Suchergebnisse - "Potassium Channels, Tandem Pore Domain"

Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391).

Autoren: Tanaka M Sekioka Y Hashimoto G et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 23554-23572. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/antagonists & inhibitors , Potassium Channels, Tandem Pore Domain*/metabolism , Alkynes*/chemistry , Alkynes*/pharmacology , Alkynes*/pharmacokinetics , Alkynes*/chemical synthesis , Pyrazoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/pharmacokinetics , Pyrazoles*/chemical synthesis , Piperidines*/pharmacology , Piperidines*/chemistry , Piperidines*/pharmacokinetics , Piperidines*/chemical synthesis , Central Nervous System*/metabolism , Central Nervous System*/drug effects , Potassium Channel Blockers*/pharmacology , Potassium Channel Blockers*/pharmacokinetics , Potassium Channel Blockers*/chemistry, Animals ; Rats ; Structure-Activity Relationship ; Humans ; Male ; Drug Discovery ; Rats, Sprague-Dawley

TREK1 Channels Shape Spindle-Like Oscillations, Neuronal Activity, and Short-Term Synaptic Plasticity in Thalamocortical Circuits.

Autoren: Labbaf A Krauth V Rychlik N et al.

Quelle: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Nov 05; Vol. 45 (45). Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/physiology , Potassium Channels, Tandem Pore Domain*/genetics , Neuronal Plasticity*/physiology , Cerebral Cortex*/physiology , Cerebral Cortex*/cytology , Thalamus*/physiology , Neurons*/physiology, Animals ; Mice ; Male ; Mice, Knockout ; Mice, Inbred C57BL ; Action Potentials/physiology ; GABAergic Neurons/physiology

Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outflow and Intraocular Pressure.

Autoren: Redmon SN Yarishkin O Rudzitis CN et al.

Quelle: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Nov 03; Vol. 66 (14), pp. 57.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/genetics , Potassium Channels, Tandem Pore Domain*/physiology , Potassium Channels, Tandem Pore Domain*/biosynthesis , Potassium Channels, Tandem Pore Domain*/metabolism , Intraocular Pressure*/physiology , Intraocular Pressure*/drug effects , Trabecular Meshwork*/metabolism , Trabecular Meshwork*/drug effects , Glucocorticoids*/pharmacology , Ocular Hypertension*/metabolism , Ocular Hypertension*/chemically induced , Ocular Hypertension*/physiopathology , Aqueous Humor*/metabolism , Gene Expression Regulation*, Animals ; Mice ; Humans ; Dexamethasone/pharmacology ; Rats ; Male ; Mice, Inbred C57BL ; Real-Time Polymerase Chain Reaction ; Tonometry, Ocular ; Cells, Cultured ; Disease Models, Animal ; Rats, Sprague-Dawley ; Immunohistochemistry ; Mechanotransduction, Cellular/physiology ; TRPV Cation Channels/genetics

Estradiol enhances thermoregulation induced by ostruthin, a TREK channel agonist, in ovariectomized rats.

Autoren: Uchida Y Kamijo S Samejima Y et al.

Quelle: The journal of physiological sciences : JPS [J Physiol Sci] 2025 Nov; Vol. 75 (3), pp. 100044. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 101262417 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-6562 (Electronic) Linking ISSN: 18806546 NLM ISO Abbreviation: J Physiol Sci Subsets: MEDLINE

MeSH-Schlagworte: Estradiol*/pharmacology , Potassium Channels, Tandem Pore Domain*/agonists , Potassium Channels, Tandem Pore Domain*/metabolism , Body Temperature Regulation*/drug effects , Body Temperature Regulation*/physiology, Animals ; Female ; Ovariectomy ; Rats ; Rats, Sprague-Dawley ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Triiodothyronine/blood

Voltage-sensing mechanism underlying the gating process of two-pore-domain potassium channels.

Autoren: Ben-Abu Y Mourokh L

Quelle: Physical review. E [Phys Rev E] 2025 Oct; Vol. 112 (4-1), pp. 044402.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Physical Society Country of Publication: United States NLM ID: 101676019 Publication Model: Print Cited Medium: Internet ISSN: 2470-0053 (Electronic) Linking ISSN: 24700045 NLM ISO Abbreviation: Phys Rev E Subsets: MEDLINE

MeSH-Schlagworte: Ion Channel Gating* , Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/chemistry, Models, Biological ; Models, Molecular ; Membrane Potentials

The research progress into cellular mechanosensitive ion channels mediating cancer pain.

