Výsledky vyhledávání - "Protein Isoforms"

Advances in the chemical synthesis of human proteoforms.

Autoři: Yang Z Xiao Y Shi Y a další

Zdroj: Science China. Life sciences [Sci China Life Sci] 2025 Sep; Vol. 68 (9), pp. 2515-2549. Date of Electronic Publication: 2025 Apr 08.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Proteins*/chemistry , Proteins*/genetics , Proteins*/metabolism , Protein Isoforms*/chemistry , Protein Isoforms*/genetics , Protein Isoforms*/metabolism, Humans ; Animals ; Protein Biosynthesis ; Synthetic Biology ; Disease/genetics ; Protein Domains ; Protein Folding

Novel Isoforms of Adhesion G Protein-Coupled Receptor B1 (ADGRB1/BAI1) Generated from an Alternative Promoter in Intron 17.

Autoři: Parag RR Yamamoto T Saito K a další

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Jan; Vol. 62 (1), pp. 900-917. Date of Electronic Publication: 2024 Jun 28.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Introns*/genetics , Protein Isoforms*/genetics , Protein Isoforms*/metabolism , Promoter Regions, Genetic*/genetics , Receptors, G-Protein-Coupled*/genetics , Receptors, G-Protein-Coupled*/metabolism, Animals ; Humans ; Mice ; Angiogenic Proteins/genetics ; Angiogenic Proteins/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Exons/genetics ; Brain/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Alternative Splicing/genetics

A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43.

Autoři: Baum R Nguyen VD Maalouf M a další

Zdroj: The Journal of cell biology [J Cell Biol] 2025 Mar 03; Vol. 224 (3). Date of Electronic Publication: 2024 Dec 31.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Connexin 43*/metabolism , Connexin 43*/genetics , Actins*/metabolism , Actins*/genetics , Protein Isoforms*/metabolism , Protein Isoforms*/genetics, Animals ; Humans ; Protein Transport ; Protein Binding ; Protein Domains ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Gap Junctions/metabolism ; Gap Junctions/genetics ; Rats ; HeLa Cells ; Microtubules/metabolism

Expression of the IGF‑1Ea isoform in human placentas from third trimester normal and idiopathic intrauterine growth restriction singleton pregnancies: Correlations with clinical and histopathological parameters.

Autoři: Fasoulopoulos A Varras M Varra FN a další

Zdroj: Molecular medicine reports [Mol Med Rep] 2025 Mar; Vol. 31 (3). Date of Electronic Publication: 2025 Jan 10.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Fetal Growth Retardation*/metabolism , Fetal Growth Retardation*/pathology , Fetal Growth Retardation*/genetics , Insulin-Like Growth Factor I*/metabolism , Insulin-Like Growth Factor I*/genetics , Placenta*/metabolism , Placenta*/pathology , Pregnancy Trimester, Third*/metabolism , Protein Isoforms*/metabolism , Protein Isoforms*/genetics, Humans ; Female ; Pregnancy ; Adult ; Male ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Trophoblasts/metabolism ; Trophoblasts/pathology ; Immunohistochemistry

Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms.

Autoři: Hu L Xu H Xu Y a další

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Feb 05; Vol. 283, pp. 117179. Date of Electronic Publication: 2024 Dec 17.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Histone-Lysine N-Methyltransferase*/metabolism , Histone-Lysine N-Methyltransferase*/antagonists & inhibitors , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Cell Proliferation*/drug effects , Protein Isoforms*/metabolism , Protein Isoforms*/antagonists & inhibitors , Protein Isoforms*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Amines/chemistry ; Amines/pharmacology ; Amines/chemical synthesis ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug ; Drug Discovery ; Cell Line, Tumor ; Proteolysis/drug effects ; Ligands ; Repressor Proteins

Differential expression of quick-to-court gene isoforms in Drosophila male and female.

Autoři: Gogoleva NE Cherezov RO Lyupina YV a další

Zdroj: Gene [Gene] 2025 Jan 20; Vol. 934, pp. 149010. Date of Electronic Publication: 2024 Oct 18.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Protein Isoforms*/genetics , Protein Isoforms*/metabolism , Testis*/metabolism, Animals ; Male ; Female ; Ovary/metabolism ; Drosophila melanogaster/genetics ; Gene Expression Regulation ; Brain/metabolism ; Sexual Behavior, Animal/physiology ; Drosophila/genetics

ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures.

Autoři: Yang Y Kumar H Xie Y a další

Zdroj: Nucleic acids research [Nucleic Acids Res] 2025 Jan 06; Vol. 53 (D1), pp. D331-D339.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Protein Isoforms*/genetics , Protein Isoforms*/metabolism , Protein Isoforms*/chemistry , Alternative Splicing* , Databases, Protein* , Knowledge Bases*, Humans ; Protein Conformation ; Models, Molecular ; Molecular Sequence Annotation

Bioinformatics analysis of proteins interacting with different actin isoforms.

