Výsledky vyhledávání - "R-Loop Structures"

BET family BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop-mediated HR.

Autoři: Qian J Watanabe T Watanabe R a další

Zdroj: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116461. Date of Electronic Publication: 2025 Oct 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Lysine Acetyltransferase 5*/metabolism , Chromatin Assembly and Disassembly* , DNA Breaks, Double-Stranded* , Homologous Recombination* , R-Loop Structures*, Humans ; Chromatin/metabolism ; Tumor Suppressor p53-Binding Protein 1/metabolism ; Histones/metabolism ; Acetylation ; BRCA1 Protein/metabolism ; Bromodomain Containing Proteins ; Transcription Factors ; Mi-2 Nucleosome Remodeling and Deacetylase Complex

Biochemical Characterization of R-Loop Degradation by Chloroplast-Localized RNase H1 from Arabidopsis thaliana .

Autoři: Gavrilova AA Kuznetsova AA Novopashina DS a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 17; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 17.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Arabidopsis*/enzymology , Arabidopsis*/genetics , Arabidopsis*/metabolism , Ribonuclease H*/metabolism , Ribonuclease H*/genetics , Chloroplasts*/enzymology , Chloroplasts*/genetics , Chloroplasts*/metabolism , R-Loop Structures* , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics, Substrate Specificity ; Kinetics

ZPR1 Is Dispensable for HPV R-Loop Resolution but Regulates Host R-Loop Dynamics.

Autoři: Moffitt R Brooks S Androphy EJ a další

Zdroj: Viruses [Viruses] 2025 Nov 13; Vol. 17 (11). Date of Electronic Publication: 2025 Nov 13.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Výrazy ze slovníku MeSH: R-Loop Structures* , Papillomavirus Infections*/virology , Host-Pathogen Interactions* , Papillomaviridae*/genetics, Humans ; Oncogene Proteins, Viral/metabolism ; Oncogene Proteins, Viral/genetics ; Promoter Regions, Genetic ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Protein Binding

Dcr1 senses R-loops for RNAPII termination at sites of replication stress and repair pathway choice.

Autoři: Wang Z Zhang Y Guo T a další

Zdroj: Molecular cell [Mol Cell] 2025 Nov 06; Vol. 85 (21), pp. 3947-3964.e10. Date of Electronic Publication: 2025 Oct 28.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Výrazy ze slovníku MeSH: Schizosaccharomyces*/genetics , Schizosaccharomyces*/metabolism , Schizosaccharomyces*/enzymology , Schizosaccharomyces pombe Proteins*/genetics , Schizosaccharomyces pombe Proteins*/metabolism , RNA Polymerase II*/metabolism , RNA Polymerase II*/genetics , DNA Replication* , R-Loop Structures* , DNA Repair* , DNA, Fungal*/genetics , DNA, Fungal*/metabolism , Transcription Termination, Genetic*, Genomic Instability ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; DNA Polymerase III/genetics ; DNA Polymerase III/metabolism

Evolutionary interplay between viruses and R-loops.

Autoři: Karányi Z Képes Z Szabó Z a další

Zdroj: FEBS letters [FEBS Lett] 2025 Nov; Vol. 599 (21), pp. 3012-3028. Date of Electronic Publication: 2025 May 31.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

Výrazy ze slovníku MeSH: Viruses*/genetics , Viruses*/pathogenicity , R-Loop Structures*/genetics , Evolution, Molecular*, Humans ; Animals ; Genome, Viral ; Epigenesis, Genetic

Dual roles of N ⁶ -methyladenosine in R-loop regulation of gene transcription and genome stability.

Autoři: Li F Zhang F Li J a další

Zdroj: Science China. Life sciences [Sci China Life Sci] 2025 Nov; Vol. 68 (11), pp. 3190-3202. Date of Electronic Publication: 2025 Jul 09.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Adenosine*/analogs & derivatives , Adenosine*/metabolism , Genomic Instability*/genetics , Methyltransferases*/metabolism , Methyltransferases*/genetics , Transcription, Genetic* , R-Loop Structures*/genetics, Animals ; Mice ; Mouse Embryonic Stem Cells/metabolism ; DNA Damage ; Cell Proliferation ; Gene Expression Regulation

Break-induced replication is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells.

