Výsledky vyhľadávania - "Pyridines"

Green synthesis, anti-inflammatory evaluation and molecular docking of novel pyridines via one pot multi-component reaction using ultrasonic irradiation.

Autori: Elkanzi NAA Ali AM Abdelaziz MA a ďalší

Zdroj: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 5487-5497. Date of Electronic Publication: 2024 Dec 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Výrazy zo slovníka MeSH: Molecular Docking Simulation* , Anti-Inflammatory Agents*/chemical synthesis , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Pyridines*/chemical synthesis , Pyridines*/chemistry , Pyridines*/pharmacology , Green Chemistry Technology*/methods , Ultrasonic Waves*, Humans ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2/chemistry ; Chemistry Techniques, Synthetic ; Ibuprofen/pharmacology

Synthesis of New Phenothiazine/3-cyanoquinoline and Phenothiazine/3-aminothieno[2,3-b]pyridine(-quinoline) Heterodimers.

Autori: Dotsenko VV Kindop VK Daus ES a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 08; Vol. 26 (19). Date of Electronic Publication: 2025 Oct 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Phenothiazines*/chemistry , Phenothiazines*/chemical synthesis , Quinolines*/chemistry , Quinolines*/chemical synthesis , Pyridines*/chemistry , Pyridines*/chemical synthesis, Molecular Docking Simulation ; Dimerization ; Molecular Structure ; Cyclization

Synthesis, spectroscopic characterization, DFT calculations, in silico-ADMET and molecular docking analysis of novel quinoline-substituted 5H-chromeno [2,3-b] pyridine derivatives as antibacterial agents.

Autori: Kancherla R Lohith TN Deshmukh S a ďalší

Zdroj: Molecular diversity [Mol Divers] 2025 Oct; Vol. 29 (5), pp. 3997-4017. Date of Electronic Publication: 2024 Sep 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Molecular Docking Simulation* , Pyridines*/chemistry , Pyridines*/pharmacology , Pyridines*/chemical synthesis , Quinolines*/chemistry , Quinolines*/pharmacology, Density Functional Theory ; Microbial Sensitivity Tests ; DNA Gyrase/metabolism ; DNA Gyrase/chemistry

Multifaceted potency of green synthesized pyridine derived Schiff base: A comprehensive study of antimicrobial, antioxidant, anti-inflammatory, cytotoxic, and Enzymatic properties with density Functional Theory and bioinformatics insights.

Autori: Rajimon KJ Alzahrani AYA Thangaiyan P a ďalší

Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Dec 15; Vol. 792, pp. 152959. Date of Electronic Publication: 2025 Nov 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Pyridines*/chemistry , Pyridines*/pharmacology , Pyridines*/chemical synthesis , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/chemical synthesis , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Anti-Infective Agents*/chemical synthesis, Schiff Bases/chemistry ; Schiff Bases/pharmacology ; Schiff Bases/chemical synthesis ; Humans ; MCF-7 Cells ; Molecular Docking Simulation ; Density Functional Theory ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Molecular Dynamics Simulation ; Green Chemistry Technology ; Computational Biology ; alpha-Amylases/antagonists & inhibitors ; alpha-Amylases/metabolism ; Microbial Sensitivity Tests

Design, synthesis, biological activity and molecular docking studies of triazolopyridine derivatives as ASK1 inhibitors.

Autori: Su S Peng M Han X a ďalší

Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118417. Date of Electronic Publication: 2025 Sep 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: MAP Kinase Kinase Kinase 5*/antagonists & inhibitors , MAP Kinase Kinase Kinase 5*/metabolism , Drug Design* , Molecular Docking Simulation* , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Pyridines*/chemistry , Pyridines*/pharmacology , Pyridines*/chemical synthesis , Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Line

Structure activity relationship exploration of imidazo[1,2-a]pyridine series to reverse isoform selectivity and identify potent SIK1 selective inhibitors.

Autori: Peixoto C De Lemos E Cherel L a ďalší

Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130397. Date of Electronic Publication: 2025 Sep 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Pyridines*/chemistry , Pyridines*/pharmacology , Pyridines*/chemical synthesis , Imidazoles*/chemistry , Imidazoles*/pharmacology , Imidazoles*/chemical synthesis, Structure-Activity Relationship ; Humans ; Molecular Structure ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Dose-Response Relationship, Drug

Discovery of novel xanthotoxin-pyridine quaternary ammonium derivatives with membrane-targeting mode of action as potential antimicrobials against methicillin-resistant Staphylococcus aureus.

