Výsledky vyhľadávania - "Protein-Arginine Deiminases"

Structural and mechanistic insights into peptidylarginine deiminase (PAD2/PAD4) mediated citrullination and therapeutic targeting: A review.

Autori: Bashir F Awais H Waseem A a ďalší

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 332 (Pt 1), pp. 148586. Date of Electronic Publication: 2025 Oct 27.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Citrullination* , Protein-Arginine Deiminase Type 2*/chemistry , Protein-Arginine Deiminase Type 2*/metabolism , Protein-Arginine Deiminase Type 2*/antagonists & inhibitors , Protein-Arginine Deiminase Type 4*/chemistry , Protein-Arginine Deiminase Type 4*/metabolism , Protein-Arginine Deiminase Type 4*/antagonists & inhibitors , Protein-Arginine Deiminases*/chemistry , Protein-Arginine Deiminases*/metabolism, Humans ; Animals ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Substrate Specificity ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Protein Conformation

Synthesis and evaluation of a novel class of spiro[chromene-2,2'-indoline] derivatives as potent inhibitors of peptidylarginine deiminase IV to treat rheumatoid arthritis.

Autori: Yang CW Lee YZ Hsu HY a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 117985. Date of Electronic Publication: 2025 Jul 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Arthritis, Rheumatoid*/drug therapy , Arthritis, Rheumatoid*/metabolism , Protein-Arginine Deiminase Type 4*/antagonists & inhibitors , Protein-Arginine Deiminase Type 4*/metabolism , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/therapeutic use , Indoles*/chemistry , Indoles*/chemical synthesis , Indoles*/pharmacology , Indoles*/therapeutic use , Spiro Compounds*/chemical synthesis , Spiro Compounds*/chemistry , Spiro Compounds*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/chemical synthesis , Benzopyrans*/pharmacology , Protein-Arginine Deiminases*/antagonists & inhibitors , Protein-Arginine Deiminases*/metabolism, Animals ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Humans ; Dose-Response Relationship, Drug ; Male ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/chemically induced

Relative Expression of Peptidylarginine Deiminase 2 and Sex Steroid Receptors in XX and XY Mouse Placenta.

Autori: Wewer A Bennitt A Hinners E a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 29; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Placenta*/metabolism , Protein-Arginine Deiminase Type 2*/metabolism , Protein-Arginine Deiminase Type 2*/genetics , Receptors, Androgen*/metabolism , Receptors, Androgen*/genetics , Protein-Arginine Deiminases*/metabolism , Protein-Arginine Deiminases*/genetics , Receptors, Estrogen*/metabolism , Receptors, Estrogen*/genetics, Animals ; Female ; Pregnancy ; Mice ; Male ; Mice, Inbred C57BL

Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem-Like Cells in Ovarian Cancer.

Autori: Xue T Liu X Song C a ďalší

Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Oct; Vol. 12 (39), pp. e01014. Date of Electronic Publication: 2025 Aug 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/genetics , Protein-Arginine Deiminases*/metabolism , Protein-Arginine Deiminases*/genetics , Citrullination*, Female ; Humans ; Animals ; Mice ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Cisplatin/pharmacology

Sex-dependent effects of peptidylarginine deiminases on neutrophil function and long-term outcomes after spinal cord injury.

Autori: Reid SK Tran AV Leal-Garcia ME a ďalší

Zdroj: Experimental neurology [Exp Neurol] 2025 Nov; Vol. 393, pp. 115414. Date of Electronic Publication: 2025 Aug 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Spinal Cord Injuries*/pathology , Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/drug therapy , Neutrophils*/drug effects , Neutrophils*/metabolism , Protein-Arginine Deiminases*/metabolism , Sex Characteristics* , Recovery of Function*/physiology , Recovery of Function*/drug effects, Animals ; Mice ; Female ; Male ; Mice, Inbred C57BL ; Protein-Arginine Deiminase Type 4 ; Ornithine/analogs & derivatives ; Ornithine/pharmacology ; Mice, Knockout

Deciphering the pathogenicity of PADI4 missense variant L117M in rheumatoid arthritis: An integrated in silico and gene expression study.

