Suchergebnisse - "Protein Aggregation"

Understanding Structural Destabilization and Amyloid Aggregation in ALS-Related Neurodegenerative Disorder: An In Silico and Experimental Analysis of SOD1 Variants.

Autoren: Soleimanifard N Seyedalipour B Baziyar P et al.

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Nov 05; Vol. 16 (21), pp. 4203-4223. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/metabolism , Superoxide Dismutase-1*/genetics , Superoxide Dismutase-1*/metabolism , Superoxide Dismutase-1*/chemistry , Amyloid*/metabolism , Protein Aggregation, Pathological*/genetics , Protein Aggregation, Pathological*/metabolism, Humans ; Molecular Dynamics Simulation ; Mutation/genetics ; Protein Folding ; Protein Structure, Secondary ; Protein Aggregates

Sulfonamide Inhibitors of Amyloid Aggregation: A Promising Path against Neurodegenerative Diseases.

Autoren: Smirnovienė J Matulis D

Quelle: ChemMedChem [ChemMedChem] 2025 Oct 06; Vol. 20 (19), pp. e202500324. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

MeSH-Schlagworte: Neurodegenerative Diseases*/drug therapy , Neurodegenerative Diseases*/metabolism , Sulfonamides*/chemistry , Sulfonamides*/pharmacology , Sulfonamides*/therapeutic use , Amyloid*/antagonists & inhibitors , Amyloid*/metabolism , Protein Aggregation, Pathological*/drug therapy , Protein Aggregation, Pathological*/metabolism , Amyloidogenic Proteins*/antagonists & inhibitors , Amyloidogenic Proteins*/metabolism, Humans ; Protein Aggregates/drug effects ; Animals ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Molecular Structure

Dimer Dissociation and Aggregation Hot-spot Exposure Synergistically Accelerate Light Chain Variable Domain Aggregation Associated With AL Amyloidosis.

Autoren: Puri S Palkar S Kumawat A et al.

Quelle: Journal of molecular biology [J Mol Biol] 2025 Dec 15; Vol. 437 (24), pp. 169468. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin Light Chains*/chemistry , Immunoglobulin Light Chains*/metabolism , Protein Multimerization* , Immunoglobulin Light-chain Amyloidosis*/metabolism , Protein Aggregates* , Protein Aggregation, Pathological*/metabolism, Humans ; Hydrogen-Ion Concentration ; Protein Domains ; Amyloid/metabolism ; Amyloid/chemistry

Nucleolar aggregation of key neuropathological proteins in the postmortem neurodegenerative brain.

Autoren: Lourenco GF Torres-Pacheco ME Fu Y et al.

Quelle: Acta neuropathologica [Acta Neuropathol] 2025 Dec 03; Vol. 150 (1), pp. 60. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE

MeSH-Schlagworte: Brain*/pathology , Brain*/metabolism , Neurodegenerative Diseases*/pathology , Neurodegenerative Diseases*/metabolism , Cell Nucleolus*/metabolism , Cell Nucleolus*/pathology , Protein Aggregation, Pathological*/pathology , Protein Aggregation, Pathological*/metabolism, Humans ; Aged ; Female ; Male ; tau Proteins/metabolism ; alpha-Synuclein/metabolism ; Aged, 80 and over ; Middle Aged ; DNA-Binding Proteins/metabolism ; Neurons/pathology ; Neurons/metabolism ; Amyloid beta-Peptides/metabolism ; RNA-Binding Protein FUS/metabolism

Modifications of NU-9, a potent protein aggregation inhibitor. Properties and activity in a cellular model of amyotrophic lateral sclerosis.

Autoren: Elmansy MF Soares P Dos Remedios JRD et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109190. Date of Electronic Publication: 2025 Nov 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Amyotrophic Lateral Sclerosis*/drug therapy , Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/pathology , Protein Aggregates*/drug effects , Protein Aggregation, Pathological*/drug therapy, Animals ; Rats ; PC12 Cells ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism

Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models.

Autoren: Basellini MJ Granadino-Roldán JM Torres-Ortega PV et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Dec; Vol. 62 (12), pp. 15741-15758. Date of Electronic Publication: 2025 Jul 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: alpha-Synuclein*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Parkinson Disease*/drug therapy , Parkinson Disease*/pathology , Parkinson Disease*/metabolism , Iridoids*/pharmacology , Iridoids*/therapeutic use , Protein Aggregates*/drug effects , Polyphenols*/pharmacology , Protein Aggregation, Pathological*/drug therapy , Protein Aggregation, Pathological*/pathology , Olea*/chemistry , Pyrans*/pharmacology, Animals ; Iridoid Glucosides ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/metabolism ; Humans ; Disease Models, Animal ; Cell Line, Tumor ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/pathology ; Dopaminergic Neurons/metabolism ; Cyclopentane Monoterpenes ; Acetates

The mechanism of pathogenic α 1 -antitrypsin aggregation in the human liver.

