Výsledky vyhľadávania - "Receptor"

Association between Toll-like receptor 9 signaling defect and developing post-infectious irritable bowel syndrome.

Autori: Kotani S Mishima Y Kishimoto K a ďalší

Zdroj: Frontiers in immunology [Front Immunol] 2025 Nov 10; Vol. 16, pp. 1672117. Date of Electronic Publication: 2025 Nov 10 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Irritable Bowel Syndrome*/metabolism , Irritable Bowel Syndrome*/etiology , Irritable Bowel Syndrome*/microbiology , Irritable Bowel Syndrome*/immunology , Irritable Bowel Syndrome*/genetics , Toll-Like Receptor 9*/genetics , Toll-Like Receptor 9*/metabolism , Signal Transduction* , Enterobacteriaceae Infections*/complications , Enterobacteriaceae Infections*/immunology , Enterobacteriaceae Infections*/microbiology, Animals ; Mice, Knockout ; Mice ; Gastrointestinal Microbiome ; Citrobacter rodentium ; Disease Models, Animal ; Mice, Inbred C57BL ; Male ; Colon/metabolism ; Colon/microbiology ; Colon/pathology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Receptor, Bradykinin B2/metabolism ; Receptor, Bradykinin B2/genetics ; Receptor, Bradykinin B1/metabolism ; Receptor, Bradykinin B1/genetics ; Dysbiosis

2,5-Dimethoxy-4-methylamphetamine (DOM)-induced gait alterations in mice: Dissecting the role of 5-HT 2A/2C receptor-mediated mechanisms.

Autori: Li B Jiang S Yao Y a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 05; Vol. 1006, pp. 178170. Date of Electronic Publication: 2025 Sep 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptor, Serotonin, 5-HT2A*/metabolism , Gait*/drug effects , Receptor, Serotonin, 5-HT2C*/metabolism , DOM 2,5-Dimethoxy-4-Methylamphetamine*/pharmacology , Hallucinogens*/pharmacology, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Serotonin 5-HT2 Receptor Antagonists/pharmacology ; Locomotion/drug effects ; Serotonin 5-HT2 Receptor Agonists

(-)-OSU6162 reduces freezing elicited by context-conditioned fear in rats.

Autori: Atanasovski D Hagsäter SM Myrehag M a ďalší

Zdroj: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2025 Dec; Vol. 39 (12), pp. 1491-1497. Date of Electronic Publication: 2025 Nov 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fear*/drug effects , Piperidines*/pharmacology , Dopamine D2 Receptor Antagonists*/pharmacology , Freezing Reaction, Cataleptic*/drug effects , Conditioning, Psychological*/drug effects, Animals ; Male ; Rats ; Receptors, sigma/antagonists & inhibitors ; Receptors, sigma/metabolism ; Sigma-1 Receptor ; Amphetamine/pharmacology ; Rats, Wistar ; Motor Activity/drug effects ; Behavior, Animal/drug effects ; Receptors, Dopamine D2/metabolism ; Receptor, Serotonin, 5-HT2A/metabolism

Stimulation of angiotensin II type 2 receptor recruit skeletal and cardiac muscle microvasculature in humans.

Autori: Tan WKA Jahn LA Hartline L a ďalší

Zdroj: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2025 Nov 01; Vol. 329 (5), pp. E755-E763. Date of Electronic Publication: 2025 Oct 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptor, Angiotensin, Type 2*/metabolism , Receptor, Angiotensin, Type 2*/agonists , Muscle, Skeletal*/blood supply , Muscle, Skeletal*/drug effects , Muscle, Skeletal*/metabolism , Angiotensin II*/pharmacology , Microvessels*/drug effects , Microvessels*/metabolism, Humans ; Male ; Adult ; Female ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Benzimidazoles/pharmacology ; Biphenyl Compounds ; Glucose Clamp Technique ; Insulin/pharmacology ; Young Adult ; Tetrazoles/pharmacology ; Myocardium/metabolism ; Hemodynamics/drug effects ; Microcirculation/drug effects ; Brachial Artery/drug effects ; Regional Blood Flow/drug effects ; Receptor, Angiotensin, Type 1

Charge-dependent localization of Toll-like receptor 5 at the plasma membrane.

