Výsledky vyhledávání - "Pyrazoles"

Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents.

Autoři: Fatima A Aslam S Janiad S a další

Zdroj: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 5773-5792. Date of Electronic Publication: 2025 Jan 23.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrazoles*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Insecticides*/chemical synthesis , Insecticides*/pharmacology , Insecticides*/chemistry , Drug Design*, Animals ; Molecular Docking Simulation ; Structure-Activity Relationship ; Isoptera/drug effects

Evaluation of the Antifungal Properties of Azomethine-Pyrazole Derivatives from a Structural Perspective.

Autoři: Murillo MI Restrepo-Acevedo AC Rocha-Roa C a další

Zdroj: ChemistryOpen [ChemistryOpen] 2025 Oct; Vol. 14 (10), pp. e202500132. Date of Electronic Publication: 2025 Apr 28.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101594811 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2191-1363 (Electronic) Linking ISSN: 21911363 NLM ISO Abbreviation: ChemistryOpen Subsets: MEDLINE

Výrazy ze slovníku MeSH: Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Thiosemicarbazones*/chemistry , Thiosemicarbazones*/pharmacology , Thiosemicarbazones*/chemical synthesis , Candida*/drug effects , Azo Compounds*/chemistry , Azo Compounds*/pharmacology , Azo Compounds*/chemical synthesis, Microbial Sensitivity Tests ; Cryptococcus neoformans/drug effects ; Structure-Activity Relationship

Development of pyrazole and pyrazolopyrimidine derivatives as promising anti-MRSA agents targeting penicillin-binding protein (PBP2a) and mecA gene.

Autoři: Ragab A Abusaif MS Selim HMRM a další

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Oct; Vol. 165, pp. 108977. Date of Electronic Publication: 2025 Sep 09.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrazoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/chemical synthesis , Methicillin-Resistant Staphylococcus aureus*/drug effects , Methicillin-Resistant Staphylococcus aureus*/genetics , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Penicillin-Binding Proteins*/genetics , Penicillin-Binding Proteins*/antagonists & inhibitors , Penicillin-Binding Proteins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/antagonists & inhibitors , Bacterial Proteins*/metabolism , Pyrimidines*/pharmacology , Pyrimidines*/chemistry , Pyrimidines*/chemical synthesis, Microbial Sensitivity Tests ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Biofilms/drug effects ; Antifungal Agents/pharmacology ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry

Integrated computational approaches for identification of potent pyrazole-based glycogen synthase kinase-3β (GSK-3β) inhibitors: 3D-QSAR, virtual screening, docking, MM/GBSA, EC, MD simulation studies.

Autoři: Niharika DG Salaria P Reddy MA

Zdroj: Molecular diversity [Mol Divers] 2025 Oct; Vol. 29 (5), pp. 4177-4201. Date of Electronic Publication: 2024 Nov 19.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Výrazy ze slovníku MeSH: Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/chemistry , Glycogen Synthase Kinase 3 beta*/metabolism , Quantitative Structure-Activity Relationship* , Molecular Docking Simulation* , Molecular Dynamics Simulation* , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/pharmacology, Humans ; Drug Evaluation, Preclinical

Highly efficient analysis of fipronil and ethiprole in milk using ternary deep eutectic solvent-functionalized UiO-66-based tip-SPE - HPLC.

Autoři: Han Y Ma R Wang J a další

Zdroj: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 3), pp. 146583. Date of Electronic Publication: 2025 Sep 29.

Způsob vydávání: Journal Article; Evaluation Study

Informace o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Milk*/chemistry , Pyrazoles*/isolation & purification , Pyrazoles*/analysis , Solid Phase Extraction*/methods , Solid Phase Extraction*/instrumentation , Insecticides*/isolation & purification , Insecticides*/analysis , Pesticide Residues*/isolation & purification , Pesticide Residues*/analysis, Animals ; Chromatography, High Pressure Liquid/methods ; Chromatography, High Pressure Liquid/instrumentation ; Food Contamination/analysis ; Cattle ; Adsorption ; Deep Eutectic Solvents/chemistry

Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics.

