Výsledky vyhledávání - "PrPSc Proteins/pathogenicity"

Skin‐derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure

Autoři: Mohan, Joanne Hopkins, John Mabbott, Neil

Zdroj: Mohan, J, Hopkins, J & Mabbott, N 2005, ' Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure ', Immunology, vol. 116, no. 1, pp. 122-33 . https://doi.org/10.1111/j.1365-2567.2005.02207.x

Témata: PrPSc Proteins/genetics, RNA, Messenger/genetics, Lipopolysaccharides, PrPSc Proteins, PrPSc Proteins/pathogenicity, Gene Expression, Antigens, Surface/metabolism, Antigens, Surface/analysis, Cell Line, Immunophenotyping, Prion Diseases, Mice, 03 medical and health sciences, 0302 clinical medicine, Animals, Lipopolysaccharides/immunology, PrPC Proteins, Langerhans Cells/microbiology, RNA, Messenger, Prion Diseases/microbiology, Skin, PrPSc Proteins/biosynthesis, Prion Diseases/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Skin/microbiology, Brain, Cell Differentiation, PrPC Proteins/biosynthesis, PrPC Proteins/genetics, Prion Diseases/immunology, Langerhans Cells, Antigens, Surface, Brain/microbiology, Reverse Transcriptase Polymerase Chain Reaction/methods

Popis souboru: application/pdf

Přístupová URL adresa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802412
https://pubmed.ncbi.nlm.nih.gov/16108824
https://www.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2567.2005.02207.x
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2005.02207.x/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802412/figure/fig06/
https://www.research.ed.ac.uk/portal/en/publications/skinderived-dendritic-cells-acquire-and-degrade-the-scrapie-agent-following-in-vitro-exposure(5d27625e-a6f7-447e-a716-3b8d1996a670)/export.html
https://www.research.ed.ac.uk/portal/en/publications/skinderived-dendritic-cells-acquire-and-degrade-the-scrapie-agent-following-in-vitro-exposure(5d27625e-a6f7-447e-a716-3b8d1996a670).html
http://core.ac.uk/display/28975346
https://hdl.handle.net/20.500.11820/5d27625e-a6f7-447e-a716-3b8d1996a670
https://www.pure.ed.ac.uk/ws/files/11577156/Skin_derived_dendritic_cells_acquire_and_degrade_the_scrapie_agent_following_in_vitro_exposure.pdf

Neuroinvasion by Scrapie following Inoculation via the Skin Is Independent of Migratory Langerhans Cells

Autoři: Mohan, Joanne Bruce, Moira Mabbott, Neil

Zdroj: Mohan, J, Bruce, M & Mabbott, N 2005, ' Neuroinvasion by scrapie following inoculation via the skin is independent of migratory Langerhans cells ', J Virol, vol. 79, no. 3, pp. 1888-97 .

Témata: 0301 basic medicine, Mice, Inbred BALB C, 0303 health sciences, CD40 Ligand/genetics, PrPSc Proteins, CD40 Ligand, Langerhans Cells/metabolism, PrPSc Proteins/pathogenicity, Brain, Caspase Inhibitors, 3. Good health, Mice, Inbred C57BL, Mice, 03 medical and health sciences, Langerhans Cells, Brain/metabolism, Scrapie/pathology, Skin/metabolism, Animals, Brain/pathology, Disease Susceptibility, Scrapie/physiopathology, Scrapie, Skin

Popis souboru: application/pdf

Přístupová URL adresa: https://jvi.asm.org/content/79/3/1888.full.pdf
https://pubmed.ncbi.nlm.nih.gov/15650212
http://www.research.ed.ac.uk/portal/files/11456610/Neuroinvasion_by_scrapie_following_inoculation_via_the_skin_is_independent_of_migratory_Langerhans_cells.pdf
https://www.ncbi.nlm.nih.gov/pubmed/15650212
https://www.research.ed.ac.uk/portal/files/11456610/Neuroinvasion_by_scrapie_following_inoculation_via_the_skin_is_independent_of_migratory_Langerhans_cells.pdf
https://pubmed.ncbi.nlm.nih.gov/15650212/
https://journals.asm.org/doi/pdf/10.1128/JVI.79.3.1888-1897.2005
http://europepmc.org/articles/PMC544109
https://www.pure.ed.ac.uk/ws/files/11456610/Neuroinvasion_by_scrapie_following_inoculation_via_the_skin_is_independent_of_migratory_Langerhans_cells.pdf
https://hdl.handle.net/20.500.11820/3ce11f38-569b-4e52-ace6-bdd72f3aa1b1

Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility

Autoři: Mabbott, Neil Young, J. McConnell, I. a další

Zdroj: Mabbott, N, Young, J, McConnell, I & Bruce, M 2003, ' Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility ', Journal of Virology, vol. 77, no. 12, pp. 6845-54 .