Autori: Huh JW Park K Song HS a ďalší

Zdroj: Molecules and cells [Mol Cells] 2025 Nov; Vol. 48 (11), pp. 100275. Date of Electronic Publication: 2025 Sep 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 9610936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0219-1032 (Electronic) Linking ISSN: 10168478 NLM ISO Abbreviation: Mol Cells Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cell Membrane*/metabolism , Toll-Like Receptor 5*/metabolism , Toll-Like Receptor 5*/genetics , Toll-Like Receptor 5*/chemistry, Humans ; HEK293 Cells ; Toll-Like Receptor 9/metabolism ; Toll-Like Receptor 9/genetics ; Protein Transport ; Endocytosis ; Membrane Transport Proteins/metabolism ; Animals ; Protein Domains

Crosstalk between M1 muscarinic acetylcholine receptor and endocannabinoid system promotes attenuation of inflammation in ulcerative colitis.

Autori: de Aguiar Magalhães D Guimarães Sousa S da Silva Monteiro CE a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178368. Date of Electronic Publication: 2025 Nov 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Colitis, Ulcerative*/metabolism , Colitis, Ulcerative*/pathology , Colitis, Ulcerative*/chemically induced , Colitis, Ulcerative*/drug therapy , Receptor, Muscarinic M1*/metabolism , Receptor, Muscarinic M1*/agonists , Endocannabinoids*/metabolism, Animals ; Male ; Mice ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Colon/pathology ; Colon/drug effects ; Colon/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Receptor, Cannabinoid, CB2/antagonists & inhibitors ; NF-kappa B/metabolism ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/drug therapy ; Cyclooxygenase 2/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Peroxidase/metabolism ; Acetic Acid ; Cannabinoid Receptor Antagonists/pharmacology

Mechanisms of Glucagon-Like Peptide 1 Receptor Agonist-Induced Facial Lipodystrophy and a Path Toward Prevention.

Autori: Kruglikov IL; Scientific Department, Wellcomet GmbH, Bruchsal, Germany.

Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2025 Dec; Vol. 24 (12), pp. e70584.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glucagon-Like Peptide-1 Receptor Agonists* , Lipodystrophy*/chemically induced , Lipodystrophy*/prevention & control , Hypoglycemic Agents*/adverse effects, Humans ; Face ; Glucagon-Like Peptide-1 Receptor/metabolism ; Receptor, IGF Type 1/metabolism ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism

Prolyl isomerase Pin4 impacts estrogen receptor transactivation by enhancing phosphorylation and consequently promotes the proliferation of breast cancer cells.

Autori: Inoue MK Ueda R Nakanishi M a ďalší

Zdroj: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2025 Dec; Vol. 1872 (8), pp. 120044. Date of Electronic Publication: 2025 Aug 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Estrogen Receptor alpha*/metabolism , Estrogen Receptor alpha*/genetics , Transcriptional Activation* , NIMA-Interacting Peptidylprolyl Isomerase*/genetics , NIMA-Interacting Peptidylprolyl Isomerase*/metabolism , Peptidylprolyl Isomerase*/metabolism , Peptidylprolyl Isomerase*/genetics, Humans ; Cell Proliferation/genetics ; Female ; Phosphorylation ; Nuclear Receptor Coactivator 3/metabolism ; Nuclear Receptor Coactivator 3/genetics ; Gene Expression Regulation, Neoplastic ; MCF-7 Cells ; Cell Line, Tumor

Efficient bovine sex selection via Toll-like receptors 7/8 agonist 24e through the GSK3α/β-hexokinase pathway.