Autoři: Wu T Li Y Zhao Y a další

Zdroj: Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116386. Date of Electronic Publication: 2025 Oct 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: DNA Breaks, Double-Stranded* , DNA Replication* , R-Loop Structures* , DNA Repair* , DNA Helicases*/metabolism , DNA Helicases*/deficiency , DNA Helicases*/genetics , RNA Helicases*/metabolism , RNA Helicases*/deficiency , RNA Helicases*/genetics, Humans ; Rad52 DNA Repair and Recombination Protein/metabolism ; Rad52 DNA Repair and Recombination Protein/genetics ; Multifunctional Enzymes/deficiency ; Proliferating Cell Nuclear Antigen/metabolism ; Ubiquitination ; DNA-Binding Proteins/metabolism ; DNA, Single-Stranded/metabolism

The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress.

Autoři: Ummethum H Murriello AC Werner M a další

Zdroj: EMBO reports [EMBO Rep] 2025 Oct; Vol. 26 (19), pp. 4691-4722. Date of Electronic Publication: 2025 Aug 26.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: R-Loop Structures* , Transcription, Genetic* , DNA Replication* , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics, Humans ; RNA Polymerase II/metabolism ; Promoter Regions, Genetic ; DEAD-box RNA Helicases/metabolism ; DEAD-box RNA Helicases/genetics ; Protein Binding ; DNA Helicases/metabolism ; Trinucleotide Repeats ; Chromatin/metabolism

R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review).

Autoři: Hsieh CH Liu YW Chuang PC

Zdroj: Molecular medicine reports [Mol Med Rep] 2026 Jan; Vol. 33 (1). Date of Electronic Publication: 2025 Oct 17.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/therapy , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/genetics , Liver Neoplasms*/therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Genomic Instability* , R-Loop Structures*/genetics, Humans ; DNA Damage ; Gene Expression Regulation, Neoplastic ; Animals ; Epigenesis, Genetic

ADAR1 RNA-Editing Enzyme Regulates Telomeric R-Loop Formation.

Autoři: Ichihashi E Kubota M Shiromoto Y a další

Zdroj: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2026; Vol. 2949, pp. 109-127.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Adenosine Deaminase*/metabolism , Adenosine Deaminase*/genetics , RNA Editing* , Telomere*/genetics , Telomere*/metabolism , Telomere*/chemistry , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , R-Loop Structures*, Humans ; RNA/genetics ; RNA/metabolism ; RNA/chemistry

Possible role of human ribonuclease dicer in the regulation of R loops.

Autoři: Wojcik K Krzeminska P Kurzynska-Kokorniak A

Zdroj: FEBS open bio [FEBS Open Bio] 2025 Sep; Vol. 15 (9), pp. 1406-1418. Date of Electronic Publication: 2025 Mar 24.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101580716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-5463 (Electronic) Linking ISSN: 22115463 NLM ISO Abbreviation: FEBS Open Bio Subsets: MEDLINE

Výrazy ze slovníku MeSH: Ribonuclease III*/metabolism , Ribonuclease III*/genetics , R-Loop Structures*/genetics , R-Loop Structures*/physiology , DEAD-box RNA Helicases*/metabolism , DEAD-box RNA Helicases*/genetics, Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Genomic Instability/genetics ; MicroRNAs/metabolism ; MicroRNAs/genetics

Comprehensive identification of proteins interacting with long non-coding RNA TUG1 in R-loop regulation.

Autoři: Xie J Suzuki MM Iijima K a další

Zdroj: Journal of biochemistry [J Biochem] 2025 Sep 30; Vol. 178 (4), pp. 251-265.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376600 Publication Model: Print Cited Medium: Internet ISSN: 1756-2651 (Electronic) Linking ISSN: 0021924X NLM ISO Abbreviation: J Biochem Subsets: MEDLINE

Výrazy ze slovníku MeSH: RNA, Long Noncoding*/metabolism , RNA, Long Noncoding*/genetics , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , R-Loop Structures*, Humans ; HEK293 Cells ; Protein Binding

Protein-mediated stabilization and nicking of the nontemplate DNA strand dramatically affect R-loop formation in vitro.

Autoři: Holleman E Catley TE Sereiva T a další

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Sep 23; Vol. 122 (38), pp. e2509309122. Date of Electronic Publication: 2025 Sep 18.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy ze slovníku MeSH: R-Loop Structures* , DNA*/chemistry , DNA*/metabolism , DNA*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , DNA, Single-Stranded*/chemistry , DNA, Single-Stranded*/metabolism, Microscopy, Atomic Force ; Transcription, Genetic ; Nucleic Acid Conformation

Opposing roles of two R-loop associated G-quadruplexes in tuning transcription activity.

