Search Results - "RANDOMIZED CONTROLLED TRIALS AS TOPIC"

Clinical trial methods for family medicine and primary care.

Authors: Mash R Fatusin BB Madela-Mntla E et al.

Source: African journal of primary health care & family medicine [Afr J Prim Health Care Fam Med] 2025 Jul 25; Vol. 17 (2), pp. e1-e8. Date of Electronic Publication: 2025 Jul 25.

Publication Type: Journal Article

Journal Info: Publisher: OpenJournals Pub Country of Publication: South Africa NLM ID: 101520860 Publication Model: Electronic Cited Medium: Internet ISSN: 2071-2936 (Electronic) Linking ISSN: 20712928 NLM ISO Abbreviation: Afr J Prim Health Care Fam Med Subsets: MEDLINE

MeSH Terms: Research Design* , Primary Health Care*/ethics , Family Practice*/ethics , Family Practice*/methods , Randomized Controlled Trials as Topic*/ethics , Randomized Controlled Trials as Topic*/methods, Africa South of the Sahara ; Non-Randomized Controlled Trials as Topic ; Humans ; Patient Selection/ethics

Experimentation Without Randomised Controls.

Authors: Simon SD; Department of Biomedical and Health Informatics, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.

Source: Journal of oral rehabilitation [J Oral Rehabil] 2025 Aug; Vol. 52 (8), pp. 1167-1174. Date of Electronic Publication: 2025 Apr 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0433604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2842 (Electronic) Linking ISSN: 0305182X NLM ISO Abbreviation: J Oral Rehabil Subsets: MEDLINE

MeSH Terms: Research Design* , Non-Randomized Controlled Trials as Topic*/methods, Humans ; Randomized Controlled Trials as Topic

Incorporating non-randomized evidence in cochrane intervention reviews: a scoping review.

Authors: Axon E Kanellopoulou A Tsokani S et al.

Source: Journal of clinical epidemiology [J Clin Epidemiol] 2025 Jul; Vol. 183, pp. 111814. Date of Electronic Publication: 2025 May 03.

Publication Type: Journal Article; Scoping Review

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE

MeSH Terms: Non-Randomized Controlled Trials as Topic*/methods , Evidence-Based Medicine* , Review Literature as Topic*, Humans ; Randomized Controlled Trials as Topic ; Research Design

Integration of non-randomized studies with randomized controlled trials in meta-analyses of clinical studies: a meta-epidemiological study on effect estimation of interventions.

Authors: Mei F Yao M Wang Y et al.

Source: BMC medicine [BMC Med] 2024 Dec 02; Vol. 22 (1), pp. 571. Date of Electronic Publication: 2024 Dec 02.

Publication Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/standards , Epidemiologic Studies*, Humans ; Non-Randomized Controlled Trials as Topic/methods ; Meta-Analysis as Topic ; Systematic Reviews as Topic/methods

A meta-epidemiological analysis of post-hoc comparisons and primary endpoint interpretability among randomized noncomparative trials in clinical medicine.

Authors: Sherry AD Msaouel P Ludmir EB

Source: Journal of clinical epidemiology [J Clin Epidemiol] 2024 Nov; Vol. 175, pp. 111540. Date of Electronic Publication: 2024 Sep 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/statistics & numerical data , Randomized Controlled Trials as Topic*/standards, Humans ; Epidemiologic Studies ; Non-Randomized Controlled Trials as Topic ; Research Design/standards ; Data Interpretation, Statistical ; Endpoint Determination/statistics & numerical data ; Endpoint Determination/methods

Impact of active placebo controls on estimated drug effects in randomized trials: a meta-epidemiological study.

Authors: Laursen DRT Broager MI Damkjær MW et al.

Source: Journal of clinical epidemiology [J Clin Epidemiol] 2025 Dec; Vol. 188, pp. 111998. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article; Meta-Analysis

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/statistics & numerical data , Randomized Controlled Trials as Topic*/methods, Humans ; Placebos ; Epidemiologic Studies

Persistent carry-over in a two-period randomised crossover design for behavioural interventions without the expectation of return to baseline after intervention cessation.

Authors: Kulnik ST Carrozzo AE Crutzen R

Source: Trials [Trials] 2025 Dec 04; Vol. 26 (1), pp. 561. Date of Electronic Publication: 2025 Dec 04.