Autori: Wang D Di A Zhang X a ďalší

Zdroj: Theriogenology [Theriogenology] 2025 Dec; Vol. 248, pp. 117590. Date of Electronic Publication: 2025 Jul 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Sex Preselection*/methods , Sex Preselection*/veterinary , Toll-Like Receptors*/agonists , Toll-Like Receptors*/genetics , Toll-Like Receptors*/physiology , Toll-Like Receptor Agonists*, Animals ; Cattle ; Toll-Like Receptor 7/agonists ; Toll-Like Receptor 7/genetics ; Toll-Like Receptor 7/metabolism ; Toll-Like Receptor 8/agonists ; Toll-Like Receptor 8/genetics ; Toll-Like Receptor 8/metabolism ; Glycogen Synthase Kinases/genetics ; Glycogen Synthase Kinases/metabolism ; Hexokinase/genetics ; Hexokinase/metabolism ; Signal Transduction/physiology ; Male ; Female ; Dairying ; Flow Cytometry/economics ; Flow Cytometry/methods ; Flow Cytometry/veterinary ; X Chromosome/physiology ; NF-kappa B/metabolism ; Spermatozoa/metabolism ; Spermatozoa/physiology ; Sex Chromosomes

Pregnane X receptor activation regulate amyloid transport to improve cognition functions in Alzheimer's disease.

Autori: Gu T Ma S Liu W a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 15; Vol. 1007, pp. 178310. Date of Electronic Publication: 2025 Oct 31.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/metabolism , Alzheimer Disease*/drug therapy , Alzheimer Disease*/physiopathology , Alzheimer Disease*/pathology , Alzheimer Disease*/psychology , Pregnane X Receptor*/agonists , Pregnane X Receptor*/metabolism , Amyloid beta-Peptides*/metabolism , Cognition*/drug effects , Peptide Fragments*/metabolism, Animals ; Humans ; Mice ; Male ; Endothelial Cells/metabolism ; Endothelial Cells/drug effects ; Mice, Inbred C57BL ; Brain/metabolism ; Brain/drug effects ; Brain/blood supply ; Low Density Lipoprotein Receptor-Related Protein-1/metabolism ; Cerebrovascular Circulation/drug effects ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Disease Models, Animal

Extracellular microRNAs modulate human microglial function through TLR8.

Autori: Weidling H Motta E Kuhrt LD a ďalší

Zdroj: Frontiers in immunology [Front Immunol] 2025 Nov 14; Vol. 16, pp. 1645062. Date of Electronic Publication: 2025 Nov 14 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Toll-Like Receptor 8*/metabolism , Toll-Like Receptor 8*/genetics , Microglia*/metabolism , Microglia*/immunology , MicroRNAs*/genetics , MicroRNAs*/metabolism, Humans ; Toll-Like Receptor 7/metabolism ; Toll-Like Receptor 7/genetics ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/immunology ; Induced Pluripotent Stem Cells/metabolism ; Glioma/genetics ; Glioma/metabolism ; Glioma/immunology ; Phagocytosis ; Cells, Cultured ; Neurons/metabolism ; Coculture Techniques ; Signal Transduction ; Cytokines/metabolism

Discovery of Novel Triple A1/A2A/A2B Adenosine Receptor Antagonists for Cancer Immunotherapy.

Autori: Jun S Lee Y Lee H a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 23117-23139. Date of Electronic Publication: 2025 Oct 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Immunotherapy*/methods , Neoplasms*/therapy , Neoplasms*/immunology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Adenosine A2 Receptor Antagonists*/pharmacology , Adenosine A2 Receptor Antagonists*/chemistry , Drug Discovery*, Humans ; Animals ; Mice ; Cell Line, Tumor ; Receptor, Adenosine A2B/metabolism ; Structure-Activity Relationship ; HEK293 Cells ; Receptor, Adenosine A1/metabolism ; Cell Proliferation/drug effects ; Receptor, Adenosine A2A/metabolism

Targeting Upregulation of Neuronal IGF1/IGF1R Signalling in the Spinal Cord Prevents Cisplatin-Induced Peripheral Neuropathy in Mice.

