Suchergebnisse - "RAS"

EC359 Enhances Trametinib Efficacy in Ras / Raf -Driven Ovarian Cancer by Suppressing LIFR Signaling.

Autoren: Arnold WC Panneerdoss DM Subramani B et al.

Quelle: Biomolecules [Biomolecules] 2025 Sep 30; Vol. 15 (10). Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

MeSH-Schlagworte: Pyrimidinones*/pharmacology , Pyrimidinones*/therapeutic use , Pyridones*/pharmacology , Pyridones*/therapeutic use , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Leukemia Inhibitory Factor Receptor alpha Subunit*/metabolism , Leukemia Inhibitory Factor Receptor alpha Subunit*/antagonists & inhibitors , Leukemia Inhibitory Factor Receptor alpha Subunit*/genetics , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/metabolism , raf Kinases*/metabolism , raf Kinases*/genetics, Female ; Humans ; Animals ; Signal Transduction/drug effects ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; ras Proteins/metabolism ; ras Proteins/genetics ; Cell Survival/drug effects

Ras-mediated dynamic and biphasic regulation of cell migration.

Autoren: Lin Y Parajón E Yuan Q et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul 29; Vol. 122 (30), pp. e2503847122. Date of Electronic Publication: 2025 Jul 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Cell Movement*/physiology , ras Proteins*/metabolism , ras Proteins*/genetics, Signal Transduction ; Humans ; Animals ; ras GTPase-Activating Proteins/metabolism ; ras GTPase-Activating Proteins/genetics ; Optogenetics ; Cell Membrane/metabolism

The RAS-MEK-ERK pathway in low-grade serous ovarian cancer.

Autoren: Stover EH Lee EK Shapiro GI et al.

Quelle: Gynecologic oncology [Gynecol Oncol] 2025 Sep; Vol. 200, pp. 22-32. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0365304 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6859 (Electronic) Linking ISSN: 00908258 NLM ISO Abbreviation: Gynecol Oncol Subsets: MEDLINE

MeSH-Schlagworte: Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/enzymology , Cystadenocarcinoma, Serous*/drug therapy , Cystadenocarcinoma, Serous*/genetics , Cystadenocarcinoma, Serous*/pathology , Cystadenocarcinoma, Serous*/metabolism , MAP Kinase Signaling System*/drug effects , ras Proteins*/metabolism , ras Proteins*/genetics, Humans ; Female ; Carcinoma, Ovarian Epithelial ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins p21(ras)/genetics

BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction.

Autoren: Simanshu DK Xu R Stice JP et al.

Quelle: Science (New York, N.Y.) [Science] 2025 Jul 24; Vol. 389 (6758), pp. 409-415. Date of Electronic Publication: 2025 Jun 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/adverse effects , Class I Phosphatidylinositol 3-Kinases*/antagonists & inhibitors , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/metabolism , Phosphoinositide-3 Kinase Inhibitors*/adverse effects , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use , ras Proteins*/metabolism , ras Proteins*/antagonists & inhibitors, Animals ; Female ; Humans ; Mice ; Rats ; Cell Line, Tumor ; Glucose/metabolism ; Hyperglycemia/chemically induced ; Mice, Nude ; Mutation ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins p21(ras)/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; Signal Transduction ; HEK293 Cells ; Xenograft Model Antitumor Assays ; MCF-7 Cells ; Thiazoles

Inverted chimeric RNAi molecules synergistically cotarget MYC and KRAS in KRAS-driven cancers.

Autoren: Chareddy YS Huggins HP Sahoo SS et al.

Quelle: The Journal of clinical investigation [J Clin Invest] 2025 Jul 22; Vol. 135 (19). Date of Electronic Publication: 2025 Jul 22 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

MeSH-Schlagworte: Proto-Oncogene Proteins c-myc*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/antagonists & inhibitors , RNA, Small Interfering*/genetics , RNA Interference* , Neoplasms*/genetics , Neoplasms*/therapy , Neoplasms*/metabolism , ras Proteins*/genetics , ras Proteins*/antagonists & inhibitors , ras Proteins*/metabolism, Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Animals ; Mice ; Cell Line, Tumor

USP25 maintains KRAS expression and inhibiting the deubiquitinase suppresses KRAS signaling in human cancer.

