Výsledky vyhľadávania - "Quinazolinones"

Design and Synthesis of Holu-7, a Quinazolinone Derivative With an Active Stereo Geometry and Polar 2,4-Dihydroxyphenyl Group, as a Selective Anticancer Agent.

Autori: Lai KC Hsieh HH Lu YL a ďalší

Zdroj: Chemical biology & drug design [Chem Biol Drug Des] 2025 Dec; Vol. 106 (6), pp. e70209.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE

Výrazy zo slovníka MeSH: Quinazolinones*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/pharmacology , Drug Design*, Humans ; Cell Line, Tumor ; Molecular Docking Simulation ; Tubulin/metabolism ; Tubulin/chemistry ; HCT116 Cells ; Molecular Dynamics Simulation ; Structure-Activity Relationship ; Stereoisomerism ; G2 Phase Cell Cycle Checkpoints/drug effects

Design, synthesis, and biological evaluation of quinazolin-4-one-based selective HDAC6 inhibitors targeting serine 531, histidine 614 residues, and the L1 and L2 loop.

Autori: Gupta SK Oh YJ Kim M a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118184. Date of Electronic Publication: 2025 Sep 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Drug Design* , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemistry , Quinazolinones*/chemical synthesis, Humans ; Cell Proliferation/drug effects ; Animals ; Structure-Activity Relationship ; Mice ; Molecular Structure ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Dose-Response Relationship, Drug ; Apoptosis/drug effects ; Microsomes, Liver/metabolism

Design, synthesis and biological evaluation of novel quinazolinedione derivatives as non-covalent SARS-CoV-2 3CL protease inhibitors.

Autori: Taoda Y Hori A Tadano G a ďalší

Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130400. Date of Electronic Publication: 2025 Sep 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Coronavirus 3C Proteases*/antagonists & inhibitors , Coronavirus 3C Proteases*/metabolism , SARS-CoV-2*/enzymology , SARS-CoV-2*/drug effects , Drug Design* , Antiviral Agents*/pharmacology , Antiviral Agents*/chemical synthesis , Antiviral Agents*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemistry , Quinazolinones*/chemical synthesis , Protease Inhibitors*/pharmacology , Protease Inhibitors*/chemical synthesis , Protease Inhibitors*/chemistry, Animals ; Humans ; Rats ; Structure-Activity Relationship ; Crystallography, X-Ray ; Molecular Structure ; COVID-19 Drug Treatment ; Molecular Docking Simulation

Evaluation of quinazolin-4(3H)-one derivatives containing the bioactive acetohydrazide group as fungicidal candidates.

Autori: Zhang W Liu J Qi S a ďalší

Zdroj: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2025 Dec; Vol. 215, pp. 106667. Date of Electronic Publication: 2025 Aug 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fungicides, Industrial*/pharmacology , Fungicides, Industrial*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemistry , Hydrazines*/chemistry , Hydrazines*/pharmacology, Animals ; Microbial Sensitivity Tests ; Rhizoctonia/drug effects ; Ascomycota/drug effects ; Zebrafish ; Fungi/drug effects ; Botrytis

SCR Organism: Rhizoctonia solani; Botrytis cinerea; Sclerotinia sclerotiorum

Synthesis and evaluation of 5, 6-dihydro-8 H -isoquinolino[1, 2- b ]quinazolin-8-one derivatives as novel non-lipogenic ABCA1 up-regulators with inhibitory effects on macrophage-derived foam cell formation.

Autori: Yang C Chen L Jiang Y a ďalší

Zdroj: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2470310. Date of Electronic Publication: 2025 Feb 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: ATP Binding Cassette Transporter 1*/genetics , ATP Binding Cassette Transporter 1*/metabolism , Foam Cells*/drug effects , Foam Cells*/metabolism , Foam Cells*/cytology , Up-Regulation*/drug effects , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis , Quinazolinones*/chemistry, Humans ; Structure-Activity Relationship ; Mice ; Animals ; Molecular Structure ; Dose-Response Relationship, Drug ; RAW 264.7 Cells ; Hep G2 Cells ; Macrophages/drug effects ; Macrophages/metabolism

Quinazolinone derivatives as potential anti‑tumor agents: Structural features and molecular mechanisms in inducing cell death (Review).

