Suchergebnisse - "Pyrazoles chemistry"

Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors

Autoren: Pellattiero, Anna Quirin, Charlotte Magrin, Federico et al.

Quelle: Sci Adv

Schlagwörter: Pyrazoles/pharmacology, Small Molecule Libraries/chemistry, Antineoplastic Agents, Pyrazoles/chemistry, OPA1 protein, human, GTP Phosphohydrolases/antagonists & inhibitors, Drug Resistance, Neoplasm/drug effects, Biochimie, biophysique & biologie moléculaire, GTP Phosphohydrolases, Small Molecule Libraries, Cytochromes c/metabolism, Enzyme Inhibitors/chemistry, Structure-Activity Relationship, Cell Line, Tumor, Mitochondria/metabolism, Antineoplastic Agents/chemistry, Small Molecule Libraries/pharmacology, Humans, Enzyme Inhibitors, Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors, Enzyme Inhibitors/pharmacology, Apoptosis/drug effects, Cytochromes c, GTP Phosphohydrolases/chemistry, Life sciences, Mitochondria/drug effects, Proto-Oncogene Proteins c-bcl-2, Sciences du vivant, Pyrazoles, Proto-Oncogene Proteins c-bcl-2/metabolism, Biomedicine and Life Sciences, GTP Phosphohydrolases/metabolism, Antineoplastic Agents/pharmacology, Biochemistry, biophysics & molecular biology

A novel series of pyrazole-platinum(II) complexes as potential anti-cancer agents that induce cell cycle arrest and apoptosis in breast cancer cells

Autoren: Robert Czarnomysy Arkadiusz Surażyński Anna Bielawska et al.

Quelle: J Enzyme Inhib Med Chem
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1006-1023 (2018)

Schlagwörter: 0301 basic medicine, Organoplatinum compounds - pharmacology, Dose-response relationship, Organoplatinum Compounds, Antineoplastic agents - pharmacology, Apoptosis, mitochondrial - drug effects, Anti-cancer drugs, Pyrazoles - pharmacology, Tumor Cells, Cultured, Cell survival - drug effects, Antineoplastic agents - chemical synthesis, MCF-7 cells, antitumor, Membrane Potential, Mitochondrial, 0303 health sciences, Molecular Structure, apoptosis, drug, Organoplatinum compounds - chemistry, Breast neoplasms - drug therapy, Antineoplastic agents - chemistry, 3. Good health, Drug screening assays, Caspases, MCF-7 Cells, Female, Research Paper, Cell Survival, Apoptosis - drug effects, Pyrazoles - chemistry, Antineoplastic Agents, Breast Neoplasms, RM1-950, Tumor cells, Organoplatinum compounds - chemical synthesis, Breast neoplasms - pathology, Structure-Activity Relationship, 03 medical and health sciences, Breast neoplasms - metabolism, Humans, cultured, Membrane potential, Cell Proliferation, Caspases - metabolism, Dose-Response Relationship, Drug, Cell Cycle Checkpoints, Structure-activity relationship, pyrazole, Cell proliferation - drug effects, Pyrazoles, Cell cycle checkpoints - drug effects, Therapeutics. Pharmacology, Drug Screening Assays, Antitumor, Molecular structure, platinum complexes

Zugangs-URL: https://www.tandfonline.com/doi/pdf/10.1080/14756366.2018.1471687?needAccess=true
https://pubmed.ncbi.nlm.nih.gov/29862867
https://doaj.org/article/89137bcbedde488aab1d120cbad87201
https://pubmed.ncbi.nlm.nih.gov/29862867/
https://doaj.org/article/89137bcbedde488aab1d120cbad87201
http://europepmc.org/articles/PMC6009892
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009892
https://tandfonline.com/doi/ref/10.1080/14756366.2018.1471687
https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1471687

Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors

Weitere Verfasser: Areum Park Jieon Hwang Joo-Youn Lee et al.

