Suchergebnisse - "RNA Polymerase II (mesh)"

Molecular model of TFIIH recruitment to the transcription-coupled repair machinery

Autoren: Paul, Tanmoy Yan, Chunli Yu, Jina et al.

Quelle: Nature Communications. 16(1)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 31 Biological Sciences (for-2020), Genetics (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), Generic health relevance (hrcs-hc), Transcription Factor TFIIH (mesh), DNA Repair (mesh), Humans (mesh), RNA Polymerase II (mesh), DNA Helicases (mesh), DNA Repair Enzymes (mesh), Poly-ADP-Ribose Binding Proteins (mesh), Transcription, Genetic (mesh), Models, Molecular (mesh), DNA Damage (mesh), Protein Binding (mesh), DNA-Binding Proteins (mesh), DNA (mesh), Excision Repair (mesh), Carrier Proteins (mesh), Humans (mesh), DNA Damage (mesh), DNA Repair Enzymes (mesh), DNA Helicases (mesh), RNA Polymerase II (mesh), Carrier Proteins (mesh), DNA-Binding Proteins (mesh), DNA (mesh), DNA Repair (mesh), Transcription, Genetic (mesh), Protein Binding (mesh), Models, Molecular (mesh), Transcription Factor TFIIH (mesh), Poly-ADP-Ribose Binding Proteins (mesh), Excision Repair (mesh), Transcription Factor TFIIH (mesh), DNA Repair (mesh), Humans (mesh), RNA Polymerase II (mesh), DNA Helicases (mesh), DNA Repair Enzymes (mesh), Poly-ADP-Ribose Binding Proteins (mesh), Transcription, Genetic (mesh), Models, Molecular (mesh), DNA Damage (mesh), Protein Binding (mesh), DNA-Binding Proteins (mesh), DNA (mesh), Excision Repair (mesh), Carrier Proteins (mesh)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/7rd6j35k
https://escholarship.org/content/qt7rd6j35k/qt7rd6j35k.pdf

PRC2-EZH1 contributes to circadian gene expression by orchestrating chromatin states and RNA polymerase II complex stability

Autoren: Liu, Peng Nadeef, Seba Serag, Maged F et al.

Quelle: The EMBO Journal. 43(23)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 3102 Bioinformatics and Computational Biology (for-2020), 31 Biological Sciences (for-2020), Genetics (rcdc), Sleep Research (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), Generic health relevance (hrcs-hc), RNA Polymerase II (mesh), Animals (mesh), Chromatin (mesh), Polycomb Repressive Complex 2 (mesh), Mice (mesh), Circadian Rhythm (mesh), ARNTL Transcription Factors (mesh), Gene Expression Regulation (mesh), Transcription, Genetic (mesh), Circadian Rhythm, EZH1, Transcription, Circadian Rhythm, EZH1, Transcription, Chromatin (mesh), Animals (mesh), Mice (mesh), RNA Polymerase II (mesh), Transcription, Genetic (mesh), Gene Expression Regulation (mesh), Circadian Rhythm (mesh), ARNTL Transcription Factors (mesh), Polycomb Repressive Complex 2 (mesh), Circadian Rhythm, EZH1, H3K27me3, Transcription, RNA Polymerase II (mesh), Animals (mesh), Chromatin (mesh), Polycomb Repressive Complex 2 (mesh), Mice (mesh), Circadian Rhythm (mesh), ARNTL Transcription Factors (mesh), Gene Expression Regulation (mesh), Transcription, Genetic (mesh), 06 Biological Sciences (for), 08 Information and Computing Sciences (for), 11 Medical and Health Sciences (for), Developmental Biology (science-metrix), 31 Biological sciences (for-2020), 32 Biomedical and clinical sciences (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/158439vq
https://escholarship.org/content/qt158439vq/qt158439vq.pdf

Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation

Autoren: Zhang, Xuan Xu, Jun Hu, Jing et al.

Quelle: Nature Communications. 15(1)

Schlagwörter: 31 Biological Sciences (for-2020), 3102 Bioinformatics and Computational Biology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 3105 Genetics (for-2020), Intellectual and Developmental Disabilities (IDD) (rcdc), Aging (rcdc), Brain Disorders (rcdc), Genetics (rcdc), Human Genome (rcdc), Rare Diseases (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), Cockayne Syndrome (mesh), RNA Polymerase II (mesh), Animals (mesh), Humans (mesh), Poly-ADP-Ribose Binding Proteins (mesh), DNA Repair Enzymes (mesh), Mice (mesh), DNA Helicases (mesh), Genomic Instability (mesh), R-Loop Structures (mesh), DNA Repair (mesh), Transcription Elongation, Genetic (mesh), Mice, Knockout (mesh), Animals (mesh), Mice, Knockout (mesh), Humans (mesh), Mice (mesh), Cockayne Syndrome (mesh), Genomic Instability (mesh), DNA Repair Enzymes (mesh), DNA Helicases (mesh), RNA Polymerase II (mesh), DNA Repair (mesh), Transcription Elongation, Genetic (mesh), Poly-ADP-Ribose Binding Proteins (mesh), R-Loop Structures (mesh), Cockayne Syndrome (mesh), RNA Polymerase II (mesh), Animals (mesh), Humans (mesh), Poly-ADP-Ribose Binding Proteins (mesh), DNA Repair Enzymes (mesh), Mice (mesh), DNA Helicases (mesh), Genomic Instability (mesh), R-Loop Structures (mesh), DNA Repair (mesh), Transcription Elongation, Genetic (mesh), Mice, Knockout (mesh)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/6fs1p2gb
https://escholarship.org/content/qt6fs1p2gb/qt6fs1p2gb.pdf

CLSY docking to Pol IV requires a conserved domain critical for small RNA biogenesis and transposon silencing

Autoren: Felgines, Luisa Rymen, Bart Martins, Laura M et al.

