amiodarone in patients from an in vitro toxicity test by in vitro–in vivo extrapolation

Authors: Engi Abd el-Hady Algharably Emma Di Consiglio Emanuela Testai et al.

Source: Arch Toxicol

Subject Terms: 0301 basic medicine, Amiodarone, Biological Availability, In Vitro Techniques, Models, Biological, Organ Toxicity and Mechanisms, 03 medical and health sciences, Dose–response modeling, Toxicity Tests, Neurotoxicity, Animals, Humans, Tissue Distribution, 0303 health sciences, Dose-Response Relationship, Drug, Physiologically based pharmacokinetic modeling, Reverse dosimetry, In silico, Brain, Rats, 3. Good health, Neurotoxicity Syndromes/physiopathology [MeSH], Area Under Curve [MeSH], Neurotoxicity Syndromes/etiology [MeSH], Models, Biological [MeSH], In Vitro Techniques [MeSH], Anti-Arrhythmia Agents/pharmacokinetics [MeSH], Toxicity Tests [MeSH], Tissue Distribution [MeSH], Amiodarone/pharmacokinetics [MeSH], Dose-Response Relationship, Drug [MeSH], Brain/drug effects [MeSH], Anti-Arrhythmia Agents/administration, Humans [MeSH], Rats [MeSH], Amiodarone/administration, Animals [MeSH], Amiodarone/toxicity [MeSH], Brain/metabolism [MeSH], Biological Availability [MeSH], Anti-Arrhythmia Agents/toxicity [MeSH], Animal alternative, 13. Climate action, Area Under Curve, Neurotoxicity Syndromes, Anti-Arrhythmia Agents, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

Access URL: https://link.springer.com/content/pdf/10.1007/s00204-021-02989-2.pdf
https://pubmed.ncbi.nlm.nih.gov/33606068
https://moh-it.pure.elsevier.com/en/publications/prediction-of-the-dose-range-for-adverse-neurological-effects-of-
https://pubmed.ncbi.nlm.nih.gov/33606068/
https://europepmc.org/article/MED/33606068
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032623
https://www.scilit.net/article/92fed640a8437833ec34a4e4d4feebd6
https://link.springer.com/article/10.1007/s00204-021-02989-2
https://repository.publisso.de/resource/frl:6451703

Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

Authors: Ivonne M.C.M. Rietjens Bert Spenkelink Ans Punt et al.

Source: J Appl Toxicol

Subject Terms: 0301 basic medicine, reverse dosimetry, Radiology, Nuclear Medicine and Imaging, Swine, Organic chemistry, DNA adduct formation, Kidney, Biochemistry, Mice, DNA Adducts, Endocrinology, Tandem Mass Spectrometry, Research Articles, Chromatography, 0303 health sciences, Mechanisms of Drug-Induced Hepatotoxicity, Life Sciences, Toxicokinetics, Chemistry, Aristolochic Acids, Medicine, Adduct, Carcinogen, physiologically based kinetic (PBK) modeling, Spectrometry, Mass, Electrospray Ionization, Pharmacology, Toxicology and Pharmaceutics, Biophysics, Animal Testing Alternatives, Models, Biological, Electrospray ionization, 03 medical and health sciences, Aristolochic Acid, In vitro, Health Sciences, In vivo, Aristolochic Acid Nephropathy and Urothelial Cancer, Genetics, aristolochic acid I (AAI), Animals, Humans, in vitro-in vivo extrapolation, Biology, Pharmacology, Aristolochic acid, Dose-Response Relationship, Drug, Mass spectrometry, DNA, Rats, FOS: Biological sciences, DNA adduct, LLC-PK1 Cells, Chromatography, Liquid

File Description: text

Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.4024
https://pubmed.ncbi.nlm.nih.gov/33034907
https://pubmed.ncbi.nlm.nih.gov/33034907/
https://onlinelibrary.wiley.com/doi/10.1002/jat.4024
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jat.4024
http://www.ncbi.nlm.nih.gov/pubmed/33034907
https://www.ncbi.nlm.nih.gov/pubmed/33034907
https://research.wur.nl/en/publications/defining-in-vivo-dose-response-curves-for-kidney-dna-adduct-forma
https://doi.org/10.1002/jat.4024

Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Authors: Suparmi, Suparmi Wesseling, Sebastiaan Rietjens, Ivonne M.C.M.

