Search Results - "RHODOPSIN"

Small angle neutron scattering study of rhodopsin oligomerization and G-protein coupling in a physiologically relevant lipid membrane.

Authors: Soubias O Nickels JD Hines KG et al.

Source: Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2025 Dec; Vol. 1867 (8), pp. 184454. Date of Electronic Publication: 2025 Sep 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731713 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2642 (Electronic) Linking ISSN: 00052736 NLM ISO Abbreviation: Biochim Biophys Acta Biomembr Subsets: MEDLINE

MeSH Terms: Rhodopsin*/chemistry , Rhodopsin*/metabolism , Transducin*/metabolism , Transducin*/chemistry , GTP-Binding Proteins*/metabolism , GTP-Binding Proteins*/chemistry , Membrane Lipids*/chemistry , Membrane Lipids*/metabolism, Scattering, Small Angle ; Neutron Diffraction/methods ; Protein Multimerization ; Animals ; Cattle ; Lipid Bilayers/chemistry ; Lipid Bilayers/metabolism

Transcriptional downregulation of rhodopsin is associated with desensitization of rods to light-induced damage in a murine model of retinitis pigmentosa.

Authors: Takita S Harikrishnan H Miyagi M et al.

Source: Human molecular genetics [Hum Mol Genet] 2025 Nov 02; Vol. 34 (22), pp. 1884-1901.

Publication Type: Journal Article

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

MeSH Terms: Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/pathology , Retinitis Pigmentosa*/metabolism , Rhodopsin*/genetics , Rhodopsin*/metabolism , Retinal Rod Photoreceptor Cells*/metabolism , Retinal Rod Photoreceptor Cells*/pathology , Retinal Rod Photoreceptor Cells*/radiation effects, Animals ; Mice ; Disease Models, Animal ; Down-Regulation ; Light/adverse effects ; Mutation ; Cyclic Nucleotide Phosphodiesterases, Type 6/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 6/metabolism ; Humans ; Transducin/genetics ; Transducin/metabolism

Molecular and functional characterization of the retinitis pigmentosa G90V mutation in a conformationally stabilized rhodopsin background.

Authors: Fernandez-Gonzalez P Jencz S Smith SO et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 330 (Pt 2), pp. 148078. Date of Electronic Publication: 2025 Oct 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Rhodopsin*/genetics , Rhodopsin*/chemistry , Rhodopsin*/metabolism , Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/metabolism , Mutation*, Protein Stability ; Models, Molecular ; Disulfides/chemistry ; Animals ; Humans ; Protein Conformation ; Retinaldehyde/metabolism ; Retinaldehyde/chemistry

Apusomonad rhodopsins: A new family of ultraviolet to blue light-absorbing rhodopsin channels.

Authors: Galindo LJ Takaramoto S Nagata T et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Oct 21; Vol. 122 (42), pp. e2510619122. Date of Electronic Publication: 2025 Oct 13.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Light* , Rhodopsin*/metabolism , Rhodopsin*/genetics , Rhodopsin*/chemistry , Ultraviolet Rays* , Rhodopsins, Microbial*/metabolism , Rhodopsins, Microbial*/genetics, Phylogeny ; Blue Light

Light-induced FTIR Spectroscopy of Visual Rhodopsin Microcrystals Grown in Lipidic Cubic Phase.

Authors: Mizuno Y Panneels V Furutani Y et al.

Source: Journal of molecular biology [J Mol Biol] 2025 Dec 15; Vol. 437 (24), pp. 169487. Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH Terms: Rhodopsin*/chemistry , Light* , Lipids*/chemistry, Spectroscopy, Fourier Transform Infrared/methods ; Animals ; Cattle ; Crystallization ; Crystallography, X-Ray

A Survey of Opsin Localization, Glycosylation, and Light/Chromophore Influence on Degeneration in 26 Rhodopsin-Associated RP Models.

Authors: Loewen AD Tam BM Chiu CN et al.

Source: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Dec 01; Vol. 66 (15), pp. 9.

