Výsledky vyhľadávania - "Pyridines/pharmacokinetics"

Time Course of the Interaction Between Oral Short-Term Ritonavir Therapy with Three Factor Xa Inhibitors and the Activity of CYP2D6, CYP2C19, and CYP3A4 in Healthy Volunteers

Autori: Brit S. Rohr Evelyn Krohmer Kathrin I. Foerster a ďalší

Zdroj: Clin Pharmacokinet

Predmety: Male, Adult, Ritonavir/administration, Rivaroxaban/pharmacokinetics [MeSH], Cytochrome P-450 CYP2D6/metabolism [MeSH], Pyridones/administration, Thiazoles/pharmacokinetics [MeSH], Administration, Oral [MeSH], Midazolam/pharmacokinetics [MeSH], Male [MeSH], Omeprazole/administration, Drug Interactions [MeSH], Healthy Volunteers [MeSH], Factor Xa Inhibitors/pharmacokinetics [MeSH], Omeprazole/pharmacokinetics [MeSH], Original Research Article, Midazolam/administration, Thiazoles/administration, Cytochrome P-450 CYP3A/metabolism [MeSH], Omeprazole/pharmacology [MeSH], Pyrazoles/pharmacokinetics [MeSH], Female [MeSH], Pyridines/pharmacology [MeSH], Pyridones/pharmacokinetics [MeSH], Adult [MeSH], Humans [MeSH], Pyrazoles/pharmacology [MeSH], Pyridines/administration, Factor Xa Inhibitors/administration, Pyrazoles/administration, Cytochrome P-450 CYP2C19/genetics [MeSH], Pyridines/pharmacokinetics [MeSH], Ritonavir/pharmacology [MeSH], Young Adult [MeSH], Cytochrome P-450 CYP2C19/metabolism [MeSH], Thiazoles/pharmacology [MeSH], Rivaroxaban/administration, Ritonavir/pharmacokinetics [MeSH], Pyridones, Pyridines, Midazolam, Administration, Oral, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Rivaroxaban, Humans, Cytochrome P-450 CYP3A, Drug Interactions, Three Factor Xa Inhibitors, Ritonavir, Ritonavir Therapy, Time Course, Healthy Volunteers, 3. Good health, Cytochrome P-450 CYP2C19, Thiazoles, Cytochrome P-450 CYP2D6, Pyrazoles, Female, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik, Omeprazole, Factor Xa Inhibitors

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38393578
https://repository.publisso.de/resource/frl:6518513
https://refubium.fu-berlin.de/handle/fub188/43125
https://doi.org/10.1007/s40262-024-01350-x
https://doi.org/10.17169/refubium-42841

Effect of Clarithromycin, a Strong CYP3A and P-glycoprotein Inhibitor, on the Pharmacokinetics of Edoxaban in Healthy Volunteers and the Evaluation of the Drug Interaction with Other Oral Factor Xa Inhibitors by a Microdose Cocktail Approach

Autori: Alexander Lenard Simon A. Hermann Felicitas Stoll a ďalší

Zdroj: Cardiovasc Drugs Ther

Predmety: Male, Adult, Pyridines, Pyridones, Administration, Oral, Middle Aged, Healthy Volunteers, 3. Good health, Thiazoles, Young Adult, Rivaroxaban, Clarithromycin, Area Under Curve, Humans, Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A, Pyrazoles, Original Article, Drug Interactions, Female, ATP Binding Cassette Transporter, Subfamily B, Member 1, Healthy volunteers, Area Under Curve [MeSH], Pyridones/blood [MeSH], ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism [MeSH], Thiazoles/blood [MeSH], Rivaroxaban/pharmacokinetics [MeSH], Pyridones/administration, Thiazoles/pharmacokinetics [MeSH], Administration, Oral [MeSH], Male [MeSH], Cytochrome P-450 CYP3A Inhibitors/pharmacology [MeSH], Drug Interactions [MeSH], Healthy Volunteers [MeSH], Pyrazoles/blood [MeSH], Factor Xa Inhibitors/pharmacokinetics [MeSH], Thiazoles/administration, Factor Xa inhibitors, Cytochrome P-450 CYP3A/metabolism [MeSH], Pyrazoles/pharmacokinetics [MeSH], ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists, Female [MeSH], Pyridines/pharmacology [MeSH], Pyridones/pharmacokinetics [MeSH], Adult [MeSH], Humans [MeSH], Microdose, Pyrazoles/pharmacology [MeSH], Pyridines/administration, Drug-drug interaction, Factor Xa Inhibitors/administration, Middle Aged [MeSH], Clarithromycin/pharmacokinetics [MeSH], Pyrazoles/administration, Pyridines/pharmacokinetics [MeSH], Clarithromycin/pharmacology [MeSH], Pyridines/blood [MeSH], Young Adult [MeSH], Clarithromycin/administration, Thiazoles/pharmacology [MeSH], Rivaroxaban/administration, Factor Xa Inhibitors

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36870039
https://repository.publisso.de/resource/frl:6508933

Effects of MDL 100,240, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase on the vasopressor response to exogenous angiotensin I and angiotensin II challenges in healthy volunteers.