Autori: Santhiya P Tharan SB Govindaraju K a ďalší

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2025 Aug; Vol. 319 (Pt 3), pp. 145466. Date of Electronic Publication: 2025 Jun 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein-Arginine Deiminase Type 4*/genetics , Protein-Arginine Deiminase Type 4*/chemistry , Protein-Arginine Deiminase Type 4*/metabolism , Arthritis, Rheumatoid*/genetics , Arthritis, Rheumatoid*/pathology , Mutation, Missense* , Protein-Arginine Deiminases*/genetics , Protein-Arginine Deiminases*/chemistry, Humans ; Polymorphism, Single Nucleotide ; Molecular Dynamics Simulation ; Genetic Predisposition to Disease ; Computational Biology/methods ; Computer Simulation

Cardiac PAD2 expression and myocardial citrullination decline with age in female mice independent of estrogen.

Autori: Shorthill SK Klinger FR Yusifov A a ďalší

Zdroj: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2025 Jul 01; Vol. 329 (1), pp. H271-H281. Date of Electronic Publication: 2025 Jun 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein-Arginine Deiminase Type 2*/metabolism , Protein-Arginine Deiminase Type 2*/genetics , Aging*/metabolism , Myocardium*/enzymology , Myocardium*/metabolism , Citrullination* , Protein-Arginine Deiminases*/metabolism , Protein-Arginine Deiminases*/genetics , Estrogens* , Hydrolases*/metabolism , Hydrolases*/genetics , Estradiol*/pharmacology, Animals ; Female ; Ovariectomy ; Mice, Inbred C57BL ; Male ; Mice ; Age Factors

The Citrullinating Enzyme PADI4 Binds to Lipids: Identification of New Target Interactions for Cancer Therapy.

Autori: Araujo-Abad S García-Peñarrubia B Giudici AM a ďalší

Zdroj: Journal of molecular biology [J Mol Biol] 2025 Sep 01; Vol. 437 (17), pp. 169297. Date of Electronic Publication: 2025 Jun 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein-Arginine Deiminase Type 4*/metabolism , Protein-Arginine Deiminase Type 4*/chemistry , Protein-Arginine Deiminase Type 4*/antagonists & inhibitors , Neoplasms*/metabolism , Neoplasms*/drug therapy , Lipid Metabolism* , Protein-Arginine Deiminases*/metabolism, Humans ; Protein Binding ; Cell Line, Tumor ; Phosphatidylserines/metabolism ; Citrulline/metabolism ; Phosphatidylcholines/metabolism ; Phosphatidic Acids/metabolism ; Citrullination ; Catalytic Domain

Pentatrichomonas hominis induces extracellular traps formation of macrophages via the TLR2/NADPH/PAD4 pathway.

Autori: Zhai QA Zhang XC Zhang HB a ďalší

Zdroj: Parasites & vectors [Parasit Vectors] 2025 Jul 01; Vol. 18 (1), pp. 248. Date of Electronic Publication: 2025 Jul 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305 (Electronic) Linking ISSN: 17563305 NLM ISO Abbreviation: Parasit Vectors Subsets: MEDLINE

Výrazy zo slovníka MeSH: Toll-Like Receptor 2*/metabolism , Toll-Like Receptor 2*/genetics , Extracellular Traps*/immunology , Extracellular Traps*/metabolism , Protein-Arginine Deiminase Type 4*/metabolism , Macrophages, Peritoneal*/parasitology , Macrophages, Peritoneal*/immunology , Protein-Arginine Deiminases*/metabolism , Macrophages*/immunology , Macrophages*/parasitology, Animals ; Mice ; Signal Transduction ; Reactive Oxygen Species/metabolism

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca ²⁺ dependent allosteric binding site.

Autori: Dakin LA Xing L Hall J a ďalší

Zdroj: Nature communications [Nat Commun] 2025 May 16; Vol. 16 (1), pp. 4579. Date of Electronic Publication: 2025 May 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium*/metabolism , Protein-Arginine Deiminase Type 4*/antagonists & inhibitors , Protein-Arginine Deiminase Type 4*/metabolism , Protein-Arginine Deiminase Type 4*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Protein-Arginine Deiminases*/antagonists & inhibitors , Protein-Arginine Deiminases*/metabolism , Protein-Arginine Deiminases*/chemistry , Protein-Arginine Deiminase Type 1*/antagonists & inhibitors , Protein-Arginine Deiminase Type 1*/metabolism , Protein-Arginine Deiminase Type 1*/chemistry, Humans ; Allosteric Site/drug effects ; Crystallography, X-Ray ; Ligands ; Citrullination/drug effects ; Neutrophils/metabolism ; Neutrophils/drug effects ; Protein Binding ; Citrulline/metabolism

Polymorphic Variants of Peptidylarginine Deiminase Gene from P. gingivalis -Searching for Targets for Supportive Therapy of Periodontitis.