Autoren: Ma H Guan H Sun X et al.

Quelle: The Journal of biological chemistry [J Biol Chem] 2025 Jul; Vol. 301 (7), pp. 110337. Date of Electronic Publication: 2025 Jun 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH-Schlagworte: Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Ubiquitin Thiolesterase*/antagonists & inhibitors , Signal Transduction*/drug effects , Gene Expression Regulation, Neoplastic* , Proto-Oncogene Proteins*/genetics , Proto-Oncogene Proteins*/metabolism , Neoplasms*/genetics , Neoplasms*/metabolism , Neoplasms*/pathology , ras Proteins*/genetics , ras Proteins*/metabolism, Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Animals ; Mice ; Cell Line, Tumor ; Ubiquitination ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Endopeptidase Complex/genetics

Targeting the SHOC2-RAS interaction in RAS-mutant cancers.

Autoren: Hauseman ZJ Stauffer F Beyer KS et al.

Quelle: Nature [Nature] 2025 Jun; Vol. 642 (8066), pp. 232-241. Date of Electronic Publication: 2025 May 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH-Schlagworte: Mutation* , Membrane Proteins*/genetics , Membrane Proteins*/metabolism , Membrane Proteins*/chemistry , Membrane Proteins*/antagonists & inhibitors , Intracellular Signaling Peptides and Proteins*/metabolism , Intracellular Signaling Peptides and Proteins*/chemistry , Intracellular Signaling Peptides and Proteins*/antagonists & inhibitors , Neoplasms*/genetics , Neoplasms*/pathology , Neoplasms*/drug therapy , Neoplasms*/metabolism , ras Proteins*/genetics , ras Proteins*/metabolism, Humans ; Animals ; Mice ; Cell Line, Tumor ; Models, Molecular ; Protein Binding/drug effects ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism ; GTP Phosphohydrolases/chemistry ; Crystallography, X-Ray ; Female ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Melanoma/genetics ; Melanoma/pathology ; Melanoma/drug therapy ; Melanoma/metabolism ; Molecular Targeted Therapy ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/chemistry ; High-Throughput Screening Assays

Molecular, clinical, and prognostic implications of RAS pathway alterations in adult acute myeloid leukemia.

Autoren: Zhang F Liu Y Zhu Y et al.

Quelle: Leukemia & lymphoma [Leuk Lymphoma] 2025 Apr; Vol. 66 (4), pp. 753-763. Date of Electronic Publication: 2025 Jan 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE

MeSH-Schlagworte: Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/mortality , Leukemia, Myeloid, Acute*/pathology , Leukemia, Myeloid, Acute*/diagnosis , Leukemia, Myeloid, Acute*/metabolism , Mutation* , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Biomarkers, Tumor*/genetics , ras Proteins*/metabolism , ras Proteins*/genetics, Humans ; Male ; Female ; Middle Aged ; Adult ; Prognosis ; Aged ; Retrospective Studies ; Young Adult ; Aged, 80 and over ; Signal Transduction ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/genetics ; Adolescent ; Proto-Oncogene Proteins p21(ras)/genetics ; GTP Phosphohydrolases/genetics ; Membrane Proteins

Targeting Hyperactive Ras Signaling in Pediatric Cancer.

Autoren: Levinson A Shannon K Huang BJ

Quelle: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2025 May 05; Vol. 15 (5). Date of Electronic Publication: 2025 May 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101571139 Publication Model: Electronic Cited Medium: Internet ISSN: 2157-1422 (Electronic) Linking ISSN: 21571422 NLM ISO Abbreviation: Cold Spring Harb Perspect Med Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/genetics , Neoplasms*/drug therapy , Signal Transduction*/drug effects , Signal Transduction*/genetics , ras Proteins*/genetics , ras Proteins*/metabolism , Molecular Targeted Therapy* , Antineoplastic Agents*/therapeutic use, Humans ; Child ; Neurofibromatosis 1/genetics ; Mutation ; Germ-Line Mutation ; Proto-Oncogene Proteins p21(ras)/genetics

Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve Is a Therapeutic Strategy for Pancreatic Cancer.

Autoren: DeLiberty JM Roach MK Stalnecker CA et al.

