Výsledky vyhľadávania - "Receptors, Chimeric Antigen"

International consensus guidelines for the conduct and reporting of CAR T-cell clinical trials in AML.

Autori: Naik S Aplenc R Baumeister SHC a ďalší

Zdroj: Blood advances [Blood Adv] 2025 Dec 09; Vol. 9 (23), pp. 6047-6058.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

Výrazy zo slovníka MeSH: Leukemia, Myeloid, Acute*/therapy , Immunotherapy, Adoptive*/methods , Immunotherapy, Adoptive*/adverse effects , Clinical Trials as Topic*/standards , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/immunology , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism, Humans ; Consensus ; Research Design

With BiTEs at the kiddie table, where do CARs come in for pediatric B-ALL?

Autori: Li AM Maude SL

Zdroj: Hematology. American Society of Hematology. Education Program [Hematology Am Soc Hematol Educ Program] 2025 Dec 05; Vol. 2025 (1), pp. 443-449.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 100890099 Publication Model: Print Cited Medium: Internet ISSN: 1520-4383 (Electronic) Linking ISSN: 15204383 NLM ISO Abbreviation: Hematology Am Soc Hematol Educ Program Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antibodies, Bispecific*/therapeutic use , Immunotherapy, Adoptive*/methods , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/therapy , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/immunology , Receptors, Chimeric Antigen*/therapeutic use , Receptors, Chimeric Antigen*/immunology, Humans ; Child ; Antigens, CD19/immunology

Have CARs stalled for non-B-cell malignancies? Where are we, and where are we going?

Autori: Sillbert S Lamble A

Zdroj: Hematology. American Society of Hematology. Education Program [Hematology Am Soc Hematol Educ Program] 2025 Dec 05; Vol. 2025 (1), pp. 424-431.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 100890099 Publication Model: Print Cited Medium: Internet ISSN: 1520-4383 (Electronic) Linking ISSN: 15204383 NLM ISO Abbreviation: Hematology Am Soc Hematol Educ Program Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/therapeutic use , Immunotherapy, Adoptive*/methods , Leukemia, Myeloid, Acute*/therapy , Leukemia, Myeloid, Acute*/immunology, Humans ; Gene Editing

CAR T-cell therapy and bispecific antibodies in the management of multiple myeloma.

Autori: Dima D Banerjee R Hansen DK

Zdroj: Hematology. American Society of Hematology. Education Program [Hematology Am Soc Hematol Educ Program] 2025 Dec 05; Vol. 2025 (1), pp. 324-333.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 100890099 Publication Model: Print Cited Medium: Internet ISSN: 1520-4383 (Electronic) Linking ISSN: 15204383 NLM ISO Abbreviation: Hematology Am Soc Hematol Educ Program Subsets: MEDLINE

Výrazy zo slovníka MeSH: Multiple Myeloma*/therapy , Multiple Myeloma*/immunology , Antibodies, Bispecific*/therapeutic use , Immunotherapy, Adoptive*/methods , Receptors, Chimeric Antigen*/therapeutic use , Receptors, Chimeric Antigen*/immunology, Humans ; B-Cell Maturation Antigen/immunology

Genetically Encoded DNA Origami for CAR-T-Based Immunotherapy.

Autori: Fan J Liu H Yang C a ďalší

Zdroj: Nano letters [Nano Lett] 2025 Dec 03; Vol. 25 (48), pp. 16885-16893. Date of Electronic Publication: 2025 Nov 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/chemistry , DNA*/chemistry , DNA*/genetics , T-Lymphocytes*/immunology , Immunotherapy, Adoptive*/methods , Immunotherapy* , Neoplasms*/therapy , Neoplasms*/immunology, Humans ; Cell Line, Tumor

DR5 CAR-NK cells demonstrate superior scalability and potent antitumor activity with favorable safety.

Autori: Chen Q Xia M Tang M a ďalší

Zdroj: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6063-6081. Date of Electronic Publication: 2025 Oct 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Killer Cells, Natural*/immunology , Killer Cells, Natural*/metabolism , Killer Cells, Natural*/transplantation , Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/metabolism , Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics , Receptors, TNF-Related Apoptosis-Inducing Ligand*/immunology , Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism , Immunotherapy, Adoptive*/methods , Neoplasms*/therapy , Neoplasms*/immunology, Animals ; Humans ; Mice ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Apoptosis ; Genetic Vectors/genetics

Orthogonal CRISPR systems for targeted integration and multiplex base editing enable nonviral engineering of allogeneic CAR-T cells.

Autori: Mikkelsen NS Ravendran S Broksø AD a ďalší

Zdroj: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6082-6100. Date of Electronic Publication: 2025 Aug 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Gene Editing*/methods , CRISPR-Cas Systems* , T-Lymphocytes*/metabolism , T-Lymphocytes*/immunology , Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/immunology, Humans ; Immunotherapy, Adoptive/methods ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/enzymology ; Transgenes ; Staphylococcus aureus/genetics ; Staphylococcus aureus/enzymology

Expression of membrane-bound Interleukin-15 sustains the growth and survival of CAR-NK cells.