Quelle: Nature Communications. 15(1)

Schlagwörter: 31 Biological Sciences (for-2020), 3102 Bioinformatics and Computational Biology (for-2020), Genetics (rcdc), Human Genome (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), Generic health relevance (hrcs-hc), DNA Transposable Elements (mesh), Arabidopsis Proteins (mesh), DNA-Directed RNA Polymerases (mesh), Gene Silencing (mesh), Arabidopsis (mesh), RNA, Small Interfering (mesh), Gene Expression Regulation, Plant (mesh), RNA Polymerase II (mesh), Protein Binding (mesh), Protein Domains (mesh), Conserved Sequence (mesh), Arabidopsis (mesh), DNA-Directed RNA Polymerases (mesh), RNA Polymerase II (mesh), Arabidopsis Proteins (mesh), RNA, Small Interfering (mesh), DNA Transposable Elements (mesh), Gene Expression Regulation, Plant (mesh), Gene Silencing (mesh), Conserved Sequence (mesh), Protein Binding (mesh), Protein Domains (mesh), DNA Transposable Elements (mesh), Arabidopsis Proteins (mesh), DNA-Directed RNA Polymerases (mesh), Gene Silencing (mesh), Arabidopsis (mesh), RNA, Small Interfering (mesh), Gene Expression Regulation, Plant (mesh), RNA Polymerase II (mesh), Protein Binding (mesh), Protein Domains (mesh), Conserved Sequence (mesh)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/2x46d2gj
https://escholarship.org/content/qt2x46d2gj/qt2x46d2gj.pdf

Manipulation of RNA polymerase III by Herpes Simplex Virus-1

Autoren: Dremel, Sarah E Sivrich, Frances L Tucker, Jessica M et al.

Quelle: Nature Communications. 13(1)

Schlagwörter: 3107 Microbiology (for-2020), 31 Biological Sciences (for-2020), 32 Biomedical and Clinical Sciences (for-2020), Genetics (rcdc), Sexually Transmitted Infections (rcdc), Infectious Diseases (rcdc), 2.2 Factors relating to the physical environment (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), Infection (hrcs-hc), Genome, Viral (mesh), Herpesvirus 1, Human (mesh), Humans (mesh), Promoter Regions, Genetic (mesh), RNA Polymerase II (mesh), RNA Polymerase III (mesh), RNA, Messenger (mesh), RNA, Transfer (mesh), RNA, Untranslated (mesh), Transcription Factors (mesh), Transcription, Genetic (mesh), Transcriptional Activation (mesh), Virus Replication (mesh), Humans (mesh), Herpesvirus 1, Human (mesh), RNA Polymerase II (mesh), RNA Polymerase III (mesh), Transcription Factors (mesh), RNA, Messenger (mesh), RNA, Transfer (mesh), RNA, Untranslated (mesh), Virus Replication (mesh), Transcription, Genetic (mesh), Genome, Viral (mesh), Promoter Regions, Genetic (mesh), Transcriptional Activation (mesh), Genome, Viral (mesh), Herpesvirus 1, Human (mesh), Humans (mesh), Promoter Regions, Genetic (mesh), RNA Polymerase II (mesh), RNA Polymerase III (mesh), RNA, Messenger (mesh), RNA, Transfer (mesh), RNA, Untranslated (mesh), Transcription Factors (mesh), Transcription, Genetic (mesh), Transcriptional Activation (mesh), Virus Replication (mesh)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/19d476n8
https://escholarship.org/content/qt19d476n8/qt19d476n8.pdf

Identification of the human DPR core promoter element using machine learning

Autoren: Vo ngoc, Long Huang, Cassidy Yunjing Cassidy, California Jack et al.

Quelle: Nature. 585(7825)

Schlagwörter: 31 Biological Sciences (for-2020), 3102 Bioinformatics and Computational Biology (for-2020), Machine Learning and Artificial Intelligence (rcdc), Genetics (rcdc), Base Sequence (mesh), Cells (mesh), Computer Simulation (mesh), Consensus Sequence (mesh), Datasets as Topic (mesh), Gene Expression Regulation (mesh), HeLa Cells (mesh), High-Throughput Nucleotide Sequencing (mesh), Humans (mesh), Models, Genetic (mesh), Mutagenesis (mesh), Promoter Regions, Genetic (mesh), RNA Polymerase II (mesh), Support Vector Machine (mesh), TATA Box (mesh), Transcription, Genetic (mesh), Cells (mesh), Hela Cells (mesh), Humans (mesh), RNA Polymerase II (mesh), Transcription, Genetic (mesh), Gene Expression Regulation (mesh), Mutagenesis (mesh), Base Sequence (mesh), TATA Box (mesh), Consensus Sequence (mesh), Models, Genetic (mesh), Computer Simulation (mesh), Promoter Regions, Genetic (mesh), High-Throughput Nucleotide Sequencing (mesh), Datasets as Topic (mesh), Support Vector Machine (mesh), Base Sequence (mesh), Cells (mesh), Computer Simulation (mesh), Consensus Sequence (mesh), Datasets as Topic (mesh), Gene Expression Regulation (mesh), HeLa Cells (mesh), High-Throughput Nucleotide Sequencing (mesh), Humans (mesh), Models, Genetic (mesh), Mutagenesis (mesh), Promoter Regions, Genetic (mesh), RNA Polymerase II (mesh), Support Vector Machine (mesh), TATA Box (mesh), Transcription, Genetic (mesh), General Science & Technology (science-metrix)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/1wj60543
https://escholarship.org/content/qt1wj60543/qt1wj60543.pdf

