Suchergebnisse - "Reprogramming"

The impact of metabolic reprogramming in hepatocellular carcinoma on T cell.

Autoren: Liao DX An X Huang GX et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Nov 10; Vol. 16, pp. 1696113. Date of Electronic Publication: 2025 Nov 10 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/therapy , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/metabolism , Liver Neoplasms*/immunology , Liver Neoplasms*/therapy , Liver Neoplasms*/pathology , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , Cellular Reprogramming*, Humans ; Tumor Microenvironment/immunology ; Animals ; Immunotherapy ; Metabolic Reprogramming

Role of metabolic reprogramming of cancer‑associated fibroblasts in tumor development and progression (Review).

Autoren: Li R Li Y

Quelle: International journal of oncology [Int J Oncol] 2025 Nov; Vol. 67 (5). Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9306042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2423 (Electronic) Linking ISSN: 10196439 NLM ISO Abbreviation: Int J Oncol Subsets: MEDLINE

MeSH-Schlagworte: Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Tumor Microenvironment* , Neoplasms*/pathology , Neoplasms*/metabolism , Neoplasms*/drug therapy , Cellular Reprogramming*, Humans ; Disease Progression ; Drug Resistance, Neoplasm ; Animals ; Cell Proliferation ; Energy Metabolism ; Metabolic Reprogramming

Metabolic reprogramming of NK cells drives anti-tumor immunity.

Autoren: Yang P Wang W Liu Q et al.

Quelle: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2025 Nov; Vol. 215, pp. 104859. Date of Electronic Publication: 2025 Jul 21.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Netherlands NLM ID: 8916049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0461 (Electronic) Linking ISSN: 10408428 NLM ISO Abbreviation: Crit Rev Oncol Hematol Subsets: MEDLINE

MeSH-Schlagworte: Killer Cells, Natural*/immunology , Killer Cells, Natural*/metabolism , Neoplasms*/immunology , Neoplasms*/metabolism , Neoplasms*/therapy , Neoplasms*/pathology , Cellular Reprogramming*, Humans ; Tumor Microenvironment/immunology ; Animals ; Energy Metabolism ; Immunotherapy/methods ; Metabolic Reprogramming

Exosome-mediated metabolic reprogramming: effects on thyroid cancer progression and tumor microenvironment remodeling.

Autoren: Li S Han H Yang K et al.

Quelle: Molecular cancer [Mol Cancer] 2025 Oct 08; Vol. 24 (1), pp. 247. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE

MeSH-Schlagworte: Tumor Microenvironment* , Thyroid Neoplasms*/metabolism , Thyroid Neoplasms*/pathology , Thyroid Neoplasms*/etiology , Exosomes*/metabolism , Cellular Reprogramming*, Humans ; Animals ; Disease Progression ; Metabolic Reprogramming

FOXO1-driven metabolic reprogramming of hematomal CD8 ⁺ T cells drives the expansion of perihematomal edema following intracerebral hemorrhage.

Autoren: Lin J Ren H Wang Y et al.

Quelle: Cellular & molecular immunology [Cell Mol Immunol] 2025 Dec; Vol. 22 (12), pp. 1629-1641. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Chinese Society of Immunology;; _b Nature Pub. Group Country of Publication: China NLM ID: 101242872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-0226 (Electronic) Linking ISSN: 16727681 NLM ISO Abbreviation: Cell Mol Immunol Subsets: MEDLINE

MeSH-Schlagworte: Cerebral Hemorrhage*/complications , Cerebral Hemorrhage*/immunology , Cerebral Hemorrhage*/pathology , Cerebral Hemorrhage*/metabolism , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Forkhead Box Protein O1*/metabolism , Hematoma*/immunology , Hematoma*/pathology , Hematoma*/metabolism , Brain Edema*/pathology , Brain Edema*/immunology , Brain Edema*/etiology , Brain Edema*/metabolism , Cellular Reprogramming*, Animals ; Humans ; Mice, Inbred C57BL ; Mice ; Male ; Interferon-gamma/metabolism ; Microglia/metabolism ; Female ; Metabolic Reprogramming

Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy.

Autoren: Frlic T Pavlin M

Quelle: Frontiers in immunology [Front Immunol] 2025 Nov 19; Vol. 16, pp. 1688995. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Immunotherapy, Adoptive*/methods , Neoplasms*/therapy , Neoplasms*/immunology , Neoplasms*/metabolism , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/genetics , Cellular Reprogramming* , T-Lymphocytes*/metabolism , T-Lymphocytes*/immunology, Humans ; Tumor Microenvironment/immunology ; Animals ; Epigenesis, Genetic ; Cell Differentiation ; Immunologic Memory ; Metabolic Reprogramming

PPARγ, a key modulator of metabolic reprogramming, stemness and chemoresistance associated with retrodifferentiation in human hepatocellular carcinomas.

Autoren: Daniel Y Rauch C Moutaux L et al.