Quelle: Cancer research [Cancer Res] 2025 Apr 15; Vol. 85 (8), pp. 1479-1495.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

MeSH-Schlagworte: Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Phosphatidylinositol 3-Kinases*/metabolism , Phosphatidylinositol 3-Kinases*/genetics , MAP Kinase Signaling System*/drug effects , Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/metabolism , ras Proteins*/metabolism , ras Proteins*/antagonists & inhibitors, Humans ; Animals ; Mice ; Autophagy/drug effects ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Cell Proliferation/drug effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Phosphoinositide-3 Kinase Inhibitors ; Chloroquine/pharmacology ; Proto-Oncogene Proteins p21(ras)/genetics ; Drug Synergism ; Morpholines/pharmacology

A New Dawn for Targeted Cancer Therapy: Small Molecule Covalent Binding Inhibitor Targeting K-Ras (G12C).

Autoren: Li N Liu CF Zhang W et al.

Quelle: Current medicinal chemistry [Curr Med Chem] 2025; Vol. 32 (4), pp. 647-677.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Molecular Targeted Therapy*/standards , Molecular Targeted Therapy*/trends , Neoplasms*/therapy , Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors , Proto-Oncogene Proteins p21(ras)*/genetics, Humans ; Genes, ras/genetics ; Signal Transduction/genetics ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/therapeutic use

The C2 domain augments Ras GTPase-activating protein catalytic activity.

Autoren: Paul ME Chen D Vish KJ et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Feb 11; Vol. 122 (6), pp. e2418433122. Date of Electronic Publication: 2025 Feb 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: p120 GTPase Activating Protein*/metabolism , p120 GTPase Activating Protein*/genetics , p120 GTPase Activating Protein*/chemistry , ras GTPase-Activating Proteins*/metabolism , ras GTPase-Activating Proteins*/chemistry , ras GTPase-Activating Proteins*/genetics, Animals ; Humans ; Mice ; Protein Domains ; Models, Molecular ; Catalysis ; ras Proteins/metabolism ; Crystallography, X-Ray ; Amino Acid Sequence

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.

Autoren: Czyzyk D Yan W Messing S et al.

Quelle: Nature communications [Nat Commun] 2025 Jan 09; Vol. 16 (1), pp. 525. Date of Electronic Publication: 2025 Jan 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Class I Phosphatidylinositol 3-Kinases*/metabolism , Class I Phosphatidylinositol 3-Kinases*/genetics , Class I Phosphatidylinositol 3-Kinases*/chemistry , Proto-Oncogene Proteins p21(ras)*/metabolism , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/chemistry , Protein Binding*, Humans ; Protein Isoforms/metabolism ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; ras Proteins/metabolism ; ras Proteins/chemistry ; Mutation ; Models, Molecular ; Catalytic Domain ; Transcription Factors

Excitable Ras dynamics-based screens reveal RasGEFX is required for macropinocytosis and random cell migration.

Autoren: Iwamoto K Matsuoka S Ueda M

Quelle: Nature communications [Nat Commun] 2025 Jan 02; Vol. 16 (1), pp. 117. Date of Electronic Publication: 2025 Jan 02.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Dictyostelium*/metabolism , Dictyostelium*/genetics , Dictyostelium*/cytology , Dictyostelium*/physiology , Pinocytosis*/physiology , ras Proteins*/metabolism , Cell Movement* , Chemotaxis*/physiology, Protozoan Proteins/metabolism ; Protozoan Proteins/genetics ; Guanosine Triphosphate/metabolism ; Cyclic AMP/metabolism ; Signal Transduction ; ras Guanine Nucleotide Exchange Factors/metabolism ; ras Guanine Nucleotide Exchange Factors/genetics

Decoding RAS mutations in thyroid cancer: A meta-analysis unveils specific links to distant metastasis and increased mortality.

Autoren: Riccio I Laforteza A Landau MB et al.

Quelle: American journal of otolaryngology [Am J Otolaryngol] 2025 Jan-Feb; Vol. 46 (1), pp. 104570. Date of Electronic Publication: 2024 Dec 17.

