Search Results - "Pyridines/therapeutic use [MeSH]"

EFFECT of daily antiseptic bathing with octenidine on ICU-acquired bacteremia and ICU-acquired multidrug-resistant organisms: a multicenter, cluster-randomized, double-blind, placebo-controlled, cross-over study

Authors: Tiffany Schaumburg Norbert Köhler Yasmine Breitenstein et al.

Source: Intensive Care Med

Subject Terms: Male, Cross Infection, Cross-Over Studies, Original, Pyridines, Bacteremia, Baths, Middle Aged, Intensive Care Units/statistics, Double-Blind Method [MeSH], Cross Infection/prevention, Aged [MeSH], Octenidine, Intensive care unit, Male [MeSH], Bacteremia/prevention, Anti-Infective Agents, Local/pharmacology [MeSH], Imines [MeSH], Baths/methods [MeSH], Female [MeSH], Pyridines/pharmacology [MeSH], Drug Resistance, Multiple, Bacterial/drug effects [MeSH], Pyridines/therapeutic use [MeSH], Antiseptic bathing, Humans [MeSH], Pyridines/administration, Middle Aged [MeSH], Anti-Infective Agents, Local/therapeutic use [MeSH], Cross-Over Studies [MeSH], Anti-Infective Agents, Local/administration, Germany [MeSH], Multidrug-resistant organisms, Intensive Care Units, Double-Blind Method, Drug Resistance, Multiple, Bacterial, Germany, Anti-Infective Agents, Local, Humans, Female, Imines, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/39417875
https://repository.publisso.de/resource/frl:6507122

Selective Internal Radiation Therapy Using Y-90 Resin Microspheres for Metastatic Colorectal Cancer: An Updated Systematic Review and Network Meta-Analysis

Authors: André L. F. Azeredo-da-Silva Victor Hugo F. de Jesus Ion Agirrezabal et al.

Source: Adv Ther

Subject Terms: Pyrrolidines, Pyridines, Phenylurea Compounds, Network Meta-Analysis, Brachytherapy, Microspheres, Trifluridine, Drug Combinations, Humans, SIRT, Phenylurea Compounds/therapeutic use [MeSH], Pyridines/therapeutic use [MeSH], Drug Combinations [MeSH], Humans [MeSH], Liver metastasis, Colorectal Neoplasms/drug therapy [MeSH], Regorafenib, Colorectal Neoplasms/radiotherapy [MeSH], Yttrium Radioisotopes/therapeutic use [MeSH], Thymine [MeSH], Brachytherapy/methods [MeSH], Phenylurea Compounds/adverse effects [MeSH], Microspheres [MeSH], Brachytherapy/adverse effects [MeSH], Trifluridine/therapeutic use [MeSH], Original Research, Best supportive, Pyrrolidines/therapeutic use [MeSH], Trifluridine–tipiracil, Yttrium Radioisotopes, Colorectal Neoplasms, Thymine

Access URL: https://pubmed.ncbi.nlm.nih.gov/38407790
https://repository.publisso.de/resource/frl:6502870

Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma

Authors: Gutzmer, Ralf Leiter, Ulrike Mohr, Peter et al.

Source: BMC Cancer
Bmc Cancer
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Instituto de Investigación Sanitaria La Fe (IIS La Fe)
BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)

Subject Terms: Male, Adult, Aged, 80 and over, ddc:610, Skin Neoplasms, Pyridines, Research, Biphenyl Compounds, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Antineoplastic Agents, Middle Aged, Dysgeusia, Sonidegib, Hedgehog pathway inhibitors, Young Adult, 03 medical and health sciences, Treatment Outcome, 0302 clinical medicine, Carcinoma, Basal Cell, Basal cell carcinoma, Humans, Female, RC254-282, Antineoplastic Agents/adverse effects [MeSH], Aged, 80 and over [MeSH], Carcinoma, Basal Cell/drug therapy [MeSH], Aged [MeSH], Pyridines/adverse effects [MeSH], Antineoplastic Agents/administration, Skin Neoplasms/drug therapy [MeSH], Biphenyl Compounds/therapeutic use [MeSH], Male [MeSH], Dysgeusia/epidemiology [MeSH], Biphenyl Compounds/adverse effects [MeSH], Dysgeusia/chemically induced [MeSH], Female [MeSH], Pyridines/therapeutic use [MeSH], Adult [MeSH], Humans [MeSH], Pyridines/administration, Treatment Outcome [MeSH], Middle Aged [MeSH], Carcinoma, Basal Cell/pathology [MeSH], Skin Neoplasms/pathology [MeSH], Young Adult [MeSH], Antineoplastic Agents/therapeutic use [MeSH], Aged