Quelle: Cell death & disease [Cell Death Dis] 2025 Nov 17; Vol. 16 (1), pp. 831. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/drug therapy , PPAR gamma*/metabolism , PPAR gamma*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/drug therapy , Drug Resistance, Neoplasm* , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/drug effects , Cell Differentiation*/drug effects , Cellular Reprogramming*, Humans ; Cell Line, Tumor ; Mitochondria/metabolism ; Glycolysis ; PPAR alpha/metabolism ; PPAR alpha/genetics ; Gene Expression Regulation, Neoplastic ; Metabolic Reprogramming

Metabolic reprogramming in amyotrophic lateral sclerosis ependymal stem cells by FM19G11 nanotherapy.

Autoren: Cattaneo M Bonanomi M Chirizzi C et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 13; Vol. 15 (1), pp. 39847. Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/drug therapy , Nanoparticles*/chemistry , Ependyma*/metabolism , Ependyma*/cytology , Ependyma*/pathology , Ependyma*/drug effects , Stem Cells*/metabolism , Stem Cells*/drug effects , Cellular Reprogramming*/drug effects, Animals ; Mice ; Male ; Metabolomics ; Metabolome/drug effects ; Mice, Transgenic ; Disease Models, Animal ; Motor Neurons/metabolism ; Humans ; Metabolic Reprogramming

Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes.

Autoren: Serra M Smiriglia A Migliore C et al.

Quelle: Cell death & disease [Cell Death Dis] 2025 Nov 10; Vol. 16 (1), pp. 816. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH-Schlagworte: Hepatocytes*/metabolism , Hepatocytes*/drug effects , Hepatocytes*/cytology , Cell Proliferation*/drug effects , Cellular Reprogramming*/drug effects , Lead*/toxicity, Animals ; Humans ; Rats ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/genetics ; Glycolysis/drug effects ; Pentose Phosphate Pathway/drug effects ; Oxidative Phosphorylation/drug effects ; Kelch-Like ECH-Associated Protein 1/metabolism ; Nitrates/toxicity ; Metabolic Reprogramming

Metabolic reprogramming through PIM3 inhibition reverses hypoxia-induced CAR-T cell dysfunction in solid tumors.

Autoren: Zhou M Xu L Hu J et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Nov 06; Vol. 23 (1), pp. 1230. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Chimeric Antigen*/metabolism , Neoplasms*/pathology , Neoplasms*/metabolism , Neoplasms*/immunology , Neoplasms*/therapy , Immunotherapy, Adoptive* , Cellular Reprogramming*/drug effects , T-Lymphocytes*/metabolism, Humans ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Glycolysis ; Apoptosis ; Mice ; Cell Hypoxia ; Tumor Microenvironment ; Gene Expression Regulation, Neoplastic ; Phenotype ; Metabolic Reprogramming ; Proto-Oncogene Proteins c-pim-1

[Protein lysine demethylation regulates metabolic reprogramming during muscle stem cells fate].

Transliterierter Titel: La déméthylation des lysines des protéines régule la reprogrammation métabolique au cours du devenir des cellules souches musculaires.

Autoren: Cicciarello D Scionti I

Quelle: Medecine sciences : M/S [Med Sci (Paris)] 2025 Nov; Vol. 41 Hors série n° 2, pp. 43-47. Date of Electronic Publication: 2025 Nov 28.

Publikationsart: Journal Article; Review; English Abstract

Info zur Zeitschrift: Publisher: EDK Country of Publication: France NLM ID: 8710980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1958-5381 (Electronic) Linking ISSN: 07670974 NLM ISO Abbreviation: Med Sci (Paris) Subsets: MEDLINE

MeSH-Schlagworte: Lysine*/metabolism , Stem Cells*/cytology , Stem Cells*/metabolism , Stem Cells*/physiology , Muscle, Skeletal*/cytology , Muscle, Skeletal*/physiology , Muscle, Skeletal*/metabolism , Cellular Reprogramming*/physiology, Humans ; Animals ; Cell Differentiation/physiology ; Cell Differentiation/genetics ; Regeneration/physiology ; Demethylation ; Epigenesis, Genetic ; Histone Demethylases/metabolism ; Histone Demethylases/physiology ; Metabolic Reprogramming

APOL1 risk variants induce metabolic reprogramming of podocytes in patient-derived kidney organoids.

Autoren: Song H Dumas SJ Wang G et al.

Quelle: Stem cell reports [Stem Cell Reports] 2025 Oct 14; Vol. 20 (10), pp. 102650. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE

MeSH-Schlagworte: Podocytes*/metabolism , Podocytes*/cytology , Apolipoprotein L1*/genetics , Apolipoprotein L1*/metabolism , Organoids*/metabolism , Organoids*/cytology , Cellular Reprogramming*/genetics , Kidney*/metabolism , Kidney*/pathology, Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/cytology ; Mitochondria/metabolism ; Oxidative Phosphorylation ; Glycolysis ; Interferon-gamma/pharmacology ; Metabolomics ; Citric Acid Cycle ; Metabolic Reprogramming

Deciphering metabolic reprogramming of immune cells within the tumor microenvironment.

