Suchergebnisse - "RNA splicing"

Ultra-Conserved Poison Exons Enable Rapid and Safe Splicing Factor Gene Expression Switches: A Hypothesis.

Autoren: Dalgliesh C Ghorbani F Wollman AJM et al.

Quelle: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2025 Dec; Vol. 47 (12), pp. e70081. Date of Electronic Publication: 2025 Nov 02.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 8510851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-1878 (Electronic) Linking ISSN: 02659247 NLM ISO Abbreviation: Bioessays Subsets: MEDLINE

MeSH-Schlagworte: Exons*/genetics , Alternative Splicing*/genetics , Gene Expression Regulation* , RNA Splicing Factors*/genetics , RNA Splicing Factors*/metabolism, Animals ; Humans ; Serine-Arginine Splicing Factors/genetics ; RNA Splicing ; Male ; Meiosis/genetics ; Conserved Sequence

Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3' splice sites.

Autoren: Herbert A Hatfield A Randazza A et al.

Quelle: RNA biology [RNA Biol] 2025 Dec; Vol. 22 (1), pp. 1-15. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101235328 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8584 (Electronic) Linking ISSN: 15476286 NLM ISO Abbreviation: RNA Biol Subsets: MEDLINE

MeSH-Schlagworte: RNA Splicing Factors*/genetics , RNA Splicing Factors*/metabolism , RNA Splice Sites* , Mutation* , Phosphoproteins*/genetics , Phosphoproteins*/metabolism , RNA Precursors*/genetics , RNA Precursors*/chemistry, Humans ; Nucleic Acid Conformation ; Alternative Splicing ; RNA Splicing ; Spliceosomes/metabolism ; Spliceosomes/genetics

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations.

Autoren: Zhou S Lizarazo S Chorghade S et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 25; Vol. 16 (1), pp. 10460. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: RNA, Messenger*/metabolism , RNA, Messenger*/genetics , RNA Splicing*/genetics , Neoplasms*/genetics , Neoplasms*/metabolism , Neoplasms*/pathology, Humans ; RNA Splicing Factors/metabolism ; RNA Splicing Factors/genetics ; Cell Line, Tumor ; Ribonucleoprotein, U2 Small Nuclear/metabolism ; Ribonucleoprotein, U2 Small Nuclear/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic

The RNA recognition motif (RRM) of the Arabidopsis RS2Z32 and RS2Z33 splicing factors coordinates protein-protein and protein-RNA interactions, and contributes to their nucleocytoplasmic dynamics.

Autoren: Fanara S Schloesser M Gérard M et al.

Quelle: Journal of experimental botany [J Exp Bot] 2025 Nov 17; Vol. 76 (20), pp. 5814-5829.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 9882906 Publication Model: Print Cited Medium: Internet ISSN: 1460-2431 (Electronic) Linking ISSN: 00220957 NLM ISO Abbreviation: J Exp Bot Subsets: MEDLINE

MeSH-Schlagworte: Arabidopsis*/metabolism , Arabidopsis*/genetics , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Arabidopsis Proteins*/chemistry , RNA Splicing Factors*/metabolism , RNA Splicing Factors*/genetics , RNA Recognition Motif* , RNA, Plant*/metabolism , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics, Cell Nucleus/metabolism ; Protein Binding ; RNA Splicing

Identification of a CD138-Negative Therapy-Resistant Subpopulation in Multiple Myeloma with Vulnerability to Splicing Factor Inhibition.

Autoren: Kamiya T Ajiro M Oshima M et al.

Quelle: Blood cancer discovery [Blood Cancer Discov] 2025 Nov 03; Vol. 6 (6), pp. 602-622.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE

MeSH-Schlagworte: Multiple Myeloma*/genetics , Multiple Myeloma*/drug therapy , Multiple Myeloma*/pathology , Multiple Myeloma*/metabolism , Drug Resistance, Neoplasm*/genetics , Syndecan-1*/genetics , Syndecan-1*/metabolism , RNA Splicing Factors*/antagonists & inhibitors , RNA Splicing Factors*/genetics , RNA-Binding Proteins*/genetics , RNA-Binding Proteins*/antagonists & inhibitors , RNA-Binding Proteins*/metabolism, Humans ; RNA Splicing ; Single-Cell Analysis

SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes.

