Search Results - "Reperfusion Injury"

15-lipoxygenase blockade switches off pan-organ ischaemia-reperfusion injury by inhibiting pyroptosis.

Authors: Li J Zhang H Dai M et al.

Source: Molecular biomedicine [Mol Biomed] 2025 Oct 10; Vol. 6 (1), pp. 77. Date of Electronic Publication: 2025 Oct 10.

Publication Type: Journal Article

Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE

MeSH Terms: Arachidonate 15-Lipoxygenase*/metabolism , Arachidonate 15-Lipoxygenase*/genetics , Pyroptosis*/drug effects , Reperfusion Injury*/pathology , Reperfusion Injury*/metabolism , Reperfusion Injury*/drug therapy , Lipoxygenase Inhibitors*/pharmacology, Animals ; Reactive Oxygen Species/metabolism ; Mice ; Mitochondria/metabolism ; Mitochondria/drug effects ; Mice, Inbred C57BL ; Male ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/metabolism ; Arachidonate 12-Lipoxygenase

N-Acetylcysteine enhances low-dose estrogen efficacy against ischemia-reperfusion injury in estrogen-deprived obese insulin-resistant rats.

Authors: Sivasinprasasn S Chattipakorn K Pratchayasakul W et al.

Source: Menopause (New York, N.Y.) [Menopause] 2025 Jan 01; Vol. 32 (1), pp. 81-90. Date of Electronic Publication: 2024 Dec 03.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott-Raven Publishers Country of Publication: United States NLM ID: 9433353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0374 (Electronic) Linking ISSN: 10723714 NLM ISO Abbreviation: Menopause Subsets: MEDLINE

MeSH Terms: Insulin Resistance* , Rats, Wistar* , Acetylcysteine*/pharmacology , Acetylcysteine*/administration & dosage , Obesity*/drug therapy , Obesity*/complications , Estrogens*/administration & dosage , Estrogens*/pharmacology , Ovariectomy* , Myocardial Reperfusion Injury*/drug therapy , Myocardial Reperfusion Injury*/prevention & control , Estradiol*/blood , Estradiol*/pharmacology , Estradiol*/administration & dosage, Animals ; Female ; Rats ; Diet, High-Fat/adverse effects ; Ventricular Function, Left/drug effects ; Reperfusion Injury/drug therapy ; Reperfusion Injury/prevention & control ; Disease Models, Animal

Modulation of mitochondrial permeability transition pores in reperfusion injury: Mechanisms and therapeutic approaches.

Authors: Morciano G Pinton P

Source: European journal of clinical investigation [Eur J Clin Invest] 2025 Jan; Vol. 55 (1), pp. e14331. Date of Electronic Publication: 2024 Oct 10.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE

MeSH Terms: Mitochondrial Permeability Transition Pore*/metabolism , Myocardial Reperfusion Injury*/metabolism , Mitochondrial Membrane Transport Proteins*/metabolism , Mitochondrial Membrane Transport Proteins*/physiology, Humans ; Mitochondrial Proton-Translocating ATPases/metabolism ; Oxidative Stress/physiology ; Animals ; Mitochondria, Heart/metabolism ; Reperfusion Injury ; Mitochondrial Membranes/metabolism

Hydrogen sulfide plays an important role by regulating microRNA in different ischemia-reperfusion injury.

Authors: Zhang Q Zhang Y Guo S et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Nov; Vol. 229, pp. 116503. Date of Electronic Publication: 2024 Aug 22.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Hydrogen Sulfide*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism , Reperfusion Injury*/metabolism , Reperfusion Injury*/genetics, Humans ; Animals ; Gene Expression Regulation ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/genetics

Effects of Cerium Oxide on Kidney and Liver Tissue Damage in an Experimental Myocardial Ischemia-Reperfusion Model of Distant Organ Damage.

Authors: Güneş I Dursun AD Özdemir Ç et al.

Source: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2024 Dec 11; Vol. 60 (12). Date of Electronic Publication: 2024 Dec 11.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE

MeSH Terms: Cerium*/pharmacology , Cerium*/therapeutic use , Liver*/drug effects , Liver*/blood supply , Kidney*/drug effects , Disease Models, Animal* , Myocardial Reperfusion Injury*/drug therapy, Animals ; Rats ; Male ; Rats, Wistar ; Random Allocation ; Reperfusion Injury/drug therapy

Extracellular Vesicles: a Promising Therapy for Treatment of Central Nervous System Ischemia Reperfusion Injury.