Autori: Rousso, P. Buclin, T. Nussberger, J. a ďalší

Predmety: Adult, Angiotensin I/administration & dosage, Angiotensin II/administration & dosage, Angiotensin-Converting Enzyme Inhibitors/pharmacokinetics, Angiotensin-Converting Enzyme Inhibitors/pharmacology, Antihypertensive Agents/pharmacokinetics, Antihypertensive Agents/pharmacology, Area Under Curve, Benzazepines/pharmacokinetics, Benzazepines/pharmacology, Blood Pressure/drug effects, Double-Blind Method, Enzyme Inhibitors/pharmacokinetics, Enzyme Inhibitors/pharmacology, Humans, Male, Neprilysin/antagonists & inhibitors, Placebos, Pyridines/pharmacokinetics, Pyridines/pharmacology, Reference Values

Relation: Journal of Cardiovascular Pharmacology; https://iris.unil.ch/handle/iris/98446; serval:BIB_3E9FAC34D6E6; 000072247800012; 9514186

Dostupnosť: https://iris.unil.ch/handle/iris/98446
https://doi.org/10.1097/00005344-199803000-00012

Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid.

Autori: Cusini, A. Vernazza, P.L. Yerly, S. a ďalší

Prispievatelia: Cusini, A. Vernazza, P.L. Yerly, S. a ďalší

Predmety: Adult, Anti-Retroviral Agents/administration & dosage, Anti-Retroviral Agents/pharmacokinetics, Antiretroviral Therapy, Highly Active/methods, Benzoxazines/administration & dosage, Benzoxazines/pharmacokinetics, Cerebrospinal Fluid/chemistry, Cerebrospinal Fluid/virology, Female, HIV Infections/drug therapy, HIV Infections/virology, HIV-1/isolation & purification, Humans, Lopinavir/administration & dosage, Lopinavir/pharmacokinetics, Male, Middle Aged, Oligopeptides/administration & dosage, Oligopeptides/pharmacokinetics, Plasma/chemistry, Plasma/virology, Pyridines/administration & dosage, Pyridines/pharmacokinetics, RNA, Viral/cerebrospinal fluid, Treatment Outcome, Viral Load

Relation: Journal of Acquired Immune Deficiency Syndromes; https://iris.unil.ch/handle/iris/189170; serval:BIB_84E92CDBD71B; 000312645400012

Dostupnosť: https://iris.unil.ch/handle/iris/189170
https://doi.org/10.1097/QAI.0b013e318274e2b0

Ritonavir-boosted atazanavir-lopinavir combination: a pharmacokinetic interaction study of total, unbound plasma and cellular exposures.

Autori: Colombo, S. Buclin, T. Franc, C. a ďalší

Predmety: Adult, Atazanavir Sulfate, Blood Proteins/metabolism, Drug Interactions, Drug Therapy, Combination, Female, HIV Infections/drug therapy, HIV Infections/virology, HIV Protease Inhibitors/administration & dosage, HIV Protease Inhibitors/adverse effects, HIV Protease Inhibitors/metabolism, HIV Protease Inhibitors/pharmacokinetics, Humans, Lopinavir, Male, Middle Aged, Oligopeptides/administration & dosage, Oligopeptides/adverse effects, Oligopeptides/metabolism, Oligopeptides/pharmacokinetics, Protein Binding, Pyridines/administration & dosage, Pyridines/adverse effects, Pyridines/metabolism, Pyridines/pharmacokinetics, Pyrimidinones/administration & dosage, Pyrimidinones/adverse effects, Pyrimidinones/metabolism, Pyrimidinones/pharmacokinetics

Relation: Antiviral Therapy; https://iris.unil.ch/handle/iris/134805; serval:BIB_B50E136DB0CD; 000236309000006

Dostupnosť: https://iris.unil.ch/handle/iris/134805
https://doi.org/10.1177/135965350601100112

Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer

Autori: Minkyung Lee Hae-June Lee In Suh Park a ďalší

Prispievatelia: Minkyung Lee Hae-June Lee In Suh Park a ďalší

Zdroj: Neuropharmacology. 133:512-517

Predmety: Male, 0301 basic medicine, Amyloid, Mutation / genetics, Metabotropic Glutamate 5 / metabolism, Pyridines, Image Processing, Presenilin-1 / genetics, Receptor, Metabotropic Glutamate 5, Brain / diagnostic imaging, Amyloid beta-Protein Precursor / genetics, Down-Regulation, Mice, Transgenic, Pyridines / pharmacokinetics, Down-Regulation / drug effects, Transgenic, Amyloid beta-Protein Precursor, Mice, 03 medical and health sciences, Computer-Assisted, 0302 clinical medicine, Alzheimer Disease, Nitriles, Image Processing, Computer-Assisted, Presenilin-1, Animals, Alzheimer Disease / pathology, Down-Regulation / genetics, Amyloid beta-Peptides, Amyloid beta-Peptides / metabolism, Animal, Nitriles / pharmacokinetics, Brain, Brain / metabolism, Magnetic Resonance Imaging, Peptide Fragments, Amyloid / metabolism, Alzheimer Disease / genetics, Disease Models, Animal, Positron-Emission Tomography, Disease Models, Mutation, Alzheimer Disease / diagnostic imaging, Peptide Fragments / metabolism, Receptor

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/29427650
https://www.sciencedirect.com/science/article/pii/S0028390818300601
https://pubmed.ncbi.nlm.nih.gov/29427650/
https://www.ncbi.nlm.nih.gov/pubmed/29427650
http://europepmc.org/abstract/MED/29427650

Preventive Effect of Clazosentan against Cerebral Vasospasm after Clipping Surgery for Aneurysmal Subarachnoid Hemorrhage in Japanese and Korean Patients

Autori: Miki Fujimura Jin-Yang Joo Jong-Soo Kim a ďalší

Prispievatelia: Miki Fujimura Jin-Yang Joo Jong-Soo Kim a ďalší

Zdroj: Cerebrovascular Diseases. 44:59-67

Predmety: Pyrimidines/therapeutic use, Male, Time Factors, Cerebral Infarction/etiology, Pyridines, Tetrazoles/therapeutic use, Intracranial/physiopathology, Tetrazoles, Neurosurgical Procedures, Sulfonamides/pharmacokinetics, Dioxanes, 0302 clinical medicine, Japan, Intracranial/etiology, Pyridines/pharmacokinetics, Endothelin A Receptor Antagonists/adverse effects, Sulfonamides, Angiography, Cerebral Infarction, Subarachnoid Hemorrhage/diagnostic imaging, Middle Aged, Vasospasm, 3. Good health, Treatment Outcome, Vasodilator Agents/adverse effects, Dioxanes/pharmacokinetics, Cerebral Angiography/methods, Dioxanes/adverse effects, Female, Tetrazoles/adverse effects, Dioxanes/therapeutic use, Adult, Endothelin A Receptor Antagonists, Pyridines/therapeutic use, Cerebral Infarction/prevention & control, Cerebral Infarction/diagnostic imaging, Endothelin A Receptor Antagonists/therapeutic use, 03 medical and health sciences, Subarachnoid Hemorrhage/physiopathology, Double-Blind Method, Republic of Korea, Humans, Endothelin A Receptor Antagonists/pharmacokinetics, Pyrimidines/pharmacokinetics, Vasodilator Agents/pharmacokinetics, Pyridines/adverse effects, Aged, Vasodilator Agents/therapeutic use, Tetrazoles/pharmacokinetics, Pyrimidines/adverse effects, Sulfonamides/therapeutic use, Angiography, Digital Subtraction, Sulfonamides/adverse effects, Subarachnoid Hemorrhage, Intracranial/diagnostic imaging, Cerebral Angiography, Pyrimidines, Subarachnoid Hemorrhage/surgery, Neurosurgical Procedures/adverse effects, Cerebral Infarction/physiopathology, Digital Subtraction

Prístupová URL adresa: https://www.karger.com/Article/Pdf/475824
https://pubmed.ncbi.nlm.nih.gov/28463833
https://europepmc.org/article/MED/28463833
https://tohoku.pure.elsevier.com/en/publications/preventive-effect-of-clazosentan-against-cerebral-vasospasm-after
https://pubmed.ncbi.nlm.nih.gov/28463833/
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154441
https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/154441/1/T201701474.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475234

Optimal timing of [ 18 F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects

Autori: Jae Yong Choi Soo Hee Choi Chul Hyoung Lyoo a ďalší

Prispievatelia: Jae Yong Choi Soo Hee Choi Chul Hyoung Lyoo a ďalší

Zdroj: Applied Radiation and Isotopes. 107:127-132

Predmety: Adult, Male, 0301 basic medicine, Positron-Emission Tomography/methods, Positron-Emission Tomography/statistics & numerical data, Serotonin, Positron emission tomography, Optimal acquisition time, Standardized uptake value ratio, Multimodal Imaging, Fluorine Radioisotopes*/pharmacokinetics, Young Adult, 03 medical and health sciences, Pyridines*/pharmacokinetics, 0302 clinical medicine, Reference Values, Humans, Tomography, 5-HT1A/metabolism, X-Ray Computed, Serotonin 1A receptor, Piperazines*/pharmacokinetics, Radiopharmaceuticals*/pharmacokinetics, [(18)F]Mefway, Receptor

Popis súboru: 127~132

Prístupová URL adresa: https://www.ncbi.nlm.nih.gov/pubmed/26492323/
https://yonsei.pure.elsevier.com/en/publications/optimal-timing-of-sup18supfmefway-pet-for-imaging-the-serotonin-1
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146535
https://www.sciencedirect.com/science/article/pii/S0969804315302049
http://europepmc.org/abstract/MED/26492323

P-Glycoprotein, not BCRP, Limits the Brain Uptake of [18F]Mefway in Rodent Brain

Autori: Kyeong Min Kim Woon Ki Cho Jin Sook Song a ďalší

Prispievatelia: Kyeong Min Kim Woon Ki Cho Jin Sook Song a ďalší

Zdroj: Molecular Imaging and Biology. 18:267-273

Predmety: Male, Fluorine Radioisotopes, Pyridines, ATP Binding Cassette Transporter, Knockout, Quinolines/administration & dosage, P-glycoprotein, Piperazines, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, [18F]Mefway, 0302 clinical medicine, Member 2/metabolism, Member 1/metabolism, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, ATP Binding Cassette Transporter, Subfamily B, Member 1, Sub-Family G, Mice, Knockout, Piperazines/blood, Sub-Family B, Pyridines/pharmacokinetics, Brain, Piperazines/pharmacokinetics, Brain/diagnostic imaging, Fluorine Radioisotopes/pharmacokinetics, Brain/metabolism, Breast cancer resistance protein, Pyridines/blood, Rats, PET, Positron-Emission Tomography, Quinolines, ATP-Binding Cassette, Sprague-Dawley

Popis súboru: 267~73

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/26250653
http://europepmc.org/abstract/MED/26250653
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146590
https://dspace.ewha.ac.kr/handle/2015.oak/217485
https://yonsei.pure.elsevier.com/en/publications/p-glycoprotein-not-bcrp-limits-the-brain-uptake-of-sup18sup-fmefw
https://link.springer.com/article/10.1007/s11307-015-0883-z
https://link.springer.com/article/10.1007/s11307-015-0883-z/fulltext.html

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Autori: Pethe, Kevin Bifani, Pablo Jang, Jichan a ďalší

Prispievatelia: Pethe, Kevin Bifani, Pablo Jang, Jichan a ďalší

Zdroj: Nature Medicine. 19:1157-1160

Predmety: 0301 basic medicine, Pyridines, Extensively Drug-Resistant Tuberculosis, Drug Evaluation, Preclinical, Cell Proliferation/drug effects, Rats, Sprague-Dawley, Extensively Drug-ResistantTuberculosis/drugtherapy, Electron Transport Complex III, Mice, 03 medical and health sciences, Adenosine Triphosphate, Piperidines, Piperidines/pharmacokinetics, Animals, Adenosine Triphosphate/biosynthesis, Imidazoles/pharmacokinetics, Mycobacteriumtuberculosis/drug effects, Pyridines/pharmacology, Inbred BALB C, Pyridines/pharmacokinetics, Cell Proliferation, Electron Transport Complex III/genetics, Mice, Inbred BALB C, 0303 health sciences, Animal, Imidazoles, Mycobacterium tuberculosis, Sciences bio-médicales et agricoles, Preclinical, Rats, 3. Good health, Disease Models, Animal, Imidazoles/pharmacology, Electron Transport Complex III/antagonists & inhibitors, Disease Models, Piperidines/pharmacology, Drug Evaluation, Sprague-Dawley

Popis súboru: No full-text files

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/23913123
https://core.ac.uk/display/16744803
https://pubmed.ncbi.nlm.nih.gov/23913123/
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88231
https://www.ncbi.nlm.nih.gov/pubmed/23913123
http://okina.univ-angers.fr/publications/ua11055
http://core.ac.uk/display/16744803

In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: Persistent agonist binding inhibits the expression of antiallodynic effects