Autoren: Wang Y Chen W Wang Z et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Oct 06; Vol. 23 (1), pp. 1055. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Tumor Microenvironment*/immunology , Cellular Reprogramming*, Animals ; Humans ; Mice ; Macrophages/metabolism ; Mitochondria/metabolism ; Oxidative Stress ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/metabolism ; Cell Line, Tumor ; Myeloid Cells/metabolism ; Metabolic Reprogramming

Metabolic reprogramming of pancreatic beta cells in type 2 diabetes and its therapeutic strategy.

Autoren: Miao L Miao R Yao Y et al.

Quelle: Ageing research reviews [Ageing Res Rev] 2026 Jan; Vol. 113, pp. 102938. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE

MeSH-Schlagworte: Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/therapy , Diabetes Mellitus, Type 2*/pathology , Insulin-Secreting Cells*/metabolism , Insulin-Secreting Cells*/pathology , Cellular Reprogramming*/physiology, Humans ; Animals ; Metabolic Reprogramming

The role of m6A reader IGF2BPs in tumor metabolic reprogramming.

Autoren: Zhou X Li G Su X et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2026 Jan; Vol. 243 (Pt 1), pp. 117452. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/metabolism , Neoplasms*/genetics , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Adenosine*/analogs & derivatives , Adenosine*/metabolism , Cellular Reprogramming*/physiology, Humans ; Animals ; Lipid Metabolism/physiology ; Glycolysis/physiology ; Insulin-Like Growth Factor II/metabolism ; Metabolic Reprogramming

Targeting the crosstalk of metabolism reprogramming and replication stress: novel strategy to combat cancer.

Autoren: Liu W Jiang X Ma Y et al.

Quelle: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Sep 26; Vol. 42 (11), pp. 494. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/metabolism , Neoplasms*/drug therapy , Neoplasms*/genetics , DNA Replication*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Cellular Reprogramming*/drug effects, Humans ; DNA Damage/drug effects ; Animals ; Metabolic Reprogramming

[Research progress on cellular metabolic reprogramming in skin fibrosis].

Autoren: Qian S Dai S Guo C et al.

Quelle: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2025 Sep 25; Vol. 54 (5), pp. 592-601. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article; Review; English Abstract

Info zur Zeitschrift: Publisher: Zhejiang da xue xue bao bian ji bu Country of Publication: China NLM ID: 100927946 Publication Model: Electronic Cited Medium: Print ISSN: 1008-9292 (Print) Linking ISSN: 10089292 NLM ISO Abbreviation: Zhejiang Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE

MeSH-Schlagworte: Skin*/pathology , Skin*/metabolism , Skin Diseases*/metabolism , Skin Diseases*/pathology , Cellular Reprogramming*, Humans ; Fibrosis/metabolism ; Signal Transduction ; Fibroblasts/metabolism ; Fibroblasts/pathology ; TOR Serine-Threonine Kinases/metabolism ; Metabolic Reprogramming

Nonhistone lactylation: A hub for tumour metabolic reprogramming and epigenetic regulation.

Autoren: Zhang D Liang C Wu C et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Aug 12; Vol. 23 (1), pp. 901. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Epigenesis, Genetic* , Neoplasms*/metabolism , Neoplasms*/genetics , Lactic Acid*/metabolism , Cellular Reprogramming*, Humans ; Animals ; Tumor Microenvironment ; Glycolysis ; Metabolic Reprogramming

Cancer-associated fibroblasts and metabolic reprogramming predict pathologic response to neoadjuvant PD-1 blockade in resected non-small cell lung cancer.

Autoren: Zhao J Liu M Zhu C et al.

Quelle: Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2025 Aug; Vol. 48 (4), pp. 1105-1119. Date of Electronic Publication: 2025 May 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-3436 (Electronic) Linking ISSN: 22113428 NLM ISO Abbreviation: Cell Oncol (Dordr) Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/surgery , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Cancer-Associated Fibroblasts*/drug effects , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/surgery , Neoadjuvant Therapy* , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/metabolism , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , Cellular Reprogramming*, Humans ; Tumor Microenvironment ; Metabolic Reprogramming

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer.

Autoren: Dondajewska E Allepuz-Fuster P Maurizy C et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Aug; Vol. 12 (31), pp. e03022. Date of Electronic Publication: 2025 May 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/metabolism , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Cell Cycle Checkpoints*/genetics , Carrier Proteins*/genetics , Carrier Proteins*/metabolism , Cellular Reprogramming*/genetics, Humans ; Female ; Mitochondria/metabolism ; Cell Line, Tumor ; Cell Proliferation/genetics ; Metabolic Reprogramming