Autoři: Scalvini L Tagliazucchi L Elisi GM a další

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118056. Date of Electronic Publication: 2025 Aug 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Proteomics* , Transcription Factors*/metabolism , Transcription Factors*/antagonists & inhibitors , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/antagonists & inhibitors , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/antagonists & inhibitors , Muscle Proteins*/metabolism , Muscle Proteins*/antagonists & inhibitors, Humans ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; TEA Domain Transcription Factors ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Mass Spectrometry ; YAP-Signaling Proteins ; Cell Line, Tumor

Synthesis and biological evaluation of C-28-modified pyrazole-fused betulinic acid derivatives as potent antiosteoporosis agents.

Autoři: Zhao T Li S Qiu G a další

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118169. Date of Electronic Publication: 2025 Sep 15.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Osteoporosis*/drug therapy , Osteoporosis*/metabolism , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Triterpenes*/chemistry , Triterpenes*/pharmacology , Triterpenes*/chemical synthesis, Animals ; Pentacyclic Triterpenes/pharmacology ; Pentacyclic Triterpenes/chemistry ; Mice ; Betulinic Acid ; RAW 264.7 Cells ; Structure-Activity Relationship ; Osteoclasts/drug effects ; Osteoclasts/cytology ; Molecular Structure ; Dose-Response Relationship, Drug ; Osteogenesis/drug effects ; Female ; RANK Ligand ; Cell Differentiation/drug effects

Discovery of A20 with 4-(2-methoxyphenyl)-1H-pyrazole scaffold as a potent and selective ROCK2 inhibitor.

Autoři: Wang J Peng B Liang G a další

Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130391. Date of Electronic Publication: 2025 Aug 29.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Výrazy ze slovníku MeSH: rho-Associated Kinases*/antagonists & inhibitors , rho-Associated Kinases*/metabolism , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Drug Discovery*, Structure-Activity Relationship ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Dose-Response Relationship, Drug

Development of pyrazolo[1,5-a]pyrimidine based macrocyclic kinase inhibitors targeting AAK1.

Autoři: Mensing TE Kurz CG Amrhein JA a další

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 05; Vol. 299, pp. 118076. Date of Electronic Publication: 2025 Aug 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrimidines*/chemistry , Pyrimidines*/pharmacology , Pyrimidines*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/chemical synthesis , Intracellular Signaling Peptides and Proteins*/antagonists & inhibitors , Intracellular Signaling Peptides and Proteins*/metabolism , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/pharmacology , Macrocyclic Compounds*/chemical synthesis , Nucleoside-Phosphate Kinase*/antagonists & inhibitors , Nucleoside-Phosphate Kinase*/metabolism , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism, Humans ; Structure-Activity Relationship ; SARS-CoV-2/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug

Comprehensive Overview of Pyrazole Amide Derivatives as Novel Pesticides for Crop Protection and Pest Management.

Autoři: Luo B Hu Y Wu Y a další

Zdroj: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Dec 03; Vol. 73 (48), pp. 30582-30600. Date of Electronic Publication: 2025 Nov 21.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Amides*/chemistry , Amides*/pharmacology , Pesticides*/chemistry , Pesticides*/pharmacology, Animals ; Pest Control ; Crop Protection ; Structure-Activity Relationship ; Crops, Agricultural/drug effects ; Crops, Agricultural/growth & development ; Insecticides/chemistry ; Insecticides/pharmacology

Rapid and Sensitive Quantitation of Fipronil and Its Metabolites Fipronil Sulfone, Fipronil Sulfide, and Fipronil Desulfinyl in Zebrafish Tissues by UHPLC-MS/MS.