Autori: Strzelec K Dziedzic-Kowalska A Sieron Ł a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Feb 15; Vol. 26 (4). Date of Electronic Publication: 2025 Feb 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Porphyromonas gingivalis*/genetics , Porphyromonas gingivalis*/enzymology , Porphyromonas gingivalis*/pathogenicity , Periodontitis*/microbiology , Periodontitis*/genetics , Periodontitis*/therapy , Protein-Arginine Deiminases*/genetics , Protein-Arginine Deiminases*/metabolism , Polymorphism, Genetic* , Bacterial Proteins*/genetics, Humans ; Virulence/genetics ; Female ; Male

Citrullination at the N-terminal region of MDM2 by the PADI4 enzyme.

Autori: Neira JL Rizzuti B Palomino-Schätzlein M a ďalší

Zdroj: Protein science : a publication of the Protein Society [Protein Sci] 2025 Feb; Vol. 34 (2), pp. e70033.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein-Arginine Deiminase Type 4*/chemistry , Protein-Arginine Deiminase Type 4*/metabolism , Proto-Oncogene Proteins c-mdm2*/chemistry , Proto-Oncogene Proteins c-mdm2*/metabolism , Citrullination* , Protein-Arginine Deiminases*/chemistry , Protein-Arginine Deiminases*/metabolism , Peptides*/chemistry , Peptides*/metabolism , Peptides*/chemical synthesis, Humans

Suppressing anti-citrullinated protein antibody-induced osteoclastogenesis in rheumatoid arthritis using anti-CD64 and PAD-2 inhibitors.

Autori: Min HK Lee JY Lee SH a ďalší

Zdroj: Clinical and experimental rheumatology [Clin Exp Rheumatol] 2025 Jan; Vol. 43 (1), pp. 79-86. Date of Electronic Publication: 2024 Aug 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Clinical And Experimental Rheumatology S.A.S Country of Publication: Italy NLM ID: 8308521 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0392-856X (Print) Linking ISSN: 0392856X NLM ISO Abbreviation: Clin Exp Rheumatol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Arthritis, Rheumatoid*/immunology , Arthritis, Rheumatoid*/drug therapy , Arthritis, Rheumatoid*/pathology , Arthritis, Rheumatoid*/enzymology , Arthritis, Rheumatoid*/metabolism , Anti-Citrullinated Protein Antibodies*/immunology , Anti-Citrullinated Protein Antibodies*/pharmacology , Osteogenesis*/drug effects , Synoviocytes*/drug effects , Synoviocytes*/immunology , Synoviocytes*/metabolism , Synoviocytes*/enzymology , Synoviocytes*/pathology , Osteoclasts*/drug effects , Osteoclasts*/immunology , Osteoclasts*/pathology , Receptors, IgG*/immunology , Receptors, IgG*/metabolism , Receptors, IgG*/antagonists & inhibitors , Enzyme Inhibitors*/pharmacology , Protein-Arginine Deiminases*/antagonists & inhibitors , Protein-Arginine Deiminases*/metabolism, Humans ; Protein-Arginine Deiminase Type 2/antagonists & inhibitors ; Protein-Arginine Deiminase Type 2/metabolism ; Cells, Cultured ; RANK Ligand/metabolism ; Middle Aged ; Male ; Female ; Protein-Arginine Deiminase Type 4 ; Tumor Necrosis Factor-alpha/metabolism ; Cell Differentiation/drug effects

Citrullination in Tumor Metastasis, Inside and Outside the Cells.

Autori: Tomita T Sharma P Hiratsuka S

Zdroj: Cancer science [Cancer Sci] 2025 Dec; Vol. 116 (12), pp. 3239-3249. Date of Electronic Publication: 2025 Sep 14.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Citrullination* , Neoplasm Metastasis* , Neoplasms*/pathology , Neoplasms*/metabolism , Citrulline*/metabolism, Humans ; Animals ; Protein-Arginine Deiminases/metabolism ; Protein-Arginine Deiminases/antagonists & inhibitors ; Tumor Microenvironment ; Protein Processing, Post-Translational ; Histones/metabolism

Targeted citrullination enables p53 binding to non-canonical sites.

