Search Results - "Receptors, Cytoplasmic and Nuclear"

Antibiotic cocktail-induced changes in gut microbiota drive alteration of bile acid metabolism to restrain Th17 differentiation through the FXR-NLRP3 axis.

Authors: Shao-Yu Y Niu D Chen J et al.

Source: Gut microbes [Gut Microbes] 2025 Dec 31; Vol. 17 (1), pp. 2582944. Date of Electronic Publication: 2025 Nov 26.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Gastrointestinal Microbiome*/drug effects , Th17 Cells*/drug effects , Th17 Cells*/immunology , Th17 Cells*/cytology , Bile Acids and Salts*/metabolism , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/administration & dosage , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/genetics , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Prostatitis*/immunology , Prostatitis*/microbiology , Prostatitis*/drug therapy, Animals ; Male ; Mice ; Humans ; Mice, Inbred C57BL ; Cell Differentiation/drug effects ; Fecal Microbiota Transplantation ; Disease Models, Animal ; Interleukin-17 ; RNA, Ribosomal, 16S/genetics

SINE compounds activate exportin 1 degradation through an allosteric mechanism.

Authors: Wing CE Fung HYJ Kwanten B et al.

Source: Nature chemical biology [Nat Chem Biol] 2025 Dec; Vol. 21 (12), pp. 2002-2013. Date of Electronic Publication: 2025 Nov 21.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

MeSH Terms: Karyopherins*/metabolism , Karyopherins*/chemistry , Karyopherins*/antagonists & inhibitors , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/chemistry , Receptors, Cytoplasmic and Nuclear*/antagonists & inhibitors , Hydrazines*/pharmacology , Hydrazines*/chemistry , Triazoles*/pharmacology , Triazoles*/chemistry, Exportin 1 Protein ; Humans ; Allosteric Regulation/drug effects ; Proteolysis/drug effects ; Active Transport, Cell Nucleus/drug effects ; Cryoelectron Microscopy ; Ubiquitination ; HEK293 Cells

The nuclear export receptor CRM1/XPO1 and its diverse cargoes.

Authors: Kehlenbach RH Chook YM

Source: Trends in biochemical sciences [Trends Biochem Sci] 2025 Dec; Vol. 50 (12), pp. 1131-1144. Date of Electronic Publication: 2025 Sep 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 7610674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0968-0004 (Print) Linking ISSN: 09680004 NLM ISO Abbreviation: Trends Biochem Sci Subsets: MEDLINE

MeSH Terms: Karyopherins*/metabolism , Karyopherins*/chemistry , Karyopherins*/genetics , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/chemistry , Receptors, Cytoplasmic and Nuclear*/genetics, Exportin 1 Protein ; Humans ; Active Transport, Cell Nucleus ; Animals ; Nuclear Export Signals ; Nuclear Pore Complex Proteins/metabolism ; Cell Nucleus/metabolism ; ran GTP-Binding Protein/metabolism ; Protein Binding

Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-κB signaling pathway.

Authors: Jiao Y Ren J Xie S et al.

Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2488105. Date of Electronic Publication: 2025 Apr 07.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Gastrointestinal Microbiome*/radiation effects , Bile Acids and Salts*/metabolism , NF-kappa B*/metabolism , NF-kappa B*/genetics , Raffinose*/metabolism , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Acute Radiation Syndrome*/microbiology , Acute Radiation Syndrome*/metabolism , Hematopoiesis*/radiation effects , Bacteria*/metabolism , Bacteria*/genetics , Bacteria*/classification , Bacteria*/isolation & purification, Animals ; Mice ; Signal Transduction/radiation effects ; Mice, Inbred C57BL ; Whole-Body Irradiation/adverse effects ; Fecal Microbiota Transplantation ; Male ; Dysbiosis/microbiology

Nuclear hormone receptor regulation of PAL-1/Caudal mediates ventral nerve cord assembly in C. elegans.

Authors: Noblett N Roenspies T Flibotte S et al.