Schlagwörter: Antineoplastic Agents / chemical synthesis, Antineoplastic Agents / chemistry, Antineoplastic Agents / pharmacology, Cell Line, Tumor, Cell Proliferation / drug effects, Cell Survival / drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, Molecular Structure, Protein Kinase Inhibitors / chemical synthesis, Protein Kinase Inhibitors / chemistry, Protein Kinase Inhibitors / pharmacology, Protein Serine-Threonine Kinases / antagonists & inhibitors, Protein Serine-Threonine Kinases / metabolism, Protein-Tyrosine Kinases / antagonists & inhibitors, Protein-Tyrosine Kinases / metabolism, Pyrazoles / chemical synthesis, Pyrazoles / chemistry, Pyrazoles / pharmacology, Pyridines / chemical synthesis, Pyridines / chemistry, Pyridines / pharmacology, Structure-Activity Relationship, Colon cancer, DYRK1A, DYRK1B

Relation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS; J00326; https://ir.ymlib.yonsei.ac.kr/handle/22282913/187518; https://www.sciencedirect.com/science/article/pii/S0960894X21004534?via%3Dihub; T202124799

Verfügbarkeit: https://ir.ymlib.yonsei.ac.kr/handle/22282913/187518
https://doi.org/10.1016/j.bmcl.2021.128226
https://www.sciencedirect.com/science/article/pii/S0960894X21004534?via%3Dihub

Increasing the Stability of DNA:RNA Duplexes by Introducing Stacking Phenyl-Substituted Pyrazole, Furan, and Triazole Moieties in the Major Groove: RNA duplexes by introducing stacking phenyl-substituted pyrazole, furan and triazole moieties in the major groove

Autoren: Hornum, Mick Kumar, Pawan Podsiadly, Patricia et al.

Quelle: Hornum, M, Kumar, P, Podsiadly, P & Nielsen, P 2015, ' Increasing the stability of DNA : RNA duplexes by introducing stacking phenyl-substituted pyrazole, furan and triazole moieties in the major groove ', Journal of Organic Chemistry, vol. 80, no. 19, pp. 9592-9602 . https://doi.org/10.1021/acs.joc.5b01577

Schlagwörter: Models, Molecular, Circular Dichroism, Oligonucleotides, Molecular, Pyrazoles/chemistry, DNA, Triazoles, Deoxyuridine, 01 natural sciences, 3. Good health, 0104 chemical sciences, Models, Deoxyuridine/analogs & derivatives, Nucleic Acid Conformation, Pyrazoles, RNA, RNA/chemistry, Furans/chemistry, Oligonucleotides/chemistry, Furans, DNA/chemistry, Triazoles/chemistry

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/26334359
https://core.ac.uk/display/50708861
http://europepmc.org/abstract/MED/26334359
http://pubsdc3.acs.org/doi/abs/10.1021/acs.joc.5b01577
https://pubs.acs.org/doi/full/10.1021/acs.joc.5b01577
https://pubs.acs.org/doi/10.1021/acs.joc.5b01577
http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b01577
https://portal.findresearcher.sdu.dk/da/publications/58c4b1a7-835a-4631-aeeb-9c4b3c66b279

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

Autoren: Mariusz Mojzych Veronika Šubertová Anna Bielawska et al.

Quelle: European Journal of Medicinal Chemistry. 78:217-224

Schlagwörter: 0301 basic medicine, Dose-response relationship, Protein kinase inhibitors - chemistry, Cell Survival, Sulfonamides - chemical synthesis, Pyrazoles - chemistry, Fusion Proteins, bcr-abl, Antineoplastic agents - pharmacology, Antineoplastic Agents, HL-60 Cells, Tumor cells, Structure-Activity Relationship, 03 medical and health sciences, Sulfonamides - pharmacology, Tumor Cells, Cultured, Cell survival - drug effects, Humans, Antineoplastic agents - chemical synthesis, MCF-7 cells, cultured, Protein Kinase Inhibitors, bcr-abl - antagonists & inhibitors, antitumor, K562 cells, Cell Proliferation, Sulfonamides, 0303 health sciences, Sulfonamides - chemistry, Dose-Response Relationship, Drug, Molecular Structure, Triazines, drug, Triazines - chemistry, Protein kinase inhibitors - chemical synthesis, Structure-activity relationship, Antineoplastic agents - chemistry, HL-60 cells, Protein kinase inhibitors - pharmacology, 3. Good health, Fusion proteins, Cell proliferation - drug effects, Drug screening assays, bcr-abl - metabolism, MCF-7 Cells, Pyrazoles, Drug Screening Assays, Antitumor, K562 Cells, Molecular structure