Deficiency in classical nonhomologous end-joining–mediated repair of transcribed genes is linked to SCA3 pathogenesis

Autoren: Chakraborty, Anirban Tapryal, Nisha Venkova, Tatiana et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America. 117(14)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 31 Biological Sciences (for-2020), Genetics (rcdc), Rare Diseases (rcdc), Neurosciences (rcdc), Brain Disorders (rcdc), Neurodegenerative (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 1.1 Normal biological development and functioning (hrcs-rac), Neurological (hrcs-hc), Aged, 80 and over (mesh), Animals (mesh), Animals, Genetically Modified (mesh), Ataxin-3 (mesh), Brain (mesh), Cell Line (mesh), DNA Breaks, Double-Stranded (mesh), DNA End-Joining Repair (mesh), DNA Repair Enzymes (mesh), Disease Models, Animal (mesh), Drosophila (mesh), Female (mesh), Gene Knockdown Techniques (mesh), Humans (mesh), Induced Pluripotent Stem Cells (mesh), Machado-Joseph Disease (mesh), Male (mesh), Mice (mesh), Middle Aged (mesh), Mutation (mesh), Peptides (mesh), Phosphotransferases (Alcohol Group Acceptor) (mesh), RNA Polymerase II (mesh), RNA, Small Interfering (mesh), Repressor Proteins (mesh), ATXN3, DNA double-strand break repair, PNKP, RNA-templated TC-NHEJ, spinocerebellar ataxia type-3, Brain (mesh), Cell Line (mesh), Animals (mesh), Animals, Genetically Modified (mesh), Humans (mesh), Mice (mesh), Drosophila (mesh), Machado-Joseph Disease (mesh), Disease Models, Animal (mesh), DNA Repair Enzymes (mesh), RNA Polymerase II (mesh), Phosphotransferases (Alcohol Group Acceptor) (mesh), Peptides (mesh), Repressor Proteins (mesh), RNA, Small Interfering (mesh), Mutation (mesh), Aged, 80 and over (mesh), Middle Aged (mesh), Female (mesh), Male (mesh), DNA Breaks, Double-Stranded (mesh), Gene Knockdown Techniques (mesh), Induced Pluripotent Stem Cells (mesh), DNA End-Joining Repair (mesh), Ataxin-3 (mesh), ATXN3, DNA double-strand break repair, PNKP, RNA-templated TC-NHEJ, spinocerebellar ataxia type-3, Aged, 80 and over (mesh), Animals (mesh), Animals, Genetically Modified (mesh), Ataxin-3 (mesh), Brain (mesh), Cell Line (mesh), DNA Breaks, Double-Stranded (mesh), DNA End-Joining Repair (mesh), DNA Repair Enzymes (mesh), Disease Models, Animal (mesh), Drosophila (mesh), Female (mesh), Gene Knockdown Techniques (mesh), Humans (mesh), Induced Pluripotent Stem Cells (mesh), Machado-Joseph Disease (mesh), Male (mesh), Mice (mesh), Middle Aged (mesh), Mutation (mesh), Peptides (mesh), Phosphotransferases (Alcohol Group Acceptor) (mesh), RNA Polymerase II (mesh), RNA, Small Interfering (mesh), Repressor Proteins (mesh)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/0wj3q1p9
https://escholarship.org/content/qt0wj3q1p9/qt0wj3q1p9.pdf

Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling

Autoren: Karbassi, Elaheh Rosa-Garrido, Manuel Chapski, Douglas J et al.

Quelle: Journal of Molecular and Cellular Cardiology. 128

Schlagwörter: 31 Biological Sciences (for-2020), 3208 Medical Physiology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), Bioengineering (rcdc), Heart Disease (rcdc), Genetics (rcdc), Cardiovascular (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), Cardiovascular (hrcs-hc), Animals (mesh), Animals, Newborn (mesh), Chromatin (mesh), Gene Expression Regulation (mesh), Heart (mesh), Heart Failure (mesh), Humans (mesh), In Situ Hybridization, Fluorescence (mesh), Mice (mesh), Molecular Imaging (mesh), Myocytes, Cardiac (mesh), RNA Polymerase II (mesh), Transcription, Genetic (mesh), Transcriptional Activation (mesh), Transcriptional regulation, Epigenomics, Chromatin structure, Heart disease, Heart (mesh), Chromatin (mesh), Myocytes, Cardiac (mesh), Animals (mesh), Animals, Newborn (mesh), Humans (mesh), Mice (mesh), RNA Polymerase II (mesh), In Situ Hybridization, Fluorescence (mesh), Transcription, Genetic (mesh), Gene Expression Regulation (mesh), Heart Failure (mesh), Transcriptional Activation (mesh), Molecular Imaging (mesh), Chromatin structure, Epigenomics, Heart disease, Transcriptional regulation, Animals (mesh), Animals, Newborn (mesh), Chromatin (mesh), Gene Expression Regulation (mesh), Heart (mesh), Heart Failure (mesh), Humans (mesh), In Situ Hybridization, Fluorescence (mesh), Mice (mesh), Molecular Imaging (mesh), Myocytes, Cardiac (mesh), RNA Polymerase II (mesh), Transcription, Genetic (mesh), Transcriptional Activation (mesh), 1102 Cardiorespiratory Medicine and Haematology (for), 1116 Medical Physiology (for), Cardiovascular System & Hematology (science-metrix), 3101 Biochemistry and cell biology (for-2020), 3201 Cardiovascular medicine and haematology (for-2020), 3208 Medical physiology (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/40x1103n
https://escholarship.org/content/qt40x1103n/qt40x1103n.pdf

A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells

Autoren: Ghezzi, Chiara Wong, Alicia Chen, Bao Ying et al.