Autori: Indeglia A Valdespino A Pantella G a ďalší

Zdroj: Molecular cell [Mol Cell] 2025 Oct 02; Vol. 85 (19), pp. 3588-3604.e11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Výrazy zo slovníka MeSH: Tumor Suppressor Protein p53*/metabolism , Tumor Suppressor Protein p53*/genetics , Citrullination* , Citrulline*/metabolism, Protein-Arginine Deiminase Type 4 ; Animals ; Humans ; Mice ; Binding Sites ; Protein-Arginine Deiminases/metabolism ; Protein-Arginine Deiminases/genetics ; Protein Binding ; Hydrolases/metabolism ; Hydrolases/genetics ; Proto-Oncogene Proteins c-ets/metabolism ; Proto-Oncogene Proteins c-ets/genetics ; Promoter Regions, Genetic

Peptidylarginine deiminase (PAD): A promising target for chronic diseases treatment.

Autori: Mansouri P Behmard E Najafipour S a ďalší

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 278 (Pt 3), pp. 134576. Date of Electronic Publication: 2024 Aug 09.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein-Arginine Deiminases*/metabolism , Protein-Arginine Deiminases*/antagonists & inhibitors , Protein-Arginine Deiminases*/chemistry , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use, Humans ; Chronic Disease ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/enzymology ; Protein-Arginine Deiminase Type 4/metabolism ; Protein-Arginine Deiminase Type 4/antagonists & inhibitors ; Protein-Arginine Deiminase Type 4/chemistry ; Animals ; Protein-Arginine Deiminase Type 2/chemistry ; Protein-Arginine Deiminase Type 2/metabolism ; Citrulline/metabolism ; Citrulline/chemistry ; Molecular Targeted Therapy

Development of a Chemoproteomic Platform to Identify Sites of (Homo)citrullination within Complex Proteomes.

Autori: Mann SA Barasa L Thompson PR a ďalší

Zdroj: ACS chemical biology [ACS Chem Biol] 2025 Nov 21; Vol. 20 (11), pp. 2741-2754. Date of Electronic Publication: 2025 Oct 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Citrullination* , Proteome*/metabolism , Proteome*/chemistry , Proteomics*/methods , Citrulline*/metabolism , Citrulline*/chemistry, Humans ; Lysine/metabolism ; Lysine/chemistry ; Protein Processing, Post-Translational ; Biotin/chemistry ; Biotin/analogs & derivatives ; Protein-Arginine Deiminases/metabolism ; Arginine/metabolism

Glycosaminoglycans activate peptidylarginine deiminase 4 by enhancing calcium affinity.

Autori: Bereta GP Bielecka E Marzec K a ďalší

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 04; Vol. 122 (44), pp. e2508369122. Date of Electronic Publication: 2025 Oct 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glycosaminoglycans*/metabolism , Glycosaminoglycans*/chemistry , Glycosaminoglycans*/pharmacology , Protein-Arginine Deiminase Type 4*/metabolism , Calcium*/metabolism, Humans ; Protein-Arginine Deiminases ; Arthritis, Rheumatoid/metabolism ; Enzyme Activation

Isoform-Selective PAD2/PAD4 Substrates with Unnatural Amino Acids Enable Cellular Peptidylarginine Deiminase Activity Profiling and Reveal Vimentin Citrullination Effects in Macrophages.

Autori: Gorzeń O Mikołajczyk-Martinez A Mamun AA a ďalší

Zdroj: Biochemistry [Biochemistry] 2025 Oct 07; Vol. 64 (19), pp. 4105-4120. Date of Electronic Publication: 2025 Sep 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein-Arginine Deiminase Type 2*/metabolism , Macrophages*/metabolism , Protein-Arginine Deiminase Type 4*/metabolism , Citrullination* , Vimentin*/metabolism , Amino Acids*/metabolism , Amino Acids*/chemistry, Humans ; Substrate Specificity ; Isoenzymes/metabolism ; Kinetics ; Protein Isoforms/metabolism ; Citrulline/metabolism ; Protein-Arginine Deiminases/metabolism ; Peptides/metabolism ; Peptides/chemistry

Isolated auto-citrullinated regions of PADI4 associate to the intact protein without altering their disordered conformation.

Autori: Neira JL Rizzuti B Abian O a ďalší

Zdroj: Biophysical chemistry [Biophys Chem] 2024 Sep; Vol. 312, pp. 107288. Date of Electronic Publication: 2024 Jun 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 0403171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4200 (Electronic) Linking ISSN: 03014622 NLM ISO Abbreviation: Biophys Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein-Arginine Deiminase Type 4*/metabolism , Protein-Arginine Deiminase Type 4*/chemistry , Protein-Arginine Deiminases*/metabolism , Protein-Arginine Deiminases*/chemistry , Citrullination*, Humans ; Protein Conformation ; Peptides/chemistry ; Peptides/metabolism ; Citrulline/chemistry ; Citrulline/metabolism ; Protein Binding ; Amino Acid Sequence