Autori: Ueda, Masashi Iida, Yasuhiko Yoneyama, Tomoki a ďalší

Prispievatelia: Ueda, Masashi Iida, Yasuhiko Yoneyama, Tomoki a ďalší

Zdroj: Synapse. 65:77-83

Predmety: Male, 0301 basic medicine, Thalamus/metabolism, Pyridines, Neuralgia/metabolism, desensitization, Receptors, Nicotinic, Azetidines/therapeutic use, Rats, Sprague-Dawley, 03 medical and health sciences, Thalamus, Thalamus/drug effects, thalamus, Physical Stimulation, Receptors, Nicotinic/metabolism, Animals, Nicotinic Agonists, 5-[125I]iodo-A-85380 ([125I]5IA), Pyridines/pharmacokinetics, Pyridines/therapeutic use, Azetidines/pharmacokinetics, Hyperalgesia/drug therapy, Analysis of Variance, Nicotinic Agonists/therapeutic use, Neuralgia/drug therapy, Rats, Hyperalgesia, Autoradiography, Azetidines, Neuralgia, Sprague-Dawley, Hyperalgesia/metabolism, Nicotinic Agonists/pharmacokinetics

Popis súboru: application/pdf

Prístupová URL adresa: https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/139437/1/syn.20819.pdf
https://pubmed.ncbi.nlm.nih.gov/20506320
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/syn.20819
http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/139437/1/syn.20819.pdf
http://europepmc.org/abstract/MED/20506320
http://www.ncbi.nlm.nih.gov/pubmed/20506320
http://ci.nii.ac.jp/naid/120002949727
https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/139437

Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti‐allodynic effects

Autori: Ueda, M Iida, Y Tominaga, A a ďalší

Prispievatelia: Ueda, M Iida, Y Tominaga, A a ďalší

Zdroj: British Journal of Pharmacology. 159:1201-1210

Predmety: 5IA, Male, Pain Threshold, 0301 basic medicine, Pyridines, Azetidines/pharmacology, Pain, Receptors, Nicotinic, Ventral Thalamic Nuclei/metabolism, Azetidines/therapeutic use, Nicotinic/biosynthesis, Sciatic Neuropathy/metabolism, Iodine Radioisotopes, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Pain/drug therapy, Pain/metabolism, thalamus, Receptors, Animals, Ventral Thalamic Nuclei/drug effects, Nicotinic Agonists, nicotinic acetylcholine receptor, Pyridines/pharmacokinetics, Pyridines/therapeutic use, ventral posterolateral thalamic nucleus, neuropathic pain, Pyridines/pharmacology, Azetidines/pharmacokinetics, Ventral Thalamic Nuclei, Nicotinic Agonists/therapeutic use, Animal, Sciatic Neuropathy/drug therapy, Nicotinic/physiology, anti-allodynic effect, Rats, Disease Models, Animal, Disease Models, Autoradiography, Azetidines, Sprague-Dawley, Sciatic Neuropathy, Nicotinic Agonists/pharmacology, Nicotinic Agonists/pharmacokinetics

Popis súboru: application/pdf

Prístupová URL adresa: https://europepmc.org/articles/pmc2848924?pdf=render
https://pubmed.ncbi.nlm.nih.gov/20136830
https://okayama.pure.elsevier.com/en/publications/nicotinic-acetylcholine-receptors-expressed-in-the-ventralpostero
http://europepmc.org/articles/PMC2848924
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1476-5381.2009.00613.x
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00613.x
https://www.ncbi.nlm.nih.gov/pubmed/20136830
http://ci.nii.ac.jp/naid/120002949728

Safety and anti-tumor activity of sorafenib (Nexavar®) in combination with other anti-cancer agents: a review of clinical trials

Autori: Takimoto, Chris H Awada, Ahmad

Zdroj: Cancer Chemotherapy and Pharmacology. 61:535-548

Predmety: Niacinamide, 0301 basic medicine, Pyridines -- pharmacology, Benzenesulfonates -- adverse effects, Pyridines, Benzenesulfonates -- pharmacokinetics, Pyridines -- pharmacokinetics, Antineoplastic Agents, Pyridines -- toxicity, 03 medical and health sciences, 0302 clinical medicine, Antineoplastic Agents -- pharmacology, Antineoplastic Agents -- toxicity, Pyridines -- adverse effects, Neoplasms, Solid tumors, Antineoplastic Combined Chemotherapy Protocols, Chemotherapy, Animals, Humans, Drug Interactions, Benzenesulfonates -- pharmacology, Clinical Trials as Topic, Phenylurea Compounds, Benzenesulfonates, Antineoplastic Agents -- adverse effects, Sciences bio-médicales et agricoles, Sorafenib, Phase I/II clinical trials, Antineoplastic Agents -- pharmacokinetics, 3. Good health, Antineoplastic Combined Chemotherapy Protocols -- toxicity, Neoplasms -- drug therapy, Combination, Benzenesulfonates -- toxicity, Antineoplastic Combined Chemotherapy Protocols -- pharmacology, Targeted agent