Source: Arch Toxicol

Subject Terms: Male, Plant Poisoning, 0301 basic medicine, 0303 health sciences, Acute toxicity, Monocrotaline, Reverse dosimetry, Biologics, Models, Biological, Rats, 3. Good health, PBK modeling, Kinetics, 03 medical and health sciences, Liver, Hepatocytes, Microsomes, Liver, Animals, Computer Simulation, Pyrrolizidine Alkaloids, Toxins, Biological

Access URL: https://link.springer.com/content/pdf/10.1007/s00204-020-02798-z.pdf
https://pubmed.ncbi.nlm.nih.gov/32518961
https://pubmed.ncbi.nlm.nih.gov/32518961/
https://europepmc.org/article/PMC/PMC7415757
https://www.narcis.nl/publication/RecordID/oai%3Alibrary.wur.nl%3Awurpubs%2F566763
https://www.scilit.net/article/cbb32861d6159ca87b45d8b66da4a30a
https://link.springer.com/article/10.1007/s00204-020-02798-z
https://link.springer.com/content/pdf/10.1007/s00204-020-02798-z.pdf

Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone

Authors: Shi, Miaoying Bouwmeester, Hans Rietjens, Ivonne M.C.M. et al.

Source: Arch Toxicol

Subject Terms: 0301 basic medicine, Quantitative in vitro to in vivo extrapolation (QIVIVE), Induced Pluripotent Stem Cells, Cardiac electrophysiology, Action Potentials, Models, Biological, Proof of Concept Study, Risk Assessment, Organ Toxicity and Mechanisms, Cell Line, 03 medical and health sciences, Physiologically based kinetic (PBK) modeling, Heart Rate, Toxicity Tests, Humans, Computer Simulation, Myocytes, Cardiac, Dose-Response Relationship, Drug, Reverse dosimetry, Arrhythmias, Cardiac, Cardiotoxicity, 3. Good health, Analgesics, Opioid, Kinetics, Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM), Methadone, Protein Binding

Access URL: https://link.springer.com/content/pdf/10.1007/s00204-020-02766-7.pdf
https://pubmed.ncbi.nlm.nih.gov/32367273
https://www.narcis.nl/publication/RecordID/oai%3Alibrary.wur.nl%3Awurpubs%2F565818
https://hbo-kennisbank.nl/details/samhao:oai:www.greeni.nl:VBS:2:146839
https://research.wur.nl/en/publications/integrating-in-vitro-data-and-physiologically-based-kinetic-model
https://link.springer.com/content/pdf/10.1007/s00204-020-02766-7.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395048
https://pubmed.ncbi.nlm.nih.gov/32367273/

Development, testing, parameterisation, and calibration of a human PBK model for the plasticiser, di (2-ethylhexyl) adipate (DEHA) using in silico, in vitro and human biomonitoring data

Authors: Kevin McNally Craig Sams George Loizou

Source: Front Pharmacol
Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: Pharmacology, PBPK, reverse dosimetry, DEHA, in silico, plasticiser, Therapeutics. Pharmacology, RM1-950

Access URL: https://pubmed.ncbi.nlm.nih.gov/37033641
https://doaj.org/article/1187128b82354defbc17faaa16fa7b04

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

Authors: Engi Abdelhady Algharably Emma Di Consiglio Emanuela Testai et al.

Source: Front Pharmacol
Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: Pharmacology, PBK modelling, reverse dosimetry, dose-response modeling, organophosphorus pesticides, Therapeutics. Pharmacology, RM1-950, animal alternative, new approach methodologies (NAMs), 3. Good health

Access URL: https://pubmed.ncbi.nlm.nih.gov/36959852
https://doaj.org/article/e726f4d4360f4d9ca215a1a43ad63add

Refinement and calibration of a human PBPK model for the plasticiser, Di-(2-propylheptyl) phthalate (DPHP) using in silico, in vitro and human biomonitoring data

Authors: Kevin McNally George Loizou

Source: Front Pharmacol
Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: Pharmacology, PBPK, reverse dosimetry, in silico, biomonitoring, plasticiser, Therapeutics. Pharmacology, RM1-950, 01 natural sciences, DPHP, 0105 earth and related environmental sciences

Access URL: https://pubmed.ncbi.nlm.nih.gov/36865923
https://doaj.org/article/d7a589de61c94cee87beceb971cc03a5