Publication Type: Journal Article

Journal Info: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

MeSH Terms: Rhodopsin*/genetics , Rhodopsin*/metabolism , Disease Models, Animal* , Retinal Degeneration*/metabolism , Retinal Degeneration*/genetics , Opsins*/metabolism, Animals ; Glycosylation ; Xenopus laevis ; Humans ; Animals, Genetically Modified ; Mutation ; Light ; Microscopy, Confocal

Optogenetic silencing by combining a rhodopsin cyclase with an engineered cGMP-gated potassium channel.

Authors: Spreen A Sadanandan NP Schneider MW et al.

Source: Science advances [Sci Adv] 2025 Nov 28; Vol. 11 (48), pp. eadx1195. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Cyclic GMP*/metabolism , Rhodopsin*/metabolism , Rhodopsin*/genetics , Guanylate Cyclase*/metabolism , Guanylate Cyclase*/genetics , Potassium Channels*/metabolism , Potassium Channels*/genetics, Animals ; Mice ; Humans ; Hippocampus/metabolism ; Hippocampus/cytology ; Zebrafish ; Protein Engineering ; Myocytes, Cardiac/metabolism ; Neurons/metabolism ; HEK293 Cells

Interferometric imaging of the reversible rhodopsin dynamics in the living rat eye.

Authors: Zhuo Y Li H Bhuckory M et al.

Source: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10730. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Rhodopsin*/metabolism , Rhodopsin*/chemistry , Interferometry*/methods , Retinal Rod Photoreceptor Cells*/metabolism, Animals ; Rats ; Tomography, Optical Coherence/methods ; Rod Cell Outer Segment/metabolism ; Ultraviolet Rays

Ambient light alleviates retinal neurodegeneration in mice by powering mitochondria via the engineered optoenergetic rhodopsin.

Authors: Yang RZ Wang Y Wu Z et al.

Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2025 Oct 30; Vol. 10 (1), pp. 355. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE

MeSH Terms: Mitochondria*/metabolism , Mitochondria*/genetics , Mitochondria*/radiation effects , Rhodopsin*/genetics , Rhodopsin*/metabolism , Light* , Retinal Degeneration*/genetics , Retinal Degeneration*/pathology , Retinal Degeneration*/metabolism , Retinal Degeneration*/therapy, Animals ; Mice ; Reactive Oxygen Species/metabolism ; Humans ; Adenosine Triphosphate/genetics ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology ; Retinal Ganglion Cells/radiation effects ; Disease Models, Animal ; Endoplasmic Reticulum Stress/radiation effects ; Endoplasmic Reticulum Stress/genetics

Autosomal dominant retinitis pigmentosa: An extended family report of the Asp-190-Tyr variant.

Authors: Moreira Martins P Ferreira C Saraiva E et al.

Source: Archivos de la Sociedad Espanola de Oftalmologia [Arch Soc Esp Oftalmol (Engl Ed)] 2025 Oct; Vol. 100 (10), pp. 585-591. Date of Electronic Publication: 2025 Jul 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier España Country of Publication: Spain NLM ID: 101715860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2173-5794 (Electronic) Linking ISSN: 21735794 NLM ISO Abbreviation: Arch Soc Esp Oftalmol (Engl Ed) Subsets: MEDLINE

MeSH Terms: Retinitis Pigmentosa*/genetics , Rhodopsin*/genetics, Humans ; Female ; Middle Aged ; Male ; Retrospective Studies ; Aged ; Pedigree ; Genes, Dominant ; Phenotype ; Adult ; Extended Family

Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota.

Authors: Fujiwara T Hosaka T Hasegawa-Takano M et al.

Source: Nature microbiology [Nat Microbiol] 2025 Oct; Vol. 10 (10), pp. 2603-2615. Date of Electronic Publication: 2025 Sep 04.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

MeSH Terms: Carotenoids*/metabolism , Carotenoids*/chemistry , Bacteroidetes*/metabolism , Bacteroidetes*/genetics , Rhodopsins, Microbial*/metabolism , Rhodopsins, Microbial*/chemistry , Rhodopsin*/metabolism , Rhodopsin*/chemistry, Cryoelectron Microscopy ; Aquatic Organisms/metabolism ; Seawater/microbiology ; Light ; Energy Transfer ; Protein Binding ; Bacterial Proteins/metabolism

A method for setting the melanopsin and rhodopsin content in commercial LED sources to investigate the effects of ambient light on behavior.