Autoři: Mokin YI Povarova OI Silonov SA a další

Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Jan; Vol. 743, pp. 151165. Date of Electronic Publication: 2024 Dec 12.

Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Actins*/metabolism , Actins*/chemistry , Computational Biology*/methods , Protein Isoforms*/metabolism , Protein Isoforms*/genetics , Protein Isoforms*/chemistry, Protein Binding ; Microfilament Proteins/metabolism ; Microfilament Proteins/genetics ; Microfilament Proteins/chemistry ; Humans ; Animals ; Amino Acid Sequence

Analysis of SLC genes alternative splicing identifies the SLC7A6 RI isoform as a therapeutic target for colorectal cancer.

Autoři: Sun C Zeng B Zhou J a další

Zdroj: Cancer science [Cancer Sci] 2025 Jan; Vol. 116 (1), pp. 233-247. Date of Electronic Publication: 2024 Oct 15.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Alternative Splicing* , Protein Isoforms*/genetics , Protein Isoforms*/metabolism , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology, Humans ; Mice ; Animals ; Cell Line, Tumor ; Prognosis ; Gene Expression Regulation, Neoplastic ; Amino Acid Transport System y+/genetics ; Amino Acid Transport System y+/metabolism ; Cell Proliferation/genetics ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Ferroptosis/genetics ; Male ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/genetics

Unraveling the Diversity of RANBP2: Protein Isoforms and Implications for Cellular Function and Human Disease.

Autoři: Desgraupes S Arhel N

Zdroj: Journal of molecular biology [J Mol Biol] 2025 Dec 15; Vol. 437 (24), pp. 169452. Date of Electronic Publication: 2025 Sep 19.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Nuclear Pore Complex Proteins*/genetics , Nuclear Pore Complex Proteins*/metabolism , Nuclear Pore Complex Proteins*/chemistry , Molecular Chaperones*/genetics , Molecular Chaperones*/metabolism , Molecular Chaperones*/chemistry, Humans ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Animals ; Alternative Splicing

Neuronal CD59 isoforms IRIS-1 and IRIS-2 as regulators of neurotransmitter release with implications for Alzheimer's disease.

Autoři: Golec E Olsson R Tuysuz EC a další

Zdroj: Alzheimer's research & therapy [Alzheimers Res Ther] 2025 Jan 07; Vol. 17 (1), pp. 11. Date of Electronic Publication: 2025 Jan 07.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE

Výrazy ze slovníku MeSH: Alzheimer Disease*/metabolism , Alzheimer Disease*/genetics , Neurons*/metabolism , Protein Isoforms*/metabolism , CD59 Antigens*/metabolism , CD59 Antigens*/genetics, Humans ; Cell Line, Tumor ; Brain/metabolism ; Male ; Diabetes Mellitus, Type 2/metabolism ; Neurotransmitter Agents/metabolism ; Female ; Aged ; Astrocytes/metabolism

Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites.

Autoři: Beaudoin CA Kohli M Salvage SC a další

Zdroj: The Journal of general physiology [J Gen Physiol] 2025 Jan 06; Vol. 157 (1). Date of Electronic Publication: 2024 Dec 16.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985110R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-7748 (Electronic) Linking ISSN: 00221295 NLM ISO Abbreviation: J Gen Physiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Protein Isoforms*/metabolism, Glycosylation ; Binding Sites ; Humans ; Molecular Dynamics Simulation ; Animals ; Voltage-Gated Sodium Channels/metabolism ; Voltage-Gated Sodium Channels/chemistry ; Polysaccharides/metabolism ; Polysaccharides/chemistry

Immunocytochemistry-Based Detection of FOXO Isoforms in Human Cancer and Fibroblasts.

Autoři: Jimenez L Domínguez L Amenabar C a další

Zdroj: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2871, pp. 171-176.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Protein Isoforms*/metabolism , Immunohistochemistry*/methods , Forkhead Transcription Factors*/metabolism , Forkhead Transcription Factors*/genetics , Fibroblasts*/metabolism , Neoplasms*/metabolism , Neoplasms*/pathology , Neoplasms*/genetics, Humans ; Cell Line, Tumor ; Forkhead Box Protein O1/metabolism

Transposable element exonization generates a reservoir of evolving and functional protein isoforms.