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/24681986
https://pubmed.ncbi.nlm.nih.gov/24681986/
http://www.sciencedirect.com/science/article/pii/S0223523414002670
https://www.ncbi.nlm.nih.gov/pubmed/24681986
https://www.sciencedirect.com/science/article/pii/S0223523414002670

Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity

Autoren: Mojzych, Mariusz Bielawska, Anna Bielawski, Krzysztof et al.

Quelle: Bioorganic & Medicinal Chemistry. 22:2643-2647

Schlagwörter: 0301 basic medicine, tumor, Carbonic anhydrase inhibitors - chemical synthesis, Cell Survival, Sulfonamides - chemical synthesis, Carbonic anhydrases - metabolism, Pyrazoles - chemistry, Antineoplastic Agents, 01 natural sciences, Carbonic anhydrases - chemistry, Antineoplastic agents - toxicity, 03 medical and health sciences, Carbonic anhydrase inhibitors - chemistry, Cell Line, Tumor, Carbonic anhydrase inhibitors, Cytotoxicity, MCF-7, MDA-MB-231, Pyrazolo[4 3-e][1 2 4]triazine, Sulfonamides, Carbonic Anhydrase Inhibitors, Carbonic Anhydrases, Humans, MCF-7 Cells, Pyrazoles, Triazines, Biochemistry, Clinical Biochemistry, Molecular Biology, Molecular Medicine, Organic Chemistry, Drug Discovery3003 Pharmaceutical Science, 3003, Medicine (all), Cell survival - drug effects, Antineoplastic agents - chemical synthesis, MCF-7 cells, Sulfonamides - chemistry, Triazines - chemistry, Carbonic anhydrase inhibitors - toxicity, Antineoplastic agents - chemistry, 3. Good health, 0104 chemical sciences, Sulfonamides - toxicity, Cell line

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/24713308
https://www.sciencedirect.com/science/article/abs/pii/S0968089614002144
https://www.sciencedirect.com/science/article/pii/S0968089614002144#!
https://www.ncbi.nlm.nih.gov/pubmed/24713308

Interaction of Celecoxib with Membranes: The Role of Membrane Biophysics on its Therapeutic and Toxic Effects

Autoren: Pereira-Leite, C. Nunes, C. Lima, J. L. F. C. et al.

Quelle: The journal of physical chemistry / B 116, 13608 (2012). doi:10.1021/jp304037v

Schlagwörter: Models, Molecular, 0301 basic medicine, Sulfonamides: chemistry, Lipid Bilayers, Biophysics, 03 medical and health sciences, Pyrazoles: toxicity, Anti-Inflammatory Agents, Non-Steroidal: chemistry, Liposomes: chemistry, Sulfonamides: pharmacology, Sulfonamides, 0303 health sciences, Sulfonamides: toxicity, celecoxib, Pyrazoles: pharmacology, Anti-Inflammatory Agents, Non-Steroidal, Cell Membrane, Anti-Inflammatory Agents, Non-Steroidal: pharmacology, Anti-Inflammatory Agents, Non-Steroidal: toxicity, Lipid Bilayers: chemistry, 3. Good health, Cell Membrane: drug effects, Celecoxib, Liposomes, Pyrazoles, Pyrazoles: chemistry

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/23094761
https://pubs.acs.org/doi/abs/10.1021/jp304037v
https://pubs.acs.org/doi/10.1021/jp304037v
http://europepmc.org/abstract/MED/23094761
https://core.ac.uk/display/20518399
https://pubmed.ncbi.nlm.nih.gov/23094761/
https://bib-pubdb1.desy.de/record/143979

Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib

Autoren: Desai, Dhimant Kaushal, Naveen Gandhi, Ujjawal H et al.

