Suchergebnisse - "Quinazolines"

Design, synthesis and evaluation of clickable photoaffinity probes for nuclear lamins.

Autoren: Warren J Wang J Li BX et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130392. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Photoaffinity Labels*/chemistry , Photoaffinity Labels*/chemical synthesis , Drug Design* , Quinazolines*/chemistry , Quinazolines*/chemical synthesis , Lamins*/metabolism , Lamins*/analysis , Lamins*/chemistry , Pyrroles*/chemistry , Pyrroles*/chemical synthesis, Structure-Activity Relationship ; Humans ; Click Chemistry ; Molecular Structure

Discovery of 2-tetrahydroisoquinoline substituted quinazoline derivatives as lysine methyltransferase G9a inhibitors with in vivo antitumor efficacy.

Autoren: Shao M Gao L Xu J et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118113. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Quinazolines*/chemistry , Quinazolines*/pharmacology , Quinazolines*/chemical synthesis , Tetrahydroisoquinolines*/chemistry , Tetrahydroisoquinolines*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Histone-Lysine N-Methyltransferase*/antagonists & inhibitors , Histone-Lysine N-Methyltransferase*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Drug Discovery*, Animals ; Humans ; Mice ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Molecular Structure ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Histocompatibility Antigens/metabolism ; Apoptosis/drug effects ; Cell Line, Tumor ; Mice, Inbred BALB C

Use of dual-position and high-radioactivity ¹⁴ C labeling, high-resolution mass spectrometry for pesticide transformation in vegetable: Uptake and metabolism of quinotrione in cabbage.

Autoren: Nie E Lin Z Huang J et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 2), pp. 146440. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Brassica*/chemistry , Brassica*/metabolism , Vegetables*/chemistry , Vegetables*/metabolism , Herbicides*/metabolism , Herbicides*/chemistry , Mass Spectrometry*/methods , Quinazolines*/chemistry , Quinazolines*/metabolism, Carbon Radioisotopes/chemistry ; Food Contamination/analysis ; 4-Hydroxyphenylpyruvate Dioxygenase/metabolism ; 4-Hydroxyphenylpyruvate Dioxygenase/antagonists & inhibitors

Development of dihydroquinazoline compounds as novel therapeutics against Naegleria fowleri.

Autoren: Voisinet MM Palmentiero CM McKeon JEM et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130363. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Naegleria fowleri*/drug effects , Quinazolines*/pharmacology , Quinazolines*/chemistry , Quinazolines*/chemical synthesis , Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/chemistry , Antiprotozoal Agents*/chemical synthesis, Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Humans

Clinical Outcomes of Low-Grade Cytomegalovirus DNAemia in Hematopoietic Stem Cell Transplantation Recipients Receiving Letermovir Prophylaxis.

Autoren: Son JS Jeong EJ Jo HJ et al.

Quelle: Journal of medical virology [J Med Virol] 2025 Dec; Vol. 97 (12), pp. e70736.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

MeSH-Schlagworte: Cytomegalovirus Infections*/prevention & control , Cytomegalovirus Infections*/virology , Hematopoietic Stem Cell Transplantation*/adverse effects , Antiviral Agents*/therapeutic use , Antiviral Agents*/administration & dosage , DNA, Viral*/blood , Acetates*/therapeutic use , Acetates*/administration & dosage , Cytomegalovirus*/genetics , Cytomegalovirus*/isolation & purification , Quinazolines*/therapeutic use , Quinazolines*/administration & dosage , Viremia*, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Adult ; Republic of Korea ; Treatment Outcome ; Young Adult ; Transplant Recipients ; Aged ; Adolescent ; Tertiary Care Centers

Development and Characterization of Sensitive, Eco-Friendly, and Selective Microwave-Aided Fluorodensitometric Probe for Estimation of Alfuzosin Using Comprehensive Approach of Multicolored Analytical Chemistry and Design of Experiments.

Autoren: Prajapati P Patil Y Haque A et al.

Quelle: Luminescence : the journal of biological and chemical luminescence [Luminescence] 2025 Dec; Vol. 40 (12), pp. e70372.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley & Sons Country of Publication: England NLM ID: 100889025 Publication Model: Print Cited Medium: Internet ISSN: 1522-7243 (Electronic) Linking ISSN: 15227235 NLM ISO Abbreviation: Luminescence Subsets: MEDLINE

MeSH-Schlagworte: Microwaves* , Quinazolines*/blood , Quinazolines*/analysis , Fluorescent Dyes*/chemistry , Fluorescent Dyes*/chemical synthesis, Humans ; Limit of Detection ; Molecular Structure ; Green Chemistry Technology ; Chromatography, Thin Layer

Novel 1-Methylquinazoline and 1-Methylquinoxaline derivatives targeting FtsZ protein: Potent antibacterial agents against gram-positive bacteria.