Autori: Li J Yang Y Wang L a ďalší

Zdroj: International journal of molecular medicine [Int J Mol Med] 2025 Dec; Vol. 56 (6). Date of Electronic Publication: 2025 Sep 26.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Quinazolinones*/pharmacology , Quinazolinones*/chemistry , Quinazolinones*/therapeutic use , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/metabolism , Cell Death*/drug effects, Humans ; Animals ; Apoptosis/drug effects ; Autophagy/drug effects

Cost-utility analysis of osimertinib and dacomitinib in the first-line treatment of advanced non-small cell lung cancer with EGFR mutation.

Autori: Su L Zhang X Li M a ďalší

Zdroj: Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2025 Dec; Vol. 25 (10), pp. 1437-1444. Date of Electronic Publication: 2025 Jun 17.

Spôsob vydávania: Journal Article; Comparative Study

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101132257 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8379 (Electronic) Linking ISSN: 14737167 NLM ISO Abbreviation: Expert Rev Pharmacoecon Outcomes Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Aniline Compounds*/economics , Aniline Compounds*/administration & dosage , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/economics , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/pathology , Quinazolinones*/economics , Quinazolinones*/administration & dosage , Acrylamides*/economics , Acrylamides*/administration & dosage , Lung Neoplasms*/drug therapy , Lung Neoplasms*/economics , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology, Humans ; Cost-Benefit Analysis ; Mutation ; ErbB Receptors/genetics ; Quality-Adjusted Life Years ; China ; Antineoplastic Agents/economics ; Antineoplastic Agents/administration & dosage ; Network Meta-Analysis as Topic ; Survival Analysis ; Indoles ; Pyrimidines

A cost-effectiveness analysis of deucravacitinib vs. apremilast in moderate-to-severe psoriasis patients in Japan.

Autori: van de Wetering G Kim H Roberts D a ďalší

Zdroj: Journal of medical economics [J Med Econ] 2025 Dec; Vol. 28 (1), pp. 922-933. Date of Electronic Publication: 2025 Jun 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9892255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-837X (Electronic) Linking ISSN: 13696998 NLM ISO Abbreviation: J Med Econ Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anti-Inflammatory Agents, Non-Steroidal*/economics , Anti-Inflammatory Agents, Non-Steroidal*/therapeutic use , Psoriasis*/drug therapy , Quinazolinones*/economics , Quinazolinones*/therapeutic use , Thalidomide*/analogs & derivatives , Thalidomide*/economics , Thalidomide*/therapeutic use , Thalidomide*/analogs & derivatives, Adult ; Female ; Humans ; Male ; Middle Aged ; Cost-Benefit Analysis ; Cost-Effectiveness Analysis ; Japan ; Markov Chains ; Quality of Life ; Quality-Adjusted Life Years ; Severity of Illness Index ; Randomized Controlled Trials as Topic ; Clinical Trials, Phase III as Topic ; Multicenter Studies as Topic

Furo[2,3- f ]quinazolin-7(6 H )-one Derivatives as Potent, Selective, and Orally Bioavailable MAT2A Inhibitors for MTAP-Deficient Cancer Therapy.

Autori: Shi Z Lin K Lin L a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24213-24231. Date of Electronic Publication: 2025 Nov 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/therapeutic use , Methionine Adenosyltransferase*/antagonists & inhibitors , Methionine Adenosyltransferase*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/administration & dosage , Enzyme Inhibitors*/therapeutic use , Enzyme Inhibitors*/pharmacokinetics , Purine-Nucleoside Phosphorylase*/deficiency , Purine-Nucleoside Phosphorylase*/genetics , Quinazolinones*/pharmacology , Quinazolinones*/chemistry , Quinazolinones*/administration & dosage , Quinazolinones*/therapeutic use , Quinazolinones*/pharmacokinetics, Humans ; Animals ; Structure-Activity Relationship ; Mice ; Administration, Oral ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Biological Availability ; Neoplasms/drug therapy ; Male

Inhibition of DRP1-mediated Mitochondrial Fission and NRF2/HO-1/GPX4-mediated Ferroptosis by Mdivi-1 Protects Against Vascular Cognitive Impairment.

