Výsledky vyhľadávania - "Preclinical/methods"

Integrating Machine Learning-Based Pose Sampling with Established Scoring Functions for Virtual Screening

Autori: Thi Ngoc Lan Vu Hosein Fooladi Johannes Kirchmair

Zdroj: J Chem Inf Model

Predmety: Machine Learning, Molecular Docking Simulation, 106005 Bioinformatik, Preclinical/methods, Protein Conformation, 102001 Artificial intelligence, 102001 Artificial Intelligence, Drug Evaluation, 106005 Bioinformatics, 301207 Pharmazeutische Chemie, Article, 301207 Pharmaceutical chemistry, Proteins/chemistry

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40343848

Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening

Autori: Qin, Songkang Li, Kuan-Hao Liu, Ben-Jin a ďalší

Zdroj: Virol Sin

Predmety: Rotavirus, Rotavirus/drug effects, High-throughput screen, Immunology, Green Fluorescent Proteins, Drug Evaluation, Preclinical, Small chemical compound, Genome, Viral, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Green Fluorescent Proteins/genetics, Rotavirus Infections, Cell Line, Veterinary medicine & animal health, Reverse Genetics/methods, NSP3 protein, Rotavirus, Virology, Cricetinae, Animals, Bovine rotavirus (BRV), Rotavirus Infections/virology, Plasmids/genetics, Virus Replication/drug effects, Reporter virus, Life sciences, Médecine vétérinaire & santé animale, Reverse Genetics, Viral Nonstructural Proteins/genetics, Infectious Diseases, Optimized reverse genetics system, Rotavirus/genetics, Sciences du vivant, Molecular Medicine, Cattle, Drug Evaluation, Preclinical/methods, Research Article, Plasmids

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39349279

Establishment of a human 3D in vitro liver-bone model as a potential system for drug toxicity screening

Autori: Guanqiao Chen Yuxuan Xin Mohammad Majd Hammour a ďalší

Zdroj: Arch Toxicol

Predmety: 0301 basic medicine, 0303 health sciences, Diclofenac, Cell Survival, Anti-Inflammatory Agents, Non-Steroidal, Drug Evaluation, Preclinical, Models, Biological, Coculture Techniques, Bone and Bones, Cell Line, In Vitro Systems, 03 medical and health sciences, Liver/pathology [MeSH], Diclofenac/toxicity [MeSH], Humans [MeSH], Liver/metabolism [MeSH], Cell Line [MeSH], Liver/drug effects [MeSH], Cell Survival/drug effects [MeSH], Bone and Bones/drug effects [MeSH], 3D in vitro liver-bone co-culture model, Drug affect bone homeostasis, Liver-bone axis, Culture Media [MeSH], Spheroids, Cellular/drug effects [MeSH], Reactive Oxygen Species, Drug Evaluation, Preclinical/methods [MeSH], Interleukin-6, Coculture Techniques [MeSH], Tissue Scaffolds [MeSH], Anti-Inflammatory Agents, Non-Steroidal/toxicity [MeSH], Bone and Bones/metabolism [MeSH], Toxicity Tests/methods [MeSH], Liver, Spheroids, Cellular, Toxicity Tests, Humans

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39503877
https://repository.publisso.de/resource/frl:6513662

The Current State of Biotransformation Science – Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends

Autori: John P. Savaryn Kevin Coe Matthew A. Cerny a ďalší

Zdroj: Pharm Res

Predmety: Translational Research, Biomedical, MetID, Surveys and Questionnaires [MeSH], Biotransformation [MeSH], Humans [MeSH], Pharmaceutical Preparations/metabolism [MeSH], Drug Development/methods [MeSH], Animals [MeSH], Translational Research, Biomedical/methods [MeSH], Perspectives, Drug Evaluation, Preclinical/methods [MeSH], Drug Discovery/methods [MeSH], biotransformation, Drug Industry/methods [MeSH], IVIVC, ADME, Pharmaceutical Preparations, Drug Industry, Drug Development, Surveys and Questionnaires, Drug Discovery, Drug Evaluation, Preclinical, Humans, Animals, Biotransformation

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39496990
https://repository.publisso.de/resource/frl:6523470

Novel Inhibitors of SARS-CoV-2 RNA Identified through Virtual Screening

Autori: Cagno, Valeria Mathez, Gregory Brancale, Andrea

Zdroj: J Chem Inf Model
Journal of chemical information and modeling, vol. 64, no. 15, pp. 6190-6196