Quelle: Chemico-Biological Interactions. 188:446-456

Schlagwörter: Lipopolysaccharides, 0301 basic medicine, Cyclooxygenase 2 Inhibitors - chemistry, Sulfonamides - chemical synthesis, Anti-Inflammatory Agents - chemical synthesis, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors - pharmacology, Mice, Pyrazoles - pharmacology, Glutathione Peroxidase GPX1, Signal Transduction - drug effects, Anti-Inflammatory Agents - pharmacology, Sulfonamides, 0303 health sciences, Enzymologic - drug effects, NF-kappa B, 3. Good health, Macrophages - metabolism, Signal Transduction, Macrophages - drug effects, Pyrazoles - chemistry, Lipopolysaccharides - pharmacology, Bone Marrow Cells, Macrophages - cytology, Cyclooxygenase 2 - metabolism, Gene Expression Regulation, Enzymologic, Cell Line, Selenium, 03 medical and health sciences, Selenium - chemistry, Sulfonamides - pharmacology, Animals, Humans, Glutathione Peroxidase - metabolism, Glutathione Peroxidase, Sulfonamides - chemistry, Cyclooxygenase 2 Inhibitors, Cyclooxygenase 2 Inhibitors - chemical synthesis, Macrophages, NF-kappa B - metabolism, Anti-Inflammatory Agents - chemistry, Rats, Gene Expression Regulation, Celecoxib, Cyclooxygenase 2, Pyrazoles, Bone Marrow Cells - cytology, Pyrazoles - chemical synthesis

Zugangs-URL: https://europepmc.org/articles/pmc3004533?pdf=render
https://pubmed.ncbi.nlm.nih.gov/20883674
https://www.ncbi.nlm.nih.gov/pubmed/20883674
https://europepmc.org/abstract/MED/20883674
https://pubmed.ncbi.nlm.nih.gov/20883674/
https://pennstate.pure.elsevier.com/en/publications/synthesis-and-evaluation-of-the-anti-inflammatory-properties-of-s
http://www.sciencedirect.com/science/article/pii/S0009279710005673
https://www.sciencedirect.com/science/article/pii/S0009279710005673

ChemInform Abstract: Diversity‐Oriented Synthesis of Pyrazolo[4,3‐b]indoles by Gold‐Catalyzed Three‐Component Annulation: Application to the Development of a New Class of CK2 Inhibitors

Autoren: Hou, Zengye Oishi, Shinya Suzuki, Yamato et al.

Weitere Verfasser: Hou, Zengye Oishi, Shinya Suzuki, Yamato et al.

Quelle: ChemInform. 44

Schlagwörter: Indoles, Pyrazoles/pharmacology, Protein Kinase Inhibitors/chemical synthesis, Pyrazoles/chemistry, 01 natural sciences, Catalysis, Dose-Response Relationship, Structure-Activity Relationship, Casein Kinase II/metabolism, Humans, Casein Kinase II, Protein Kinase Inhibitors, Indoles/pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Pyrazoles/chemical synthesis, 0104 chemical sciences, Indoles/chemistry, Gold/chemistry, Protein Kinase Inhibitors/pharmacology, Casein Kinase II/antagonists & inhibitors, Pyrazoles, Protein Kinase Inhibitors/chemistry, Gold, Drug, Indoles/chemical synthesis

Dateibeschreibung: application/pdf

Zugangs-URL: https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/189820/1/c3ob40223a.pdf
https://pubmed.ncbi.nlm.nih.gov/23535832
https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/189820
https://pubs.rsc.org/en/content/articlelanding/2013/ob/c3ob40223a#!
http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/189820/1/c3ob40223a.pdf
https://core.ac.uk/display/39314522
https://www.ncbi.nlm.nih.gov/pubmed/23535832
http://onlinelibrary.wiley.com/doi/10.1002/chin.201339121/abstract

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Autoren: Huber, K. V. Salah, E. Radic, B. et al.

Weitere Verfasser: Huber, K. V. Salah, E. Radic, B. et al.

Quelle: ISSN: 0028-0836.