Popis súboru: No full-text files

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/18026728
https://www.ncbi.nlm.nih.gov/pubmed/18026728
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53573/Details
https://pubmed.ncbi.nlm.nih.gov/18026728/
https://link.springer.com/article/10.1007/s00280-007-0639-9/fulltext.html
https://link.springer.com/article/10.1007%2Fs00280-007-0639-9

Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Sorafenib: A Review of Four Phase I Trials in Patients with Advanced Refractory Solid Tumors

Autori: Strumberg, Dirk Clark, Jeffrey W Awada, Ahmad a ďalší

Zdroj: The Oncologist. 12:426-437

Predmety: Niacinamide, Pyridines, Benzenesulfonates -- therapeutic use, Neoplasms -- pathology, Benzenesulfonates -- pharmacokinetics, Pyridines -- pharmacokinetics, Antineoplastic Agents, Review, Phase I as Topic, Protein Kinase Inhibitors -- pharmacokinetics, Protein Kinase Inhibitors -- therapeutic use, 03 medical and health sciences, Antineoplastic Agents -- administration & dosage, 0302 clinical medicine, Benzenesulfonates -- administration & dosage, Neoplasms, Pyridines -- therapeutic use, Phase I clinical trials, Humans, Clinical Trials, Pyridines -- administration & dosage, Neoplasm Metastasis, Protein Kinase Inhibitors, Clinical Trials, Phase I as Topic, Phenylurea Compounds, Benzenesulfonates, Protein Kinase Inhibitors -- administration & dosage, raf Kinases -- antagonists & inhibitors, Sciences bio-médicales et agricoles, Sorafenib, Antineoplastic Agents -- pharmacokinetics, 3. Good health, Neoplasms -- drug therapy, Antineoplastic Agents -- therapeutic use, raf Kinases, BAY 43-9006

Popis súboru: 1 full-text file(s): application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/17470685
https://pubmed.ncbi.nlm.nih.gov/17470685/
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53583/Details
https://www.ncbi.nlm.nih.gov/pubmed/17470685
https://europepmc.org/article/MED/17470685
https://onlinelibrary.wiley.com/doi/abs/10.1634/theoncologist.12-4-426
https://core.ac.uk/display/8853391

Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study

Autori: Picard, F. Bruel, D. Servent, D. a ďalší

Prispievatelia: Picard, F. Bruel, D. Servent, D. a ďalší

Zdroj: Brain
129 (2006): 2047–2060.
info:cnr-pdr/source/autori:Picard F, Bruel D, Servent D, Saba W, Fruchart-Gaillard C, Schöllhorn-Peyronneau MA, Roumenov D, Brodtkorb E, Zuberi S, Gambardella A, Steinborn B, Hufnagel A, Valette H, Bottlaender M./titolo:Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study./doi:/rivista:Brain (Print)/anno:2006/pagina_da:2047/pagina_a:2060/intervallo_pagine:2047–2060/volume:129

Predmety: Adult, Male, Fluorine Radioisotopes, 616.8, Mesencephalon / diagnostic imaging, Pyridines, [SDV]Life Sciences [q-bio], Epilepsy, Frontal Lobe, Brain / diagnostic imaging, Receptors, Nicotinic, Pyridines / pharmacokinetics, Cerebellum / diagnostic imaging, 03 medical and health sciences, Cerebellum / metabolism, 0302 clinical medicine, Receptors, Nicotinic / genetics, Mesencephalon, Cerebellum, Epilepsy, Frontal Lobe / genetics, Image Processing, Computer-Assisted, Humans, genetics, Epilepsy, Frontal Lobe / diagnostic imaging, Cells, Cultured, Positron-Emission Tomography / methods, Azetidines / pharmacokinetics, fluoro-A-85380, Brain, Mesencephalon / metabolism, [SDV] Life Sciences [q-bio], Epilepsy, Frontal Lobe / metabolism, PET, Image Processing, Computer-Assisted / methods, Positron-Emission Tomography, Mutation, Receptors, Nicotinic / metabolism, ADNFLE, Azetidines, Brain / metabolism, Female, nicotinic receptor