Autori: Xu S Zhang M Xie X a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118139. Date of Electronic Publication: 2025 Sep 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Methicillin-Resistant Staphylococcus aureus*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Quaternary Ammonium Compounds*/chemistry , Quaternary Ammonium Compounds*/pharmacology , Quaternary Ammonium Compounds*/chemical synthesis , Pyridines*/chemistry , Pyridines*/pharmacology , Drug Discovery*, Animals ; Microbial Sensitivity Tests ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Biofilms/drug effects ; Dose-Response Relationship, Drug ; Humans ; Staphylococcal Infections/drug therapy ; Cell Membrane/drug effects

Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study.

Autori: Noureddin M Harrison SA Loomba R a ďalší

Zdroj: Lancet (London, England) [Lancet] 2025 Dec 06; Vol. 406 (10520), pp. 2644-2655. Date of Electronic Publication: 2025 Nov 11.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE

Výrazy zo slovníka MeSH: Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/etiology , Liver Cirrhosis*/pathology , Pyridines*/administration & dosage , Pyridines*/adverse effects , Pyridines*/therapeutic use , Fatty Liver*/drug therapy, Humans ; Double-Blind Method ; Male ; Female ; Middle Aged ; Adult ; Treatment Outcome ; Aged ; Drug Administration Schedule ; Non-alcoholic Fatty Liver Disease/drug therapy

Design, synthesis, and biological evaluation of novel pyrimidine/pyridine derivatives for Vesicular Stomatitis Virus (VSV) infection.

Autori: Ren Z Lin R Chen Y a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 05; Vol. 299, pp. 118051. Date of Electronic Publication: 2025 Aug 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antiviral Agents*/pharmacology , Antiviral Agents*/chemical synthesis , Antiviral Agents*/chemistry , Drug Design* , Pyrimidines*/pharmacology , Pyrimidines*/chemistry , Pyrimidines*/chemical synthesis , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/chemical synthesis , Vesicular Stomatitis*/drug therapy , Vesiculovirus*/drug effects , Vesicular stomatitis Indiana virus*/drug effects, Animals ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Virus Replication/drug effects ; Humans ; Microbial Sensitivity Tests

Efficacy and safety of a reduced starting dose of cabozantinib (20 mg) plus nivolumab for renal cell carcinoma in real-world practice.

Autori: Sazuka T Watanabe Y Yokochi F a ďalší

Zdroj: Japanese journal of clinical oncology [Jpn J Clin Oncol] 2025 Dec 03; Vol. 55 (12), pp. 1391-1396.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 0313225 Publication Model: Print Cited Medium: Internet ISSN: 1465-3621 (Electronic) Linking ISSN: 03682811 NLM ISO Abbreviation: Jpn J Clin Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Carcinoma, Renal Cell*/drug therapy , Carcinoma, Renal Cell*/pathology , Anilides*/administration & dosage , Anilides*/adverse effects , Nivolumab*/administration & dosage , Nivolumab*/adverse effects , Pyridines*/administration & dosage , Pyridines*/adverse effects , Kidney Neoplasms*/drug therapy , Kidney Neoplasms*/pathology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Antineoplastic Combined Chemotherapy Protocols*/administration & dosage, Humans ; Male ; Female ; Aged ; Retrospective Studies ; Aged, 80 and over ; Middle Aged ; Treatment Outcome

Re(I)-quinolinate-pyridyl complexes with disubstituted benzimidazole pharmacophores as anticancer agents.

Autori: Borkar RL Putta CL Platto M a ďalší

Zdroj: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2025 Dec 02; Vol. 54 (47), pp. 17531-17545. Date of Electronic Publication: 2025 Dec 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101176026 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9234 (Electronic) Linking ISSN: 14779226 NLM ISO Abbreviation: Dalton Trans Subsets: MEDLINE

Výrazy zo slovníka MeSH: Benzimidazoles*/chemistry , Benzimidazoles*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Coordination Complexes*/chemistry , Coordination Complexes*/pharmacology , Coordination Complexes*/chemical synthesis , Pyridines*/chemistry , Pyridines*/pharmacology, Humans ; Animals ; Cell Proliferation/drug effects ; Mice ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Apoptosis/drug effects ; Molecular Structure

Premenopausal Patients With Clinically Aggressive Metastatic Breast Cancer Successfully Treated With a First-Line Palbociclib-Containing Regimen: Two Cases and Literature Review.