Autoren: Aldobiyan I Elliston ELK Heyer-Chauhan N et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 18; Vol. 122 (46), pp. e2507535122. Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: alpha 1-Antitrypsin*/chemistry , alpha 1-Antitrypsin*/metabolism , alpha 1-Antitrypsin*/genetics , Liver*/metabolism , Liver*/pathology , alpha 1-Antitrypsin Deficiency*/genetics , alpha 1-Antitrypsin Deficiency*/metabolism , alpha 1-Antitrypsin Deficiency*/pathology , Protein Aggregation, Pathological*/metabolism , Protein Aggregation, Pathological*/genetics, Humans ; Cryoelectron Microscopy ; Protein Aggregates ; Models, Molecular

Unraveling the structure-activity relationships of organometallic ferrocene-pyrazole and ferrocene-pyrimidine curcumin analogues in amyloid-β aggregation and glioblastoma treatment.

Autoren: Kovač V Huntosova V Fedorova V et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 13; Vol. 15 (1), pp. 39867. Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Ferrous Compounds*/chemistry , Ferrous Compounds*/pharmacology , Glioblastoma*/drug therapy , Glioblastoma*/metabolism , Glioblastoma*/pathology , Metallocenes*/chemistry , Metallocenes*/pharmacology , Curcumin*/pharmacology , Curcumin*/chemistry , Curcumin*/analogs & derivatives , Amyloid beta-Peptides*/metabolism , Amyloid beta-Peptides*/chemistry , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrimidines*/chemistry , Pyrimidines*/pharmacology , Protein Aggregation, Pathological*/drug therapy , Protein Aggregation, Pathological*/metabolism, Humans ; Structure-Activity Relationship ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Apoptosis/drug effects ; Protein Aggregates/drug effects ; Cell Survival/drug effects

PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease.

Autoren: Phuong HT Tomas RF Akmese C et al.

Quelle: Acta neuropathologica [Acta Neuropathol] 2025 Nov 08; Vol. 150 (1), pp. 49. Date of Electronic Publication: 2025 Nov 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Brain*/pathology , Brain*/metabolism , Protein Aggregation, Pathological*/pathology , Protein Aggregation, Pathological*/metabolism, Humans ; Male ; Female ; Aged ; Aged, 80 and over ; tau Proteins/metabolism ; Plaque, Amyloid/pathology ; Plaque, Amyloid/metabolism ; Middle Aged ; Amyloid beta-Peptides/metabolism ; Protein Aggregates ; Neurofibrillary Tangles/pathology ; Neurofibrillary Tangles/metabolism

On the potential roles of TDP-43 in the formation of membraneless organelles and their transformation into toxic aggregates.

Autoren: Sergeeva OS Neklesova MV Reushev VA et al.

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Nov 08; Vol. 788, pp. 152808. Date of Electronic Publication: 2025 Oct 15.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/chemistry , Organelles*/metabolism , Organelles*/pathology , Protein Aggregation, Pathological*/metabolism , Protein Aggregation, Pathological*/pathology , TDP-43 Proteinopathies*/metabolism , TDP-43 Proteinopathies*/pathology, Humans ; Animals ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Protein Aggregates ; Frontotemporal Dementia/metabolism ; Frontotemporal Dementia/pathology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology

Polyserine-mediated targeting of FAF2/UBXD8 ameliorates tau aggregation.

Autoren: Van Alstyne M Brown G Nguyen VL et al.

Quelle: Neuron [Neuron] 2025 Nov 05; Vol. 113 (21), pp. 3601-3615.e7. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE

MeSH-Schlagworte: tau Proteins*/metabolism , tau Proteins*/genetics , Protein Aggregation, Pathological*/metabolism , Tauopathies*/metabolism , Tauopathies*/pathology , Tauopathies*/genetics, Animals ; Mice ; Mice, Transgenic ; Humans ; Drosophila ; Disease Models, Animal

Membranes as targets and modifiers of mutant huntingtin aggregation.

Autoren: Legleiter J; Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA. Electronic address: jlegleiter@unr.edu.

Quelle: Trends in biochemical sciences [Trends Biochem Sci] 2025 Nov; Vol. 50 (11), pp. 1015-1026. Date of Electronic Publication: 2025 Sep 09.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 7610674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0968-0004 (Print) Linking ISSN: 09680004 NLM ISO Abbreviation: Trends Biochem Sci Subsets: MEDLINE

MeSH-Schlagworte: Huntingtin Protein*/genetics , Huntingtin Protein*/metabolism , Huntingtin Protein*/chemistry , Huntington Disease*/metabolism , Huntington Disease*/genetics , Huntington Disease*/pathology , Cell Membrane*/metabolism , Protein Aggregation, Pathological*/metabolism , Protein Aggregation, Pathological*/genetics, Humans ; Animals ; Mutation ; Protein Aggregates ; Peptides

Nano-conjugation of small molecule modulators of protein aggregation: Enhancing the therapeutic precision.

Autoren: Manzoor SI Ahanger IA Kamli MR et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 331 (Pt 2), pp. 148293. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Protein Aggregates*/drug effects , Protein Aggregation, Pathological*/drug therapy , Protein Aggregation, Pathological*/metabolism , Small Molecule Libraries*/chemistry , Small Molecule Libraries*/pharmacology , Small Molecule Libraries*/therapeutic use , Nanoparticles*/chemistry, Humans ; Animals ; Precision Medicine

A high-throughput drug screening assay for anti-tau aggregation using split GFP and flow cytometry.