Témata: Lymphotoxin-beta, 0301 basic medicine, Scrapie/drug therapy, PrPSc Proteins, Lymphoid Tissue, Recombinant Fusion Proteins, PrPSc Proteins/pathogenicity, Dendritic Cells, Follicular/cytology, Spleen/metabolism, Receptors, Tumor Necrosis Factor, Dendritic Cells, Follicular/drug effects, Mice, Peyer's Patches, 03 medical and health sciences, 0302 clinical medicine, Lymphotoxin beta Receptor, Membrane Proteins/antagonists & inhibitors, Lymphoid Tissue/metabolism, Animals, Lymphotoxin-alpha/antagonists & inhibitors, Peyer's Patches/metabolism, Lymphotoxin-alpha, Scrapie/physiopathology, PrPSc Proteins/biosynthesis, Membrane Proteins, Cell Differentiation, Immunohistochemistry, 3. Good health, Mice, Inbred C57BL, Cell Differentiation/drug effects, Immunoglobulin G, Disease Susceptibility, Dendritic Cells, Follicular, Spleen, Scrapie

Popis souboru: application/pdf

Přístupová URL adresa: https://jvi.asm.org/content/77/12/6845.full.pdf
https://pubmed.ncbi.nlm.nih.gov/12768004
https://www.research.ed.ac.uk/portal/files/11456671/Follicular_dendritic_cell_dedifferentiation_by_treatment_with_an_inhibitor_of_the_lymphotoxin.pdf
https://pubmed.ncbi.nlm.nih.gov/12768004/
https://europepmc.org/article/MED/12768004
https://www.research.ed.ac.uk/portal/en/publications/follicular-dendritic-cell-dedifferentiation-by-treatment-with-an-inhibitor-of-the-lymphotoxin-pathway-dramatically-reduces-scrapie-susceptibility(4943a1ba-1bc5-46fd-b659-b577bd57eac2).html
https://journals.asm.org/doi/pdf/10.1128/JVI.77.12.6845-6854.2003
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156207
https://hdl.handle.net/20.500.11820/4943a1ba-1bc5-46fd-b659-b577bd57eac2
https://www.pure.ed.ac.uk/ws/files/11456671/Follicular_dendritic_cell_dedifferentiation_by_treatment_with_an_inhibitor_of_the_lymphotoxin.pdf

Tumor Necrosis Factor Alpha-Deficient, but Not Interleukin-6-Deficient, Mice Resist Peripheral Infection with Scrapie

Autoři: Mabbott, Neil Williams, Alun Farquhar, Christine a další

Zdroj: Mabbott, N, Williams, A, Farquhar, C, Pasparakis, M, Kollias, G & Bruce, M 2000, ' Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie ', Journal of Virology, vol. 74, no. 7, pp. 3338-44 .

Témata: Mice, Knockout, 0301 basic medicine, PrPSc Proteins, Interleukin-6, Tumor Necrosis Factor-alpha, PrPSc Proteins/pathogenicity, PrPSc Proteins/metabolism, 3. Good health, Mice, Inbred C57BL, Mice, 03 medical and health sciences, 0302 clinical medicine, Scrapie/genetics, Tumor Necrosis Factor-alpha/genetics, Animals, Genetic Predisposition to Disease, Interleukin-6/genetics, Scrapie

Popis souboru: application/pdf

Přístupová URL adresa: https://jvi.asm.org/content/74/7/3338.full.pdf
https://pubmed.ncbi.nlm.nih.gov/10708451
https://www.ncbi.nlm.nih.gov/pubmed/10708451
http://www.research.ed.ac.uk/portal/files/11472514/Tumor_necrosis_factor_alpha_deficient_but_not_interleukin_6_deficient_mice_resist_peripheral_infection_with_scrapie.pdf
https://pubmed.ncbi.nlm.nih.gov/10708451/
https://jvi.asm.org/content/74/7/3338.short
https://www.research.ed.ac.uk/portal/files/11472514/Tumor_necrosis_factor_alpha_deficient_but_not_interleukin_6_deficient_mice_resist_peripheral_infection_with_scrapie.pdf
https://europepmc.org/abstract/MED/10708451
https://www.pure.ed.ac.uk/ws/files/11472514/Tumor_necrosis_factor_alpha_deficient_but_not_interleukin_6_deficient_mice_resist_peripheral_infection_with_scrapie.pdf
https://hdl.handle.net/20.500.11820/7cdf1cf5-0e71-45e3-b32a-fca49e4a2216

Relevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters

Autoři: Kratzel, Christine Krüger, Dominique Beekes, Michael

Témata: Animals, Female, Male, Blotting, Western, Cricetinae, Disease Models, Animal, Lymph Node Excision, Lymph Nodes/metabolism, Lymph Nodes/physiopathology, Mesocricetus, PrPSc Proteins/metabolism, PrPSc Proteins/pathogenicity, Scrapie/physiopathology, 610 Medizin, ddc:610

Popis souboru: application/pdf

Relation: http://edoc.rki.de/oa/articles/reYJz5gyqJ5Gw/PDF/22OA0Wz7NEGZs.pdf; http://edoc.rki.de/176904/389; http://dx.doi.org/10.25646/314

Dostupnost: http://edoc.rki.de/oa/articles/reYJz5gyqJ5Gw/PDF/22OA0Wz7NEGZs.pdf
http://edoc.rki.de/176904/389
https://nbn-resolving.org/urn:nbn:de:0257-100214
https://doi.org/10.1186/1746-6148-3-22
https://doi.org/10.25646/314

Scrapie Agent (Strain 263K) Can Transmit Disease via the Oral Route after Persistence in Soil over Years

Autoři: Seidel, Bjoern Thomzig, Achim Buschmann, Anne a další

Témata: Animals, Western, Cricetinae, Biological Assay, Blotting, PrPSc Proteins/isolation & purification, PrPSc Proteins/pathogenicity, Soil, 610 Medizin, ddc:610

Popis souboru: application/pdf

Relation: http://edoc.rki.de/oa/articles/reFy9TM5nUOyg/PDF/25YTZmRlJTyfk.pdf; http://edoc.rki.de/176904/456; http://dx.doi.org/10.25646/381

Dostupnost: http://edoc.rki.de/oa/articles/reFy9TM5nUOyg/PDF/25YTZmRlJTyfk.pdf
http://edoc.rki.de/176904/456
https://nbn-resolving.org/urn:nbn:de:0257-1001634
https://doi.org/10.1371/journal.pone.0000435
https://doi.org/10.25646/381

Prion strains depend on different endocytic routes for productive infection.

Autoři: Fehlinger, Andrea Wolf, Hanna Groschup, Martin H a další

Zdroj: Scientific reports 7(1), 6923 (2017). doi:10.1038/s41598-017-07260-2

Témata: info:eu-repo/classification/ddc/600, Animals, Biological Transport, Caveolin 1: metabolism, Cell Line, Cell Membrane: metabolism, Endocytosis, Mice, PrPSc Proteins: metabolism, PrPSc Proteins: pathogenicity, Prion Diseases: metabolism, Cav1 protein, mouse, Caveolin 1, PrPSc Proteins

Geografické téma: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/2045-2322; info:eu-repo/semantics/altIdentifier/pmid/pmid:28761068; https://pub.dzne.de/record/139807

Dostupnost: https://pub.dzne.de/record/139807
https://pub.dzne.de/search?p=id:%22DZNE-2020-06129%22

Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells

Autoři: Stanton, James B Schneider, David A Dinkel, Kelcey D a další

Zdroj: PLoS One
PLoS ONE, Vol 7, Iss 11, p e51173 (2012)

Témata: 0301 basic medicine, Curcumin, PrPSc Proteins, Prions, Cells, Science, Pestivirus - drug effects, Furans - pharmacology, Messenger - genetics, PrPSc Proteins - pathogenicity, Small Molecule Libraries, Small Molecule Libraries - chemistry, 03 medical and health sciences, Microglia - metabolism, Cations, Animals, Scrapie - metabolism, RNA, Messenger, Furans, Small Molecule Libraries - pharmacology, Benzimidazoles - chemistry, Cells, Cultured, Furans - chemistry, Cultured, Sheep, Cell Death, Prions - genetics, Prions - metabolism, Messenger - metabolism, Microglia - drug effects, Cell Death - drug effects, Curcumin - pharmacology, Pestivirus, RNA, Medicine, PrPSc Proteins - antagonists & inhibitors, Benzimidazoles, Microglia, Scrapie - pathology, Benzimidazoles - pharmacology, Research Article, Scrapie