Autori: Fu PA Hsu YC Hsu HP a ďalší

Zdroj: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2025 Dec; Vol. 8 (12), pp. e70417.

Spôsob vydávania: Journal Article; Case Reports; Review

Informácie o časopise: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101747728 Publication Model: Print Cited Medium: Internet ISSN: 2573-8348 (Electronic) Linking ISSN: 25738348 NLM ISO Abbreviation: Cancer Rep (Hoboken) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Pyridines*/administration & dosage , Pyridines*/therapeutic use , Piperazines*/administration & dosage , Piperazines*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Humans ; Female ; Premenopause ; Adult ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Treatment Outcome ; Protein Kinase Inhibitors/administration & dosage

Fuzuloparib with or without apatinib in patients with HER2-negative metastatic breast cancer with germline BRCA1/2 mutations (FABULOUS): interim analysis of a multicentre, three-arm, open-label, randomised, phase 3 trial.

Autori: Li H Liu J Ouyang Q a ďalší

Zdroj: The Lancet. Oncology [Lancet Oncol] 2025 Dec; Vol. 26 (12), pp. 1563-1574.

Spôsob vydávania: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study

Informácie o časopise: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Germ-Line Mutation* , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/mortality , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Pyridines*/administration & dosage , Pyridines*/adverse effects , BRCA2 Protein*/genetics , BRCA1 Protein*/genetics, Humans ; Female ; Middle Aged ; Adult ; Receptor, ErbB-2 ; Aged ; Young Adult ; Poly(ADP-ribose) Polymerase Inhibitors/administration & dosage ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Adolescent ; Progression-Free Survival

Identification of 2,4-disubstitued pyridine derivatives as potent FMS-like tyrosine receptor kinase 3 (FLT3) inhibitors.

Autori: Wang Z Liu X Hou Y a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109229. Date of Electronic Publication: 2025 Nov 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: fms-Like Tyrosine Kinase 3*/antagonists & inhibitors , fms-Like Tyrosine Kinase 3*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Humans ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Molecular Structure ; Animals ; Dose-Response Relationship, Drug ; Mice ; Drug Screening Assays, Antitumor ; Apoptosis/drug effects ; Leukemia, Myeloid, Acute/drug therapy ; Cell Line, Tumor

Selpercatinib Increases Radioactive Iodine Avidity in RET-Fusion Pediatric Thyroid Carcinoma.

Autori: Potter SL Rainusso N Sher AC a ďalší

Zdroj: Pediatrics [Pediatrics] 2025 Dec 01; Vol. 156 (6).

Spôsob vydávania: Journal Article; Case Reports

Informácie o časopise: Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 0376422 Publication Model: Print Cited Medium: Internet ISSN: 1098-4275 (Electronic) Linking ISSN: 00314005 NLM ISO Abbreviation: Pediatrics Subsets: MEDLINE

Výrazy zo slovníka MeSH: Iodine Radioisotopes*/therapeutic use , Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/drug therapy , Thyroid Neoplasms*/radiotherapy , Thyroid Neoplasms*/diagnostic imaging , Thyroid Neoplasms*/metabolism , Proto-Oncogene Proteins c-ret*/genetics , Proto-Oncogene Proteins c-ret*/antagonists & inhibitors , Thyroid Cancer, Papillary*/genetics , Thyroid Cancer, Papillary*/drug therapy , Pyridines*/therapeutic use , Pyridines*/pharmacology , Pyrazoles*/therapeutic use , Pyrazoles*/pharmacology, Humans ; Adolescent ; Female ; Male

Pyrazolopyridine derivatives as potent ASK1 inhibitors: design, synthesis, and biological evaluation.