Publication Type: Journal Article; Letter

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE

MeSH Terms: Research Design*/statistics & numerical data , Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/statistics & numerical data , Health Behavior* , Behavior Therapy*/methods, Humans ; Cross-Over Studies ; Sample Size ; Time Factors ; Computer Simulation ; Treatment Outcome

Cluster-Level Analyses to Estimate a Risk Difference in a Cluster Randomized Trial With Confounding Individual-Level Covariates: A Simulation Study.

Authors: Pereira Macedo JA Giraudeau B

Corporate Authors: Pereira Macedo JA Giraudeau B

Source: Statistics in medicine [Stat Med] 2025 Dec; Vol. 44 (28-30), pp. e70341.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8215016 Publication Model: Print Cited Medium: Internet ISSN: 1097-0258 (Electronic) Linking ISSN: 02776715 NLM ISO Abbreviation: Stat Med Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/statistics & numerical data , Randomized Controlled Trials as Topic*/methods, Cluster Analysis ; Humans ; Computer Simulation ; Likelihood Functions ; Bias ; Confounding Factors, Epidemiologic ; Models, Statistical ; Normal Distribution

Bayesian Prediction of Event Times Using Mixture Model for Blinded Randomized Controlled Trials.

Authors: Fu J Zhao D Skanji D et al.

Source: Statistics in medicine [Stat Med] 2025 Dec; Vol. 44 (28-30), pp. e70310.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8215016 Publication Model: Print Cited Medium: Internet ISSN: 1097-0258 (Electronic) Linking ISSN: 02776715 NLM ISO Abbreviation: Stat Med Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/statistics & numerical data , Models, Statistical*, Bayes Theorem ; Humans ; Computer Simulation ; Time Factors ; Clinical Trials, Phase III as Topic/methods ; Clinical Trials, Phase III as Topic/statistics & numerical data

Theory of clinical therapeutic progress: reconciling equipoise with fat-tailed (skewed) outcomes.

Authors: Hozo I Djulbegovic B

Source: Journal of clinical epidemiology [J Clin Epidemiol] 2025 Dec; Vol. 188, pp. 112004. Date of Electronic Publication: 2025 Sep 29.

Publication Type: Journal Article; Systematic Review

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/statistics & numerical data , Randomized Controlled Trials as Topic*/ethics , Therapeutic Equipoise* , Neoplasms*/therapy, Humans ; Models, Statistical ; Research Design ; Treatment Outcome ; Uncertainty

Research waste among randomized controlled trials in preterm infants: a Cross-sectional study.

Authors: Shen C Qiu J Qiao Y et al.

Source: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2025 Dec; Vol. 38 (1), pp. 2498559. Date of Electronic Publication: 2025 May 05.

Publication Type: Journal Article; Systematic Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/statistics & numerical data , Randomized Controlled Trials as Topic*/standards , Infant, Premature* , Research Design*, Humans ; Cross-Sectional Studies ; Infant, Newborn

Ethics and consent in randomized clinical trial integrity: A scoping systematic review.

Authors: AlaaEldein Elsuity M Butt FA Saeed Khan K et al.

Source: Semergen [Semergen] 2025 Dec; Vol. 51 (9), pp. 102579. Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article; Scoping Review

Journal Info: Publisher: Saned, S.A Country of Publication: Spain NLM ID: 9610769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1578-8865 (Electronic) Linking ISSN: 11383593 NLM ISO Abbreviation: Semergen Subsets: MEDLINE

MeSH Terms: Informed Consent*/ethics , Informed Consent*/standards , Randomized Controlled Trials as Topic*/ethics , Randomized Controlled Trials as Topic*/standards , Ethics, Research*, Humans ; Research Design/standards

Quantitative evaluation of recruitment strategies in a cluster-randomized trial: segmented regression and cost analysis from the AOK-Family + study.

Authors: Litke N Wensing M Hermeling L et al.

Source: BMC medical research methodology [BMC Med Res Methodol] 2025 Nov 28; Vol. 25 (1), pp. 269. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288 (Electronic) Linking ISSN: 14712288 NLM ISO Abbreviation: BMC Med Res Methodol Subsets: MEDLINE

MeSH Terms: Patient Selection* , Randomized Controlled Trials as Topic*/economics , Randomized Controlled Trials as Topic*/methods, Humans ; Female ; Pregnancy ; Germany ; Adult ; Costs and Cost Analysis ; Social Media

How to manage missing covariates in randomized controlled trials: a comparison of strategies.