Autori: Fu CR Chen JH Yang YC a ďalší

Zdroj: European journal of pain (London, England) [Eur J Pain] 2025 Nov; Vol. 29 (10), pp. e70161.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 9801774 Publication Model: Print Cited Medium: Internet ISSN: 1532-2149 (Electronic) Linking ISSN: 10903801 NLM ISO Abbreviation: Eur J Pain Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cisplatin*/toxicity , Insulin-Like Growth Factor I*/metabolism , Receptor, IGF Type 1*/metabolism , Receptor, IGF Type 1*/genetics , Peripheral Nervous System Diseases*/chemically induced , Peripheral Nervous System Diseases*/prevention & control , Peripheral Nervous System Diseases*/metabolism , Spinal Cord*/metabolism, Animals ; Mice ; Up-Regulation ; Male ; Signal Transduction/drug effects ; G-Protein-Coupled Receptor Kinase 2/metabolism ; G-Protein-Coupled Receptor Kinase 2/genetics ; Antineoplastic Agents/toxicity ; Disease Models, Animal ; Mice, Inbred C57BL ; Hyperalgesia/chemically induced ; Hyperalgesia/metabolism ; Neurons/metabolism

"Do It Yourself" Synthetic Cannabinoid Receptor Agonist Precursors as a Ban-Evading Strategy: Comparison of the Pharmacological Characteristics of Precursors and Their Final Products.

Autori: Deventer MH Krotulski AJ Stove CP

Zdroj: Drug testing and analysis [Drug Test Anal] 2025 Nov; Vol. 17 (11), pp. 2148-2158. Date of Electronic Publication: 2025 Jul 09.

Spôsob vydávania: Journal Article; Comparative Study

Informácie o časopise: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-7611 (Electronic) Linking ISSN: 19427603 NLM ISO Abbreviation: Drug Test Anal Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cannabinoid Receptor Agonists*/pharmacology , Cannabinoid Receptor Agonists*/chemical synthesis , Cannabinoid Receptor Agonists*/chemistry , Cannabinoids*/pharmacology, Humans ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/metabolism ; China ; beta-Arrestin 2/metabolism ; HEK293 Cells ; Indoles/pharmacology ; Drug and Narcotic Control/legislation & jurisprudence

Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging.

Autori: Namkung Y Slutzki T Pedroso J a ďalší

Zdroj: Molecular metabolism [Mol Metab] 2025 Nov; Vol. 101, pp. 102254. Date of Electronic Publication: 2025 Sep 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptor, Melanocortin, Type 1*/metabolism , Receptor, Melanocortin, Type 1*/genetics , Melanocortins*/metabolism, Animals ; Mice ; Agouti-Related Protein/metabolism ; alpha-MSH/metabolism ; Receptor, Melanocortin, Type 4/metabolism ; Receptor, Melanocortin, Type 4/genetics ; Humans ; Green Fluorescent Proteins/metabolism ; Green Fluorescent Proteins/genetics ; HEK293 Cells ; Male ; Mice, Inbred C57BL

Constitutive Androstane Receptor in Macrophages Regulates Toll-Like Receptor 4-Mediated Innate Immune Responses Against Endotoxemic Liver Injury.

Autori: Cao R Zhao T Wang Y a ďalší

Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (42), pp. e06725. Date of Electronic Publication: 2025 Aug 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/genetics , Toll-Like Receptor 4*/immunology , Macrophages*/metabolism , Macrophages*/immunology , Immunity, Innate*/immunology , Immunity, Innate*/genetics , Endotoxemia*/immunology , Endotoxemia*/metabolism , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/genetics, Animals ; Mice ; Humans ; Constitutive Androstane Receptor ; Mice, Inbred C57BL ; Male ; Mice, Knockout ; Signal Transduction ; Liver/metabolism ; Liver/immunology ; Lipopolysaccharides ; RAW 264.7 Cells

Single-cell sequencing uncovers sensory neuron-mediated CGRP signaling as a driver of sarcoma progression.