Quelle: Nature Communications. 10(1)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 31 Biological Sciences (for-2020), Biotechnology (rcdc), Cancer (rcdc), Lung (rcdc), Lung Cancer (rcdc), Genetics (rcdc), 5.1 Pharmaceuticals (hrcs-rac), 1.1 Normal biological development and functioning (hrcs-rac), Cancer (hrcs-hc), A549 Cells (mesh), Carcinoma, Non-Small-Cell Lung (mesh), Cell Line, Tumor (mesh), Class I Phosphatidylinositol 3-Kinases (mesh), Cyclin-Dependent Kinases (mesh), Glucose (mesh), Glucose Transporter Type 1 (mesh), High-Throughput Screening Assays (mesh), Humans (mesh), Lung Neoplasms (mesh), Phenylenediamines (mesh), Phosphorylation (mesh), Protein Kinase Inhibitors (mesh), Pyrazoles (mesh), Pyrimidines (mesh), Quinazolines (mesh), RNA Polymerase II (mesh), RNA, Messenger (mesh), Signal Transduction (mesh), Triazines (mesh), Cyclin-Dependent Kinase-Activating Kinase (mesh), Cell Line, Tumor (mesh), Humans (mesh), Carcinoma, Non-Small-Cell Lung (mesh), Lung Neoplasms (mesh), Phenylenediamines (mesh), Pyrazoles (mesh), Pyrimidines (mesh), Triazines (mesh), Quinazolines (mesh), RNA Polymerase II (mesh), Cyclin-Dependent Kinases (mesh), Glucose (mesh), RNA, Messenger (mesh), Protein Kinase Inhibitors (mesh), Signal Transduction (mesh), Phosphorylation (mesh), Glucose Transporter Type 1 (mesh), High-Throughput Screening Assays (mesh), Class I Phosphatidylinositol 3-Kinases (mesh), A549 Cells (mesh), Cyclin-Dependent Kinase-Activating Kinase (mesh), A549 Cells (mesh), Carcinoma, Non-Small-Cell Lung (mesh), Cell Line, Tumor (mesh), Class I Phosphatidylinositol 3-Kinases (mesh), Cyclin-Dependent Kinases (mesh), Glucose (mesh), Glucose Transporter Type 1 (mesh), High-Throughput Screening Assays (mesh), Humans (mesh), Lung Neoplasms (mesh), Phenylenediamines (mesh), Phosphorylation (mesh), Protein Kinase Inhibitors (mesh), Pyrazoles (mesh), Pyrimidines (mesh), Quinazolines (mesh), RNA Polymerase II (mesh), RNA, Messenger (mesh), Signal Transduction (mesh), Triazines (mesh), Cyclin-Dependent Kinase-Activating Kinase (mesh)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/62f4s4x1
https://escholarship.org/content/qt62f4s4x1/qt62f4s4x1.pdf

Influenza virus infection causes global RNAPII termination defects

Autoren: Zhao, Nan Sebastiano, Vittorio Moshkina, Natasha et al.

Quelle: Nature Structural & Molecular Biology. 25(9)

Schlagwörter: 31 Biological Sciences (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 3107 Microbiology (for-2020), 3202 Clinical Sciences (for-2020), 3207 Medical Microbiology (for-2020), Emerging Infectious Diseases (rcdc), Genetics (rcdc), Influenza (rcdc), Pneumonia & Influenza (rcdc), Biodefense (rcdc), Infectious Diseases (rcdc), 2.2 Factors relating to the physical environment (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), 1.1 Normal biological development and functioning (hrcs-rac), Infection (hrcs-hc), Humans (mesh), Influenza A virus (mesh), Influenza, Human (mesh), RNA Polymerase II (mesh), Terminator Regions, Genetic (mesh), Virulence (mesh), Humans (mesh), Influenza A virus (mesh), RNA Polymerase II (mesh), Virulence (mesh), Influenza, Human (mesh), Terminator Regions, Genetic (mesh), Humans (mesh), Influenza A virus (mesh), Influenza, Human (mesh), RNA Polymerase II (mesh), Terminator Regions, Genetic (mesh), Virulence (mesh), 03 Chemical Sciences (for), 06 Biological Sciences (for), 11 Medical and Health Sciences (for), Biophysics (science-metrix), Developmental Biology (science-metrix), 31 Biological sciences (for-2020), 32 Biomedical and clinical sciences (for-2020), 34 Chemical sciences (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/3mk9r88p
https://escholarship.org/content/qt3mk9r88p/qt3mk9r88p.pdf

The cryo-electron microscopy structure of human transcription factor IIH

Autoren: Greber, Basil J Nguyen, Thi Hoang Duong Fang, Jie et al.

Quelle: Nature. 549(7672)

Schlagwörter: 51 Physical Sciences (for-2020), 5104 Condensed Matter Physics (for-2020), Genetics (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), Generic health relevance (hrcs-hc), Adenosine Triphosphatases (mesh), Adenosine Triphosphate (mesh), Cryoelectron Microscopy (mesh), Humans (mesh), Models, Molecular (mesh), Mutation (mesh), Protein Subunits (mesh), RNA Polymerase II (mesh), Transcription Factor TFIIH (mesh), Transcription Initiation, Genetic (mesh), Humans (mesh), RNA Polymerase II (mesh), Protein Subunits (mesh), Adenosine Triphosphate (mesh), Cryoelectron Microscopy (mesh), Mutation (mesh), Models, Molecular (mesh), Transcription Factor TFIIH (mesh), Adenosine Triphosphatases (mesh), Transcription Initiation, Genetic (mesh), Adenosine Triphosphatases (mesh), Adenosine Triphosphate (mesh), Cryoelectron Microscopy (mesh), Humans (mesh), Models, Molecular (mesh), Mutation (mesh), Protein Subunits (mesh), RNA Polymerase II (mesh), Transcription Factor TFIIH (mesh), Transcription Initiation, Genetic (mesh), General Science & Technology (science-metrix)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/4s13w81q
https://escholarship.org/content/qt4s13w81q/qt4s13w81q.pdf

Near-atomic resolution visualization of human transcription promoter opening

Autoren: He, Yuan Yan, Chunli Fang, Jie et al.