Authors: Wang L Zhu X Jia P et al.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Dec 04; Vol. 63 (1), pp. 250. Date of Electronic Publication: 2025 Dec 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Extracellular Vesicles*/metabolism , Extracellular Vesicles*/transplantation , Reperfusion Injury*/therapy , Reperfusion Injury*/pathology , Central Nervous System*/pathology, Humans ; Animals

The novel sphingosine-1-phosphate receptor modulator KRP-203 prevents myocardial ischemia-reperfusion injury by preserving mitochondrial function through activation of the RISK and SAFE signaling pathways.

Authors: Wu N Wang L Yu S et al.

Source: Cell biology and toxicology [Cell Biol Toxicol] 2025 Nov 27; Vol. 41 (1), pp. 159. Date of Electronic Publication: 2025 Nov 27.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE

MeSH Terms: Myocardial Reperfusion Injury*/prevention & control , Myocardial Reperfusion Injury*/metabolism , Myocardial Reperfusion Injury*/pathology , Signal Transduction*/drug effects , Sphingosine-1-Phosphate Receptors*/metabolism , Mitochondria*/drug effects , Mitochondria*/metabolism , Receptors, Lysosphingolipid*/metabolism , Sphingosine 1 Phosphate Receptor Modulators*/pharmacology, Animals ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Male ; Apoptosis/drug effects ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mice, Inbred C57BL

Exploring the potential role of fibroblast growth factors in alleviating hepatic ischemia-reperfusion injury: From in vitro insights to clinical investigations.

Authors: Thepbunchonchai A Chattipakorn N Chattipakorn SC

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Oct 15; Vol. 1005, pp. 178089. Date of Electronic Publication: 2025 Aug 26.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: Fibroblast Growth Factors*/metabolism , Fibroblast Growth Factors*/therapeutic use , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Reperfusion Injury*/drug therapy , Liver*/pathology , Liver*/metabolism , Liver*/blood supply , Liver*/drug effects, Humans ; Animals ; Signal Transduction

Salidroside Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Ferroptosis Through the MAFK/lncRNA PTOV1-AS2/miR-525-5p/ACE2 Axis.

Authors: Yu X Xu B Zhang M et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Dec 15; Vol. 39 (23), pp. e71291.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Glucosides*/pharmacology , MicroRNAs*/genetics , MicroRNAs*/metabolism , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Phenols*/pharmacology , Ferroptosis*/drug effects , Reperfusion Injury*/metabolism , Reperfusion Injury*/drug therapy , Reperfusion Injury*/pathology , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Lung/metabolism ; Lung/drug effects ; Lung/pathology ; Signal Transduction/drug effects ; Humans ; Cell Line

Tadalafil protects against renal fibrosis after ischemia-reperfusion injury by inhibiting Akt/NF-κB signaling pathway.

Authors: Li Z Liu A Qian A et al.

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 15; Vol. 1009, pp. 178388. Date of Electronic Publication: 2025 Nov 19.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: Tadalafil*/pharmacology , Tadalafil*/therapeutic use , Reperfusion Injury*/complications , Reperfusion Injury*/pathology , Reperfusion Injury*/drug therapy , Reperfusion Injury*/metabolism , NF-kappa B*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Signal Transduction*/drug effects , Kidney*/pathology , Kidney*/drug effects , Kidney*/metabolism , Phosphodiesterase 5 Inhibitors*/pharmacology , Phosphodiesterase 5 Inhibitors*/therapeutic use , Kidney Diseases*/pathology , Kidney Diseases*/prevention & control , Kidney Diseases*/metabolism, Animals ; Fibrosis ; Mice ; Male ; Mice, Inbred C57BL ; Cell Proliferation/drug effects ; Mesangial Cells/drug effects ; Mesangial Cells/pathology

Paeoniflorin attenuates hepatic ischemia-reperfusion injury by modulating Tmem176b ⁺ macrophages polarization.