Autori: Liu H Han X Hu M a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109176. Date of Electronic Publication: 2025 Oct 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: MAP Kinase Kinase Kinase 5*/antagonists & inhibitors , MAP Kinase Kinase Kinase 5*/metabolism , Pyrazoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/chemical synthesis , Drug Design* , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Cell Survival/drug effects ; Cell Line

Physiologically Based Pharmacokinetic Modeling of Lemborexant: Exploration of Doses for Populations with Hepatic Impairment.

Autori: Wu W Pan G Cai X a ďalší

Zdroj: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Dec; Vol. 65 (12), pp. 1746-1756. Date of Electronic Publication: 2025 Sep 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Models, Biological* , Orexin Receptor Antagonists*/pharmacokinetics , Orexin Receptor Antagonists*/administration & dosage , Orexin Receptor Antagonists*/blood , Liver Diseases*/metabolism , Pyridines*/pharmacokinetics , Pyridines*/administration & dosage , Pyridines*/blood , Pyrimidines*/pharmacokinetics , Pyrimidines*/administration & dosage , Pyrimidines*/blood, Humans ; Male ; Middle Aged ; Adult ; Female ; Young Adult ; Aged ; Dose-Response Relationship, Drug ; Area Under Curve

Efficacy of regorafenib following first-line immune checkpoint inhibitor failure in patients with advanced hepatocellular carcinoma: A multicenter study.

Autori: Cheng Y Wang JY Lu Y a ďalší

Korporácia: Cheng Y Wang JY Lu Y a ďalší

Zdroj: Hepatobiliary & pancreatic diseases international : HBPD INT [Hepatobiliary Pancreat Dis Int] 2025 Dec; Vol. 24 (6), pp. 656-665. Date of Electronic Publication: 2025 Sep 22.

Spôsob vydávania: Journal Article; Multicenter Study

Informácie o časopise: Publisher: Elsevier Country of Publication: Singapore NLM ID: 101151457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1499-3872 (Print) NLM ISO Abbreviation: Hepatobiliary Pancreat Dis Int Subsets: MEDLINE

Výrazy zo slovníka MeSH: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/mortality , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/immunology , Phenylurea Compounds*/therapeutic use , Phenylurea Compounds*/adverse effects , Phenylurea Compounds*/administration & dosage , Liver Neoplasms*/drug therapy , Liver Neoplasms*/mortality , Liver Neoplasms*/pathology , Liver Neoplasms*/immunology , Pyridines*/therapeutic use , Pyridines*/adverse effects , Pyridines*/administration & dosage , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/adverse effects , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/adverse effects, Humans ; Male ; Female ; Middle Aged ; Aged ; China ; Retrospective Studies ; Progression-Free Survival ; Adult ; Treatment Failure ; Treatment Outcome ; Time Factors

Target identification and mechanism of action of the neonicotinoid Cycloxaprid.

Autori: Qiao X Zhang YC Qin J a ďalší

Zdroj: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2025 Dec; Vol. 215, pp. 106702. Date of Electronic Publication: 2025 Sep 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Nicotinic*/metabolism , Receptors, Nicotinic*/genetics , Receptors, Nicotinic*/chemistry , Insecticides*/pharmacology , Insecticides*/toxicity , Insecticides*/chemistry , Neonicotinoids*/pharmacology , Neonicotinoids*/chemistry , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/toxicity, Animals ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/genetics ; Xenopus laevis ; Oocytes/drug effects ; Oocytes/metabolism ; Drosophila Proteins/metabolism ; Drosophila Proteins/genetics ; Heterocyclic Compounds, 3-Ring

Advances in the synthesis of dehydroacetic acid based pyrazole-pyridine conjugates with promising anti-malarial and anti-inflammatory potentials.

Autori: Rani P Dhillon S Kumari G a ďalší

Zdroj: Future medicinal chemistry [Future Med Chem] 2025 Dec; Vol. 17 (23), pp. 2835-2849. Date of Electronic Publication: 2025 Nov 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antimalarials*/pharmacology , Antimalarials*/chemistry , Antimalarials*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyridines*/chemistry , Pyridines*/pharmacology , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemical synthesis , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/chemistry, Plasmodium falciparum/drug effects ; Molecular Docking Simulation ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2/chemistry ; Humans ; Structure-Activity Relationship ; Animals ; Molecular Structure ; Mice