Výsledky vyhľadávania - "Proteasome Inhibitors"

Pharmacovigilance and signal detection of adverse drug events associated with proteasome inhibitors in multiple myeloma: a real-world analysis using the FAERS database.

Autori: Luo J Chen S Zhang M a ďalší

Zdroj: Hematology (Amsterdam, Netherlands) [Hematology] 2025 Dec; Vol. 30 (1), pp. 2534758. Date of Electronic Publication: 2025 Jul 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Multiple Myeloma*/drug therapy , Pharmacovigilance* , Proteasome Inhibitors*/adverse effects , Proteasome Inhibitors*/therapeutic use , Adverse Drug Reaction Reporting Systems* , Drug-Related Side Effects and Adverse Reactions*/epidemiology , Drug-Related Side Effects and Adverse Reactions*/etiology, Humans ; Male ; Female ; Databases, Factual ; Middle Aged ; Aged ; United States ; Bortezomib/adverse effects

Identification of Novel β-Lactam Derivatives as Proteasome Inhibitors for Antitumor Therapy.

Autori: Cao Y Xu G Gao L a ďalší

Zdroj: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2025 Nov; Vol. 358 (11), pp. e70136.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/chemical synthesis , Proteasome Inhibitors*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , beta-Lactams*/pharmacology , beta-Lactams*/chemistry , beta-Lactams*/chemical synthesis, Structure-Activity Relationship ; Humans ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Apoptosis/drug effects ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug ; Proteasome Endopeptidase Complex/metabolism

Marizomib in the therapy of brain tumors-how far did we go and where do we stand?

Autori: Kusaczuk M Piskorz WM Domasik J

Zdroj: Pharmacological reports : PR [Pharmacol Rep] 2025 Oct; Vol. 77 (5), pp. 1177-1195. Date of Electronic Publication: 2025 May 29.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2299-5684 (Electronic) Linking ISSN: 17341140 NLM ISO Abbreviation: Pharmacol Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Brain Neoplasms*/drug therapy , Lactones*/therapeutic use , Lactones*/pharmacology , Lactones*/pharmacokinetics , Proteasome Inhibitors*/therapeutic use , Proteasome Inhibitors*/pharmacology , Glioblastoma*/drug therapy , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology, Humans ; Animals ; Blood-Brain Barrier/metabolism ; Pyrroles

Healthcare resource utilization and costs in patients with multiple myeloma who received 1 to 3 prior lines of therapy, including a proteasome inhibitor and an immunomodulatory drug, and were exposed to and discontinued lenalidomide in the United States.

Autori: Jagannath S Kharat A Chinaeke E a ďalší

Zdroj: Journal of medical economics [J Med Econ] 2025 Dec; Vol. 28 (1), pp. 1989-1998. Date of Electronic Publication: 2025 Nov 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9892255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-837X (Electronic) Linking ISSN: 13696998 NLM ISO Abbreviation: J Med Econ Subsets: MEDLINE

Výrazy zo slovníka MeSH: Multiple Myeloma*/drug therapy , Multiple Myeloma*/economics , Lenalidomide*/therapeutic use , Lenalidomide*/economics , Lenalidomide*/administration & dosage , Proteasome Inhibitors*/therapeutic use , Proteasome Inhibitors*/economics , Proteasome Inhibitors*/administration & dosage , Patient Acceptance of Health Care*/statistics & numerical data , Immunomodulating Agents*/therapeutic use , Immunomodulating Agents*/economics , Health Resources*/statistics & numerical data , Health Resources*/economics, Humans ; Male ; Middle Aged ; Female ; Retrospective Studies ; United States ; Aged ; Insurance Claim Review ; Adult ; Immunologic Factors/therapeutic use ; Immunologic Factors/economics ; Health Expenditures/statistics & numerical data ; Antineoplastic Agents/economics ; Antineoplastic Agents/therapeutic use

Unveiling the Potential of a New β-Cyclodextrin-Suxibuzone Conjugate in Proteasome Regulation.

Autori: Bognanni N Zimbone S Giuffrida ML a ďalší

Zdroj: ChemMedChem [ChemMedChem] 2025 Nov 28; Vol. 20 (23), pp. e202500401. Date of Electronic Publication: 2025 Oct 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proteasome Endopeptidase Complex*/metabolism , beta-Cyclodextrins*/chemistry , beta-Cyclodextrins*/pharmacology , Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/chemistry , Proteasome Inhibitors*/chemical synthesis , Hydrazones*/chemistry , Hydrazones*/pharmacology, Humans ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Molecular Structure ; Structure-Activity Relationship

Discovery of Novel Potent and Safe Immunoproteasome Inhibitors with Bridged Ring for Anti-Inflammatory Therapy.