Source: Developmental biology [Dev Biol] 2025 Dec; Vol. 528, pp. 13-26. Date of Electronic Publication: 2025 Sep 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE

MeSH Terms: Caenorhabditis elegans*/embryology , Caenorhabditis elegans*/metabolism , Caenorhabditis elegans*/genetics , Caenorhabditis elegans Proteins*/metabolism , Caenorhabditis elegans Proteins*/genetics , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Homeodomain Proteins*/metabolism , Homeodomain Proteins*/genetics, Animals ; Motor Neurons/metabolism ; Motor Neurons/cytology ; Gene Expression Regulation, Developmental ; Promoter Regions, Genetic ; Mutation

FXR-mediated antigen-specific CD8 ⁺ T cell enhances antitumor immunity in intrahepatic cholangiocarcinoma.

Authors: Liu S Liang Z Zhu L et al.

Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Nov 28; Vol. 13 (11). Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE

MeSH Terms: Cholangiocarcinoma*/immunology , Cholangiocarcinoma*/pathology , Cholangiocarcinoma*/drug therapy , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Bile Duct Neoplasms*/immunology , Bile Duct Neoplasms*/drug therapy , Bile Duct Neoplasms*/pathology, Animals ; Mice ; Humans ; Mice, Knockout ; Immunotherapy/methods ; Cell Line, Tumor

3-O-Acetyloleanolic acid alleviates autoimmune liver injury by targeting FXR.

Authors: Wang Y Li Z Xiao W et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157273. Date of Electronic Publication: 2025 Sep 19.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Oleanolic Acid*/analogs & derivatives , Oleanolic Acid*/pharmacology , Hepatitis, Autoimmune*/drug therapy, Animals ; Mice ; Concanavalin A ; Male ; Liver/drug effects ; Liver/pathology ; Humans ; Mice, Inbred C57BL ; Chemical and Drug Induced Liver Injury/drug therapy

Rational design and synthesis of 6-(piperazin-1-yl)imidazo[1,2-b]pyridazine derivatives as dual FXR/PPARδ agonists for treatment of pulmonary fibrosis.

Authors: Yue L Jiang N Fan X et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118013. Date of Electronic Publication: 2025 Jul 31.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Pyridazines*/pharmacology , Pyridazines*/chemistry , Pyridazines*/chemical synthesis , Pyridazines*/therapeutic use , Receptors, Cytoplasmic and Nuclear*/agonists , Receptors, Cytoplasmic and Nuclear*/metabolism , Drug Design* , PPAR delta*/agonists , PPAR delta*/metabolism , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/chemically induced , Pulmonary Fibrosis*/metabolism , Pulmonary Fibrosis*/pathology , Imidazoles*/chemistry , Imidazoles*/pharmacology , Imidazoles*/chemical synthesis, Animals ; Mice ; Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Bleomycin ; Mice, Inbred C57BL ; Male

Farnesoid X Receptor Agonist INT-787 Inhibits Hepatic Mitochondrial Dysfunction in a Diet-Induced ob/ob Mouse Model of MASH.

Authors: Di Pasqua LG Palladini G Croce AC et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 14; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 14.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Receptors, Cytoplasmic and Nuclear*/agonists , Receptors, Cytoplasmic and Nuclear*/metabolism , Mitochondria, Liver*/drug effects , Mitochondria, Liver*/metabolism , Fatty Liver*/metabolism , Fatty Liver*/drug therapy , Fatty Liver*/etiology , Fatty Liver*/pathology, Animals ; Mice ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Male ; Liver/metabolism ; Liver/drug effects ; Liver/pathology ; Reactive Oxygen Species/metabolism ; Mice, Obese ; Mitochondria/drug effects ; Mitochondria/metabolism ; Glutathione/metabolism ; Adenosine Triphosphate/metabolism ; Bile Acids and Salts

Targeting FXR in hepatocytes: a promising approach to enhance fibrinolysis and reduce deep vein thrombosis risk.

Authors: Li B Fan H Wu H et al.

Source: Blood [Blood] 2025 Nov 13; Vol. 146 (20), pp. 2464-2478.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

MeSH Terms: Hepatocytes*/metabolism , Hepatocytes*/drug effects , Hepatocytes*/pathology , Fibrinolysis*/drug effects , Venous Thrombosis*/metabolism , Venous Thrombosis*/prevention & control , Venous Thrombosis*/etiology , Venous Thrombosis*/genetics , Venous Thrombosis*/pathology , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Receptors, Cytoplasmic and Nuclear*/agonists, Animals ; Mice ; Humans ; Plasminogen Activator Inhibitor 1/genetics ; Plasminogen Activator Inhibitor 1/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity/metabolism ; Obesity/complications ; Obesity/genetics

Genomic Crosstalk Between Nuclear Receptors in Hormone-dependent Cancers.