Autoren: Ding Z Liu Q Zhang J

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Oct; Vol. 62 (10), pp. 12523-12538. Date of Electronic Publication: 2025 May 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Synapses*/metabolism , Synapses*/genetics , Memory*/physiology , RNA Splicing*/genetics, Animals ; Hippocampus/metabolism ; Mice, Inbred C57BL ; Mice ; RNA Splicing Factors/metabolism ; Dendritic Spines/metabolism ; Male ; Alternative Splicing/genetics ; Disks Large Homolog 4 Protein/metabolism ; Humans ; Neurons/metabolism ; Serine-Arginine Splicing Factors/metabolism

Influenza NS1 drives N ⁶ -methyladenosine (m ⁶ A)-mediated autoregulation of viral mRNA splicing.

Autoren: Liao Y Liu J Wang P et al.

Quelle: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2572761. Date of Electronic Publication: 2025 Oct 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH-Schlagworte: Adenosine*/analogs & derivatives , Adenosine*/metabolism , Viral Nonstructural Proteins*/genetics , Viral Nonstructural Proteins*/metabolism , RNA Splicing* , RNA, Viral*/genetics , RNA, Viral*/metabolism , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Influenza A virus*/genetics , Influenza A virus*/physiology, Humans ; Serine-Arginine Splicing Factors/metabolism ; Serine-Arginine Splicing Factors/genetics ; Animals ; Virus Replication ; Influenza, Human/virology ; RNA-Binding Proteins/metabolism ; RNA Splicing Factors ; Nerve Tissue Proteins

New mechanistic insights into prespliceosome formation-roles of DEAD-box proteins Prp5 and Sub2.

Autoren: Kao CY Tsai WY Su YL et al.

Quelle: RNA (New York, N.Y.) [RNA] 2025 Nov 17; Vol. 31 (12), pp. 1901-1911. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE

MeSH-Schlagworte: DEAD-box RNA Helicases*/metabolism , DEAD-box RNA Helicases*/genetics , Spliceosomes*/metabolism , Spliceosomes*/genetics , RNA Splicing* , Saccharomyces cerevisiae Proteins*/metabolism , Saccharomyces cerevisiae Proteins*/genetics , Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/metabolism, Adenosine Triphosphate/metabolism ; RNA Splicing Factors/metabolism

Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4.

Autoren: Bonnal S Bajew S Martinez-Corral R et al.

Quelle: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Oct; Vol. 32 (10), pp. 2022-2034. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Spliceosomes*/metabolism , RNA Splicing* , Exons* , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Nerve Tissue Proteins*/metabolism , Nerve Tissue Proteins*/genetics, Animals ; Humans ; RNA Splicing Factors/metabolism ; Mice

Genetic variants of LncRNA associated with splicing regulation and their impact on ovarian cancer development.

Autoren: Zou L Zhang M He S et al.

Quelle: Functional & integrative genomics [Funct Integr Genomics] 2025 Sep 02; Vol. 25 (1), pp. 185. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 100939343 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-7948 (Electronic) Linking ISSN: 1438793X NLM ISO Abbreviation: Funct Integr Genomics Subsets: MEDLINE

MeSH-Schlagworte: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Quantitative Trait Loci* , RNA Splicing*, Humans ; Female ; Gene Expression Regulation, Neoplastic ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism ; Gene Regulatory Networks

The pre-mRNA splicing factor ZOP1 contributes to the regulation of plant immunity.

Autoren: Wang Y Huang W Zhang P et al.