Autoren: Zhang S Ding H Ma Y et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109282. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Bacterial Proteins*/antagonists & inhibitors , Bacterial Proteins*/metabolism , Quinoxalines*/pharmacology , Quinoxalines*/chemistry , Quinoxalines*/chemical synthesis , Cytoskeletal Proteins*/antagonists & inhibitors , Cytoskeletal Proteins*/metabolism , Gram-Positive Bacteria*/drug effects , Quinazolines*/pharmacology , Quinazolines*/chemistry , Quinazolines*/chemical synthesis, Microbial Sensitivity Tests ; Animals ; Structure-Activity Relationship ; Mice ; Molecular Structure ; Dose-Response Relationship, Drug ; Humans ; Staphylococcus aureus/drug effects

Green and sustainable approaches to Quinazoline-based anticancer agents: Synthesis and structure activity relationship (SAR).

Autoren: Kumari P Kumar A Bhatia R

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109231. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Quinazolines*/pharmacology , Quinazolines*/chemical synthesis , Quinazolines*/chemistry , Green Chemistry Technology*, Humans ; Structure-Activity Relationship ; Animals ; Drug Screening Assays, Antitumor ; Molecular Structure ; Cell Proliferation/drug effects ; Chlorocebus aethiops

Efficacy of intranasal delivery of VEGFR inhibitors to cervical lymph nodes for inhibiting tongue cancer metastasis in mice.

Autoren: Furubayashi T Kobayashi M Hamada N et al.

Quelle: Journal of drug targeting [J Drug Target] 2025 Dec; Vol. 33 (10), pp. 1932-1941. Date of Electronic Publication: 2025 Jul 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9312476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2330 (Electronic) Linking ISSN: 10267158 NLM ISO Abbreviation: J Drug Target Subsets: MEDLINE

MeSH-Schlagworte: Tongue Neoplasms*/drug therapy , Tongue Neoplasms*/pathology , Sulfonamides*/administration & dosage , Sulfonamides*/pharmacokinetics , Sulfonamides*/pharmacology , Pyrimidines*/administration & dosage , Pyrimidines*/pharmacokinetics , Pyrimidines*/pharmacology , Quinazolines*/administration & dosage , Quinazolines*/pharmacokinetics , Quinazolines*/pharmacology , Lymph Nodes*/drug effects , Lymph Nodes*/pathology , Lymph Nodes*/metabolism , Vascular Endothelial Growth Factor Receptor-3*/antagonists & inhibitors, Animals ; Mice ; Lymphatic Metastasis/prevention & control ; Administration, Intranasal ; Indazoles ; Cell Line, Tumor ; Male ; Female ; Humans ; Mice, Nude ; Mice, Inbred BALB C ; Indoles

Pharmacokinetic profile and in vivo anticancer efficacy of anagrelide administered subcutaneously in rodents.

Autoren: Toivanen K De Sutter L Wozniak A et al.

Quelle: Drug delivery [Drug Deliv] 2025 Dec; Vol. 32 (1), pp. 2463433. Date of Electronic Publication: 2025 Feb 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9417471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0464 (Electronic) Linking ISSN: 10717544 NLM ISO Abbreviation: Drug Deliv Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/pharmacology , Quinazolines*/pharmacokinetics , Quinazolines*/administration & dosage , Quinazolines*/pharmacology, Animals ; Rats, Sprague-Dawley ; Rats ; Mice ; Injections, Subcutaneous ; Humans ; Xenograft Model Antitumor Assays ; Administration, Oral ; Male ; Cell Line, Tumor ; Dose-Response Relationship, Drug

Synthesis and evaluation of novel substituted N-(2-phenylbutyl)-5,6,7,8-tetrahydro-quinazolin-4-amines as allosteric modulators of HIV-DAT-tat interaction.