Přístupová URL adresa: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0051173&type=printable
https://pubmed.ncbi.nlm.nih.gov/23226483
https://doaj.org/article/eece9982e5e540a78fb8bf7bf72928a2
https://dx.plos.org/10.1371/journal.pone.0051173
http://ui.adsabs.harvard.edu/abs/2012PLoSO...751173S/abstract
https://www.ncbi.nlm.nih.gov/pubmed/23226483
https://pubmed.ncbi.nlm.nih.gov/23226483/
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051173
http://europepmc.org/articles/PMC3511409

Efficient Transmission and Characterization of Creutzfeldt–Jakob Disease Strains in Bank Voles

Autoři: Nonno, Romolo Di Bari, Michele A Cardone, Franco a další

Zdroj: PLoS Pathog
PLoS Pathogens, Vol 2, Iss 2, p e12 (2006)
Nonno, R, Di Bari, M A, Cardone, F, Vaccari, G, Fazzi, P, Dell'Omo, G, Cartoni, C, Ingrosso, L, Boyle, A, Galeno, R, Sbriccoli, M, Lipp, H-P, Bruce, M, Pocchiari, M & Agrimi, U 2006, ' Efficient transmission and characterization of Creutzfeldt-Jakob disease strains in bank voles ', PLoS Pathogens, vol. 2, no. 2, pp. e12 .

Témata: 0301 basic medicine, PrPSc Proteins, QH301-705.5, Molecular Sequence Data, PrPSc Proteins/pathogenicity, Mice, Transgenic, Creutzfeldt-Jakob Syndrome, Mice, 03 medical and health sciences, Species Specificity, Animals, Humans, Brain/pathology, Amino Acid Sequence, Biology (General), 0303 health sciences, Arvicolinae, Creutzfeldt-Jakob Syndrome/transmission, Brain, RC581-607, 3. Good health, Disease Models, Animal, Disease Susceptibility, Immunologic diseases. Allergy, Creutzfeldt-Jakob Syndrome/pathology, Sequence Alignment, Research Article

Popis souboru: application/pdf

Přístupová URL adresa: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.0020012&type=printable
https://pubmed.ncbi.nlm.nih.gov/16518470
https://doaj.org/article/545a1b1acbf7493ab3bccb4b17b37ca0
https://hdl.handle.net/20.500.11820/188d8b4f-9cf2-4cb5-acbc-60e37d9288d5
https://www.pure.ed.ac.uk/ws/files/13447543/Efficient_transmission_and_characterization_of_Creutzfeldt_Jakob_disease_strains_in_bank_voles.pdf

Letter to the Editor

Autoři: Taylor, D M Fernie, Karen Steele, P J

Zdroj: Taylor, D M, Fernie, K & Steele, P J 1999, ' Infectivity of scrapie prions ', Molecular Medicine, vol. 5, no. 10, pp. 701 .

Témata: 0301 basic medicine, Mice, 0303 health sciences, 03 medical and health sciences, Virulence, ANIMALS, Brain/microbiology, Lethal dose 50, PrPSc Proteins/pathogenicity

Popis souboru: application/pdf

Přístupová URL adresa: https://molmed.biomedcentral.com/track/pdf/10.1007/BF03401989
https://europepmc.org/article/MED/10602779
http://www.research.ed.ac.uk/portal/en/publications/infectivity-of-scrapie-prions(568f0eee-828f-4f90-ad77-8dc9282c73ed).html
https://www.research.ed.ac.uk/portal/en/publications/infectivity-of-scrapie-prions(568f0eee-828f-4f90-ad77-8dc9282c73ed)/export.html
https://www.research.ed.ac.uk/portal/files/13267115/letter_1999_mm.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230477/
http://www.research.ed.ac.uk/portal/files/13267115/letter_1999_mm.pdf
https://www.pure.ed.ac.uk/ws/files/13267115/letter_1999_mm.pdf
https://hdl.handle.net/20.500.11820/568f0eee-828f-4f90-ad77-8dc9282c73ed