Autoři: Liu M Guo Y Liu J a další

Zdroj: Journal of separation science [J Sep Sci] 2025 Dec; Vol. 48 (12), pp. e70326.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101088554 Publication Model: Print Cited Medium: Internet ISSN: 1615-9314 (Electronic) Linking ISSN: 16159306 NLM ISO Abbreviation: J Sep Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrazoles*/metabolism , Pyrazoles*/analysis , Insecticides*/metabolism , Insecticides*/analysis, Animals ; Zebrafish/metabolism ; Chromatography, High Pressure Liquid ; Tandem Mass Spectrometry

Effectiveness and safety of Baricitinib in alopecia areata: a prospective cohort study.

Autoři: Muñoz-Barba D García-Moronta C Haselgruber-de Francisco S a další

Zdroj: The Journal of dermatological treatment [J Dermatolog Treat] 2025 Dec; Vol. 36 (1), pp. 2583877. Date of Electronic Publication: 2025 Nov 24.

Způsob vydávání: Journal Article; Observational Study

Informace o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8918133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1753 (Electronic) Linking ISSN: 09546634 NLM ISO Abbreviation: J Dermatolog Treat Subsets: MEDLINE

Výrazy ze slovníku MeSH: Alopecia Areata*/drug therapy , Alopecia Areata*/diagnosis , Azetidines*/adverse effects , Azetidines*/therapeutic use , Azetidines*/administration & dosage , Sulfonamides*/adverse effects , Sulfonamides*/therapeutic use , Sulfonamides*/administration & dosage , Pyrazoles*/adverse effects , Pyrazoles*/therapeutic use, Humans ; Purines/adverse effects ; Female ; Male ; Prospective Studies ; Adult ; Middle Aged ; Treatment Outcome ; Severity of Illness Index ; Young Adult ; Follow-Up Studies

Exploration Novel of Pyrazole and Isoxazole Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Structure Activity Relationship Study, and Antibiofilm Activity With Molecular Docking Simulation.

Autoři: Saadon KE Ragab A Taha NMH a další

Zdroj: Drug development research [Drug Dev Res] 2025 Dec; Vol. 86 (8), pp. e70189.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrazoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/chemical synthesis , Biofilms*/drug effects , Isoxazoles*/pharmacology , Isoxazoles*/chemistry , Isoxazoles*/chemical synthesis , Antifungal Agents*/pharmacology , Antifungal Agents*/chemical synthesis , Antifungal Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemical synthesis , Anti-Infective Agents*/chemistry, Molecular Docking Simulation ; Microbial Sensitivity Tests ; Structure-Activity Relationship ; Drug Design ; Candida albicans/drug effects ; Bacillus subtilis/drug effects

Design, synthesis, in silico studies, molecular docking, ADMET and anticancer activity of novel N -substituted-4-pyrazole derivatives.

Autoři: El-Kasabi HG Girges MM F El-Sayed A a další

Zdroj: Future medicinal chemistry [Future Med Chem] 2025 Dec; Vol. 17 (23), pp. 2821-2833. Date of Electronic Publication: 2025 Nov 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrazoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/chemical synthesis , Molecular Docking Simulation* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Drug Design*, Humans ; Caco-2 Cells ; Apoptosis/drug effects ; Drug Screening Assays, Antitumor ; Tumor Necrosis Factor-alpha/metabolism ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Caspase 3/metabolism ; Molecular Structure ; ErbB Receptors/metabolism ; ErbB Receptors/chemistry ; bcl-2-Associated X Protein/metabolism ; bcl-2-Associated X Protein/chemistry

Selpercatinib Increases Radioactive Iodine Avidity in RET-Fusion Pediatric Thyroid Carcinoma.

Autoři: Potter SL Rainusso N Sher AC a další

Zdroj: Pediatrics [Pediatrics] 2025 Dec 01; Vol. 156 (6).