Quelle: Plant physiology [Plant Physiol] 2025 Sep 01; Vol. 199 (1).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society of Plant Biologists Country of Publication: United States NLM ID: 0401224 Publication Model: Print Cited Medium: Internet ISSN: 1532-2548 (Electronic) Linking ISSN: 00320889 NLM ISO Abbreviation: Plant Physiol Subsets: MEDLINE

MeSH-Schlagworte: Plant Immunity*/genetics , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Arabidopsis*/immunology , Arabidopsis*/genetics , Arabidopsis*/metabolism , RNA Splicing Factors*/metabolism , RNA Splicing Factors*/genetics , RNA Precursors*/metabolism , RNA Precursors*/genetics, Gene Expression Regulation, Plant ; Plant Diseases/immunology ; Plant Diseases/microbiology ; RNA Splicing ; Disease Resistance/genetics ; Mutation

Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer.

Autoren: Naro C Ruta V Sette C

Quelle: Trends in molecular medicine [Trends Mol Med] 2025 Jul; Vol. 31 (7), pp. 610-624. Date of Electronic Publication: 2024 Dec 07.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966035 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-499X (Electronic) Linking ISSN: 14714914 NLM ISO Abbreviation: Trends Mol Med Subsets: MEDLINE

MeSH-Schlagworte: Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/therapy , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/metabolism , RNA Splicing* , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/drug therapy , Gene Expression Regulation, Neoplastic*, Humans ; Animals ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism ; Molecular Targeted Therapy

The cancer-associated SF3B1 ^K700E spliceosome mutation confers enhanced sensitivity to BV-6-induced cytotoxicity.

Autoren: Roets LE Blayney JK McMillan HP et al.

Quelle: Cell death & disease [Cell Death Dis] 2025 Jul 01; Vol. 16 (1), pp. 476. Date of Electronic Publication: 2025 Jul 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH-Schlagworte: RNA Splicing Factors*/genetics , RNA Splicing Factors*/metabolism , Phosphoproteins*/genetics , Phosphoproteins*/metabolism , Spliceosomes*/genetics , Spliceosomes*/metabolism , Spliceosomes*/drug effects , Neoplasms*/genetics , Neoplasms*/pathology , Neoplasms*/drug therapy , Mutation*/genetics, Humans ; Cell Line, Tumor ; Apoptosis/drug effects ; Apoptosis/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA Splicing/drug effects

Spliced to kill: RNA mis-splicing derived cancer neoantigens.

Autoren: Prabhu AV Azar-Koussa C Siegfried Z et al.

Quelle: Trends in cancer [Trends Cancer] 2025 Jul; Vol. 11 (7), pp. 611-613. Date of Electronic Publication: 2025 Jun 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101665956 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-8025 (Electronic) Linking ISSN: 24058025 NLM ISO Abbreviation: Trends Cancer Subsets: MEDLINE

MeSH-Schlagworte: Antigens, Neoplasm*/immunology , Antigens, Neoplasm*/genetics , Neoplasms*/immunology , Neoplasms*/genetics , Neoplasms*/therapy , RNA Splicing*/genetics, Humans ; Cancer Vaccines/immunology ; T-Lymphocytes/immunology ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; RNA Splicing Factors/genetics ; Mutation ; Immunotherapy, Adoptive/methods ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/immunology

Cotyledon opening during seedling deetiolation is determined by ABA-mediated splicing regulation.

Autoren: Martín G Confraria A Zapata I et al.

Quelle: EMBO reports [EMBO Rep] 2025 Jul; Vol. 26 (14), pp. 3663-3678. Date of Electronic Publication: 2025 Jun 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

MeSH-Schlagworte: Abscisic Acid*/metabolism , Abscisic Acid*/pharmacology , Cotyledon*/genetics , Cotyledon*/metabolism , Cotyledon*/growth & development , Seedlings*/genetics , Seedlings*/growth & development , Seedlings*/metabolism , Arabidopsis*/genetics , Arabidopsis*/growth & development , Arabidopsis*/metabolism , Alternative Splicing* , RNA Splicing* , Etiolation*/genetics, Gene Expression Regulation, Plant ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Light ; RNA Splicing Factors/metabolism ; RNA Splicing Factors/genetics

New mechanistic insights into Prp22-mediated exon ligation and mRNA release.