Autoren: Ibrahium OMH Ademoye TA Fortin JS et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 29; Vol. 15 (1), pp. 37866. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: tau Proteins*/metabolism , tau Proteins*/genetics , tau Proteins*/chemistry , High-Throughput Screening Assays*/methods , Green Fluorescent Proteins*/metabolism , Green Fluorescent Proteins*/genetics , Flow Cytometry*/methods , Protein Aggregates*/drug effects , Protein Aggregation, Pathological*/drug therapy , Protein Aggregation, Pathological*/metabolism, Humans ; HEK293 Cells ; Drug Evaluation, Preclinical/methods ; Drug Discovery

Exogenous Huntingtin-Exon1 Aggregates Exhibit Distinct Levels of Toxicity to Caenorhabditis elegans .

Autoren: Ezeigbo E Keith K Ellis ZL et al.

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Oct 15; Vol. 16 (20), pp. 4037-4049. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Huntingtin Protein*/genetics , Huntingtin Protein*/metabolism , Huntingtin Protein*/toxicity , Protein Aggregates* , Protein Aggregation, Pathological*/metabolism, Animals ; Caenorhabditis elegans ; Exons ; Humans

Inhibition of PolyGA Dipeptide Repeat Protein Aggregation by Nucleic Acid Aptamers in C9 Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Models.

Autoren: Jain S Das D Mukherjee A et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Oct; Vol. 62 (10), pp. 12445-12460. Date of Electronic Publication: 2025 May 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/drug therapy , Amyotrophic Lateral Sclerosis*/pathology , Frontotemporal Dementia*/drug therapy , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/metabolism , Frontotemporal Dementia*/pathology , Aptamers, Nucleotide*/pharmacology , Aptamers, Nucleotide*/therapeutic use , Dipeptides*/metabolism , C9orf72 Protein*/metabolism , C9orf72 Protein*/genetics , Protein Aggregates*/drug effects , Peptides*/metabolism , Protein Aggregation, Pathological*/drug therapy, Humans ; Cell Survival/drug effects ; Autophagy/drug effects ; Neurons/metabolism ; Neurons/drug effects ; Neurons/pathology ; Oxidative Stress/drug effects

The Aggregation Continuum of α-Synuclein and Its Relevance to Brain Aging.

Autoren: Rana A Nikam T Sreepathi B et al.

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Oct 01; Vol. 16 (19), pp. 3634-3652. Date of Electronic Publication: 2025 Sep 20.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: alpha-Synuclein*/metabolism , Aging*/metabolism , Aging*/pathology , Brain*/metabolism , Brain*/pathology , Protein Aggregation, Pathological*/metabolism , Protein Aggregation, Pathological*/pathology, Humans ; Animals ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Protein Aggregates/physiology ; Neurons/metabolism ; Neurons/pathology

Aβ42 promotes the aggregation of α-synuclein splice isoforms via heterogeneous nucleation.

Autoren: Röntgen A Toprakcioglu Z Vendruscolo M

Quelle: FEBS letters [FEBS Lett] 2025 Oct; Vol. 599 (19), pp. 2750-2767. Date of Electronic Publication: 2025 Jul 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

MeSH-Schlagworte: alpha-Synuclein*/metabolism , alpha-Synuclein*/genetics , alpha-Synuclein*/chemistry , Amyloid beta-Peptides*/metabolism , Amyloid beta-Peptides*/chemistry , Amyloid beta-Peptides*/genetics , Peptide Fragments*/metabolism , Peptide Fragments*/chemistry , Protein Aggregates* , Protein Aggregation, Pathological*/metabolism , Protein Aggregation, Pathological*/genetics, Humans ; Protein Isoforms/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/chemistry ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Parkinson Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/genetics

Beyond prion-like spreading in neurodegenerative disease.

Autoren: Meisl G Rowe JB Klenerman D

Quelle: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70789.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

MeSH-Schlagworte: Neurodegenerative Diseases*/pathology , Neurodegenerative Diseases*/metabolism , Neurodegenerative Diseases*/classification , Prions*/metabolism , Prion Diseases* , Brain*/metabolism , Brain*/pathology , Protein Aggregation, Pathological*/metabolism, Humans ; Animals

Rising Stars: Molecular Mechanisms and Chemical Interventions of α-Synuclein Amyloid Aggregation in Parkinson's Disease.

Autoren: Zhang S Liu K Li D et al.

Quelle: Journal of molecular biology [J Mol Biol] 2025 Dec 15; Vol. 437 (24), pp. 169475. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: alpha-Synuclein*/metabolism , alpha-Synuclein*/chemistry , alpha-Synuclein*/genetics , Parkinson Disease*/metabolism , Parkinson Disease*/pathology , Parkinson Disease*/drug therapy , Amyloid*/metabolism , Amyloid*/chemistry , Protein Aggregation, Pathological*/metabolism, Humans ; Animals ; Protein Aggregates ; Autophagy