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39538176
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=21993
https://doaj.org/article/f6af041d3b7c44cf9ec6506be11d5de8
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/11827
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/files/11827/GutzmerRalf14112024.pdf
https://nbn-resolving.org/urn:nbn:de:hbz:294-118274
https://repository.publisso.de/resource/frl:6493652

Clinical characterization, prognostic, and predictive values of HER2-low in patients with early breast cancer in the PALLAS trial (ABCSG-42/AFT-05/BIG-14–13/PrE0109)

Authors: Guilherme Nader-Marta Christian Singer Dominik Hlauschek et al.

Source: Breast Cancer Res
Breast Cancer Research, Vol 26, Iss 1, Pp 1-10 (2024)

Subject Terms: Endocrine therapy, Adult, Receptor, ErbB-2, Pyridines, Research, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Breast Neoplasms, Palbociclib, Middle Aged, Antibody–drug conjugates, Aged [MeSH], HER2-low, Receptor, ErbB-2/metabolism [MeSH], Breast cancer, Receptor, ErbB-2/genetics [MeSH], Neoplasm Staging [MeSH], Piperazines/therapeutic use [MeSH], Breast Neoplasms/mortality [MeSH], Breast Neoplasms/pathology [MeSH], Female [MeSH], Pyridines/therapeutic use [MeSH], Receptors, Estrogen/metabolism [MeSH], Adult [MeSH], Humans [MeSH], Breast Neoplasms/genetics [MeSH], Breast Neoplasms/drug therapy [MeSH], Breast Neoplasms/metabolism [MeSH], Middle Aged [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Biomarkers, Tumor/metabolism [MeSH], Prognosis [MeSH], Prognosis, Piperazines, Receptors, Estrogen, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Female, RC254-282, Aged, Neoplasm Staging

Access URL: https://pubmed.ncbi.nlm.nih.gov/39375745
https://doaj.org/article/c4f4965043a847fba7a786c64cdbe554
https://repository.publisso.de/resource/frl:6500183

Trametinib in combination with hydroxychloroquine or palbociclib in advanced metastatic pancreatic cancer: data from a retrospective, multicentric cohort (AIO AIO-TF/PAK-0123)

Authors: David Witte Ina Pretzell Timm M Reissig et al.

Contributors: David Witte Ina Pretzell Timm M Reissig et al.

Source: J Cancer Res Clin Oncol

Subject Terms: Research, Pancreatic cancer, MEK inhibitor, CDK inhibitor, Autophagy, Targeted therapy, Molecular guided treatment, Male, Adult, Aged, 80 and over, Pyridones, Pyridines, Aged, 80 and over [MeSH], Aged [MeSH], Pancreatic Neoplasms/pathology [MeSH], Hydroxychloroquine/therapeutic use [MeSH], Pyridones/administration, Pyridones/therapeutic use [MeSH], Piperazines/administration, Male [MeSH], Piperazines/therapeutic use [MeSH], Female [MeSH], Pyridines/therapeutic use [MeSH], Adult [MeSH], Humans [MeSH], Pyridines/administration, Retrospective Studies [MeSH], Middle Aged [MeSH], Pancreatic Neoplasms/drug therapy [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Pyrimidinones/administration, Hydroxychloroquine/administration, Pyrimidinones/therapeutic use [MeSH], Medizin, Pyrimidinones, Middle Aged, Piperazines, ddc, Pancreatic Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Retrospective Studies, Aged, Hydroxychloroquine

File Description: application/pdf; pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39352477
https://resolver.sub.uni-goettingen.de/purl?gro-2/146427
https://repository.publisso.de/resource/frl:6498139
https://mediatum.ub.tum.de/1770790
https://www.ncbi.nlm.nih.gov/pubmed/39352477
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85205447265
https://doi.org/10.1007/s00432-024-05954-5

Vorasidenib bei niedriggradigen Gliomen – neues Therapieprinzip mit offenen Fragen zu den Langzeitergebnissen

Authors: Seidel, Clemens Nicolay, Nils H.

Source: Strahlenther Onkol

Subject Terms: Glioma/drug therapy [MeSH], Brain Neoplasms/radiotherapy [MeSH], Pyridines/therapeutic use [MeSH], Diamines/therapeutic use [MeSH], Humans [MeSH], Pyridines/adverse effects [MeSH], Literatur Kommentiert, Brain Neoplasms/drug therapy [MeSH], Diamines/adverse effects [MeSH]

Access URL: https://repository.publisso.de/resource/frl:6516110

Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy

Authors: Zuckermann, Marc He, Chen Andrews, Jared et al.