Autoren: Chung CS Tseng CK Chen HC et al.

Quelle: Nucleic acids research [Nucleic Acids Res] 2025 Aug 27; Vol. 53 (16).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH-Schlagworte: Exons* , Saccharomyces cerevisiae Proteins*/metabolism , Saccharomyces cerevisiae Proteins*/genetics , Saccharomyces cerevisiae Proteins*/chemistry , RNA, Messenger*/metabolism , RNA, Messenger*/genetics , DEAD-box RNA Helicases*/metabolism , DEAD-box RNA Helicases*/genetics , DEAD-box RNA Helicases*/chemistry , RNA Splicing*, Adenosine Triphosphate/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Spliceosomes/metabolism ; Spliceosomes/genetics ; RNA Precursors/metabolism ; RNA Precursors/genetics ; RNA Splice Sites ; Hydrolysis ; Protein Binding ; RNA Splicing Factors

A Genetically-Informed Network Model of Myelodysplastic Syndrome: From Splicing Aberrations to Therapeutic Vulnerabilities.

Autoren: Yu S Kim J Kim MS

Quelle: Genes [Genes (Basel)] 2025 Aug 01; Vol. 16 (8). Date of Electronic Publication: 2025 Aug 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

MeSH-Schlagworte: Myelodysplastic Syndromes*/genetics , Myelodysplastic Syndromes*/pathology , Myelodysplastic Syndromes*/therapy , RNA Splicing* , Gene Regulatory Networks*, Humans ; Mutation ; Precision Medicine ; RNA Splicing Factors/genetics

CDK11, a splicing-associated kinase regulating gene expression.

Autoren: Hluchý M Blazek D

Quelle: Trends in cell biology [Trends Cell Biol] 2025 Aug; Vol. 35 (8), pp. 702-716. Date of Electronic Publication: 2024 Sep 07.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: RNA Splicing*/genetics , Cyclin-Dependent Kinases*/metabolism , Cyclin-Dependent Kinases*/genetics , Gene Expression Regulation*, Humans ; Animals ; Spliceosomes/metabolism ; RNA Splicing Factors ; Cell Cycle

Chromatin-bound U2AF2 splicing factor ensures exon inclusion.

Autoren: Wu W Ahmad K Henikoff S

Quelle: Molecular cell [Mol Cell] 2025 May 15; Vol. 85 (10), pp. 1982-1998.e4. Date of Electronic Publication: 2025 May 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH-Schlagworte: Exons* , Chromatin*/metabolism , Chromatin*/genetics , Ribonucleoproteins*/metabolism , Ribonucleoproteins*/genetics , Nuclear Proteins*/metabolism , Nuclear Proteins*/genetics , RNA Splicing* , Alternative Splicing*, Humans ; Splicing Factor U2AF/metabolism ; Splicing Factor U2AF/genetics ; K562 Cells ; RNA Splicing Factors/metabolism ; RNA Splicing Factors/genetics ; Histones/metabolism ; Histones/genetics ; Promoter Regions, Genetic ; Introns ; RNA Polymerase II/metabolism ; Phosphoproteins/metabolism ; Phosphoproteins/genetics ; Protein Binding ; Methylation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism

Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets.

Autoren: Fuentes-Fayos AC G-García ME Sánchez-Medianero T et al.

Quelle: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Jun 28; Vol. 13 (1), pp. 142. Date of Electronic Publication: 2025 Jun 28.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

MeSH-Schlagworte: Craniopharyngioma*/genetics , Craniopharyngioma*/metabolism , Craniopharyngioma*/pathology , Pituitary Neoplasms*/genetics , Pituitary Neoplasms*/metabolism , Pituitary Neoplasms*/pathology , Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/genetics , RNA Splicing Factors*/metabolism , RNA Splicing Factors*/genetics , Serine-Arginine Splicing Factors*/metabolism , Serine-Arginine Splicing Factors*/genetics, Humans ; Male ; Female ; Spliceosomes/metabolism ; RNA Splicing ; Adult ; Middle Aged ; RNA-Binding Proteins