Quelle: Nature. 533(7603)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 51 Physical Sciences (for-2020), 31 Biological Sciences (for-2020), Genetics (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), Generic health relevance (hrcs-hc), Cryoelectron Microscopy (mesh), DNA (mesh), DNA Helicases (mesh), DNA-Binding Proteins (mesh), HeLa Cells (mesh), Humans (mesh), Models, Molecular (mesh), Movement (mesh), Multiprotein Complexes (mesh), Promoter Regions, Genetic (mesh), Protein Conformation (mesh), RNA Polymerase II (mesh), Saccharomyces cerevisiae (mesh), Transcription Elongation, Genetic (mesh), Transcription Factors, TFII (mesh), Transcription Initiation, Genetic (mesh), Hela Cells (mesh), Humans (mesh), Saccharomyces cerevisiae (mesh), Multiprotein Complexes (mesh), DNA Helicases (mesh), RNA Polymerase II (mesh), DNA-Binding Proteins (mesh), Transcription Factors, TFII (mesh), DNA (mesh), Cryoelectron Microscopy (mesh), Protein Conformation (mesh), Movement (mesh), Models, Molecular (mesh), Promoter Regions, Genetic (mesh), Transcription Elongation, Genetic (mesh), Transcription Initiation, Genetic (mesh), Cryoelectron Microscopy (mesh), DNA (mesh), DNA Helicases (mesh), DNA-Binding Proteins (mesh), HeLa Cells (mesh), Humans (mesh), Models, Molecular (mesh), Movement (mesh), Multiprotein Complexes (mesh), Promoter Regions, Genetic (mesh), Protein Conformation (mesh), RNA Polymerase II (mesh), Saccharomyces cerevisiae (mesh), Transcription Elongation, Genetic (mesh), Transcription Factors, TFII (mesh), Transcription Initiation, Genetic (mesh), General Science & Technology (science-metrix)

Zugangs-URL: https://escholarship.org/uc/item/00p826rv

Proteomics studies of the interactome of RNA polymerase II C-terminal repeated domain

Autoren: Pineda, Gabriel Shen, Zhouxin de Albuquerque, Claudio Ponte et al.

Quelle: BMC Research Notes. 8(1)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 1.1 Normal biological development and functioning (hrcs-rac), Generic health relevance (hrcs-hc), Amino Acid Sequence (mesh), Binding Sites (mesh), Cell Cycle Proteins (mesh), Gamma Rays (mesh), Gene Expression Regulation (mesh), HeLa Cells (mesh), Humans (mesh), Models, Molecular (mesh), Molecular Sequence Data (mesh), Mutation (mesh), Neoplasm Proteins (mesh), Peptides (mesh), Phosphorylation (mesh), Protein Binding (mesh), Protein Interaction Domains and Motifs (mesh), Protein Structure, Secondary (mesh), Proteomics (mesh), RNA Polymerase II (mesh), Sequence Alignment (mesh), Serine (mesh), Signal Transduction (mesh), Tyrosine (mesh), Hela Cells (mesh), Humans (mesh), RNA Polymerase II (mesh), Tyrosine (mesh), Serine (mesh), Peptides (mesh), Cell Cycle Proteins (mesh), Neoplasm Proteins (mesh), Sequence Alignment (mesh), Proteomics (mesh), Signal Transduction (mesh), Gene Expression Regulation (mesh), Binding Sites (mesh), Amino Acid Sequence (mesh), Protein Structure, Secondary (mesh), Protein Binding (mesh), Phosphorylation (mesh), Mutation (mesh), Gamma Rays (mesh), Models, Molecular (mesh), Molecular Sequence Data (mesh), Protein Interaction Domains and Motifs (mesh), Amino Acid Sequence (mesh), Binding Sites (mesh), Cell Cycle Proteins (mesh), Gamma Rays (mesh), Gene Expression Regulation (mesh), HeLa Cells (mesh), Humans (mesh), Models, Molecular (mesh), Molecular Sequence Data (mesh), Mutation (mesh), Neoplasm Proteins (mesh), Peptides (mesh), Phosphorylation (mesh), Protein Binding (mesh), Protein Interaction Domains and Motifs (mesh), Protein Structure, Secondary (mesh), Proteomics (mesh), RNA Polymerase II (mesh), Sequence Alignment (mesh), Serine (mesh), Signal Transduction (mesh), Tyrosine (mesh), 0601 Biochemistry and Cell Biology (for), 1199 Other Medical and Health Sciences (for), Bioinformatics (science-metrix), 32 Biomedical and clinical sciences (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/2h19q3b4
https://escholarship.org/content/qt2h19q3b4/qt2h19q3b4.pdf

Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

Autoren: Wang, Lanfeng Zhou, Yu Xu, Liang et al.