Authors: Zhang S Si Y Dziak JJ

Source: BMC medical research methodology [BMC Med Res Methodol] 2025 Nov 25; Vol. 25 (1), pp. 264. Date of Electronic Publication: 2025 Nov 25.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288 (Electronic) Linking ISSN: 14712288 NLM ISO Abbreviation: BMC Med Res Methodol Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/statistics & numerical data , Research Design*, Humans ; Data Interpretation, Statistical ; Models, Statistical ; Bias ; Computer Simulation

Estimating treatment effect in randomised controlled trials with continuous outcomes subject to non-compliance: a logistic regression-based multiple imputation approach.

Authors: Du R Li J Zhu J et al.

Source: Trials [Trials] 2025 Nov 21; Vol. 26 (1), pp. 531. Date of Electronic Publication: 2025 Nov 21.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/statistics & numerical data , Randomized Controlled Trials as Topic*/methods , Research Design*/statistics & numerical data , Patient Compliance*, Humans ; Logistic Models ; Computer Simulation ; Treatment Outcome ; Data Interpretation, Statistical ; Sample Size ; Intention to Treat Analysis ; Selection Bias ; Antidepressive Agents/therapeutic use

Benefits of group sequential design and sample size re-estimation for randomised controlled trials evaluating the prevention of ventilator-associated pneumonia: a simulation study informed by real world data.

Authors: Jackson H Sauser J van Werkhoven CH et al.

Source: BMC medical research methodology [BMC Med Res Methodol] 2025 Nov 12; Vol. 25 (1), pp. 254. Date of Electronic Publication: 2025 Nov 12.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288 (Electronic) Linking ISSN: 14712288 NLM ISO Abbreviation: BMC Med Res Methodol Subsets: MEDLINE

MeSH Terms: Pneumonia, Ventilator-Associated*/prevention & control , Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/statistics & numerical data , Research Design*, Humans ; Sample Size ; Computer Simulation ; Prospective Studies

Lack of precision in the reporting of sex and gender in cancer clinical trials with a PRO endpoint: an exploratory literature review.

Authors: Krepper D Thurner AMM Komlenac N et al.

Source: BMC medical research methodology [BMC Med Res Methodol] 2025 Nov 11; Vol. 25 (1), pp. 253. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288 (Electronic) Linking ISSN: 14712288 NLM ISO Abbreviation: BMC Med Res Methodol Subsets: MEDLINE

MeSH Terms: Neoplasms*/therapy , Patient Reported Outcome Measures* , Randomized Controlled Trials as Topic*/standards , Randomized Controlled Trials as Topic*/statistics & numerical data , Research Design*/standards, Humans ; Female ; Male ; Sex Factors

Applicability of randomized controlled trial evidence on surgery for lumbar disc herniations to clinical reality: a comparison with the nationwide FinSpine registry.

Authors: Rantalaiho IK Pernaa KI Huttunen JM et al.

Source: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2025 Nov 04; Vol. 20 (1), pp. 955. Date of Electronic Publication: 2025 Nov 04.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X (Electronic) Linking ISSN: 1749799X NLM ISO Abbreviation: J Orthop Surg Res Subsets: MEDLINE

MeSH Terms: Registries*/standards , Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/standards , Lumbar Vertebrae*/surgery , Intervertebral Disc Displacement*/surgery, Humans ; Treatment Outcome

Quantile Effect on Duration of Response: A Zero-Inflated Censored Regression Approach.

Authors: Sun N Wang J Tiwari R

Source: Pharmaceutical statistics [Pharm Stat] 2025 Nov-Dec; Vol. 24 (6), pp. e70053.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 101201192 Publication Model: Print Cited Medium: Internet ISSN: 1539-1612 (Electronic) Linking ISSN: 15391604 NLM ISO Abbreviation: Pharm Stat Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/statistics & numerical data , Models, Statistical*, Humans ; Regression Analysis ; Computer Simulation ; Time Factors ; Leukemia, Myeloid, Acute/drug therapy ; Treatment Outcome ; Data Interpretation, Statistical

Estimating Causal Treatment Effects in the Sequential Parallel Comparison Design (SPCD).

Authors: Song Y Fava M Kim C et al.

Source: Statistics in medicine [Stat Med] 2025 Nov; Vol. 44 (25-27), pp. e70319.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8215016 Publication Model: Print Cited Medium: Internet ISSN: 1097-0258 (Electronic) Linking ISSN: 02776715 NLM ISO Abbreviation: Stat Med Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/statistics & numerical data , Research Design*, Humans ; Computer Simulation ; Placebo Effect ; Treatment Outcome ; Models, Statistical ; Causality ; Data Interpretation, Statistical ; Intention to Treat Analysis