Autori: Wu J Cai S Su J a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24579-24602. Date of Electronic Publication: 2025 Nov 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/chemistry , Proteasome Inhibitors*/therapeutic use , Proteasome Inhibitors*/pharmacokinetics , Proteasome Inhibitors*/chemical synthesis , Drug Discovery* , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/therapeutic use , Anti-Inflammatory Agents*/chemistry, Animals ; Humans ; Mice ; Structure-Activity Relationship ; Arthritis, Experimental/drug therapy ; Proteasome Endopeptidase Complex/metabolism ; Male

Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria.

Autori: Gahalawat S Ray S Zhang X a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 23485-23520. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antimalarials*/pharmacology , Antimalarials*/chemistry , Antimalarials*/pharmacokinetics , Antimalarials*/therapeutic use , Antimalarials*/chemical synthesis , Plasmodium falciparum*/drug effects , Plasmodium falciparum*/enzymology , Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/chemistry , Proteasome Inhibitors*/pharmacokinetics , Proteasome Inhibitors*/therapeutic use , Proteasome Inhibitors*/chemical synthesis , Malaria*/drug therapy, Structure-Activity Relationship ; Humans ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Endopeptidase Complex/chemistry ; Animals

Rapaprotin, an Endopeptidase-Activated Proteasome Inhibitor that Induces 26S Disassembly.

Autori: Peng H Guo Z Wang WL a ďalší

Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Nov 10; Vol. 64 (46), pp. e202500288. Date of Electronic Publication: 2025 Sep 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/chemistry , Proteasome Endopeptidase Complex*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Humans ; Cell Line, Tumor ; Apoptosis/drug effects ; Molecular Structure

Safety of proteasome inhibitor drugs for the treatment of multiple myeloma post-marketing: a pharmacovigilance investigation based on the FDA adverse event reporting system.

Autori: Yu D Cheng T Liu T a ďalší

Zdroj: Expert opinion on drug safety [Expert Opin Drug Saf] 2025 Nov; Vol. 24 (11), pp. 1333-1340. Date of Electronic Publication: 2024 Aug 20.

Spôsob vydávania: Journal Article; Comparative Study

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101163027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-764X (Electronic) Linking ISSN: 14740338 NLM ISO Abbreviation: Expert Opin Drug Saf Subsets: MEDLINE

Výrazy zo slovníka MeSH: Multiple Myeloma*/drug therapy , Proteasome Inhibitors*/adverse effects , Proteasome Inhibitors*/administration & dosage , Oligopeptides*/adverse effects , Oligopeptides*/administration & dosage , Antineoplastic Agents*/adverse effects , Antineoplastic Agents*/administration & dosage , Bortezomib*/adverse effects , Bortezomib*/administration & dosage, Humans ; United States ; Adverse Drug Reaction Reporting Systems/statistics & numerical data ; United States Food and Drug Administration ; Male ; Pharmacovigilance ; Aged ; Middle Aged ; Female ; Product Surveillance, Postmarketing ; Adult ; Sex Factors ; Age Factors ; Bayes Theorem

Aza-peptide aldehydes and ketones: synthesis and evaluation as human 20S proteasome inhibitors.

Autori: Corrigan TS Border SE Lotti Diaz LM a ďalší

Zdroj: Future medicinal chemistry [Future Med Chem] 2025 Oct; Vol. 17 (20), pp. 2479-2492. Date of Electronic Publication: 2025 Oct 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/chemical synthesis , Proteasome Inhibitors*/chemistry , Ketones*/chemistry , Ketones*/pharmacology , Ketones*/chemical synthesis , Aldehydes*/chemistry , Aldehydes*/pharmacology , Aldehydes*/chemical synthesis , Proteasome Endopeptidase Complex*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Aza Compounds*/chemistry , Aza Compounds*/pharmacology , Aza Compounds*/chemical synthesis , Peptides*/chemistry , Peptides*/pharmacology , Peptides*/chemical synthesis, Humans ; Structure-Activity Relationship ; Cell Survival/drug effects ; Multiple Myeloma/drug therapy ; Drug Screening Assays, Antitumor ; Cell Line, Tumor ; Molecular Structure ; Cell Proliferation/drug effects

Immunoproteasome Inhibition Positively Impacts the Gut-Muscle Axis in Duchenne Muscular Dystrophy.