Quelle: Nature. 523(7562)

Schlagwörter: 31 Biological Sciences (for-2020), 3105 Genetics (for-2020), Genetics (rcdc), Generic health relevance (hrcs-hc), 5-Methylcytosine (mesh), Crystallography, X-Ray (mesh), Cytosine (mesh), DNA Methylation (mesh), DNA Repair (mesh), Epigenesis, Genetic (mesh), Hydrogen Bonding (mesh), Kinetics (mesh), RNA Polymerase II (mesh), Saccharomyces cerevisiae (mesh), Substrate Specificity (mesh), Templates, Genetic (mesh), Thymine DNA Glycosylase (mesh), Transcription Elongation, Genetic (mesh), Saccharomyces cerevisiae (mesh), Cytosine (mesh), 5-Methylcytosine (mesh), Thymine DNA Glycosylase (mesh), RNA Polymerase II (mesh), Crystallography, X-Ray (mesh), DNA Methylation (mesh), DNA Repair (mesh), Epigenesis, Genetic (mesh), Substrate Specificity (mesh), Kinetics (mesh), Templates, Genetic (mesh), Hydrogen Bonding (mesh), Transcription Elongation, Genetic (mesh), 5-Methylcytosine (mesh), Crystallography, X-Ray (mesh), Cytosine (mesh), DNA Methylation (mesh), DNA Repair (mesh), Epigenesis, Genetic (mesh), Hydrogen Bonding (mesh), Kinetics (mesh), RNA Polymerase II (mesh), Saccharomyces cerevisiae (mesh), Substrate Specificity (mesh), Templates, Genetic (mesh), Thymine DNA Glycosylase (mesh), Transcription Elongation, Genetic (mesh), General Science & Technology (science-metrix)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/1mj1d6rx
https://escholarship.org/content/qt1mj1d6rx/qt1mj1d6rx.pdf

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

Autoren: McHugh, Colleen A Chen, Chun-Kan Chow, Amy et al.

Quelle: Nature. 521(7551)

Schlagwörter: 31 Biological Sciences (for-2020), 3102 Bioinformatics and Computational Biology (for-2020), Genetics (rcdc), Generic health relevance (hrcs-hc), Acetylation (mesh), Animals (mesh), Cell Line (mesh), DNA-Binding Proteins (mesh), Embryonic Stem Cells (mesh), Female (mesh), Gene Silencing (mesh), Heterogeneous-Nuclear Ribonucleoprotein U (mesh), Histone Deacetylases (mesh), Histones (mesh), Male (mesh), Mass Spectrometry (mesh), Mice (mesh), Nuclear Proteins (mesh), Nuclear Receptor Co-Repressor 2 (mesh), Polycomb Repressive Complex 2 (mesh), Protein Binding (mesh), RNA Polymerase II (mesh), RNA, Long Noncoding (mesh), RNA-Binding Proteins (mesh), Receptors, Cytoplasmic and Nuclear (mesh), Transcription, Genetic (mesh), X Chromosome (mesh), X Chromosome Inactivation (mesh), Lamin B Receptor (mesh), Cell Line (mesh), X Chromosome (mesh), Animals (mesh), Mice (mesh), Histone Deacetylases (mesh), RNA Polymerase II (mesh), RNA-Binding Proteins (mesh), Heterogeneous-Nuclear Ribonucleoprotein U (mesh), DNA-Binding Proteins (mesh), Nuclear Proteins (mesh), Histones (mesh), Receptors, Cytoplasmic and Nuclear (mesh), Transcription, Genetic (mesh), Gene Silencing (mesh), Protein Binding (mesh), Acetylation (mesh), Female (mesh), Male (mesh), X Chromosome Inactivation (mesh), Mass Spectrometry (mesh), Embryonic Stem Cells (mesh), Nuclear Receptor Co-Repressor 2 (mesh), Polycomb Repressive Complex 2 (mesh), RNA, Long Noncoding (mesh), Lamin B Receptor (mesh), Acetylation (mesh), Animals (mesh), Cell Line (mesh), DNA-Binding Proteins (mesh), Embryonic Stem Cells (mesh), Female (mesh), Gene Silencing (mesh), Heterogeneous-Nuclear Ribonucleoprotein U (mesh), Histone Deacetylases (mesh), Histones (mesh), Male (mesh), Mass Spectrometry (mesh), Mice (mesh), Nuclear Proteins (mesh), Nuclear Receptor Co-Repressor 2 (mesh), Polycomb Repressive Complex 2 (mesh), Protein Binding (mesh), RNA Polymerase II (mesh), RNA, Long Noncoding (mesh), RNA-Binding Proteins (mesh), Receptors, Cytoplasmic and Nuclear (mesh), Transcription, Genetic (mesh), X Chromosome (mesh), X Chromosome Inactivation (mesh), Lamin B Receptor (mesh), General Science & Technology (science-metrix)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/92z8k9kc
https://escholarship.org/content/qt92z8k9kc/qt92z8k9kc.pdf

RNA helicase DDX21 coordinates transcription and ribosomal RNA processing

Autoren: Calo, Eliezer Flynn, Ryan A Martin, Lance et al.

Quelle: Nature. 518(7538)

Schlagwörter: 31 Biological Sciences (for-2020), 3102 Bioinformatics and Computational Biology (for-2020), Genetics (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), Generic health relevance (hrcs-hc), Chromatin (mesh), DEAD-box RNA Helicases (mesh), Genes, rRNA (mesh), Humans (mesh), Positive Transcriptional Elongation Factor B (mesh), Protein Binding (mesh), RNA Polymerase I (mesh), RNA Polymerase II (mesh), RNA Processing, Post-Transcriptional (mesh), RNA, Ribosomal (mesh), RNA, Small Nucleolar (mesh), RNA-Binding Proteins (mesh), Ribonucleoproteins, Small Nuclear (mesh), Transcription, Genetic (mesh), Chromatin (mesh), Humans (mesh), RNA Polymerase I (mesh), RNA Polymerase II (mesh), RNA-Binding Proteins (mesh), Ribonucleoproteins, Small Nuclear (mesh), Positive Transcriptional Elongation Factor B (mesh), RNA, Small Nucleolar (mesh), RNA, Ribosomal (mesh), Transcription, Genetic (mesh), RNA Processing, Post-Transcriptional (mesh), Protein Binding (mesh), Genes, rRNA (mesh), DEAD-box RNA Helicases (mesh), Chromatin (mesh), DEAD-box RNA Helicases (mesh), Genes, rRNA (mesh), Humans (mesh), Positive Transcriptional Elongation Factor B (mesh), Protein Binding (mesh), RNA Polymerase I (mesh), RNA Polymerase II (mesh), RNA Processing, Post-Transcriptional (mesh), RNA, Ribosomal (mesh), RNA, Small Nucleolar (mesh), RNA-Binding Proteins (mesh), Ribonucleoproteins, Small Nuclear (mesh), Transcription, Genetic (mesh), General Science & Technology (science-metrix)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/1gc321p7
https://escholarship.org/content/qt1gc321p7/qt1gc321p7.pdf