Autori: Liu XM Chen F Cheng YJ a ďalší

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 19; Vol. 63 (1), pp. 76. Date of Electronic Publication: 2025 Nov 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ferroptosis*/drug effects , NF-E2-Related Factor 2*/metabolism , Mitochondrial Dynamics*/drug effects , Dynamins*/metabolism , Dynamins*/antagonists & inhibitors , Cognitive Dysfunction*/metabolism , Cognitive Dysfunction*/prevention & control , Cognitive Dysfunction*/drug therapy , Quinazolinones*/pharmacology , Quinazolinones*/therapeutic use , Heme Oxygenase-1*/metabolism , Neuroprotective Agents*/pharmacology, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Mice ; Cell Line ; Mitochondria/metabolism ; Mitochondria/drug effects ; Signal Transduction/drug effects

trans-Styrylquinazolinone CYP1B1 inhibitors as potential therapeutics in A549 cells.

Autori: Cai J Yang F Yang M a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118000. Date of Electronic Publication: 2025 Aug 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cytochrome P-450 CYP1B1*/antagonists & inhibitors , Cytochrome P-450 CYP1B1*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Quinazolinones*/pharmacology , Quinazolinones*/chemistry , Quinazolinones*/chemical synthesis , Styrenes*/pharmacology , Styrenes*/chemistry , Styrenes*/chemical synthesis, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; A549 Cells ; Molecular Structure ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug

Structure-Activity Relationships of Azaquinazolinone Derivatives as ¹⁸ F-Labeled PET Probes Targeting Ghrelin Receptors.

Autori: Watanabe H Saito H Nakashima K a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 22288-22300. Date of Electronic Publication: 2025 Oct 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Ghrelin*/metabolism , Fluorine Radioisotopes*/chemistry , Quinazolinones*/chemistry , Quinazolinones*/chemical synthesis , Quinazolinones*/pharmacokinetics , Quinazolinones*/metabolism , Positron-Emission Tomography*/methods , Radiopharmaceuticals*/chemistry , Radiopharmaceuticals*/chemical synthesis , Radiopharmaceuticals*/pharmacokinetics , Aza Compounds*/chemistry , Aza Compounds*/chemical synthesis , Aza Compounds*/pharmacokinetics, Animals ; Structure-Activity Relationship ; Mice ; Tissue Distribution ; Humans ; Male ; Pancreas/diagnostic imaging ; Pancreas/metabolism ; Positron Emission Tomography Computed Tomography

Aqueous Microdroplets Induce the Metamorphosis of Indole into Quinazolinone Pharmacophores.

Autori: Nandy A Banerjee S

Zdroj: Journal of the American Chemical Society [J Am Chem Soc] 2025 Nov 12; Vol. 147 (45), pp. 41242-41247. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Výrazy zo slovníka MeSH: Indoles*/chemistry , Water*/chemistry , Quinazolinones*/chemistry , Quinazolinones*/chemical synthesis, Molecular Structure

Ethanol-mediated one-pot synthesis of 3-phenyl-3,4,5,12-tetrahydrobenzo[4,5]imidazo[2,1-b]quinazolin-1(2H)-ones as PDGFRA inhibitors.

Autori: Parmar MP Kashyap S Vala DP a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117914. Date of Electronic Publication: 2025 Jul 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Ethanol*/chemistry , Receptor, Platelet-Derived Growth Factor alpha*/antagonists & inhibitors , Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis , Quinazolinones*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Cell Line, Tumor

Design, Synthesis, and Biological Evaluation of 1,2,3-Triazole-Quinazolinone Derivatives as Promising α-Glucosidase Inhibitors with Favorable Drug-Like Properties.

Autori: Sirichai T Uipanit S Borwornpinyo S a ďalší

Zdroj: Chemistry, an Asian journal [Chem Asian J] 2025 Nov; Vol. 20 (22), pp. e70365. Date of Electronic Publication: 2025 Oct 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101294643 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1861-471X (Electronic) Linking ISSN: 1861471X NLM ISO Abbreviation: Chem Asian J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glycoside Hydrolase Inhibitors*/chemical synthesis , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Quinazolinones*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis , Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry , Drug Design*, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Saccharomyces cerevisiae/enzymology ; Molecular Structure ; Dose-Response Relationship, Drug

Design, Synthesis, Anticancer Properties, and Molecular Dynamics of New Quinazolinonethioacetohydrazide-1,2,3-Triazoles.