Predmety: Molecular Docking Simulation, Models, Molecular, User-Computer Interface, SARS-CoV-2, Drug Evaluation, Preclinical, RNA, Viral, Humans, Nucleic Acid Conformation, Antiviral Agents, SARS-CoV-2/drug effects, Antiviral Agents/pharmacology, Antiviral Agents/chemistry, RNA, Viral/metabolism, RNA, Viral/antagonists & inhibitors, RNA, Viral/genetics, Drug Evaluation, Preclinical/methods

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39037082
https://serval.unil.ch/resource/serval:BIB_3C7478C5D69A.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_3C7478C5D69A
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3C7478C5D69A8

Galleria mellonella as an Antimicrobial Screening Model

Autori: Barton, Thomas E Duignan, Liberty Kadioglu, Aras a ďalší

Zdroj: Journal of visualized experiments : JoVE. (212)

Predmety: Animal, Drug Evaluation, Preclinical, Anti-Infective Agents/pharmacology, Moths, Pseudomonas aeruginosa/drug effects, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents, Larva/drug effects, Disease Models, Animal, Anti-Infective Agents, Moths/microbiology, Preclinical/methods, Larva, Disease Models, Pseudomonas aeruginosa, Drug Evaluation, Animals, Pseudomonas Infections, Pseudomonas Infections/microbiology

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39465915

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Autori: Oliveira, Gabriel S. Bento, Clara M. Pombinho, António a ďalší

Prispievatelia: Oliveira, Gabriel S. Bento, Clara M. Pombinho, António a ďalší

Zdroj: Journal of visualized experiments

Predmety: Mycobacterium abscessus / drug effects, Mycobacterium abscessus, Pharmacology. Therapy, Mycobacterium Infections, Nontuberculous / microbiology, Drug Evaluation, Preclinical, Mycobacterium Infections, Nontuberculous, Anti-Bacterial Agents / pharmacology, Mycobacterium Infections, Nontuberculous / drug therapy, High-Throughput Screening Assays, Anti-Bacterial Agents, High-Throughput Screening Assays / methods, Drug Evaluation, Preclinical / methods, Anti-Bacterial Agents / chemistry, Humans

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39526621
https://hdl.handle.net/10216/165538
https://hdl.handle.net/10067/2093020151162165141
https://repository.uantwerpen.be/docstore/d:irua:25946

An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo

Autori: Celia Lujan Eleanor Jane Tyler Simone Ecker a ďalší

Zdroj: Genome Med
Genome Medicine, Vol 16, Iss 1, Pp 1-15 (2024)
Genome Medicine, vol 16, iss 1

Predmety: Aging, Cells, Clinical Sciences, Longevity, Drug Evaluation, Preclinical, QH426-470, Senescence, Epigenesis, Genetic, Genetic, Drug Discovery, CellPopAge epigenetic Clock, Genetics, Humans, Animals, Rapamycin, Cellular Senescence, Cells, Cultured, Sirolimus, Cultured, Drug discovery, Research, Biological Sciences, DNA Methylation, Preclinical, Advances in healthy aging and age-related diseases, DNA Methylation/drug effects [MeSH], Humans [MeSH], CpG methylation, Longevity/drug effects [MeSH], Sirolimus/pharmacology [MeSH], Animals [MeSH], Drosophila [MeSH], Drug Evaluation, Preclinical/methods [MeSH], Cellular Senescence/drug effects [MeSH], Drug Discovery/methods [MeSH], Cells, Cultured [MeSH], Ageing, Epigenesis, Genetic/drug effects [MeSH], Aging/drug effects [MeSH], 3. Good health, Good Health and Well Being, 5.1 Pharmaceuticals, Drug Evaluation, Medicine, Drosophila, Generic health relevance, Biotechnology, Epigenesis

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38956711
https://doaj.org/article/8bc7311ebeed472eb18cda1fe5ab77ae
https://repository.publisso.de/resource/frl:6518979
https://escholarship.org/content/qt2t5101p4/qt2t5101p4.pdf
https://escholarship.org/uc/item/2t5101p4