Transcriptional interference by antisense RNA is required for circadian clock function

Autoren: Xue, Zhihong Ye, Qiaohong Anson, Simon R et al.

Quelle: Nature. 514(7524)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 31 Biological Sciences (for-2020), Genetics (rcdc), Neurosciences (rcdc), Sleep Research (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), Generic health relevance (hrcs-hc), Chromatin (mesh), Circadian Clocks (mesh), Circadian Rhythm (mesh), Feedback, Physiological (mesh), Gene Expression Regulation, Fungal (mesh), Gene Silencing (mesh), Genes, Fungal (mesh), Light (mesh), Neurospora crassa (mesh), RNA Polymerase II (mesh), RNA, Antisense (mesh), RNA, Untranslated (mesh), Transcription Termination, Genetic (mesh), Transcription, Genetic (mesh), Chromatin (mesh), Neurospora crassa (mesh), RNA Polymerase II (mesh), RNA, Antisense (mesh), RNA, Untranslated (mesh), Transcription, Genetic (mesh), Gene Expression Regulation, Fungal (mesh), Gene Silencing (mesh), Circadian Rhythm (mesh), Genes, Fungal (mesh), Light (mesh), Feedback, Physiological (mesh), Circadian Clocks (mesh), Transcription Termination, Genetic (mesh), Chromatin (mesh), Circadian Clocks (mesh), Circadian Rhythm (mesh), Feedback, Physiological (mesh), Gene Expression Regulation, Fungal (mesh), Gene Silencing (mesh), Genes, Fungal (mesh), Light (mesh), Neurospora crassa (mesh), RNA Polymerase II (mesh), RNA, Antisense (mesh), RNA, Untranslated (mesh), Transcription Termination, Genetic (mesh), Transcription, Genetic (mesh), General Science & Technology (science-metrix)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/9qh626g3
https://escholarship.org/content/qt9qh626g3/qt9qh626g3.pdf

MicroRNA-23b Regulates Cyclin-Dependent Kinase–Activating Kinase Complex Through Cyclin H Repression to Modulate Endothelial Transcription and Growth Under Flow

Autoren: Wang, Kuei-Chun Nguyen, Phu Weiss, Anna et al.

Quelle: Arteriosclerosis Thrombosis and Vascular Biology. 34(7)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 3201 Cardiovascular Medicine and Haematology (for-2020), 3202 Clinical Sciences (for-2020), Biotechnology (rcdc), Genetics (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 1.1 Normal biological development and functioning (hrcs-rac), Cardiovascular (hrcs-hc), Animals (mesh), Carotid Artery Diseases (mesh), Cell Cycle Checkpoints (mesh), Cell Proliferation (mesh), Cells, Cultured (mesh), Cyclin H (mesh), Cyclin-Dependent Kinases (mesh), Disease Models, Animal (mesh), Endothelial Cells (mesh), Human Umbilical Vein Endothelial Cells (mesh), Humans (mesh), Kruppel-Like Transcription Factors (mesh), Male (mesh), Mechanotransduction, Cellular (mesh), MicroRNAs (mesh), Perfusion (mesh), Phenotype (mesh), Pulsatile Flow (mesh), RNA Interference (mesh), RNA Polymerase II (mesh), Rats (mesh), Rats, Sprague-Dawley (mesh), Regional Blood Flow (mesh), Stress, Mechanical (mesh), Time Factors (mesh), Transcription, Genetic (mesh), Transfection (mesh), Cyclin-Dependent Kinase-Activating Kinase (mesh), cell cycle, endothelial cells, hemodynamics, microRNAs, Cells, Cultured (mesh), Endothelial Cells (mesh), Animals (mesh), Humans (mesh), Rats (mesh), Rats, Sprague-Dawley (mesh), Carotid Artery Diseases (mesh), Disease Models, Animal (mesh), RNA Polymerase II (mesh), Cyclin-Dependent Kinases (mesh), MicroRNAs (mesh), Transfection (mesh), Perfusion (mesh), Mechanotransduction, Cellular (mesh), Cell Proliferation (mesh), Transcription, Genetic (mesh), RNA Interference (mesh), Regional Blood Flow (mesh), Phenotype (mesh), Stress, Mechanical (mesh), Pulsatile Flow (mesh), Time Factors (mesh), Male (mesh), Kruppel-Like Transcription Factors (mesh), Cyclin H (mesh), Human Umbilical Vein Endothelial Cells (mesh), Cell Cycle Checkpoints (mesh), Cyclin-Dependent Kinase-Activating Kinase (mesh), cell cycle, endothelial cells, hemodynamics, microRNAs, Animals (mesh), Carotid Artery Diseases (mesh), Cell Cycle Checkpoints (mesh), Cell Proliferation (mesh), Cells, Cultured (mesh), Cyclin H (mesh), Cyclin-Dependent Kinases (mesh), Disease Models, Animal (mesh), Endothelial Cells (mesh), Human Umbilical Vein Endothelial Cells (mesh), Humans (mesh), Kruppel-Like Transcription Factors (mesh), Male (mesh), Mechanotransduction, Cellular (mesh), MicroRNAs (mesh), Perfusion (mesh), Phenotype (mesh), Pulsatile Flow (mesh), RNA Interference (mesh), RNA Polymerase II (mesh), Rats (mesh), Rats, Sprague-Dawley (mesh), Regional Blood Flow (mesh), Stress, Mechanical (mesh), Time Factors (mesh), Transcription, Genetic (mesh), Transfection (mesh), Cyclin-Dependent Kinase-Activating Kinase (mesh), 1102 Cardiorespiratory Medicine and Haematology (for), 1103 Clinical Sciences (for), Cardiovascular System & Hematology (science-metrix), 3201 Cardiovascular medicine and haematology (for-2020), 3202 Clinical sciences (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/91b6s04w
https://escholarship.org/content/qt91b6s04w/qt91b6s04w.pdf