Popis súboru: application/pdf

Prístupová URL adresa: https://academic.oup.com/brain/article-pdf/129/8/2047/13734231/awl156.pdf
https://pubmed.ncbi.nlm.nih.gov/16815873
https://hal.science/hal-03634931v1
https://doi.org/10.1093/brain/awl156
https://publications.cnr.it/doc/50215
http://www.cnr.it/prodotto/i/50215
https://www.ncbi.nlm.nih.gov/pubmed/16815873
https://academic.oup.com/brain/article/129/8/2047/333868
https://pubmed.ncbi.nlm.nih.gov/16815873/
https://academic.oup.com/brain/article-abstract/129/8/2047/333868
https://hdl.handle.net/20.500.14243/430326
https://archive-ouverte.unige.ch/unige:160761
https://doi.org/10.1093/brain/awl156
http://doc.rero.ch/record/297620/files/awl156.pdf

Immobilized pH Gradient Gel Cell To Study the pH Dependence of Drug Lipophilicity

Autori: Lam, H. T. Pereira, C. M. Roussel, C. a ďalší

Zdroj: Analytical Chemistry, Vol. 78, No 5 (2006) pp. 1503-1508

Predmety: Ions, ddc:615, Cell Membrane Permeability, Pyridines, Hydrogen-Ion Concentration, Models, Biological, 01 natural sciences, 6. Clean water, Membrane Potentials, 0104 chemical sciences, Models, Chemical, Pharmaceutical Preparations, Electrochemistry, Thermodynamics, Pharmacokinetics, Pharmaceutical Preparations/chemistry, 2,4-Dinitrophenol, Electrodes, Gels, Pyridines/pharmacokinetics

Popis súboru: application/pdf

Prístupová URL adresa: https://infoscience.epfl.ch/record/89689/files/ac051808a.pdf
https://pubmed.ncbi.nlm.nih.gov/16503600
https://pubs.acs.org/doi/10.1021/ac051808a
https://pubs.acs.org/doi/abs/10.1021/ac051808a
https://archive-ouverte.unige.ch/unige:10598
https://www.ncbi.nlm.nih.gov/pubmed/16503600
https://dialnet.unirioja.es/servlet/articulo?codigo=1703568
https://infoscience.epfl.ch/record/89689
https://archive-ouverte.unige.ch/unige:10598
https://doi.org/10.1021/ac051808a
https://archive-ouverte.unige.ch/unige:10598

Phase I Trial of Sorafenib and Gemcitabine in Advanced Solid Tumors with an Expanded Cohort in Advanced Pancreatic Cancer

Autori: Siu, Lillian L Awada, Ahmad Takimoto, Chris H a ďalší

Zdroj: Clinical Cancer Research. 12:144-151

Predmety: Adult, Male, Niacinamide, 0301 basic medicine, Maximum Tolerated Dose, Pyridines, Benzenesulfonates -- therapeutic use, Benzenesulfonates -- pharmacokinetics, Pyridines -- pharmacokinetics, Deoxycytidine, Dose-Response Relationship, Deoxycytidine -- pharmacokinetics, 03 medical and health sciences, 0302 clinical medicine, Pancreatic Neoplasms -- drug therapy, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, 80 and over, Pyridines -- therapeutic use, Humans, Drug Interactions, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Phenylurea Compounds, Benzenesulfonates, Sciences bio-médicales et agricoles, Middle Aged, Sorafenib, Gemcitabine, 3. Good health, Pancreatic Neoplasms, Neoplasms -- drug therapy, Antineoplastic Combined Chemotherapy Protocols -- administration & dosage, Female, Drug, Deoxycytidine -- analogs & derivatives, Deoxycytidine -- therapeutic use

Popis súboru: 1 full-text file(s): application/pdf

Prístupová URL adresa: http://clincancerres.aacrjournals.org/content/12/1/144.full.pdf
https://pubmed.ncbi.nlm.nih.gov/16397036
https://pubmed.ncbi.nlm.nih.gov/16397036/
https://clincancerres.aacrjournals.org/content/12/1/144.full
https://clincancerres.aacrjournals.org/content/clincanres/12/1/144.full.pdf
https://www.ncbi.nlm.nih.gov/pubmed/16397036
http://clincancerres.aacrjournals.org/content/12/1/144.full
http://clincancerres.aacrjournals.org/content/12/1/144

Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours

Autori: Awada, Ahmad Hendlisz, Alain Gil, Thierry a ďalší

Zdroj: Br J Cancer
British Journal of Cancer, 92 (10

Predmety: Adult, Male, Niacinamide, 0301 basic medicine, Benzenesulfonates -- adverse effects, Efficacy, Maximum Tolerated Dose, Pyridines, Benzenesulfonates -- pharmacokinetics, Pyridines -- pharmacokinetics, Drug Administration Schedule, 03 medical and health sciences, 0302 clinical medicine, Benzenesulfonates -- administration & dosage, Kidney Neoplasms -- drug therapy, Pyridines -- adverse effects, Neoplasms, Humans, Pyridines -- administration & dosage, Pharmacokinetics, Carcinoma, Renal Cell, Solid tumours, Aged, Renal Cell -- drug therapy, Phenylurea Compounds, Carcinoma, Benzenesulfonates, Sciences bio-médicales et agricoles, Middle Aged, Sorafenib, Carcinoma, Renal Cell -- drug therapy, Kidney Neoplasms, 3. Good health, Neoplasms -- drug therapy, Clinical Study, Female, Safety, BAY 43-9006, Targeted agent

Popis súboru: 1 full-text file(s): application/pdf

Prístupová URL adresa: https://www.nature.com/articles/6602584.pdf
https://pubmed.ncbi.nlm.nih.gov/15870716
http://europepmc.org/articles/PMC2361774
https://www.nature.com/articles/6602584.pdf
http://www.ncbi.nlm.nih.gov/pubmed/15870716
https://www.nature.com/articles/6602584
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53723/Details
https://pubmed.ncbi.nlm.nih.gov/15870716/
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53723

Phase I Clinical and Pharmacokinetic Study of the Novel Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor BAY 43-9006 in Patients With Advanced Refractory Solid Tumors

Autori: Strumberg, Dirk Richly, Heike Hilger, Ralf A a ďalší

Zdroj: Journal of Clinical Oncology. 23:965-972

Predmety: Male, 0301 basic medicine, Rectal Neoplasms -- drug therapy, Benzenesulfonates -- pharmacokinetics, Phosphatidylethanolamine Binding Protein -- adverse effects, Pyridines -- pharmacokinetics, Phosphatidylethanolamine Binding Protein, Phosphatidylethanolamine Binding Protein -- administration & dosage, Phosphatidylethanolamine Binding Protein -- pharmacokinetics, Protein Kinase Inhibitors -- pharmacokinetics, Cohort Studies, 0302 clinical medicine, Benzenesulfonates -- administration & dosage, Receptors, Pyridines -- administration & dosage, Lymphocytes, Protein Kinase Inhibitors -- adverse effects, Extracellular Signal-Regulated MAP Kinases, Fatigue, Hepatocellular -- drug therapy, Benzenesulfonates, Liver Neoplasms, Protein Kinase Inhibitors -- administration & dosage, Sciences bio-médicales et agricoles, Middle Aged, 3. Good health, Colonic Neoplasms -- drug therapy, Lymphocytes -- drug effects, Colonic Neoplasms, Liver Neoplasms -- drug therapy, Female, Safety, Lymphocytes -- enzymology, Adult, Diarrhea, Niacinamide, Carcinoma, Hepatocellular, Vascular Endothelial Growth Factor -- antagonists & inhibitors, Adolescent, Antineoplastic Agents, 03 medical and health sciences, Antineoplastic Agents -- administration & dosage, Extracellular Signal-Regulated MAP Kinases -- drug effects, Humans, Aged, Fatigue -- chemically induced, Phosphorylation -- drug effects, Phenylurea Compounds, Carcinoma, Antineoplastic Agents -- adverse effects, Antineoplastic Agents -- pharmacokinetics, Diarrhea -- chemically induced

Popis súboru: No full-text files

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/15613696
https://www.jco.ascopubs.org/content/23/5/965.full.pdf
https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2005.06.124
https://www.ncbi.nlm.nih.gov/pubmed/15613696
https://ascopubs.org/doi/10.1200/JCO.2005.06.124
https://pubmed.ncbi.nlm.nih.gov/15613696/
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53722/Details

Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement

Autori: Stangier, J. Eriksson, Bengt I. Dahl, O. E. a ďalší

Zdroj: J Clin Pharmacol. 45(5):555-63

Predmety: Surgery, Kirurgi, 2-Pyridinylmethylsulfinylbenzimidazoles, Absorption, Administration, Oral, Adult, Aged, 80 and over, Area Under Curve, *Arthroplasty, Replacement, Hip, Benzimidazoles/*pharmacokinetics/pharmacology, Cross-Over Studies, Drug Interactions, Female, Food-Drug Interactions, H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors, Humans, Male, Metabolic Clearance Rate, Middle Aged, Omeprazole/*analogs & derivatives/pharmacology, Pyridines/*pharmacokinetics, Sulfoxides/pharmacology, Thrombin/*antagonists & inhibitors

Prístupová URL adresa: https://gup.ub.gu.se/publication/43933