Rapid tissue prototyping with micro-organospheres

Autori: Zhaohui Wang Matteo Boretto Rosemary Millen a ďalší

Prispievatelia: Zhaohui Wang Matteo Boretto Rosemary Millen a ďalší

Zdroj: Stem Cell Reports

Predmety: 0301 basic medicine, organoid, Microfluidics, Drug Evaluation, Preclinical, Antineoplastic Agents, SARS-COV-2, demulsification, cytostatic, Biochemistry, Article, cytotoxic, 03 medical and health sciences, patient derived organoid, Genetics, Humans, Precision Medicine, micro-organospheres, 0303 health sciences, drug resistant, deep learning, Cell Biology, Preclinical, CAR-T, 3. Good health, Organoids, Preclinical/methods, Drug Evaluation, Antineoplastic Agents/pharmacology, Developmental Biology

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/35985334
https://hdl.handle.net/20.500.11755/dcbfc875-4666-46d2-8ef9-edf44b551143
https://doi.org/10.1016/j.stemcr.2022.07.016
https://pure.knaw.nl/portal/en/publications/dcbfc875-4666-46d2-8ef9-edf44b551143
https://dspace.library.uu.nl/handle/1874/447775

International Consensus on Minimum Preclinical Testing Requirements for the Development of Innovative Therapies For Children and Adolescents with Cancer

Autori: Gilles Vassal Peter J. Houghton Stefan M. Pfister a ďalší

Prispievatelia: Gilles Vassal Peter J. Houghton Stefan M. Pfister a ďalší

Zdroj: Mol Cancer Ther

Predmety: 0301 basic medicine, Investigational/methods, Consensus, Adolescent, Drug Evaluation, Preclinical, Antineoplastic Agents, Therapies, Investigational/methods, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Neoplasms, Animals, Humans, Child, Clinical Trials as Topic/methods, Clinical Trials as Topic, Animal, Therapies, Investigational, International Agencies, Neoplasms/drug therapy, 3. Good health, Disease Models, Animal, Preclinical/methods, Therapies, Disease Models, Drug Evaluation, Drug Evaluation, Preclinical/methods, Antineoplastic Agents/pharmacology

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/34108262
https://mct.aacrjournals.org/content/early/2021/06/09/1535-7163.MCT-20-0394
https://pubmed.ncbi.nlm.nih.gov/34108262/
https://www.ncbi.nlm.nih.gov/pubmed/34108262
https://europepmc.org/article/MED/34108262
https://mct.aacrjournals.org/content/20/8/1462
https://www.scholars.northwestern.edu/en/publications/international-consensus-on-minimum-preclinical-testing-requiremen
https://dspace.library.uu.nl/handle/1874/419647
https://dspace.library.uu.nl/handle/1874/418322

Preclinical in vivo assessment of the activity of AZD7442 anti-SARS-CoV-2 monoclonal antibodies against Omicron sublineages

Autori: Driouich, Jean-Sélim Cochin, Maxime Lingas, Guillaume a ďalší

Prispievatelia: Driouich, Jean-Sélim Cochin, Maxime Lingas, Guillaume a ďalší

Zdroj: ISSN: 0753-3322.

Predmety: AZD7442, Clinical therapeutics, Monoclonal antibody, Omicron sublineages, Preclinical animal model, SARS-CoV-2, MESH: Animals, MESH: Antibodies, Monoclonal / immunology, MESH: Betacoronavirus / immunology, MESH: COVID-19 Drug Treatment, MESH: COVID-19* / immunology, MESH: COVID-19* / virology, MESH: Cricetinae, MESH: Disease Models, Animal, MESH: Drug Evaluation, Preclinical / methods, MESH: Female, MESH: Humans, MESH: Male, Monoclonal / pharmacology, MESH: Mesocricetus, MESH: SARS-CoV-2 / drug effects, MESH: SARS-CoV-2 / immunology, Monoclonal, Humanized / pharmacology, Humanized / therapeutic use, Viral / blood, Viral / immunology

Relation: info:eu-repo/semantics/altIdentifier/pmid/38897157; IRD: fdi:010093047; PUBMED: 38897157

Dostupnosť: https://hal.science/hal-04697209
https://hal.science/hal-04697209v1/document
https://hal.science/hal-04697209v1/file/1-s2.0-S0753332224008722-main.pdf
https://doi.org/10.1016/j.biopha.2024.116988

Screening of Small-Molecule Libraries Using SARS-CoV-2-Derived Sequences Identifies Novel Furin Inhibitors.