Publikationsart: Journal Article; Meta-Analysis; Systematic Review

Info zur Zeitschrift: Publisher: Saunders Country of Publication: United States NLM ID: 8000029 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-818X (Electronic) Linking ISSN: 01960709 NLM ISO Abbreviation: Am J Otolaryngol Subsets: MEDLINE

MeSH-Schlagworte: Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/mortality , Thyroid Neoplasms*/pathology , Mutation* , Genes, ras*/genetics, Humans ; Neoplasm Metastasis/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Membrane Proteins ; GTP Phosphohydrolases

An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review.

Autoren: Sabt A Tawfik HO Khaleel EF et al.

Quelle: Molecular diversity [Mol Divers] 2024 Dec; Vol. 28 (6), pp. 4581-4608. Date of Electronic Publication: 2024 Jan 30.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

MeSH-Schlagworte: Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/metabolism , Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors , Signal Transduction*/drug effects, Animals ; Humans ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/metabolism ; ras Proteins/metabolism ; ras Proteins/antagonists & inhibitors ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/chemistry

EGFR blockade confers sensitivity to pan-RAS inhibitors in KRAS-mutated cancers.

Autoren: Han J Yu B Jing J et al.

Quelle: Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2025 Oct; Vol. 48 (5), pp. 1317-1335. Date of Electronic Publication: 2025 Jul 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-3436 (Electronic) Linking ISSN: 22113428 NLM ISO Abbreviation: Cell Oncol (Dordr) Subsets: MEDLINE

MeSH-Schlagworte: ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors , Mutation*/genetics , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/therapeutic use , Neoplasms*/genetics , Neoplasms*/drug therapy , Neoplasms*/pathology , ras Proteins*/antagonists & inhibitors, Humans ; Animals ; Cell Line, Tumor ; Mice ; CRISPR-Cas Systems/genetics ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects

K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins.

Autoren: Magits W Steklov M Jang H et al.

Quelle: The EMBO journal [EMBO J] 2024 Jul; Vol. 43 (14), pp. 2862-2877. Date of Electronic Publication: 2024 Jun 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

MeSH-Schlagworte: Ubiquitination* , Proto-Oncogene Proteins p21(ras)*/metabolism , Proto-Oncogene Proteins p21(ras)*/genetics , Protein Binding*, Humans ; Signal Transduction ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Animals ; p120 GTPase Activating Protein/metabolism ; p120 GTPase Activating Protein/genetics ; Mice ; Cell Line, Tumor ; GTP Phosphohydrolases/metabolism ; GTP Phosphohydrolases/genetics ; Lysine/metabolism ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; ras Proteins/metabolism ; ras Proteins/genetics ; Neurofibromin 1

Impact of RAS, BRAF mutations and microsatellite status in peritoneal metastases from colorectal cancer treated with cytoreduction + HIPEC: scoping review.

Autoren: Zucchini V D'Acapito F Rapposelli IG et al.

Quelle: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [Int J Hyperthermia] 2025 Dec; Vol. 42 (1), pp. 2479527. Date of Electronic Publication: 2025 Mar 18.

Publikationsart: Journal Article; Scoping Review

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8508395 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5157 (Electronic) Linking ISSN: 02656736 NLM ISO Abbreviation: Int J Hyperthermia Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/therapy , Cytoreduction Surgical Procedures*/methods , Proto-Oncogene Proteins B-raf*/genetics , Hyperthermic Intraperitoneal Chemotherapy*/methods , Peritoneal Neoplasms*/secondary , Peritoneal Neoplasms*/genetics , Peritoneal Neoplasms*/therapy , ras Proteins*/genetics , Proto-Oncogene Proteins p21(ras)*/genetics, Humans ; Mutation ; Microsatellite Instability

Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response.

Autoren: Elliot AM Ribeiro Bravo I Zhao Y et al.

Quelle: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116478. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: Neutrophils*/metabolism , Neutrophils*/immunology , Neutrophils*/pathology , Proto-Oncogene Proteins p21(ras)*/metabolism , Proto-Oncogene Proteins p21(ras)*/genetics , Cell Plasticity* , ras Proteins*/metabolism, Animals ; Zebrafish ; Humans ; Epithelial-Mesenchymal Transition ; Phenotype ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Skin Neoplasms/pathology ; Skin Neoplasms/genetics ; Carcinogenesis/pathology ; Cell Proliferation