Autoren: Nguyen TH Moukha-Chafiq O Karyakarte S et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 01; Vol. 128, pp. 130345. Date of Electronic Publication: 2025 Jul 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Dopamine Plasma Membrane Transport Proteins*/metabolism , Quinazolines*/chemical synthesis , Quinazolines*/pharmacology , Quinazolines*/chemistry , tat Gene Products, Human Immunodeficiency Virus*/metabolism , HIV-1*/metabolism , HIV-1*/drug effects, Structure-Activity Relationship ; Allosteric Regulation/drug effects ; Humans ; Animals ; CHO Cells ; Cricetulus ; Cricetinae ; Molecular Structure

Molecular modeling aided design, synthesis and biological evaluation of quinazoline derivatives for the treatment of human cancer.

Autoren: Liu CS Tong JP Fang ZY et al.

Quelle: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 5709-5724. Date of Electronic Publication: 2025 Jan 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

MeSH-Schlagworte: Quinazolines*/pharmacology , Quinazolines*/chemistry , Quinazolines*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Drug Design* , Neoplasms*/drug therapy , Neoplasms*/pathology, Humans ; Cell Line, Tumor ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/chemistry ; Molecular Docking Simulation ; Apoptosis/drug effects ; Polo-Like Kinase 1 ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/chemistry ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins/chemistry ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Models, Molecular ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/chemical synthesis ; Focal Adhesion Kinase 1/antagonists & inhibitors ; Focal Adhesion Kinase 1/metabolism ; Focal Adhesion Kinase 1/chemistry

Fruquintinib plus sintilimab in previously bevacizumab-treated, pMMR/MSS refractory metastatic colorectal cancer: a phase 2 clinical trial.

Autoren: Zhang W Gong CF Huang JL et al.

Quelle: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Nov 20; Vol. 74 (12), pp. 381. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article; Clinical Trial, Phase II

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/mortality , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Bevacizumab*/therapeutic use , Bevacizumab*/pharmacology , Antibodies, Monoclonal, Humanized*/therapeutic use , Antibodies, Monoclonal, Humanized*/pharmacology , Antibodies, Monoclonal, Humanized*/administration & dosage , Quinazolines*/therapeutic use , Quinazolines*/pharmacology , Quinazolines*/administration & dosage, Humans ; Female ; Male ; Middle Aged ; Aged ; Adult ; DNA Mismatch Repair ; Neoplasm Metastasis ; Aged, 80 and over ; Drug Resistance, Neoplasm ; Benzofurans

Adjuvant Icotinib in EGFR-mutated stage IB non-small cell lung cancer with high-risk factors: A retrospective case series.

Autoren: Cheng M Zhang J Jin L et al.

Quelle: PloS one [PLoS One] 2025 Nov 19; Vol. 20 (11), pp. e0337237. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/pathology , Crown Ethers*/therapeutic use , Crown Ethers*/adverse effects , Crown Ethers*/administration & dosage , Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Quinazolines*/therapeutic use , Quinazolines*/adverse effects , Quinazolines*/administration & dosage , Antineoplastic Agents*/therapeutic use, Humans ; Male ; Female ; ErbB Receptors/genetics ; Middle Aged ; Retrospective Studies ; Aged ; Mutation ; Risk Factors ; Adult ; Chemotherapy, Adjuvant ; Neoplasm Staging ; Disease-Free Survival

Design and synthesis of novel diclofenac-based quinazoline derivatives enhancing cisplatin and radiation impacts via MyD88 and COX-2/PGE2 modulation.

Autoren: Ghorab MM El-Gazzar MGM Soliman AM et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 117997. Date of Electronic Publication: 2025 Jul 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Diclofenac*/pharmacology , Diclofenac*/chemistry , Diclofenac*/chemical synthesis , Cisplatin*/pharmacology , Cyclooxygenase 2*/metabolism , Drug Design* , Dinoprostone*/metabolism , Dinoprostone*/antagonists & inhibitors , Quinazolines*/pharmacology , Quinazolines*/chemistry , Quinazolines*/chemical synthesis , Analgesics*/pharmacology , Analgesics*/chemical synthesis , Analgesics*/chemistry , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/antagonists & inhibitors , Cyclooxygenase 2 Inhibitors*/pharmacology , Cyclooxygenase 2 Inhibitors*/chemical synthesis , Cyclooxygenase 2 Inhibitors*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/chemistry, Animals ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Chlorocebus aethiops ; Vero Cells ; Antineoplastic Agents/pharmacology ; Male ; Rats

Design, synthesis and biological evaluation of novel platelet-derived growth factor receptor-α (PDGFR-α) inhibitors based on 4-anilinoquinoline and 4-anilinoquinazoline scaffolds.