Chromatin connectivity maps reveal dynamic promoter–enhancer long-range associations

Autoren: Zhang, Yubo Wong, Chee-Hong Birnbaum, Ramon Y et al.

Quelle: Nature. 504(7479)

Schlagwörter: 31 Biological Sciences (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 3103 Ecology (for-2020), Genetics (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), Animals (mesh), Cell Line (mesh), Cell Lineage (mesh), Chromatin (mesh), Embryonic Stem Cells (mesh), Enhancer Elements, Genetic (mesh), Gene Expression Regulation (mesh), In Situ Hybridization, Fluorescence (mesh), Mice (mesh), Neural Stem Cells (mesh), Promoter Regions, Genetic (mesh), RNA Polymerase II (mesh), Transcription, Genetic (mesh), Zebrafish (mesh), Cell Line (mesh), Chromatin (mesh), Animals (mesh), Zebrafish (mesh), Mice (mesh), RNA Polymerase II (mesh), In Situ Hybridization, Fluorescence (mesh), Transcription, Genetic (mesh), Gene Expression Regulation (mesh), Cell Lineage (mesh), Embryonic Stem Cells (mesh), Enhancer Elements, Genetic (mesh), Promoter Regions, Genetic (mesh), Neural Stem Cells (mesh), Animals (mesh), Cell Line (mesh), Cell Lineage (mesh), Chromatin (mesh), Embryonic Stem Cells (mesh), Enhancer Elements, Genetic (mesh), Gene Expression Regulation (mesh), In Situ Hybridization, Fluorescence (mesh), Mice (mesh), Neural Stem Cells (mesh), Promoter Regions, Genetic (mesh), RNA Polymerase II (mesh), Transcription, Genetic (mesh), Zebrafish (mesh), General Science & Technology (science-metrix)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/3h13r9mt
https://escholarship.org/content/qt3h13r9mt/qt3h13r9mt.pdf

Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

Autoren: Britt A. Glaunsinger Joel D. Federspiel Ella Hartenian et al.

Quelle: eLife
eLife, Vol 7 (2018)
eLife, vol 7

Schlagwörter: Gene Expression Regulation (mesh), 0301 basic medicine, Biomedical and clinical sciences, Transcription, Genetic, RNA Stability, Messenger, Mass Spectrometry (mesh), RNA decay, Mass Spectrometry, RNA Transport, RNA Transport (mesh), 31 Biological sciences (for-2020), Protein Binding (mesh), 2.1 Biological and endogenous factors, TATA-Box Binding Protein (mesh), Biology (General), Promoter Regions, Genetic, Poly(A)-Binding Proteins (mesh), Humans (mesh), Staining and Labeling (mesh), RNA-Binding Proteins, Biological Sciences, Chromosomes and Gene Expression, 3. Good health, Protein Transport, Infectious Diseases, Medicine, RNA binding proteins, RNA Polymerase II, Transcription, Microtubule-Associated Proteins, Protein Binding, chromosomes, RNA Stability (mesh), QH301-705.5, 1.1 Normal biological development and functioning, infectious disease, Science, 0601 Biochemistry and Cell Biology (for), Poly(A)-Binding Proteins, Protein Transport (mesh), Promoter Regions, 03 medical and health sciences, Genetic, 42 Health sciences (for-2020), Genetics, Humans, viruses, human, RNA, Messenger, mouse, 1.1 Normal biological development and functioning (hrcs-rac), HEK293 Cells (mesh), Messenger (mesh), 31 Biological Sciences (for-2020), Exoribonucleases (mesh), Staining and Labeling, Genetics (rcdc), microbiology, RNA Polymerase II (mesh), Health sciences, 2.1 Biological and endogenous factors (hrcs-rac), TATA-Box Binding Protein, Microtubule-Associated Proteins (mesh), 3101 Biochemistry and Cell Biology (for-2020), RNA-Binding Proteins (mesh), HEK293 Cells, 32 Biomedical and clinical sciences (for-2020), Gene Expression Regulation, Infectious Diseases (rcdc), Exoribonucleases, gene expression, Genetic (mesh), RNA, Biochemistry and Cell Biology

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/30281021
https://doaj.org/article/f0996b4607ea4be4b17b0cee7a771372
https://elifesciences.org/articles/37663
https://collaborate.princeton.edu/en/publications/changes-in-mrna-abundance-drive-shuttling-of-rna-binding-proteins
http://europepmc.org/articles/PMC6203436
https://escholarship.org/uc/item/1zb1n7bh
https://doi.org/10.7554/eLife.37663
http://www.ncbi.nlm.nih.gov/pubmed/30281021
https://www.biorxiv.org/content/10.1101/295972v2
https://www.biorxiv.org/content/biorxiv/early/2018/04/06/295972.full.pdf
https://www.biorxiv.org/content/early/2018/04/06/295972
https://escholarship.org/uc/item/1zb1n7bh