Autori: Feng D Sun L Hu D a ďalší

Zdroj: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115577. Date of Electronic Publication: 2025 Sep 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Interleukin-15*/genetics , Interleukin-15*/metabolism , Killer Cells, Natural*/immunology , Killer Cells, Natural*/transplantation , Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/immunology , Immunotherapy, Adoptive*/methods , Neoplasms*/therapy , Neoplasms*/immunology, Animals ; Humans ; NK Cell Lectin-Like Receptor Subfamily K/genetics ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Mice ; K562 Cells ; Cell Survival ; Cell Proliferation ; Female

Engineering scFv immunotherapies: From CAR T cells to bispecific antibodies.

Autori: Jamali MC Gaffer AGM Hassan HG a ďalší

Zdroj: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115597. Date of Electronic Publication: 2025 Sep 29.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Single-Chain Antibodies*/immunology , Single-Chain Antibodies*/therapeutic use , Single-Chain Antibodies*/genetics , Antibodies, Bispecific*/therapeutic use , Antibodies, Bispecific*/immunology , Antibodies, Bispecific*/genetics , Neoplasms*/therapy , Neoplasms*/immunology , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/genetics , Immunotherapy, Adoptive*/methods , T-Lymphocytes*/immunology , Immunotherapy*/methods, Humans ; Animals ; Antigens, Neoplasm/immunology ; Protein Engineering

Isolated oral CD30 ⁺ /CD4 ⁺ CAR ⁺ T cell lymphoma in long-term remission after radiotherapy.

Autori: Bezerra E Lupu L de Lima M a ďalší

Zdroj: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6033-6040. Date of Electronic Publication: 2025 Sep 02.

Spôsob vydávania: Journal Article; Case Reports

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Immunotherapy, Adoptive*/methods , Immunotherapy, Adoptive*/adverse effects , Ki-1 Antigen*/metabolism , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/genetics , Lymphoma, T-Cell*/radiotherapy , Lymphoma, T-Cell*/therapy , Lymphoma, T-Cell*/diagnosis , Lymphoma, T-Cell*/etiology, Humans ; Male ; Middle Aged ; Female ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Remission Induction ; Treatment Outcome

Allogeneic stem cell-engineered EGFRvIII-specific CAR-NKT cells for treating glioblastoma with enhanced efficacy and safety.

Autori: Li YR Zhu Y Li Z a ďalší

Zdroj: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6041-6062. Date of Electronic Publication: 2025 Sep 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glioblastoma*/therapy , Glioblastoma*/immunology , Glioblastoma*/pathology , Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/metabolism , Immunotherapy, Adoptive*/methods , ErbB Receptors*/immunology , ErbB Receptors*/genetics , Natural Killer T-Cells*/immunology , Natural Killer T-Cells*/metabolism , Natural Killer T-Cells*/transplantation , Brain Neoplasms*/therapy , Brain Neoplasms*/immunology , Brain Neoplasms*/pathology, Humans ; Animals ; Mice ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Tumor Microenvironment/immunology ; Disease Models, Animal ; Receptors, Antigen, T-Cell

CAR-T cell therapy in nephrology.

Autori: Tondolo F Gessaroli E Maritati F a ďalší

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2594261. Date of Electronic Publication: 2025 Dec 03.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Immunotherapy, Adoptive*/methods , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/therapeutic use , Kidney Diseases*/therapy , Kidney Diseases*/immunology, Humans ; Nephrology/methods ; Kidney Transplantation ; T-Lymphocytes/immunology

CAR-T cell therapy for multiple myeloma: An update on the current state and future potential.

Autori: Pophali P Rosenblatt J Avigan D

Zdroj: Best practice & research. Clinical haematology [Best Pract Res Clin Haematol] 2025 Dec; Vol. 38 (4), pp. 101659. Date of Electronic Publication: 2025 Oct 04.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101120659 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1924 (Electronic) Linking ISSN: 15216926 NLM ISO Abbreviation: Best Pract Res Clin Haematol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Multiple Myeloma*/therapy , Multiple Myeloma*/immunology , Multiple Myeloma*/pathology , Immunotherapy, Adoptive*/methods , Immunotherapy, Adoptive*/adverse effects , Immunotherapy, Adoptive*/trends , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/therapeutic use , B-Cell Maturation Antigen*/immunology , B-Cell Maturation Antigen*/genetics, Humans ; Tumor Microenvironment/immunology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/pathology

CAR-T cell therapy for solid tumors: HIF-1α as a potential enhancement strategy.