Source: Mol Cancer
Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)

Subject Terms: 0301 basic medicine, Oncogene Proteins, Fusion, Pyridines, MET inhibition, Mice, 03 medical and health sciences, 0302 clinical medicine, Crizotinib, Cell Line, Tumor, Animals, Humans, Anilides, Combination therapy, Child, Protein Kinase Inhibitors, RC254-282, Radiosensitization, Preclinical trials, Brain Neoplasms, Triazines, Research, Imidazoles, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Pediatric-type diffuse high-grade glioma, Glioma, Proto-Oncogene Proteins c-met, Xenograft Model Antitumor Assays, 3. Good health, Disease Models, Animal, Cell Line, Tumor [MeSH], Neoplasm Grading [MeSH], Imidazoles [MeSH], Proto-Oncogene Proteins c-met/genetics [MeSH], Crizotinib/pharmacology [MeSH], Glioma/drug therapy [MeSH], Glioma/pathology [MeSH], Xenograft Model Antitumor Assays [MeSH], Benzamides/therapeutic use [MeSH], Child [MeSH], Disease Models, Animal [MeSH], Glioma/therapy [MeSH], Crizotinib/therapeutic use [MeSH], Benzamides/pharmacology [MeSH], Female [MeSH], Pyridines/pharmacology [MeSH], Brain Neoplasms/radiotherapy [MeSH], Brain Neoplasms/genetics [MeSH], Protein Kinase Inhibitors/pharmacology [MeSH], Pyridines/therapeutic use [MeSH], Humans [MeSH], Oncogene Proteins, Fusion/genetics [MeSH], Animals [MeSH], Protein Kinase Inhibitors/therapeutic use [MeSH], Capmatinib, Proto-Oncogene Proteins c-met/metabolism [MeSH], Mice [MeSH], Proto-Oncogene Proteins c-met/antagonists, Glioma/genetics [MeSH], Triazines [MeSH], Anilides/pharmacology [MeSH], Brain Neoplasms/drug therapy [MeSH], Oncogene Proteins, Fusion/metabolism [MeSH], Brain Neoplasms/pathology [MeSH], Benzamides, Female, Neoplasm Grading

Access URL: https://pubmed.ncbi.nlm.nih.gov/38849845
https://doaj.org/article/c4e30eaef7d54080a0db2c1628bcebbf
https://repository.publisso.de/resource/frl:6493228

Addressing treatment switching bias in the ALTA-1L trial with g-methods: exploring the impact of model specification

Authors: Al Tawil, Amani McGrath, Sean Ristl, Robin et al.

Source: BMC Med Res Methodol
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-22 (2024)

Subject Terms: Medicine (General), Lung Neoplasms, Pyridines, 01 natural sciences, IPCW, 03 medical and health sciences, R5-920, Organophosphorus Compounds, 0302 clinical medicine, Crizotinib, Parametric g-formula, Humans, Treatment switching, 0101 mathematics, Proportional Hazards Models, Randomized Controlled Trials as Topic, Models, Statistical, Treatment-confounder feedback, Research, Survival analysis, Intention to Treat Analysis, 3. Good health, Time-dependent confounding, Pyrimidines, Treatment Outcome, Clinical Trials, Phase III as Topic, Pyrazoles, Crizotinib/therapeutic use [MeSH], Intention to Treat Analysis/methods [MeSH], Clinical Trials, Phase III as Topic/methods [MeSH], Pyridines/therapeutic use [MeSH], Humans [MeSH], Treatment Outcome [MeSH], Pyrazoles/therapeutic use [MeSH], Randomized Controlled Trials as Topic/methods [MeSH], Proportional Hazards Models [MeSH], Pyrimidines/therapeutic use [MeSH], Clinical Trials, Phase III as Topic/statistics, Models, Statistical [MeSH], Randomized Controlled Trials as Topic/statistics, Lung Neoplasms/drug therapy [MeSH], Organophosphorus Compounds/therapeutic use [MeSH]

Access URL: https://pubmed.ncbi.nlm.nih.gov/39707229
https://doaj.org/article/39a5b1d6baf3408c83fa74836fe13a8f
https://repository.publisso.de/resource/frl:6491842
https://epub.ub.uni-muenchen.de/124722/

Case Series: Hyperbilirubinemia under elexacaftor/tezacaftor/ivacaftor in the presence of Gilbert’s syndrome

Authors: Weitzel, Julia Welsner, Matthias Taube, Christian et al.