Autori: Farini A Strati F Molinaro M a ďalší

Zdroj: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2025 Oct; Vol. 16 (5), pp. e70054.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Country of Publication: Germany NLM ID: 101552883 Publication Model: Print Cited Medium: Internet ISSN: 2190-6009 (Electronic) Linking ISSN: 21905991 NLM ISO Abbreviation: J Cachexia Sarcopenia Muscle Subsets: MEDLINE

Výrazy zo slovníka MeSH: Muscular Dystrophy, Duchenne*/drug therapy , Muscular Dystrophy, Duchenne*/metabolism , Muscular Dystrophy, Duchenne*/pathology , Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/therapeutic use , Muscle, Skeletal*/drug effects , Muscle, Skeletal*/metabolism , Proteasome Endopeptidase Complex*/metabolism, Animals ; Mice ; Gastrointestinal Microbiome/drug effects ; Disease Models, Animal ; Mice, Inbred mdx ; Male ; Mice, Inbred C57BL

Bortezomib for the treatment of anti-N-methyl-d-aspartate receptor encephalitis in a patient with psoriatic arthritis receiving adalimumab: A case report and literature review.

Autori: Karigowda L Brown D Wong C a ďalší

Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2025 Dec 15; Vol. 409, pp. 578754. Date of Electronic Publication: 2025 Sep 09.

Spôsob vydávania: Journal Article; Case Reports; Review

Informácie o časopise: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anti-N-Methyl-D-Aspartate Receptor Encephalitis*/drug therapy , Anti-N-Methyl-D-Aspartate Receptor Encephalitis*/chemically induced , Bortezomib*/therapeutic use , Adalimumab*/adverse effects , Adalimumab*/therapeutic use , Arthritis, Psoriatic*/drug therapy , Arthritis, Psoriatic*/complications , Antirheumatic Agents*/adverse effects , Antirheumatic Agents*/therapeutic use , Proteasome Inhibitors*/therapeutic use, Humans ; Male ; Adult

Peripheral Neuropathy Associated With Proteasome Inhibitors and Immunomodulatory Drugs: A Pharmacovigilance Disproportionality Analysis Using VigiBase.

Autori: Braga LP de Pádua CAM da Costa IHF a ďalší

Zdroj: Pharmacology research & perspectives [Pharmacol Res Perspect] 2025 Dec; Vol. 13 (6), pp. e70191.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 101626369 Publication Model: Print Cited Medium: Internet ISSN: 2052-1707 (Electronic) Linking ISSN: 20521707 NLM ISO Abbreviation: Pharmacol Res Perspect Subsets: MEDLINE

Výrazy zo slovníka MeSH: Peripheral Nervous System Diseases*/chemically induced , Peripheral Nervous System Diseases*/epidemiology , Proteasome Inhibitors*/adverse effects , Multiple Myeloma*/drug therapy , Immunomodulating Agents*/adverse effects , Antineoplastic Agents*/adverse effects, Humans ; Pharmacovigilance ; Male ; Female ; Middle Aged ; Aged ; Databases, Factual ; Adverse Drug Reaction Reporting Systems/statistics & numerical data ; Thalidomide/adverse effects ; Thalidomide/analogs & derivatives ; Adult ; Bortezomib/adverse effects

Anthracyclines attenuate Nrf1-dependent proteolytic pathways and potentiate proteasome inhibitor cytotoxicity.

Autori: Vangala JR Ward MA Albalawi B a ďalší

Zdroj: Molecular biology of the cell [Mol Biol Cell] 2025 Dec 01; Vol. 36 (12), pp. ar150. Date of Electronic Publication: 2025 Oct 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Society for Cell Biology Country of Publication: United States NLM ID: 9201390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-4586 (Electronic) Linking ISSN: 10591524 NLM ISO Abbreviation: Mol Biol Cell Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anthracyclines*/pharmacology , Proteasome Inhibitors*/pharmacology , Nuclear Respiratory Factor 1*/metabolism , NF-E2-Related Factor 1*/metabolism, Humans ; Cell Line, Tumor ; Proteolysis/drug effects ; Doxorubicin/pharmacology ; Bortezomib/pharmacology ; Proteasome Endopeptidase Complex/metabolism ; Multiple Myeloma/drug therapy ; Multiple Myeloma/metabolism ; DNA Damage/drug effects ; Antioxidant Response Elements/drug effects ; Drug Resistance, Neoplasm/drug effects

Noncanonical Pathways of Proteasome Inhibition in HPV-Negative Head & Neck Cancer.