Schlagwörter: SCID, Nucleotides/metabolism, Humans, Female, Animals, Models, Molecular, Mice, Disease Models, Animal, DNA Repair, Xenograft Model Antitumor Assays, Proteomics, Protein Conformation, Aminoquinolines/pharmacology, Antineoplastic Agents/chemistry/*pharmacology, Colonic Neoplasms/drug therapy/genetics/pathology, Crystallization, DNA Breaks, Single-Stranded/drug effects, DNA Repair Enzymes/*antagonists & inhibitors/biosynthesis/chemistry/*metabolism, Homeostasis/drug effects, inhibitors/biosynthesis/chemistry/*metabolism, Phosphoric Monoester Hydrolases/*antagonists &, Protein Kinase Inhibitors/chemistry/*pharmacology, Proto-Oncogene Proteins/genetics, Pyrazoles/chemistry/*pharmacology, Pyridines/chemistry/*pharmacology, ras Proteins/genetics, Substrate Specificity

Relation: info:eu-repo/semantics/altIdentifier/pmid/24695225; hal-02168081; https://hal.umontpellier.fr/hal-02168081; PUBMED: 24695225; PUBMEDCENTRAL: PMC4150021

Verfügbarkeit: https://hal.umontpellier.fr/hal-02168081
https://doi.org/10.1038/nature13194

Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.

Autoren: Hou, Zengye Oishi, Shinya Suzuki, Yamato et al.

Weitere Verfasser: Hou, Zengye Oishi, Shinya Suzuki, Yamato et al.

Schlagwörter: Casein Kinase II/antagonists & inhibitors, Casein Kinase II/metabolism, Catalysis, Dose-Response Relationship, Drug, Gold/chemistry, Humans, Indoles/chemical synthesis, Indoles/chemistry, Indoles/pharmacology, Molecular Structure, Protein Kinase Inhibitors/chemical synthesis, Protein Kinase Inhibitors/chemistry, Protein Kinase Inhibitors/pharmacology, Pyrazoles/chemical synthesis, Pyrazoles/chemistry, Pyrazoles/pharmacology, Structure-Activity Relationship

Dateibeschreibung: application/pdf

Relation: http://hdl.handle.net/2433/189820; Organic & biomolecular chemistry; 11; 20; 3288; 3296

Verfügbarkeit: http://hdl.handle.net/2433/189820

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation.

Autoren: Kroth, Heiko Ansaloni, Annalisa Pihlgren, Maria et al.

Quelle: The journal of biological chemistry 287(41), 34786-34800 (2012). doi:10.1074/jbc.M112.357665

Schlagwörter: info:eu-repo/classification/ddc/540, Amyloid beta-Peptides: antagonists & inhibitors, Amyloid beta-Peptides: chemistry, Cell Line, Tumor, Cytotoxins: antagonists & inhibitors, Cytotoxins: chemistry, Humans, Hydrogen Bonding, Hydrophobic and Hydrophilic Interactions, Peptide Fragments: antagonists & inhibitors, Peptide Fragments: chemistry, Protein Structure, Secondary, Pyrazoles: chemistry, Structure-Activity Relationship, 3-aminopyrazole, Amyloid beta-Peptides, Cytotoxins, Peptide Fragments, Pyrazoles, amyloid beta-protein (1-42)

Geographisches Schlagwort: DE

Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:22891248; info:eu-repo/semantics/altIdentifier/issn/0021-9258; info:eu-repo/semantics/altIdentifier/issn/1067-8816; info:eu-repo/semantics/altIdentifier/issn/1083-351X; https://pub.dzne.de/record/136651

Verfügbarkeit: https://pub.dzne.de/record/136651
https://pub.dzne.de/search?p=id:%22DZNE-2020-02973%22

NIR-mbc94, a fluorescent ligand that binds to endogenous CB(2) receptors and is amenable to high-throughput screening

Autoren: Sexton, Michelle Woodruff, Grace Horne, Eric A. et al.

Weitere Verfasser: Sexton, Michelle Woodruff, Grace Horne, Eric A. et al.