Autoren: Wang R Yao SX Pang YW et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118015. Date of Electronic Publication: 2025 Jul 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Drug Design* , Quinazolines*/chemistry , Quinazolines*/pharmacology , Quinazolines*/chemical synthesis , Quinolines*/chemistry , Quinolines*/pharmacology , Quinolines*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Receptor, Platelet-Derived Growth Factor alpha*/antagonists & inhibitors , Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Aniline Compounds*/chemistry , Aniline Compounds*/pharmacology , Aniline Compounds*/chemical synthesis, Humans ; Zebrafish ; Structure-Activity Relationship ; Animals ; Molecular Structure ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; HT29 Cells

Synthesis of 3-(arylamino) quinazoline-2,4(1H,3H)-dione derivatives via TBHP/I2: Molecular docking, MD simulation, DFT, and pharmacological evaluation as MTH1 inhibitors.

Autoren: Karim MG Mehrdad M Gheidari D et al.

Quelle: PloS one [PLoS One] 2025 Nov 13; Vol. 20 (11), pp. e0335707. Date of Electronic Publication: 2025 Nov 13 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Quinazolines*/chemistry , Quinazolines*/pharmacology , Quinazolines*/chemical synthesis , Phosphoric Monoester Hydrolases*/antagonists & inhibitors , Phosphoric Monoester Hydrolases*/chemistry , Phosphoric Monoester Hydrolases*/metabolism , DNA Repair Enzymes*/antagonists & inhibitors , DNA Repair Enzymes*/chemistry , DNA Repair Enzymes*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Iodine*/chemistry, Molecular Docking Simulation ; Molecular Dynamics Simulation ; Humans ; Density Functional Theory ; Animals

Use of Direct-to-Biology Strategies for the Discovery of 2'-Deoxynucleoside 5'-Monophosphate N-Glycosidase (DNPH1) PROTACs.

Autoren: Anderson NA Barlaam B Argyrou A et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 23421-23447. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Drug Discovery* , Quinazolines*/pharmacology , Quinazolines*/chemistry , Quinazolines*/chemical synthesis , N-Glycosyl Hydrolases*/metabolism , N-Glycosyl Hydrolases*/antagonists & inhibitors , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Humans ; Cell Line, Tumor ; Structure-Activity Relationship ; Proteolysis Targeting Chimera

Design, Synthesis, and Evaluation of a Novel ^99m Tc-Labeled Small Molecule Inhibitor (Lapatinib)-Based SPECT Tracer Targeting HER2.

Autoren: Li Z Diao L Han P et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 23620-23631. Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Receptor, ErbB-2*/antagonists & inhibitors , Receptor, ErbB-2*/metabolism , Tomography, Emission-Computed, Single-Photon* , Drug Design* , Quinazolines*/chemistry , Quinazolines*/chemical synthesis , Quinazolines*/pharmacology , Quinazolines*/pharmacokinetics , Radiopharmaceuticals*/chemical synthesis , Radiopharmaceuticals*/pharmacokinetics , Radiopharmaceuticals*/chemistry , Organotechnetium Compounds*/chemistry , Organotechnetium Compounds*/pharmacokinetics , Organotechnetium Compounds*/chemical synthesis , Technetium*/chemistry, Animals ; Humans ; Mice ; Cell Line, Tumor ; Female ; Tissue Distribution ; Structure-Activity Relationship

Design, Synthesis, and Biological Evaluation of Evodiamine Derivatives as Antibody-Drug Conjugate Payloads.

Autoren: Liu R Duan Y Jiang J et al.

Quelle: ChemMedChem [ChemMedChem] 2025 Nov 06; Vol. 20 (21), pp. e202500268. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

MeSH-Schlagworte: Quinazolines*/chemistry , Quinazolines*/pharmacology , Quinazolines*/chemical synthesis , Drug Design* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Immunoconjugates*/chemistry , Immunoconjugates*/pharmacology , Topoisomerase I Inhibitors*/pharmacology , Topoisomerase I Inhibitors*/chemical synthesis , Topoisomerase I Inhibitors*/chemistry , Topoisomerase II Inhibitors*/pharmacology , Topoisomerase II Inhibitors*/chemical synthesis , Topoisomerase II Inhibitors*/chemistry, Humans ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Molecular Structure ; Dose-Response Relationship, Drug ; DNA Topoisomerases, Type I/metabolism ; DNA Topoisomerases, Type II/metabolism ; Cell Survival/drug effects