Authors: Tang X Tan Y Gao F et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115657. Date of Electronic Publication: 2025 Oct 14.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Reperfusion Injury*/drug therapy , Reperfusion Injury*/immunology , Reperfusion Injury*/pathology , Macrophages*/drug effects , Macrophages*/immunology , Monoterpenes*/pharmacology , Monoterpenes*/therapeutic use , Glucosides*/pharmacology , Glucosides*/therapeutic use , Liver*/drug effects , Liver*/pathology , Liver*/immunology , Membrane Proteins*/metabolism , Membrane Proteins*/genetics, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Disease Models, Animal

The Nrf2/GPX4 antioxidant pathway suppresses ferroptosis to protect against hearing impairment in cochlear ischemia-reperfusion injury.

Authors: Zou T Huang S Xie R et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115655. Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , NF-E2-Related Factor 2*/agonists , Reperfusion Injury*/drug therapy , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Cochlea*/pathology , Cochlea*/drug effects , Cochlea*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/genetics , Pyrroles*/pharmacology , Pyrroles*/therapeutic use , Antioxidants*/pharmacology , Antioxidants*/metabolism , Hearing Loss, Sensorineural*, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Humans ; Pyrazines ; Thiones ; Thiophenes

Engineering polyamidoamine dendrimer nanoparticles for targeted drug delivery to proximal tubular cells after renal ischemia/reperfusion injury.

Authors: Li X Cantley LG Xu L

Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 1), pp. 114323. Date of Electronic Publication: 2025 Oct 14.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH Terms: Dendrimers*/chemistry , Dendrimers*/administration & dosage , Kidney Tubules, Proximal*/metabolism , Kidney Tubules, Proximal*/drug effects , Kidney Tubules, Proximal*/pathology , Reperfusion Injury*/drug therapy , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Nanoparticles*/chemistry , Nanoparticles*/administration & dosage , Folic Acid*/chemistry , Folic Acid*/administration & dosage , Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/metabolism , Polyamines*/chemistry , Polyamines*/administration & dosage, Animals ; Male ; Drug Delivery Systems ; Mice ; Mice, Inbred C57BL ; Cell Line ; Humans

Myocardial ischemia-reperfusion therapies based on lipase@CeO 2 nanomotors that target and permeate the myocardium and activate the PPARα pathway.

Authors: Zhang J Zhang H Anastassova N et al.

Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 2), pp. 114357. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH Terms: Myocardial Reperfusion Injury*/drug therapy , Myocardial Reperfusion Injury*/metabolism , Myocardial Reperfusion Injury*/pathology , Cerium*/administration & dosage , Cerium*/chemistry , Cerium*/therapeutic use , PPAR alpha*/metabolism , Lipase*/administration & dosage , Lipase*/chemistry , Lipase*/therapeutic use , Nanoparticles*/administration & dosage, Animals ; Myocardium/metabolism ; Myocardium/pathology ; Male ; Mice, Inbred C57BL ; Mice ; Humans ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism

Identification and experimental validation of biomarkers associated with macrophages in myocardial ischemia-reperfusion injury.

Authors: Jiang X Liu L Huang J et al.

Source: Scientific reports [Sci Rep] 2025 Dec 05; Vol. 15 (1), pp. 43241. Date of Electronic Publication: 2025 Dec 05.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Biomarkers*/metabolism , Macrophages*/metabolism , Myocardial Reperfusion Injury*/metabolism , Myocardial Reperfusion Injury*/genetics , Myocardial Reperfusion Injury*/pathology, Protein Interaction Maps ; Animals ; Gene Regulatory Networks ; Molecular Docking Simulation ; Humans ; Gene Expression Profiling ; Gene Expression Regulation ; Transcriptome

Edaravone dexborneol attenuates cerebral Ischemia-Reperfusion injury via cGAS-STING inhibition, STX17-Mediated autophagic flux restoration, and NLRP3 inflammasome suppression.

Authors: Zhang Y Wang X Wang W et al.