Autori: Iraji A Irajie C Nasouhi F a ďalší

Zdroj: Chemistry & biodiversity [Chem Biodivers] 2025 Nov; Vol. 22 (11), pp. e01526. Date of Electronic Publication: 2025 Jul 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Výrazy zo slovníka MeSH: Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Drug Design* , Molecular Dynamics Simulation* , Quinazolinones*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis, Humans ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Apoptosis/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; HEK293 Cells ; Cell Line, Tumor ; MCF-7 Cells

Discovery and SAR exploration of novel nanomolar 3,4-dihydroquinazolin-2(1H)-one non-nucleoside reverse transcriptase inhibitors.

Autori: Goffin E Torfs L Tsingis F a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 15; Vol. 296, pp. 117818. Date of Electronic Publication: 2025 May 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Reverse Transcriptase Inhibitors*/pharmacology , Reverse Transcriptase Inhibitors*/chemistry , Reverse Transcriptase Inhibitors*/chemical synthesis , HIV-1*/drug effects , HIV-1*/enzymology , HIV Reverse Transcriptase*/antagonists & inhibitors , HIV Reverse Transcriptase*/metabolism , Drug Discovery* , Anti-HIV Agents*/pharmacology , Anti-HIV Agents*/chemistry , Anti-HIV Agents*/chemical synthesis , Quinazolinones*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis, Structure-Activity Relationship ; Humans ; Molecular Structure ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests

Redox-Active Quinazolinone Thioamide Ag(I) Complexes with Potent Antibacterial Activity: Mechanistic Insights and Hydrogel-Enhanced Efficacy.

Autori: Tzaferi EI Varna D Esarev IV a ďalší

Zdroj: Molecules (Basel, Switzerland) [Molecules] 2025 Oct 13; Vol. 30 (20). Date of Electronic Publication: 2025 Oct 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Quinazolinones*/chemistry , Quinazolinones*/pharmacology , Thioamides*/chemistry , Thioamides*/pharmacology , Hydrogels*/chemistry , Hydrogels*/pharmacology , Silver*/chemistry , Silver*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/pharmacology , Coordination Complexes*/chemical synthesis, Staphylococcus aureus/drug effects ; Escherichia coli/drug effects ; Oxidation-Reduction ; Microbial Sensitivity Tests ; Structure-Activity Relationship

Screening for antimicrobial and antioxidant activities of quinazolinone based isoxazole and isoxazoline derivatives, synthesis and In silico studies.

Autori: Myakala N Thumma V Kandula K a ďalší

Zdroj: Molecular diversity [Mol Divers] 2025 Oct; Vol. 29 (5), pp. 4255-4271. Date of Electronic Publication: 2024 Nov 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Výrazy zo slovníka MeSH: Quinazolinones*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Anti-Infective Agents*/chemical synthesis , Isoxazoles*/chemistry , Isoxazoles*/pharmacology , Isoxazoles*/chemical synthesis, Molecular Docking Simulation ; Microbial Sensitivity Tests ; Structure-Activity Relationship ; Fungi/drug effects

[Expression of Concern] Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase‑9.

Autori: Jin ML Park SY Kim YH a ďalší

Zdroj: International journal of oncology [Int J Oncol] 2025 Dec; Vol. 67 (6). Date of Electronic Publication: 2025 Oct 17.

Spôsob vydávania: Journal Article; Expression of Concern

Informácie o časopise: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9306042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2423 (Electronic) Linking ISSN: 10196439 NLM ISO Abbreviation: Int J Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Quinazolinones*/pharmacology , Piperidines*/pharmacology , Matrix Metalloproteinase 9*/genetics , Matrix Metalloproteinase 9*/metabolism, Humans ; Cell Movement/drug effects ; Apoptosis/drug effects ; Female ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Down-Regulation/drug effects ; Cell Proliferation/drug effects