Authors: Campbell MJ; Board of Governors Innovation Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Source: Endocrinology [Endocrinology] 2025 Nov 06; Vol. 166 (12).

Publication Type: Journal Article; Review

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

MeSH Terms: Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Neoplasms, Hormone-Dependent*/genetics , Neoplasms, Hormone-Dependent*/metabolism , Receptor Cross-Talk* , Neoplasms*/genetics , Neoplasms*/metabolism, Humans ; Animals ; Gene Expression Regulation, Neoplastic

Increased intestinal permeability and bile acid accumulation via inhibition of the FXR-SHP pathway contribute to coumarin-induced systemic inflammation.

Authors: Shou N Wu D Wang Q et al.

Source: Microbiology spectrum [Microbiol Spectr] 2025 Nov 04; Vol. 13 (11), pp. e0141525. Date of Electronic Publication: 2025 Sep 19.

Publication Type: Journal Article

Journal Info: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE

MeSH Terms: Coumarins*/toxicity , Coumarins*/adverse effects , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Inflammation*/chemically induced , Inflammation*/metabolism , Bile Acids and Salts*/metabolism, Animals ; Permeability/drug effects ; Gastrointestinal Microbiome/drug effects ; Liver/drug effects ; Liver/metabolism ; Lipopolysaccharides/blood ; Male ; Mice ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/drug effects ; Signal Transduction/drug effects ; Intestines/drug effects ; Intestinal Barrier Function

Steroidal scaffold dichotomy: pathogenic role of 7-ketocholesterol versus protective FXR-antagonistic actions of guggulsterone in metabolic regulation.

Authors: Sabarathinam S Ganamurali N

Source: Steroids [Steroids] 2025 Nov; Vol. 223, pp. 109691. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0404536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5867 (Electronic) Linking ISSN: 0039128X NLM ISO Abbreviation: Steroids Subsets: MEDLINE

MeSH Terms: Pregnenediones*/pharmacology , Pregnenediones*/chemistry , Receptors, Cytoplasmic and Nuclear*/antagonists & inhibitors , Receptors, Cytoplasmic and Nuclear*/metabolism , Ketocholesterols*/chemistry , Ketocholesterols*/metabolism , Ketocholesterols*/pharmacology, Humans ; Animals

Constitutive androstane receptor activation modulates YAP expression and activity through ubiquitination and sumoylation.

Authors: Liang F Zhang S Zhou W et al.

Source: Toxicology letters [Toxicol Lett] 2025 Nov; Vol. 413, pp. 111728. Date of Electronic Publication: 2025 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE

MeSH Terms: Sumoylation* , Ubiquitination* , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/agonists , Receptors, Cytoplasmic and Nuclear*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics, Humans ; Constitutive Androstane Receptor ; YAP-Signaling Proteins ; HEK293 Cells ; SUMO-1 Protein/metabolism ; Signal Transduction ; Cell Cycle Proteins ; Hep G2 Cells ; Poly-ADP-Ribose Binding Proteins ; Protein Inhibitors of Activated STAT

Selective agonism of liver and gut FXR prevents cholestasis and intestinal atrophy in parenterally fed neonatal pigs.

Authors: Jiang Y Fang Z Guthrie G et al.

Source: Journal of lipid research [J Lipid Res] 2025 Nov; Vol. 66 (11), pp. 100919. Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

MeSH Terms: Receptors, Cytoplasmic and Nuclear*/agonists , Receptors, Cytoplasmic and Nuclear*/metabolism , Cholestasis*/prevention & control , Cholestasis*/metabolism , Cholestasis*/pathology , Liver*/metabolism , Liver*/drug effects , Liver*/pathology , Intestines*/pathology , Intestines*/drug effects , Intestinal Mucosa*/metabolism , Intestinal Mucosa*/pathology , Parenteral Nutrition*, Animals ; Swine ; Animals, Newborn ; Chenodeoxycholic Acid/analogs & derivatives ; Chenodeoxycholic Acid/pharmacology ; Chenodeoxycholic Acid/administration & dosage ; Bile Acids and Salts/metabolism

Geniposide induces hepatotoxicity via the bile acid-induced activation of NLRP3 inflammasome and regulation of the FXR/PERK/TXNIP pathway.

Authors: Jin Z Cheng S Liu B et al.