Autoři: Yang L Lee CY Paul T a další

Zdroj: Nucleic acids research [Nucleic Acids Res] 2025 Sep 23; Vol. 53 (18).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: G-Quadruplexes* , Transcription, Genetic* , R-Loop Structures* , DNA*/chemistry , DNA*/genetics, Fluorescence Resonance Energy Transfer ; DNA-Directed RNA Polymerases/metabolism ; RNA/chemistry ; RNA/genetics ; RNA/biosynthesis ; Viral Proteins/metabolism

DDX3X mutation and Epstein-Barr virus cooperate to induce R-loop-dependent oncogenesis.

Autoři: Cai HM Qiu YR Tan Y a další

Zdroj: Cell reports [Cell Rep] 2025 Sep 23; Vol. 44 (9), pp. 116237. Date of Electronic Publication: 2025 Sep 05.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: DEAD-box RNA Helicases*/genetics , Epstein-Barr Virus Infections*/complications , Herpesvirus 4, Human*/physiology , Neoplasms*/virology , Oncogene Proteins, Viral*/physiology , R-Loop Structures*, Humans ; Carcinogenesis ; Genomic Instability ; Molecular Dynamics Simulation ; Mutation ; Mice, Transgenic ; Male ; Female ; Animals ; Mice

The paradox of R-loops: guardians of the genome or drivers of disease?

Autoři: Mudiyanselage SDD Wulfridge P Sarma K

Zdroj: Genome research [Genome Res] 2025 Sep 02; Vol. 35 (9), pp. 1919-1928. Date of Electronic Publication: 2025 Sep 02.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9518021 Publication Model: Electronic Cited Medium: Internet ISSN: 1549-5469 (Electronic) Linking ISSN: 10889051 NLM ISO Abbreviation: Genome Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: R-Loop Structures*/genetics, Humans ; DNA Repair ; Genomic Instability ; DNA Damage ; Animals ; Chromatin/genetics ; Chromatin/chemistry ; Neoplasms/genetics ; Neurodegenerative Diseases/genetics ; Genome

Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions.

Autoři: Penzo C Özel I Martinovic M a další

Zdroj: Nature microbiology [Nat Microbiol] 2025 Sep; Vol. 10 (9), pp. 2306-2322. Date of Electronic Publication: 2025 Aug 20.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: HIV-1*/physiology , HIV-1*/genetics , Virus Integration* , R-Loop Structures* , RNA Helicases*/metabolism , RNA Helicases*/genetics, Humans ; CD4-Positive T-Lymphocytes/virology ; HIV Integrase/metabolism ; HIV Integrase/genetics ; HIV Infections/virology ; Introns ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Virus Replication ; RNA, Viral/genetics ; RNA, Viral/metabolism

Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.

Autoři: Zhang J Wang Y Cao S a další

Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Sep; Vol. 12 (35), pp. e09307. Date of Electronic Publication: 2025 Jun 23.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/drug therapy , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/drug therapy , DNA Replication*/genetics , DNA Replication*/drug effects , Proto-Oncogene Proteins c-ets*/genetics , Proto-Oncogene Proteins c-ets*/metabolism , DNA Damage*/genetics , Topoisomerase I Inhibitors*/pharmacology , R-Loop Structures*/genetics , Proto-Oncogene Proteins*/genetics , Proto-Oncogene Proteins*/metabolism, Humans ; Cell Line, Tumor ; Transcription, Genetic ; DNA Topoisomerases, Type I/metabolism ; DNA Topoisomerases, Type I/genetics

The R-loop grammar predicts R-loop formation under different topological constraints.

Autoři: Ferrari MM Poznanović S Riehl M a další

Zdroj: PLoS computational biology [PLoS Comput Biol] 2025 Aug 29; Vol. 21 (8), pp. e1013376. Date of Electronic Publication: 2025 Aug 29 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: R-Loop Structures* , DNA*/chemistry , DNA*/genetics, Computational Biology/methods ; RNA/chemistry ; RNA/genetics ; Nucleic Acid Conformation ; Plasmids/genetics ; Plasmids/chemistry ; Algorithms

NSUN2 facilitates DICER cleavage of DNA damage-associated R-loops to promote repair.

Autoři: Alagia A Ajit K Di Fazio A a další

Zdroj: Nature communications [Nat Commun] 2025 Aug 23; Vol. 16 (1), pp. 7882. Date of Electronic Publication: 2025 Aug 23.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: DNA Repair* , Ribonuclease III*/metabolism , Ribonuclease III*/genetics , R-Loop Structures* , DEAD-box RNA Helicases*/metabolism , DEAD-box RNA Helicases*/genetics , Methyltransferases*/metabolism , Methyltransferases*/genetics, Humans ; DNA Breaks, Double-Stranded ; DNA Damage ; RNA Polymerase II/metabolism