Quelle: Chemistry & Biology, Vol. 18, no. 5, p. 563-568 (2011)

Schlagwörter: Animals, Cell Line, Tumor, Drug Inverse Agonism, Fluorescent Dyes - chemistry, High-Throughput Screening Assays, Mice, Norbornanes - chemistry, pharmacology, Protein Binding, Pyrazoles - chemistry, Receptor, Cannabinoid, CB2 - antagonists & inhibitors, metabolism

Relation: boreal:105997; http://hdl.handle.net/2078.1/105997; info:pmid/21609837

Verfügbarkeit: http://hdl.handle.net/2078.1/105997
https://doi.org/10.1016/j.chembiol.2011.02.016

Rational Design of ß-Sheet Ligands Against Aß(42)-Induced Toxicity

Autoren: Hochdörffer, K. März-Berberich, J. Nagel-Steger, L. et al.

Quelle: Journal of the American Chemical Society 133, 4348 - 4358 (2011). doi:10.1021/ja107675n

Schlagwörter: info:eu-repo/classification/ddc/540, Amyloid beta-Peptides: antagonists & inhibitors, Amyloid beta-Peptides: toxicity, Binding Sites: drug effects, Ligands, Models, Molecular, Molecular Structure, Peptide Fragments: antagonists & inhibitors, Peptide Fragments: toxicity, Protein Structure, Secondary, Pyrazoles: chemical synthesis, Pyrazoles: chemistry, Pyrazoles: pharmacology, Structure-Activity Relationship, Amyloid beta-Peptides, Peptide Fragments, Pyrazoles, amyloid beta-protein (1-42)

Geographisches Schlagwort: DE

Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:21381732; info:eu-repo/semantics/altIdentifier/issn/0002-7863; info:eu-repo/semantics/altIdentifier/wos/WOS:000291715300041

Verfügbarkeit: https://juser.fz-juelich.de/record/16633
https://juser.fz-juelich.de/search?p=id:%22PreJuSER-16633%22

Dual anti-angiogenic and cytotoxic properties of ruthenium(iii) complexes containing pyrazolato and/or pyrazole ligands

Autoren: Lam Shek Ella Lai-Ming Wong Raymond Wai-Yin Sun et al.

Quelle: Dalton Transactions. :10712

Schlagwörter: Pyrazoles - chemistry, Molecular Conformation, Coordination Complexes - chemistry - toxicity, Angiogenesis Inhibitors, Apoptosis, Ascorbic Acid, Ruthenium - chemistry, Crystallography, X-Ray, Ligands, 01 natural sciences, Ruthenium, 0104 chemical sciences, Angiogenesis Inhibitors - chemistry - pharmacology, Coordination Complexes, Cell Line, Tumor, Humans, Pyrazoles, Drug Screening Assays, Antitumor, HeLa Cells

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/20023898
https://core.ac.uk/display/37949765
https://www.ncbi.nlm.nih.gov/pubmed/20023898
https://pubs.rsc.org/en/content/articlelanding/2009/dt/b912236b
http://pubs.rsc.org/en/content/articlelanding/2009/dt10.1039/b912236b
http://hdl.handle.net/10722/124067

Combining independent drug classes into superior, synergistically acting hybrid molecules

Autoren: Müller-Schiffmann, A. März-Berberich, J. Reymann, K. et al.

Quelle: Angewandte Chemie / International edition 49, 8743 - 8746 (2010). doi:10.1002/anie.201004437 ; Angewandte Chemie International Edition English

Schlagwörter: info:eu-repo/classification/ddc/540, Amino Acid Sequence, Amyloid beta-Peptides: chemistry, Animals, CHO Cells, Cricetinae, Cricetulus, Drug Design, Humans, Immunoprecipitation, Oligopeptides: chemistry, Oligopeptides: pharmacology, Protein Structure, Secondary, Pyrazoles: chemistry, Stereoisomerism, Amyloid beta-Peptides, D3 peptide, Oligopeptides, Pyrazoles, trimer-TEG-D3, aggregation, amyloid beta peptides, molecular recognition, peptides

Geographisches Schlagwort: DE

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000284045400042; info:eu-repo/semantics/altIdentifier/issn/0044-8249; info:eu-repo/semantics/altIdentifier/issn/0570-0833; info:eu-repo/semantics/altIdentifier/pmid/pmid:20922735

Verfügbarkeit: https://juser.fz-juelich.de/record/12405
https://juser.fz-juelich.de/search?p=id:%22PreJuSER-12405%22

In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors

Autoren: Swee Y Sharp Kathy Boxall Martin Rowlands et al.