Autori: Jorkesh, A. Rothenberger, S. Baldassar, L. a ďalší

Zdroj: International journal of molecular sciences, vol. 25, no. 10

Predmety: Furin/antagonists & inhibitors, Furin/metabolism, SARS-CoV-2/drug effects, SARS-CoV-2/metabolism, Humans, Small Molecule Libraries/pharmacology, Small Molecule Libraries/chemistry, Antiviral Agents/pharmacology, Antiviral Agents/chemistry, COVID-19/virology, Spike Glycoprotein, Coronavirus/metabolism, Coronavirus/antagonists & inhibitors, Coronavirus/chemistry, Coronavirus/genetics, Drug Evaluation, Preclinical/methods, Furin, HTS, SARS-CoV-2, cleavage, envelope glycoprotein, exosite, in vitro, inhibitor, peptide, protease, virus

Popis súboru: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/38791119; info:eu-repo/semantics/altIdentifier/eissn/1422-0067; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_9F00CF02496F5; https://serval.unil.ch/notice/serval:BIB_9F00CF02496F; https://serval.unil.ch/resource/serval:BIB_9F00CF02496F.P001/REF.pdf

Dostupnosť: https://serval.unil.ch/notice/serval:BIB_9F00CF02496F
https://doi.org/10.3390/ijms25105079
https://serval.unil.ch/resource/serval:BIB_9F00CF02496F.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_9F00CF02496F5

Realizing the potential of organoids—an interview with Hans Clevers

Autori: Bartfeld, Sina

Zdroj: J Mol Med (Berl)

Predmety: 0301 basic medicine, ddc:610, 0303 health sciences, 03 medical and health sciences, Organoids/drug effects [MeSH], Molecular Medicine, Reproductive Techniques, Assisted/trends [MeSH], Toxicology/methods [MeSH], Brain/cytology [MeSH], Drug Evaluation, Preclinical/trends [MeSH], Commentary, Biomedical Research/ethics [MeSH], Male [MeSH], Organoids/cytology [MeSH], Biomedical Research/trends [MeSH], Toxicology/trends [MeSH], Observational Studies as Topic [MeSH], Internal Medicine, Human Genetics, Female [MeSH], Organoids/transplantation [MeSH], History, 21st Century [MeSH], Induced Pluripotent Stem Cells/cytology [MeSH], Biomedical Research/methods [MeSH], Regenerative Medicine/trends [MeSH], Humans [MeSH], Reproductive Techniques, Assisted/ethics [MeSH], Animals [MeSH], Intestines/cytology [MeSH], Mice [MeSH], Drug Evaluation, Preclinical/methods [MeSH], Clinical Trials as Topic [MeSH], History, 20th Century [MeSH], Animal Use Alternatives [MeSH], Embryonic Stem Cells/cytology [MeSH], Pregnancy [MeSH], 3. Good health

Popis súboru: application/pdf

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00109-020-02025-3.pdf
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/searchtype/all/start/1/rows/10/nav/prev
https://link.springer.com/article/10.1007/s00109-020-02025-3
https://www.ncbi.nlm.nih.gov/pubmed/33464358
https://pubmed.ncbi.nlm.nih.gov/33464358/
https://link.springer.com/content/pdf/10.1007/s00109-020-02025-3.pdf
https://opus.bibliothek.uni-wuerzburg.de/files/23580/Bartfeld2021_Article_RealizingThePotentialOfOrganoi.pdf
https://repository.publisso.de/resource/frl:6448309

Establishment of patient-derived cancer organoids for drug-screening applications

Autori: Else Driehuis Kai Kretzschmar Hans Clevers a ďalší

Prispievatelia: Else Driehuis Kai Kretzschmar Hans Clevers a ďalší

Zdroj: Nature Protocols. 15:3380-3409

Predmety: Adult, 0301 basic medicine, 0303 health sciences, Research Support, Non-U.S. Gov't, Biopsy, Cell Culture Techniques, Drug Evaluation, Preclinical, Cell Culture Techniques/methods, Precision Medicine/methods, Neoplasms/pathology, Biopsy/methods, 3. Good health, Organoids, 03 medical and health sciences, Preclinical/methods, Neoplasms, Journal Article, Organoids/metabolism, Drug Evaluation, Humans, Drug Evaluation, Preclinical/methods, Early Detection of Cancer/methods, Precision Medicine, Early Detection of Cancer