Source: BMC Pulm Med
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-5 (2024)

Subject Terms: Adult, Male, 0301 basic medicine, Indoles, Pyrrolidines, Adolescent, Cystic Fibrosis, Pyridines, Medizin, Liver dysfunction, Case Report, Gilbert's syndrome, Quinolones, Aminophenols, Cystic fibrosis, Diseases of the respiratory system, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Humans, Elexacaftor/tezacaftor/ivacaftor, Pyrroles, Benzodioxoles, Glucuronosyltransferase, Hyperbilirubinemia, RC705-779, Cystic Fibrosis/drug therapy [MeSH], Hyperbilirubinemia/chemically induced [MeSH], Pyrazoles/adverse effects [MeSH], Benzodioxoles/adverse effects [MeSH], Drug Combinations [MeSH], Pyridines/adverse effects [MeSH], Drug intolerance, Pyrazoles/therapeutic use [MeSH], Pyrroles/adverse effects [MeSH], Benzodioxoles/therapeutic use [MeSH], Aminophenols/therapeutic use [MeSH], Male [MeSH], Indoles/adverse effects [MeSH], Adolescent [MeSH], Female [MeSH], Quinolones/adverse effects [MeSH], Pyridines/therapeutic use [MeSH], Adult [MeSH], Cystic Fibrosis/complications [MeSH], Humans [MeSH], Gilbert Disease/drug therapy [MeSH], Pyrrolidines [MeSH], Quinolines [MeSH], Young Adult [MeSH], Glucuronosyltransferase/genetics [MeSH], Gilbert Disease/genetics [MeSH], Aminophenols/adverse effects [MeSH], Quinolones/therapeutic use [MeSH], 3. Good health, Drug Combinations, Quinolines, Pyrazoles, Female, Gilbert Disease

Access URL: https://pubmed.ncbi.nlm.nih.gov/38956524
https://doaj.org/article/e7f10fbf6acf4c76954ab790ee4ad480
https://repository.publisso.de/resource/frl:6524398
https://www.ncbi.nlm.nih.gov/pubmed/38956524
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85197650229
https://doi.org/10.1186/s12890-024-03114-6

Cabozantinib for the Treatment of Advanced Hepatocellular Carcinoma: Current Data and Future Perspectives

Authors: Jörg Trojan

Source: Drugs

Subject Terms: 0301 basic medicine, ddc:610, Clinical Trials as Topic, Carcinoma, Hepatocellular, Pyridines, Liver Neoplasms, Antineoplastic Agents, Review Article, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Humans, Anilides/therapeutic use [MeSH], Pharmacology/Toxicology, Antineoplastic Agents/adverse effects [MeSH], Pyridines/therapeutic use [MeSH], Humans [MeSH], Pyridines/adverse effects [MeSH], Carcinoma, Hepatocellular/drug therapy [MeSH], Anilides/adverse effects [MeSH], Clinical Trials as Topic [MeSH], Antineoplastic Agents/therapeutic use [MeSH], Internal Medicine, Liver Neoplasms/drug therapy [MeSH], Pharmacotherapy, Anilides

File Description: application/pdf

Access URL: https://link.springer.com/content/pdf/10.1007/s40265-020-01361-5.pdf
https://pubmed.ncbi.nlm.nih.gov/32671719
https://pubmed.ncbi.nlm.nih.gov/32671719/
https://link.springer.com/content/pdf/10.1007/s40265-020-01361-5.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395054/
https://www.ncbi.nlm.nih.gov/pubmed/32671719
https://link.springer.com/article/10.1007/s40265-020-01361-5
https://repository.publisso.de/resource/frl:6465121

Point-of-care testing of coagulation in patients treated with edoxaban

Authors: Härtig, Florian Birschmann, Ingvild Peter, Andreas et al.