Autori: Li HR Xiong J Wang CH a ďalší

Zdroj: Autoimmunity [Autoimmunity] 2025 Dec; Vol. 58 (1), pp. 2579069. Date of Electronic Publication: 2025 Nov 18.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8900070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-842X (Electronic) Linking ISSN: 08916934 NLM ISO Abbreviation: Autoimmunity Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/immunology , Neoplasms*/therapy , Neoplasms*/immunology , Neoplasms*/metabolism , Immunotherapy, Adoptive*/methods , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/genetics , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism, Humans ; Tumor Microenvironment/immunology ; Animals ; Glycolysis

Base edited "universal" donor CAR T-cell strategies for acute myeloid leukaemia.

Autori: Kadirkamanathan R Georgiadis C Kloos A a ďalší

Zdroj: Leukemia [Leukemia] 2025 Dec; Vol. 39 (12), pp. 2978-2987. Date of Electronic Publication: 2025 Oct 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

Výrazy zo slovníka MeSH: Gene Editing* , Immunotherapy, Adoptive*/methods , Leukemia, Myeloid, Acute*/therapy , Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/immunology , T-Lymphocytes*/immunology, Animals ; Humans ; Mice ; HEK293 Cells ; HL-60 Cells ; Mice, Inbred NOD ; Mice, SCID ; Xenograft Model Antitumor Assays

Small-molecule control of CAR T cells.

Autori: Adams EL McGovern AC So V a ďalší

Zdroj: Nature reviews. Chemistry [Nat Rev Chem] 2025 Dec; Vol. 9 (12), pp. 809-825. Date of Electronic Publication: 2025 Oct 29.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Springer Nature Country of Publication: England NLM ID: 101703631 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2397-3358 (Electronic) Linking ISSN: 23973358 NLM ISO Abbreviation: Nat Rev Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/metabolism , T-Lymphocytes*/immunology , T-Lymphocytes*/drug effects , T-Lymphocytes*/metabolism , Small Molecule Libraries*/pharmacology , Small Molecule Libraries*/chemistry , Immunotherapy, Adoptive*/methods , Neoplasms*/therapy , Neoplasms*/immunology , Receptors, Antigen, T-Cell*, Humans ; Animals

Optimizing CAR T cell therapy for solid tumours: a clinical perspective.

Autori: Li J Liu C Zhang P a ďalší

Zdroj: Nature reviews. Clinical oncology [Nat Rev Clin Oncol] 2025 Dec; Vol. 22 (12), pp. 953-968. Date of Electronic Publication: 2025 Oct 02.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500077 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4782 (Electronic) Linking ISSN: 17594774 NLM ISO Abbreviation: Nat Rev Clin Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Immunotherapy, Adoptive*/methods , Immunotherapy, Adoptive*/adverse effects , Neoplasms*/therapy , Neoplasms*/immunology , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/therapeutic use , T-Lymphocytes*/immunology, Humans

Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy.

Autori: Guruprasad P Ramasubramanian R Nason S a ďalší

Zdroj: Nature protocols [Nat Protoc] 2025 Dec; Vol. 20 (12), pp. 3629-3654. Date of Electronic Publication: 2025 Jul 25.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

Výrazy zo slovníka MeSH: Gene Editing*/methods , CRISPR-Cas Systems*/genetics , Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/immunology , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , Neoplasms*/therapy , Neoplasms*/immunology , Immunotherapy, Adoptive*/methods, Animals ; Mice ; Humans ; Tumor Microenvironment/immunology

Anti-FAP CAR-NK cells as a novel targeted therapy against cervical cancer and cancer-associated fibroblasts.

Autori: Polten R Kutle I Stalp JL a ďalší

Zdroj: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2556714. Date of Electronic Publication: 2025 Sep 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Uterine Cervical Neoplasms*/therapy , Uterine Cervical Neoplasms*/immunology , Uterine Cervical Neoplasms*/pathology , Killer Cells, Natural*/immunology , Killer Cells, Natural*/transplantation , Killer Cells, Natural*/metabolism , Serine Endopeptidases*/immunology , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Cancer-Associated Fibroblasts*/immunology , Cancer-Associated Fibroblasts*/metabolism , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/genetics , Membrane Proteins*/immunology , Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/metabolism , Gelatinases*/immunology , Gelatinases*/antagonists & inhibitors , Gelatinases*/metabolism , Gelatinases*/genetics , Immunotherapy, Adoptive*/methods, Humans ; Female ; Tumor Microenvironment/immunology ; Endopeptidases ; Cell Line, Tumor ; Coculture Techniques

CAR-T cell therapy: A therapeutic strategy for cancer treatment.

Autori: Sharif S Sharma U Yadav AK

Zdroj: Seminars in oncology [Semin Oncol] 2025 Dec; Vol. 52 (6), pp. 152430. Date of Electronic Publication: 2025 Nov 03.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0420432 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8708 (Electronic) Linking ISSN: 00937754 NLM ISO Abbreviation: Semin Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Immunotherapy, Adoptive*/methods , Immunotherapy, Adoptive*/adverse effects , Neoplasms*/therapy , Neoplasms*/immunology , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/genetics , T-Lymphocytes*/immunology , Receptors, Antigen, T-Cell*/immunology, Humans