Způsob vydávání: Journal Article; Case Reports

Informace o časopise: Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 0376422 Publication Model: Print Cited Medium: Internet ISSN: 1098-4275 (Electronic) Linking ISSN: 00314005 NLM ISO Abbreviation: Pediatrics Subsets: MEDLINE

Výrazy ze slovníku MeSH: Iodine Radioisotopes*/therapeutic use , Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/drug therapy , Thyroid Neoplasms*/radiotherapy , Thyroid Neoplasms*/diagnostic imaging , Thyroid Neoplasms*/metabolism , Proto-Oncogene Proteins c-ret*/genetics , Proto-Oncogene Proteins c-ret*/antagonists & inhibitors , Thyroid Cancer, Papillary*/genetics , Thyroid Cancer, Papillary*/drug therapy , Pyridines*/therapeutic use , Pyridines*/pharmacology , Pyrazoles*/therapeutic use , Pyrazoles*/pharmacology, Humans ; Adolescent ; Female ; Male

Intermittent and Short-Term Empirical Ruxolitinib Regimen for Steroid-Refractory Flareups of Fibrodysplasia Ossificans Progressiva.

Autoři: Chen RL Yang TH Wang YH a další

Zdroj: Pharmacology research & perspectives [Pharmacol Res Perspect] 2025 Dec; Vol. 13 (6), pp. e70193.

Způsob vydávání: Journal Article; Case Reports

Informace o časopise: Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 101626369 Publication Model: Print Cited Medium: Internet ISSN: 2052-1707 (Electronic) Linking ISSN: 20521707 NLM ISO Abbreviation: Pharmacol Res Perspect Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrazoles*/administration & dosage , Pyrazoles*/therapeutic use , Pyrazoles*/adverse effects , Myositis Ossificans*/drug therapy , Janus Kinase Inhibitors*/administration & dosage , Janus Kinase Inhibitors*/therapeutic use , Janus Kinase Inhibitors*/adverse effects, Humans ; Nitriles ; Adolescent ; Female ; Pyrimidines

Newly synthesized pyranopyrazole nicotinamides derivatives as potent anti-inflammatory agents: In-silico, in-vitro, and in-vivo studies.

Autoři: Rizk HF Beltagy DM Ibrahim SA a další

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109205. Date of Electronic Publication: 2025 Nov 05.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/therapeutic use , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Edema*/drug therapy , Edema*/chemically induced , Niacinamide*/pharmacology , Niacinamide*/chemistry , Niacinamide*/chemical synthesis , Niacinamide*/analogs & derivatives , Niacinamide*/therapeutic use , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemical synthesis , Anti-Inflammatory Agents*/chemistry, Animals ; Rats ; Molecular Structure ; Molecular Docking Simulation ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Male ; Carrageenan ; Inflammation/drug therapy ; Inflammation/chemically induced ; Humans ; NF-kappa B/metabolism

Synthesis of novel pyrazole derivatives and neuroprotective effect investigation.

Autoři: Feng A Zeng Q Wang J a další

Zdroj: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2583820. Date of Electronic Publication: 2025 Nov 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Pyrazoles*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemical synthesis , Neuroprotective Agents*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/chemistry, Animals ; Mice ; Structure-Activity Relationship ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/antagonists & inhibitors ; Molecular Structure ; Dose-Response Relationship, Drug ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/genetics ; Cell Line ; Cell Survival/drug effects ; Microglia/drug effects ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry

Discovery of macrocyclic derivatives bearing N-sulfonyl-pyrazole moiety as new potent hematopoietic progenitor kinase 1 inhibitors.

Autoři: Wang L Li ZL Duan CX a další

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109196. Date of Electronic Publication: 2025 Nov 05.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/pharmacology , Macrocyclic Compounds*/chemical synthesis , Drug Discovery*, Humans ; Animals ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Microsomes, Liver/metabolism ; Cell Line, Tumor ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology

Pyrazolopyridine derivatives as potent ASK1 inhibitors: design, synthesis, and biological evaluation.

Autoři: Liu H Han X Hu M a další

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109176. Date of Electronic Publication: 2025 Oct 29.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: MAP Kinase Kinase Kinase 5*/antagonists & inhibitors , MAP Kinase Kinase Kinase 5*/metabolism , Pyrazoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/chemical synthesis , Drug Design* , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Cell Survival/drug effects ; Cell Line