Schlagwörter: Crystallography, Adenosine Triphosphatases/antagonists & inhibitors, Apoptosis/drug effects, Cell Cycle/drug effects, Cell Proliferation/drug effects, X-Ray, Drug Resistance, Neoplasm/drug effects, HSP90 Heat-Shock Proteins/*antagonists & inhibitors/metabolism, Heterocyclic Compounds, 2-Ring/chemistry/*pharmacology, Humans, Models, Biological, Molecular, Protein Binding, Pyrazoles/chemistry/*pharmacology, Substrate Specificity, Tumor Cells, Cultured

Relation: 10779/uos.23394839.v1; https://figshare.com/articles/journal_contribution/In_vitro_biological_characterization_of_a_novel_synthetic_diaryl_pyrazole_resorcinol_class_of_heat_shock_protein_90_inhibitors/23394839

Verfügbarkeit: https://figshare.com/articles/journal_contribution/In_vitro_biological_characterization_of_a_novel_synthetic_diaryl_pyrazole_resorcinol_class_of_heat_shock_protein_90_inhibitors/23394839

Synteza i właściwości biologiczne niektórych skondensowanych pochodnych pirazolu

Autoren: Kujawski Jacek

Quelle: Biblioteka Uniwersytetu Medycznego w Poznaniu

Schlagwörter: medycyna, pirazolu pochodne - synteza chemiczna, pirazolu pochodne - chemia, zjawiska chemiczne, krystalografia, badanie leków przedkliniczne, testy toksyczności, medicine, pyrazoles - chemical synthesis, pyrazoles - chemistry, chemical phenomena, crystallography, drug evaluation, preclinical, toxicity tests

Dateibeschreibung: application/pdf

Relation: oai:www.wbc.poznan.pl:publication:312261; http://www.wbc.poznan.pl/Content/255948/PDF/index.pdf; https://www.wbc.poznan.pl/dlibra/publication/edition/255948/content; oai:www.wbc.poznan.pl:255948

Verfügbarkeit: http://www.wbc.poznan.pl/Content/255948/PDF/index.pdf
https://www.wbc.poznan.pl/dlibra/publication/edition/255948/content

Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.

Autoren: Oishi, Shinya Suzuki, Yamato Kure, Tatsuhide et al.

Index Begriffe: Casein Kinase II/antagonists & inhibitors, Casein Kinase II/metabolism, Catalysis, Dose-Response Relationship, Drug, Gold/chemistry, Humans, Indoles/chemical synthesis, Indoles/chemistry, Indoles/pharmacology, Molecular Structure, Protein Kinase Inhibitors/chemical synthesis, Protein Kinase Inhibitors/chemistry, Protein Kinase Inhibitors/pharmacology, Pyrazoles/chemical synthesis, Pyrazoles/chemistry, Pyrazoles/pharmacology, Structure-Activity Relationship, Journal Article., AM.

URL: http://hdl.handle.net/2433/189820
http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/189820/1/c3ob40223a.pdf
23535832

NIR-mbc94, a fluorescent ligand that binds to endogenous CB(2) receptors and is amenable to high-throughput screening

Autoren: UCL - SSS/LDRI - Louvain Drug Research Institute Sexton, Michelle Woodruff, Grace et al.

Quelle: Chemistry & Biology, Vol. 18, no. 5, p. 563-568 (2011)

Index Begriffe: Animals, Cell Line, Tumor, Drug Inverse Agonism, Fluorescent Dyes - chemistry, High-Throughput Screening Assays, Mice, Norbornanes - chemistry, pharmacology, Protein Binding, Pyrazoles - chemistry, pharmacology, Receptor, Cannabinoid, CB2 - antagonists & inhibitors, metabolism, info:eu-repo/semantics/article

URL: http://hdl.handle.net/2078.1/105997