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/32929210
https://pure.knaw.nl/portal/en/publications/90d722c1-615d-4acd-bb5d-ee0c7103b584
https://hdl.handle.net/20.500.11755/90d722c1-615d-4acd-bb5d-ee0c7103b584
https://doi.org/10.1038/s41596-020-0379-4
https://www.ncbi.nlm.nih.gov/pubmed/32929210
http://www-nature-com-443.webvpn.bjmu.tsg211.com/articles/s41596-020-0379-4
https://www.nature.com/articles/s41596-020-0379-4.pdf
https://pubmed.ncbi.nlm.nih.gov/32929210/
https://www.nature.com/articles/s41596-020-0379-4
https://dspace.library.uu.nl/handle/1874/440882

Liquid chromatography-high resolution mass spectrometry for broad-spectrum drug screening of dried blood spot as microsampling procedure

Autori: Joye, T. Sidibé, J. Déglon, J. a ďalší

Zdroj: Analytica chimica acta, Vol. 1063 (2019) pp. 110-116
Analytica chimica acta, vol. 1063, pp. 110-116

Predmety: ddc:616, Illicit Drugs / blood, Illicit Drugs, ddc:614.1, Drug Evaluation, Preclinical, Dried blood spot, Data dependent acquisition, High resolution mass spectrometry, 01 natural sciences, Drug Evaluation, Preclinical / instrumentation, 0104 chemical sciences, Microsampling, Tandem Mass Spectrometry, Drug Evaluation, Preclinical / methods, Humans, Dried Blood Spot Testing, Chromatography, Liquid, Drug Evaluation, Preclinical/instrumentation, Drug Evaluation, Preclinical/methods, Street Drugs/blood, General unknown screening

Popis súboru: application/pdf

Prístupová URL adresa: https://serval.unil.ch/resource/serval:BIB_A93B0FBC6297.P001/REF.pdf
https://pubmed.ncbi.nlm.nih.gov/30967174
https://europepmc.org/article/MED/30967174
https://serval.unil.ch/resource/serval:BIB_A93B0FBC6297.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_A93B0FBC6297
https://archive-ouverte.unige.ch/unige:156804
https://www.sciencedirect.com/science/article/pii/S0003267019301850
https://www.ncbi.nlm.nih.gov/pubmed/30967174
https://archive-ouverte.unige.ch/unige:156804
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A93B0FBC62974
https://serval.unil.ch/resource/serval:BIB_A93B0FBC6297.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_A93B0FBC6297

Pre-clustering data sets using cluster4x improves the signal-to-noise ratio of high-throughput crystallography drug-screening analysis

Autori: Ginn, Helen

Zdroj: Acta Crystallogr D Struct Biol
Acta crystallographica / Section D 76(Pt 11), 1134-1144 (2020). doi:10.1107/S2059798320012619

Predmety: 0301 basic medicine, 0303 health sciences, Crystallography, X-Ray: methods, software, Drug Evaluation, Preclinical, fragment screening, Signal-To-Noise Ratio, Crystallography, X-Ray, Research Papers, 3. Good health, 03 medical and health sciences, Drug Evaluation, Preclinical: methods, Cluster Analysis, heterogeneity, Software, clustering

Prístupová URL adresa: https://journals.iucr.org/d/issues/2020/11/00/di5038/di5038.pdf
https://pubmed.ncbi.nlm.nih.gov/33135684
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604910
https://pubmed.ncbi.nlm.nih.gov/33135684/
https://journals.iucr.org/d/issues/2020/11/00/di5038/di5038.pdf
https://journals.iucr.org/d/issues/2020/11/00/di5038/index.html
https://scripts.iucr.org/cgi-bin/paper?S2059798320012619
https://bib-pubdb1.desy.de/record/546332

Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia

Autori: Arnold Kloos Yasmine Alwie Charu Gupta a ďalší

Zdroj: Leukemia

Predmety: Pyridones, Drug Evaluation, Preclinical, Antineoplastic Agents, Pyrimidinones, Leukemia, Myelomonocytic, Chronic/pathology [MeSH], Antineoplastic Agents/adverse effects [MeSH], Drug Evaluation, Preclinical/standards [MeSH], Pyridones/pharmacology [MeSH], Drug Synergism [MeSH], Antineoplastic Agents/administration, Antineoplastic Agents/pharmacology [MeSH], Oncogenesis, Receptor, Notch1/genetics [MeSH], Translational research, Pyridones/therapeutic use [MeSH], Leukemia, Myelomonocytic, Chronic/genetics [MeSH], RNA, Small Interfering/genetics [MeSH], Disease Models, Animal [MeSH], Xenograft Model Antitumor Assays/methods [MeSH], Membrane Proteins/genetics [MeSH], Female [MeSH], Clonal Evolution [MeSH], Mutation [MeSH], Leukemia, Myelomonocytic, Chronic/drug therapy [MeSH], Protein Kinase Inhibitors/pharmacology [MeSH], Pyrimidinones/pharmacology [MeSH], Humans [MeSH], Azacitidine/pharmacology [MeSH], Leukemia, Myelomonocytic, Chronic/mortality [MeSH], Animals [MeSH], Protein Kinase Inhibitors/therapeutic use [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Antineoplastic Combined Chemotherapy Protocols/adverse effects [MeSH], Mice [MeSH], Article, Drug Evaluation, Preclinical/methods [MeSH], Preclinical research, Pyrimidinones/therapeutic use [MeSH], GTP Phosphohydrolases/genetics [MeSH], GTP Phosphohydrolases, Clonal Evolution, Mice, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, RNA, Small Interfering, Receptor, Notch1, Protein Kinase Inhibitors, ddc:610, Membrane Proteins, Drug Synergism, Leukemia, Myelomonocytic, Chronic, 3. Good health, Disease Models, Animal, Mutation, Azacitidine, Female

Popis súboru: application/pdf

Prístupová URL adresa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116758
https://pubmed.ncbi.nlm.nih.gov/32576961
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116758
https://www.ncbi.nlm.nih.gov/pubmed/32576961
https://www.nature.com/articles/s41375-021-01459-z
https://www.nature.com/articles/s41375-021-01459-z.pdf
https://pubmed.ncbi.nlm.nih.gov/32576961/
https://europepmc.org/article/MED/34728793
https://repository.publisso.de/resource/frl:6471070

Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines

Autori: Francois Busquet Thomas Hartung Marcel Leist a ďalší

Zdroj: Arch Toxicol
Archives of Toxicology

Predmety: 0301 basic medicine, COVID-19 Vaccines, SARS-CoV-2, Health, Toxicology and Mutagenesis, Pneumonia, Viral, Drug Evaluation, Preclinical, Drug Repositioning, COVID-19, Viral Vaccines, General Medicine, Toxicology, Animal Testing Alternatives, 16. Peace & justice, Antiviral Agents, 3. Good health, Betacoronavirus, 03 medical and health sciences, Drug Development, Humans, Guest Editorial, Coronavirus Infections, Pandemics, Pharmacology/Toxicology, Animal Testing Alternatives [MeSH], Coronavirus Infections/drug therapy [MeSH], Occupational Medicine/Industrial Medicine, Pandemics/prevention, Humans [MeSH], COVID-19 Vaccines [MeSH], Viral Vaccines [MeSH], Coronavirus Infections/prevention, Antiviral Agents/pharmacology [MeSH], Drug Evaluation, Preclinical/methods [MeSH], Environmental Health, Drug Repositioning [MeSH], Pneumonia, Viral/drug therapy [MeSH], COVID-19 [MeSH], Pneumonia, Viral/prevention, Biomedicine, general, Betacoronavirus [MeSH], Drug Development [MeSH], SARS-CoV-2 [MeSH]

Popis súboru: application/pdf

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00204-020-02787-2.pdf
https://pubmed.ncbi.nlm.nih.gov/32447523
https://repository.publisso.de/resource/frl:6466320
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1djck1tzfprid4

Survey of ex vivo drug combination effects in chronic lymphocytic leukemia reveals synergistic drug effects and genetic dependencies