Autori: Ramesh S Qin Q Li Z a ďalší

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Oct 28; Vol. 122 (43), pp. e2500161122. Date of Electronic Publication: 2025 Oct 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcitonin Gene-Related Peptide*/metabolism , Calcitonin Gene-Related Peptide*/genetics , Sensory Receptor Cells*/metabolism , Sensory Receptor Cells*/pathology , Bone Neoplasms*/pathology , Bone Neoplasms*/metabolism , Bone Neoplasms*/genetics , Osteosarcoma*/pathology , Osteosarcoma*/metabolism , Osteosarcoma*/genetics , Sarcoma*/pathology , Sarcoma*/metabolism, Animals ; Mice ; Signal Transduction ; Humans ; Disease Progression ; Mice, Transgenic ; Single-Cell Analysis/methods ; Tumor Microenvironment ; Receptor, trkA/metabolism ; Receptor, trkA/genetics ; Cell Line, Tumor

Discovery of Highly Selective 5-HT 2A Agonists Using Structure-Guided Design.

Autori: Fenske TG McKee JL Cavalco NG a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Oct 09; Vol. 68 (19), pp. 20619-20635. Date of Electronic Publication: 2025 Sep 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Serotonin 5-HT2 Receptor Agonists*/pharmacology , Serotonin 5-HT2 Receptor Agonists*/chemistry , Serotonin 5-HT2 Receptor Agonists*/chemical synthesis , Serotonin 5-HT2 Receptor Agonists*/metabolism , Receptor, Serotonin, 5-HT2A*/metabolism , Receptor, Serotonin, 5-HT2A*/chemistry , Receptor, Serotonin, 5-HT2A*/genetics , Drug Design* , Drug Discovery*, Animals ; Structure-Activity Relationship ; Humans ; Mice ; Molecular Docking Simulation ; Receptor, Serotonin, 5-HT2C/metabolism ; Receptor, Serotonin, 5-HT2C/genetics ; Receptor, Serotonin, 5-HT2C/chemistry ; HEK293 Cells

Polychlorinated Biphenyls Alter Estrogen Receptor β-mediated Epigenetic Regulation, Promoting Endometriosis.

Autori: Park Y Sung N Kim E a ďalší

Zdroj: Endocrinology [Endocrinology] 2025 Oct 09; Vol. 166 (11).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Endometriosis*/genetics , Endometriosis*/chemically induced , Endometriosis*/metabolism , Endometriosis*/pathology , Epigenesis, Genetic*/drug effects , Polychlorinated Biphenyls*/toxicity , Polychlorinated Biphenyls*/pharmacology , Estrogen Receptor beta*/metabolism , Estrogen Receptor beta*/genetics, Female ; Animals ; Humans ; Mice ; DNA Methyltransferase 3A ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins/genetics ; Axl Receptor Tyrosine Kinase ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; Mice, Knockout ; Receptor Protein-Tyrosine Kinases/metabolism ; Disease Models, Animal ; Signal Transduction/drug effects ; Endometrium/drug effects ; Endometrium/metabolism ; Endometrium/pathology

Adenosine A 2A receptor modulation affects the development of depressive-like behaviour and dopamine D 2 receptor availability in rats exposed to repeated social defeat.

Autori: Vazquez-Matias DA Henry S Guerrin CGJ a ďalší

Zdroj: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2025 Oct 02; Vol. 142, pp. 111540. Date of Electronic Publication: 2025 Oct 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Dopamine D2*/metabolism , Receptor, Adenosine A2A*/metabolism , Depression*/metabolism , Depression*/drug therapy , Depression*/psychology , Social Defeat*, Animals ; Male ; Rats ; Phenethylamines/pharmacology ; Adenosine A2 Receptor Agonists/pharmacology ; Adenosine/analogs & derivatives ; Adenosine/pharmacology ; Adenosine A2 Receptor Antagonists/pharmacology ; Rats, Wistar ; Positron-Emission Tomography ; Anhedonia/drug effects