Autoři: Arribas YA Baudon B Rotival M a další

Zdroj: Cell [Cell] 2024 Dec 26; Vol. 187 (26), pp. 7603-7620.e22. Date of Electronic Publication: 2024 Dec 11.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

Výrazy ze slovníku MeSH: DNA Transposable Elements*/genetics , Protein Isoforms*/genetics , Protein Isoforms*/metabolism , Exons*/genetics , Alternative Splicing*/genetics, Humans ; Evolution, Molecular ; Transcriptome/genetics ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Proteomics ; Ribosomes/metabolism ; RNA Splice Sites/genetics

Structure activity relationship exploration of imidazo[1,2-a]pyridine series to reverse isoform selectivity and identify potent SIK1 selective inhibitors.

Autoři: Peixoto C De Lemos E Cherel L a další

Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130397. Date of Electronic Publication: 2025 Sep 08.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Výrazy ze slovníku MeSH: Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Pyridines*/chemistry , Pyridines*/pharmacology , Pyridines*/chemical synthesis , Imidazoles*/chemistry , Imidazoles*/pharmacology , Imidazoles*/chemical synthesis, Structure-Activity Relationship ; Humans ; Molecular Structure ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Dose-Response Relationship, Drug

Long-tailed class I myosins rely on tail-mediated phosphoinositide recognition for specific membrane recruitment.

Autoři: Rajendraprasad G Kyriazi D Franz P a další

Zdroj: Cell communication and signaling : CCS [Cell Commun Signal] 2025 Dec 04; Vol. 23 (1), pp. 519. Date of Electronic Publication: 2025 Dec 04.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE

Výrazy ze slovníku MeSH: Phosphatidylinositols*/metabolism , Dictyostelium*/metabolism , Dictyostelium*/cytology , Cell Membrane*/metabolism , Myosin Type I*/metabolism , Myosin Type I*/chemistry , Protozoan Proteins*/metabolism , Protozoan Proteins*/chemistry, Protein Binding ; Protein Isoforms/metabolism ; Protein Isoforms/chemistry

The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling.

Autoři: Bandekar SJ Dintzner EE Leon K a další

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2409184122. Date of Electronic Publication: 2025 Nov 26.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, G-Protein-Coupled*/metabolism , Receptors, G-Protein-Coupled*/genetics , Receptors, G-Protein-Coupled*/chemistry , Signal Transduction*, Humans ; Protein Domains ; Molecular Dynamics Simulation ; Alternative Splicing ; HEK293 Cells ; Protein Isoforms/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/chemistry

Actin isoform-specific interactions revealed by Vibrio VopV actin-binding repeats.

Autoři: Kudryashova E Kreutzberger MAB Niedzialkowska E a další

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2523856122. Date of Electronic Publication: 2025 Nov 25.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy ze slovníku MeSH: Actins*/metabolism , Actins*/chemistry , Actins*/genetics , Vibrio parahaemolyticus*/metabolism , Vibrio parahaemolyticus*/genetics , Vibrio parahaemolyticus*/pathogenicity , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics, Protein Isoforms/metabolism ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Binding ; Animals ; Humans ; Cryoelectron Microscopy

Isoform-specific oxidative modifications of tropoelastin by HOCl and MPO alter protein self-assembly.

Autoři: Mikkelsen KL Nybo T Davies MJ a další

Zdroj: Redox report : communications in free radical research [Redox Rep] 2025 Dec; Vol. 30 (1), pp. 2592409. Date of Electronic Publication: 2025 Nov 28.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9511366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-2928 (Electronic) Linking ISSN: 13510002 NLM ISO Abbreviation: Redox Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Hypochlorous Acid*/metabolism , Hypochlorous Acid*/chemistry , Tropoelastin*/metabolism , Tropoelastin*/chemistry , Peroxidase*/metabolism, Humans ; Oxidation-Reduction ; Protein Isoforms/metabolism ; Protein Isoforms/chemistry ; Tandem Mass Spectrometry

Ecdysone receptor B1 isoform/ultraspiracle protein 1-mediated ecdysteroid signaling regulates the growth and development: potential targets for efficient Hyphantria cunea management.

Autoři: Qiao H Jiang R Zhong G a další

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 333 (Pt 2), pp. 148594. Date of Electronic Publication: 2025 Nov 08.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Signal Transduction* , Receptors, Steroid*/metabolism , Receptors, Steroid*/genetics , Ecdysteroids*/metabolism , Insect Proteins*/genetics , Insect Proteins*/metabolism , Moths*/growth & development , Moths*/genetics , Moths*/metabolism , Transcription Factors*/metabolism , Transcription Factors*/genetics, Animals ; Larva/growth & development ; Larva/genetics ; Female ; Protein Isoforms/metabolism ; Protein Isoforms/genetics ; RNA Interference ; RNA, Double-Stranded/genetics