Authors: Nugent TW Zele AJ

Source: Behavior research methods [Behav Res Methods] 2025 Dec 02; Vol. 58 (1), pp. 14. Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101244316 Publication Model: Electronic Cited Medium: Internet ISSN: 1554-3528 (Electronic) Linking ISSN: 1554351X NLM ISO Abbreviation: Behav Res Methods Subsets: MEDLINE

MeSH Terms: Rod Opsins*/metabolism , Rhodopsin*/metabolism , Light* , Lighting*/methods , Lighting*/instrumentation, Humans ; Retinal Cone Photoreceptor Cells/physiology ; Algorithms

Reduced pupil light response to red light correlates with cone defect in Rho ^-/- mice.

Authors: Salamin E Crippa SV Martin C et al.

Source: Experimental eye research [Exp Eye Res] 2025 Dec; Vol. 261, pp. 110675. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 0370707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0007 (Electronic) Linking ISSN: 00144835 NLM ISO Abbreviation: Exp Eye Res Subsets: MEDLINE

MeSH Terms: Retinal Cone Photoreceptor Cells*/pathology , Retinal Cone Photoreceptor Cells*/metabolism , Retinal Cone Photoreceptor Cells*/physiology , Retinal Degeneration*/physiopathology , Retinal Degeneration*/metabolism , Retinal Degeneration*/genetics , Light* , Pupil*/physiology , Pupil*/radiation effects , Rhodopsin*/genetics, Animals ; Electroretinography ; Mice ; Mice, Knockout ; Rod Opsins/metabolism ; Rod Opsins/genetics ; Disease Models, Animal ; Retinal Ganglion Cells/metabolism ; Blotting, Western ; Mice, Inbred C57BL ; Photic Stimulation ; Transducin/metabolism ; Transducin/genetics ; Reflex, Pupillary/physiology ; Real-Time Polymerase Chain Reaction ; Retinal Rod Photoreceptor Cells ; Red Light ; Heterotrimeric GTP-Binding Proteins

Super-resolution microscopy reveals a Rab6a-dependent trafficking hub for rhodopsin at the mammalian rod photoreceptor Golgi.

Authors: Hekmatara M Thompson SL Haggerty KN et al.

Source: Biology open [Biol Open] 2025 Nov 15; Vol. 14 (11). Date of Electronic Publication: 2025 Nov 25.

Publication Type: Journal Article

Journal Info: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101578018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-6390 (Electronic) Linking ISSN: 20466390 NLM ISO Abbreviation: Biol Open Subsets: MEDLINE

MeSH Terms: Rhodopsin*/metabolism , Golgi Apparatus*/metabolism , Retinal Rod Photoreceptor Cells*/metabolism , rab GTP-Binding Proteins*/metabolism , rab GTP-Binding Proteins*/genetics, Animals ; Protein Transport ; Humans ; Mice ; HEK293 Cells

Small-Molecule Ligands of Rhodopsin and Their Therapeutic Potential in Retina Degeneration.

Authors: Pashandi Z Jastrzebska B

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Sep 15; Vol. 26 (18). Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Rhodopsin*/metabolism , Rhodopsin*/chemistry , Rhodopsin*/genetics , Small Molecule Libraries*/chemistry , Small Molecule Libraries*/pharmacology , Small Molecule Libraries*/therapeutic use , Retinal Degeneration*/drug therapy , Retinal Degeneration*/metabolism, Humans ; Ligands ; Animals

Structural basis for no retinal binding in flotillin-associated rhodopsins.

Authors: Kovalev K Stetsenko A Trunk F et al.