Autori: Lee HY Kim JY Wang Z a ďalší

Zdroj: Molecular carcinogenesis [Mol Carcinog] 2025 Nov; Vol. 64 (11), pp. 1838-1850. Date of Electronic Publication: 2025 Aug 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE

Výrazy zo slovníka MeSH: Head and Neck Neoplasms*/drug therapy , Head and Neck Neoplasms*/metabolism , Head and Neck Neoplasms*/pathology , Head and Neck Neoplasms*/virology , Proteasome Inhibitors*/pharmacology , Oligopeptides*/pharmacology , Squamous Cell Carcinoma of Head and Neck*/drug therapy , Squamous Cell Carcinoma of Head and Neck*/metabolism, Humans ; Animals ; Mice ; Apoptosis/drug effects ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Signal Transduction/drug effects ; Proteasome Endopeptidase Complex/metabolism ; Mice, Nude ; Antineoplastic Agents/pharmacology ; Papillomaviridae ; Proto-Oncogene Proteins c-akt/metabolism

Pulmonary toxicity induced by carfilzomib: a case report and review of the literature.

Autori: Ziarkiewicz M Zacny A Basak G a ďalší

Zdroj: Journal of medical case reports [J Med Case Rep] 2025 Oct 14; Vol. 19 (1), pp. 510. Date of Electronic Publication: 2025 Oct 14.

Spôsob vydávania: Journal Article; Case Reports; Review

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101293382 Publication Model: Electronic Cited Medium: Internet ISSN: 1752-1947 (Electronic) Linking ISSN: 17521947 NLM ISO Abbreviation: J Med Case Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oligopeptides*/adverse effects , Oligopeptides*/administration & dosage , Oligopeptides*/therapeutic use , Multiple Myeloma*/drug therapy , Lung Diseases, Interstitial*/chemically induced , Lung Diseases, Interstitial*/diagnostic imaging , Proteasome Inhibitors*/adverse effects , Antineoplastic Agents*/adverse effects, Humans ; Male ; Middle Aged ; Dexamethasone/therapeutic use ; Dexamethasone/administration & dosage ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/administration & dosage

Drug repurposing identifies proteasome inhibitors as antiproliferative agents counteracting inflammation-driven chemoresistance in triple-negative breast cancer organoids.

Autori: Sari AIP Roytrakul S Chittavanich P a ďalší

Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Sep; Vol. 190, pp. 118359. Date of Electronic Publication: 2025 Jul 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

Výrazy zo slovníka MeSH: Triple Negative Breast Neoplasms*/drug therapy , Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/therapeutic use , Drug Resistance, Neoplasm* , Cell Proliferation*/drug effects , Inflammation*/drug therapy, Drug Repositioning ; Humans ; Organoids/drug effects ; High-Throughput Screening Assays ; Protein Interaction Maps ; Protein Biosynthesis/drug effects ; Cell Cycle/drug effects ; Gene Expression Profiling ; Doxorubicin ; Antibiotics, Antineoplastic

A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis.

Autori: Soni S Anang V Zhao Y a ďalší

Zdroj: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2025 Aug 21; Vol. 44 (1), pp. 246. Date of Electronic Publication: 2025 Aug 21.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proteasome Endopeptidase Complex*/metabolism , Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/pathology , Proto-Oncogene Proteins c-bcl-2*/metabolism , Proto-Oncogene Proteins c-bcl-2*/antagonists & inhibitors , Proteasome Inhibitors*/therapeutic use , Proteasome Inhibitors*/pharmacology , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology, Humans ; Animals ; Molecular Targeted Therapy ; Signal Transduction/drug effects

Synergistic Mechanisms of Traditional Chinese Medicine and Proteasome Inhibitors in Multiple Myeloma Therapy: A Comprehensive Review.

Autori: Dai Y Zhou Y Chen H

Zdroj: Drug design, development and therapy [Drug Des Devel Ther] 2025 Aug 18; Vol. 19, pp. 7099-7109. Date of Electronic Publication: 2025 Aug 18 (Print Publication: 2025).

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Multiple Myeloma*/drug therapy , Multiple Myeloma*/pathology , Multiple Myeloma*/metabolism , Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/chemistry , Medicine, Chinese Traditional* , Antineoplastic Combined Chemotherapy Protocols*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/chemistry, Humans ; Animals ; Drug Synergism

Design and Synthesis of Potent Ridaifen Analogues: Evaluation as Anticancer, 20S Proteasomal Inhibitors, and Antiebola Virus Agents through In vitro and In Silico Studies.

Autori: Vector MA Fujiwara S Zhu Y a ďalší

Zdroj: ChemMedChem [ChemMedChem] 2025 Sep 25; Vol. 20 (18), pp. e202500451. Date of Electronic Publication: 2025 Aug 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/chemical synthesis , Proteasome Inhibitors*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/chemical synthesis , Antiviral Agents*/chemistry , Drug Design* , Proteasome Endopeptidase Complex*/metabolism , Ebolavirus*/drug effects, Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Cell Line, Tumor ; Molecular Structure ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Molecular Docking Simulation