Source: Toxicology letters [Toxicol Lett] 2025 Nov; Vol. 413, pp. 111740. Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE

MeSH Terms: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/genetics , Bile Acids and Salts*/metabolism , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Inflammasomes*/metabolism , Inflammasomes*/drug effects , Iridoids*/toxicity , Chemical and Drug Induced Liver Injury*/etiology , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/metabolism , Carrier Proteins*/metabolism , Carrier Proteins*/genetics , Liver*/drug effects , Liver*/pathology , Liver*/metabolism , eIF-2 Kinase*/metabolism , eIF-2 Kinase*/genetics, Animals ; Rats, Sprague-Dawley ; Male ; Signal Transduction/drug effects ; Rats

RNAi-mediated nuclear receptor HR96 gene knockdown inhibits feeding and gut development in Locusta migratoria.

Authors: Liu X Li J Zheng S et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 330 (Pt 2), pp. 147943. Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Locusta migratoria*/genetics , Locusta migratoria*/growth & development , Locusta migratoria*/physiology , RNA Interference* , Receptors, Cytoplasmic and Nuclear*/genetics , Receptors, Cytoplasmic and Nuclear*/metabolism , Feeding Behavior* , Insect Proteins*/genetics , Insect Proteins*/metabolism , Gastrointestinal Tract*/growth & development , Gastrointestinal Tract*/metabolism, Animals ; Gene Knockdown Techniques ; Gene Expression Regulation, Developmental

Structural Basis of Novel Bile Acid-Based Modulators of FXR.

Authors: Kydd-Sinclair D Packer GL Weymouth-Wilson AC et al.

Source: Journal of molecular biology [J Mol Biol] 2025 Nov 01; Vol. 437 (21), pp. 169383. Date of Electronic Publication: 2025 Aug 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH Terms: Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/chemistry , Receptors, Cytoplasmic and Nuclear*/agonists , Receptors, Cytoplasmic and Nuclear*/genetics , Bile Acids and Salts*/chemistry , Bile Acids and Salts*/pharmacology , Bile Acids and Salts*/metabolism, Animals ; Humans ; Mice ; Molecular Docking Simulation ; Crystallography, X-Ray ; Mice, Inbred C57BL ; Chenodeoxycholic Acid/analogs & derivatives ; Chenodeoxycholic Acid/pharmacology ; Chenodeoxycholic Acid/chemistry ; Hep G2 Cells ; Cell Line, Tumor ; Signal Transduction/drug effects

Cracking melanoma's armor: Supramolecular dual-strike on XPO1 and β-catenin to overcome resistance.

Authors: Lu Y Guo R Song W et al.

Source: Journal of advanced research [J Adv Res] 2025 Nov; Vol. 77, pp. 793-806. Date of Electronic Publication: 2025 Mar 03.

Publication Type: Journal Article

Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE

MeSH Terms: beta Catenin*/metabolism , beta Catenin*/antagonists & inhibitors , Karyopherins*/antagonists & inhibitors , Karyopherins*/metabolism , Karyopherins*/genetics , Receptors, Cytoplasmic and Nuclear*/antagonists & inhibitors , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Melanoma*/drug therapy , Melanoma*/metabolism , Melanoma*/pathology , Melanoma*/genetics , Drug Resistance, Neoplasm*/drug effects, Exportin 1 Protein ; Humans ; Animals ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Microspheres

FXR suppress Müller cell activation by regulating cGAS/STING pathway in diabetic retinopathy.

Authors: Wang ZL Zhang XY Tan CY et al.

Source: The FEBS journal [FEBS J] 2025 Nov; Vol. 292 (22), pp. 6035-6053. Date of Electronic Publication: 2025 Feb 11.

Publication Type: Journal Article

Journal Info: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

MeSH Terms: Diabetic Retinopathy*/pathology , Diabetic Retinopathy*/metabolism , Diabetic Retinopathy*/genetics , Ependymoglial Cells*/metabolism , Ependymoglial Cells*/pathology , Ependymoglial Cells*/drug effects , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Nucleotidyltransferases*/metabolism , Nucleotidyltransferases*/genetics, Animals ; Rats ; Humans ; Rats, Sprague-Dawley ; Signal Transduction ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/complications ; Male ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondria/drug effects ; Glycation End Products, Advanced ; Streptozocin ; Retina/pathology ; Retina/metabolism ; Glucose