Source: Structure (London, England : 1993) [Structure] 2025 Sep 04; Vol. 33 (9), pp. 1462-1469.e3. Date of Electronic Publication: 2025 Jul 11.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

MeSH Terms: Membrane Proteins*/chemistry , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Rhodopsins, Microbial*/chemistry , Rhodopsins, Microbial*/metabolism , Rhodopsins, Microbial*/genetics , Retinaldehyde*/metabolism , Retinaldehyde*/chemistry , Rhodopsin*/chemistry , Rhodopsin*/metabolism , Rhodopsin*/genetics , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics, Binding Sites ; Protein Binding ; Models, Molecular ; Cryoelectron Microscopy

The role of retinal chromophore photoisomerization in enhanced inward proton-pumping activity of xenorhodopsin from Nanosalina.

Authors: Ito Y Nishikino T Kandori H et al.

Source: Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2025 Aug 01; Vol. 1866 (3), pp. 149556. Date of Electronic Publication: 2025 May 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2650 (Electronic) Linking ISSN: 00052728 NLM ISO Abbreviation: Biochim Biophys Acta Bioenerg Subsets: MEDLINE

MeSH Terms: Proton Pumps*/metabolism , Proton Pumps*/chemistry , Retinaldehyde*/chemistry , Retinaldehyde*/metabolism , Halobacteriaceae*/metabolism , Rhodopsin*/chemistry , Rhodopsin*/metabolism , Rhodopsins, Microbial*/chemistry , Rhodopsins, Microbial*/metabolism, Isomerism ; Protons ; Schiff Bases/chemistry ; Light ; Spectroscopy, Fourier Transform Infrared

SCR Organism: Natronomonas

Aggregation of the Constitutively Active K296E Rhodopsin Mutant Contributes to Retinal Degeneration.

Authors: Vasudevan S Prakash V Park PS

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Jul 31; Vol. 39 (14), pp. e70848.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Rhodopsin*/genetics , Rhodopsin*/metabolism , Rhodopsin*/chemistry , Retinal Degeneration*/genetics , Retinal Degeneration*/metabolism , Retinal Degeneration*/pathology , Mutation*, Animals ; Mice ; Humans ; Cattle ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/metabolism ; Gene Knock-In Techniques ; Mice, Transgenic ; Mice, Inbred C57BL

Correcting a patient-specific Rhodopsin mutation with adenine base editor in a mouse model.

Authors: He X Yan T Song Z et al.

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Jul 02; Vol. 33 (7), pp. 3101-3113. Date of Electronic Publication: 2025 Mar 20.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH Terms: Gene Editing*/methods , Adenine*/metabolism , Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/therapy , Mutation* , Rhodopsin*/genetics, Animals ; Disease Models, Animal ; Mice ; Humans ; Gene Knock-In Techniques ; Dependovirus/genetics ; Genetic Vectors/genetics ; Electroretinography ; RNA, Guide, CRISPR-Cas Systems/genetics ; CRISPR-Cas Systems ; Retina/metabolism ; Retina/pathology ; Genetic Therapy/methods

Neuroprotection of photoreceptors by combined inhibition of both Fas and autophagy pathways in P23H mice.

Authors: Yang M Yao J Jia L et al.

Source: Cell death & disease [Cell Death Dis] 2025 Jul 01; Vol. 16 (1), pp. 469. Date of Electronic Publication: 2025 Jul 01.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH Terms: Autophagy*/drug effects , fas Receptor*/antagonists & inhibitors , fas Receptor*/metabolism , fas Receptor*/genetics , Retinitis Pigmentosa*/pathology , Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/metabolism , Retinitis Pigmentosa*/drug therapy , Neuroprotection*/drug effects , Rhodopsin*/genetics , Rhodopsin*/metabolism , Photoreceptor Cells, Vertebrate*/metabolism , Photoreceptor Cells, Vertebrate*/drug effects , Photoreceptor Cells, Vertebrate*/pathology, Animals ; Mice ; Hydroxychloroquine/pharmacology ; Disease Models, Animal ; Signal Transduction/drug effects ; Mice, Inbred C57BL