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178332. Date of Electronic Publication: 2025 Nov 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/antagonists & inhibitors , Reperfusion Injury*/drug therapy , Reperfusion Injury*/pathology , Reperfusion Injury*/metabolism , Reperfusion Injury*/prevention & control , Edaravone*/pharmacology , Edaravone*/therapeutic use , Autophagy*/drug effects , Inflammasomes*/metabolism , Nucleotidyltransferases*/metabolism , Nucleotidyltransferases*/antagonists & inhibitors , Qa-SNARE Proteins*/metabolism , Membrane Proteins*/metabolism , Membrane Proteins*/antagonists & inhibitors , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/pathology ; Microglia/drug effects ; Signal Transduction/drug effects ; Disease Models, Animal

The role of ubiquitylation in cerebral ischemia-reperfusion injury to reduce mitochondrial dysfunction and programmed cell death.

Authors: Li Z Xing J

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178337. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: Ubiquitination* , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Mitochondria*/metabolism , Mitochondria*/pathology , Mitochondria*/drug effects , Brain Ischemia*/metabolism , Brain Ischemia*/pathology , Apoptosis*, Humans ; Animals ; Ferroptosis ; Pyroptosis

Si-Miao-Yong-An decoction suppresses necroptosis by regulating the p53 pathway in myocardial ischemia/reperfusion injury.

Authors: Li X Bai L Ye M et al.

Source: Scientific reports [Sci Rep] 2025 Dec 03; Vol. 15 (1), pp. 43068. Date of Electronic Publication: 2025 Dec 03.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Drugs, Chinese Herbal*/pharmacology , Necroptosis*/drug effects , Tumor Suppressor Protein p53*/metabolism , Myocardial Reperfusion Injury*/drug therapy , Myocardial Reperfusion Injury*/metabolism , Myocardial Reperfusion Injury*/pathology , Signal Transduction*/drug effects, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Myocardium/pathology ; Myocardium/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Myocardial Infarction/drug therapy

Mixed lineage kinase 3 contributes to myocardial ischemia/reperfusion injury by regulating neutrophil activation.

Authors: Xiao Z Wei X Xie Z et al.

Source: Basic research in cardiology [Basic Res Cardiol] 2025 Dec; Vol. 120 (6), pp. 1155-1171. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article

Journal Info: Publisher: Steinkopff Country of Publication: Germany NLM ID: 0360342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1803 (Electronic) Linking ISSN: 03008428 NLM ISO Abbreviation: Basic Res Cardiol Subsets: MEDLINE

MeSH Terms: Myocardial Reperfusion Injury*/enzymology , Myocardial Reperfusion Injury*/pathology , Myocardial Reperfusion Injury*/genetics , Myocardial Reperfusion Injury*/prevention & control , Neutrophils*/enzymology , Neutrophils*/drug effects , MAP Kinase Kinase Kinases*/genetics , MAP Kinase Kinase Kinases*/metabolism , MAP Kinase Kinase Kinases*/deficiency , MAP Kinase Kinase Kinases*/antagonists & inhibitors , Neutrophil Activation*/drug effects , Myocardial Infarction*/enzymology , Myocardial Infarction*/pathology , Myocardial Infarction*/genetics , Myocardium*/pathology , Myocardium*/enzymology, Animals ; Mice, Knockout ; Mitogen-Activated Protein Kinase Kinase Kinase 11 ; Mice, Inbred C57BL ; Disease Models, Animal ; Humans ; Male ; Mice ; Signal Transduction ; Apoptosis ; CCAAT-Enhancer-Binding Protein-beta/metabolism

Exosomes derived from bone marrow mesenchymal stem cells alleviate lung ischemia-reperfusion injury in rats through miRNA-335/ SIRT3 pathway.

Authors: Zhang B Meng C Quan L et al.

Source: Drug delivery and translational research [Drug Deliv Transl Res] 2025 Dec; Vol. 15 (12), pp. 4611-4625. Date of Electronic Publication: 2025 Apr 03.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE

MeSH Terms: MicroRNAs*/metabolism , MicroRNAs*/genetics , Reperfusion Injury*/metabolism , Reperfusion Injury*/therapy , Reperfusion Injury*/pathology , Mesenchymal Stem Cells*/metabolism , Exosomes*/metabolism , Sirtuin 3*/metabolism , Sirtuin 3*/genetics, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Lung/metabolism ; Lung/pathology ; Oxidative Stress ; Apoptosis ; Signal Transduction ; Disease Models, Animal ; Sirtuins