Autori: Lukas, Marina Velten, Britta Sellner, Leopold a ďalší

Prispievatelia: Lukas, Marina Velten, Britta Sellner, Leopold a ďalší

Zdroj: Leukemia

Predmety: Proto-Oncogene Proteins c-bcl-2/antagonists, Cell Line, Tumor [MeSH], Antineoplastic Agents/adverse effects [MeSH], Chronic lymphocytic leukaemia, Drug Evaluation, Preclinical/standards [MeSH], Drug Synergism [MeSH], Antineoplastic Agents/administration, Antineoplastic Agents/pharmacology [MeSH], Translational research, High-Throughput Nucleotide Sequencing/standards [MeSH], Receptors, Antigen, B-Cell/genetics [MeSH], Receptors, Antigen, B-Cell/metabolism [MeSH], Drug Resistance, Neoplasm/genetics [MeSH], Biomarkers, Tumor [MeSH], Proto-Oncogene Proteins c-bcl-2/genetics [MeSH], Combination drug therapy, Primary Cell Culture [MeSH], Dose-Response Relationship, Drug [MeSH], High-Throughput Nucleotide Sequencing/methods [MeSH], Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis [MeSH], Protein Kinase Inhibitors/pharmacology [MeSH], Humans [MeSH], Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy [MeSH], Protein Kinase Inhibitors/therapeutic use [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Antineoplastic Combined Chemotherapy Protocols/adverse effects [MeSH], Article, Drug Evaluation, Preclinical/methods [MeSH], Leukemia, Lymphocytic, Chronic, B-Cell/genetics [MeSH], Preclinical research, Proto-Oncogene Proteins c-bcl-2/metabolism [MeSH], Reproducibility of Results [MeSH], Receptors, Antigen, B-Cell/antagonists, 0301 basic medicine, 2720 Hematology, Primary Cell Culture, Drug Evaluation, Preclinical, Receptors, Antigen, B-Cell, 610 Medicine & health, Antineoplastic Agents, 03 medical and health sciences, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, 1306 Cancer Research, Protein Kinase Inhibitors, 0303 health sciences, Dose-Response Relationship, Drug, High-Throughput Nucleotide Sequencing, Reproducibility of Results, Drug Synergism, Leukemia, Lymphocytic, Chronic, B-Cell, ddc, 3. Good health, Proto-Oncogene Proteins c-bcl-2, Drug Resistance, Neoplasm, 10032 Clinic for Oncology and Hematology, 2730 Oncology

Popis súboru: application/pdf

Prístupová URL adresa: https://www.nature.com/articles/s41375-020-0846-5.pdf
https://pubmed.ncbi.nlm.nih.gov/32404973
https://www.nature.com/articles/s41375-020-0846-5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584477
https://www.scilit.net/article/704dbae9922e5ee818df7dea73f4b69e
https://www.zora.uzh.ch/id/eprint/187724/
https://pubmed.ncbi.nlm.nih.gov/32404973/
https://www.nature.com/articles/s41375-020-0846-5.pdf
https://resolver.sub.uni-goettingen.de/purl?gro-2/73701
https://repository.publisso.de/resource/frl:6471042
https://mediatum.ub.tum.de/1580199
https://www.zora.uzh.ch/id/eprint/187724/
https://doi.org/10.5167/uzh-187724

An animal-free preclinical drug screening platform based on human precision-cut kidney slices

Autori: Mutsaers, Henricus A M Jensen, Michael Schou Kresse, Jean-Claude a ďalší

Zdroj: BMC Res Notes
BMC Research Notes, Vol 16, Iss 1, Pp 1-6 (2023)
Mutsaers, H A M, Jensen, M S, Kresse, J-C, Tingskov, S J, Madsen, M G & Nørregaard, R 2023, 'An animal-free preclinical drug screening platform based on human precision-cut kidney slices', BMC Research Notes, vol. 16, no. 1, 39. https://doi.org/10.1186/s13104-023-06303-4

Predmety: Precision-cut kidney slices, Science (General), Transforming Growth Factor beta/genetics, QH301-705.5, Drug Evaluation, Preclinical, Kidney, Animal Testing Alternatives, Q1-390, Kidney/pathology, Renal fibrosis, Transforming Growth Factor beta, Chronic kidney disease, Reduction, refinement and replacement, Animals, Humans, Biology (General), Renal Insufficiency, Chronic, Kidney Diseases/drug therapy, The 3Rs, Fibrosis, 3. Good health, Research Note, Alternatives, Medicine, Kidney Diseases, Drug Evaluation, Preclinical/methods

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36941637
https://doaj.org/article/22d6c520707049509ef450fcb7fcc673
https://pure.au.dk/portal/en/publications/9e1cf3d3-00f6-4f28-b54a-72794244d29e
https://doi.org/10.1186/s13104-023-06303-4
http://www.scopus.com/inward/record.url?scp=85150751365&partnerID=8YFLogxK