Source: J Thromb Thrombolysis

Subject Terms: Male, Pyridines, Blood Coagulation Tests [MeSH], Aged [MeSH], Factor Xa Inhibitors/therapeutic use [MeSH], Thiazoles/blood [MeSH], Drug Monitoring [MeSH], Atrial Fibrillation/drug therapy [MeSH], DOAC, Stroke, Male [MeSH], Anticoagulation reversal, Factor Xa Inhibitors/blood [MeSH], CoaguChek, Stroke/drug therapy [MeSH], Female [MeSH], Pyridines/pharmacology [MeSH], Pyridines/therapeutic use [MeSH], Humans [MeSH], Prospective Studies [MeSH], Thrombolysis, Point-of-care, International Normalized Ratio [MeSH], Middle Aged [MeSH], Point-of-Care Testing [MeSH], Thiazoles/therapeutic use [MeSH], Article, Pyridines/blood [MeSH], Factor Xa Inhibitors/pharmacology [MeSH], Thiazoles/pharmacology [MeSH], Blood Coagulation/drug effects [MeSH], Middle Aged, 3. Good health, Thiazoles, 03 medical and health sciences, 0302 clinical medicine, Point-of-Care Testing, Atrial Fibrillation, Humans, Female, Blood Coagulation Tests, International Normalized Ratio, Prospective Studies, Drug Monitoring, Blood Coagulation, Aged, Factor Xa Inhibitors

Access URL: https://link.springer.com/content/pdf/10.1007/s11239-020-02143-2.pdf
https://pubmed.ncbi.nlm.nih.gov/32436010
https://europepmc.org/article/PMC/PMC7515947
https://link.springer.com/content/pdf/10.1007/s11239-020-02143-2.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515947
https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/106232
https://link.springer.com/article/10.1007/s11239-020-02143-2?error=cookies_not_supported&code=47968d88-0a13-4d4d-bf29-eebde757e3f1
https://publikationen.uni-tuebingen.de/xmlui/handle/10900/106232
https://repository.publisso.de/resource/frl:6468590

Effective treatment of locally advanced periocular basal cell carcinoma with oral hedgehog pathway inhibitor?

Authors: Xiaoyi Hou Alexander C. Rokohl Monika Ortmann et al.

Source: Graefes Arch Clin Exp Ophthalmol

Subject Terms: 03 medical and health sciences, 0302 clinical medicine, Basal cell carcinoma, Carcinoma, Basal Cell/drug therapy [MeSH], Aged [MeSH], Pyridines/therapeutic use [MeSH], Humans [MeSH], Eyelid, Hedgehog Proteins/therapeutic use [MeSH], Letter to the Editor, Biphenyl Compounds/therapeutic use [MeSH], Sonidegib, Male [MeSH], Antineoplastic Agents/therapeutic use [MeSH], Neoplasm Recurrence, Local [MeSH], Eyelid Neoplasms/drug therapy [MeSH], Eyelid carcinoma, Hedgehog pathway inhibitor

Access URL: https://link.springer.com/content/pdf/10.1007/s00417-020-04779-5.pdf
https://kups.ub.uni-koeln.de/33033/
https://link.springer.com/content/pdf/10.1007/s00417-020-04779-5.pdf
https://link.springer.com/article/10.1007/s00417-020-04779-5
https://pubmed.ncbi.nlm.nih.gov/32514773/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550312
https://repository.publisso.de/resource/frl:6467500

Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumor regrowth

Authors: Dennis Doleschel Sabine Hoff Anne Rix et al.

Source: J Exp Clin Cancer Res
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Journal of experimental & clinical cancer research 40(1), 288 (2021). doi:10.1186/s13046-021-02043-0

Subject Terms: Regorafenib, Pyridines, Research, Phenylurea Compounds, Programmed Cell Death 1 Receptor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Drug Synergism, Pyridines/pharmacology [MeSH], Cell Line, Tumor [MeSH], Macrophage polarization, Phenylurea Compounds/therapeutic use [MeSH], Pyridines/therapeutic use [MeSH], Humans [MeSH], Metastasis, Anti-PD1 antibody, Drug Synergism [MeSH], Colorectal Neoplasms/drug therapy [MeSH], Colorectal cancer, Animals [MeSH], Programmed Cell Death 1 Receptor/antagonists, Immunotherapy/methods [MeSH], Mice [MeSH], Preclinical, Phenylurea Compounds/pharmacology [MeSH], 3. Good health, Mice, Cell Line, Tumor, Animals, Humans, Immunotherapy, Colorectal Neoplasms, RC254-282

Access URL: https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-021-02043-0
https://pubmed.ncbi.nlm.nih.gov/34517894
https://doaj.org/article/f1af03bb86884972b957d7874ccb7a22
https://www.ncbi.nlm.nih.gov/pubmed/34517894
https://europepmc.org/article/MED/34517894
https://pubmed.ncbi.nlm.nih.gov/34517894/
https://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02043-0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436536
https://link.springer.com/content/pdf/10.1186/s13046-021-02043-0.pdf
https://repository.publisso.de/resource/frl:6463831
https://publications.rwth-aachen.de/record/851408