Autoren: Liu C Li H Hang L

Quelle: Channels (Austin, Tex.) [Channels (Austin)] 2025 Dec; Vol. 19 (1), pp. 2517109. Date of Electronic Publication: 2025 Jun 14.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101321614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-6969 (Electronic) Linking ISSN: 19336950 NLM ISO Abbreviation: Channels (Austin) Subsets: MEDLINE

MeSH-Schlagworte: Mechanotransduction, Cellular* , Ion Channels*/metabolism , Cancer Pain*/metabolism , Cancer Pain*/drug therapy , Potassium Channels, Tandem Pore Domain*/metabolism , Neoplasms*/metabolism, Humans ; Animals

The HIF1α-PUM1-KCNK3 axis drives pulmonary hypertension by destabilizing KCNK3 mRNA in pulmonary artery smooth muscle cells.

Autoren: Deng X Liu Y Liang Y et al.

Quelle: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2026 Feb; Vol. 1872 (2), pp. 168092. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE

MeSH-Schlagworte: Hypertension, Pulmonary*/metabolism , Hypertension, Pulmonary*/pathology , Hypertension, Pulmonary*/genetics , Pulmonary Artery*/metabolism , Pulmonary Artery*/pathology , Potassium Channels, Tandem Pore Domain*/genetics , Potassium Channels, Tandem Pore Domain*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics , Myocytes, Smooth Muscle*/metabolism , Myocytes, Smooth Muscle*/pathology , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics, Animals ; Humans ; Rats ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Male ; RNA Stability ; Rats, Sprague-Dawley ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Nerve Tissue Proteins

TREK-1 channel blockade mediates the antidepressant-like effects of hydroxynorketamine.

Autoren: Song Y Du W Yu X et al.

Quelle: Neuropharmacology [Neuropharmacology] 2026 Feb 01; Vol. 283, pp. 110751. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/antagonists & inhibitors , Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/genetics , Antidepressive Agents*/pharmacology , Ketamine*/analogs & derivatives , Ketamine*/pharmacology , Depression*/drug therapy , Depression*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Neuronal Plasticity/drug effects ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Stress, Psychological/metabolism ; Stress, Psychological/drug therapy ; Disks Large Homolog 4 Protein/metabolism ; Humans

K2P channels and ultrasound neuromodulation: A mechanosensitive memory perspective.

Autoren: Ben-Abu Y; Physics Unit, Sapir Academic College, Sderot, Hof Ashkelon 79165, Israel; Clarendon Laboratory, Department of Physics, University of Oxford, OX1 3PU, UK. Electronic address: yuvalb@sapir.ac.il.

Quelle: Biophysical chemistry [Biophys Chem] 2026 Jan; Vol. 328, pp. 107530. Date of Electronic Publication: 2025 Sep 22.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 0403171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4200 (Electronic) Linking ISSN: 03014622 NLM ISO Abbreviation: Biophys Chem Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/chemistry , Ultrasonic Waves*, Humans ; Animals

TREK- 1 Ameliorates Secondary Brain Injury by Regulating Inflammatory Microenvironment via CX3 CL1-CX3 CR1 Pathway After Intracerebral Hemorrhage.

Autoren: Fang Y Sadike D Jiang N et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Sep; Vol. 62 (9), pp. 11382-11402. Date of Electronic Publication: 2025 Apr 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Cerebral Hemorrhage*/metabolism , Cerebral Hemorrhage*/complications , Cerebral Hemorrhage*/pathology , Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/deficiency , CX3C Chemokine Receptor 1*/metabolism , Signal Transduction* , Chemokine CX3CL1*/metabolism , Brain Injuries*/metabolism , Brain Injuries*/pathology , Inflammation*/pathology , Inflammation*/metabolism, Animals ; Mice, Inbred C57BL ; Male ; Mice ; Mice, Knockout ; Microglia/metabolism ; Microglia/pathology ; Neuroinflammatory Diseases/metabolism ; Neuroinflammatory Diseases/pathology

Exploring Esketamine's Therapeutic Role for Perinatal Depression via TASK-1 Tandem Pore Potassium Channels.

Autoren: Zhu L Chen J Liu Y et al.

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Aug 20; Vol. 16 (16), pp. 3225-3238. Date of Electronic Publication: 2025 Jul 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Ketamine*/pharmacology , Ketamine*/therapeutic use , Antidepressive Agents*/pharmacology , Antidepressive Agents*/therapeutic use , Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/drug effects , Depression*/drug therapy , Depression*/metabolism , Nerve Tissue Proteins*/metabolism, Female ; Animals ; Pregnancy ; Humans ; Mice ; Adult

Atomistic mechanism of noncanonical voltage gating in K 2P channels.

Autoren: Aldakul YK Schewe M Coll-Diez C et al.

Quelle: Science advances [Sci Adv] 2025 Aug 08; Vol. 11 (32), pp. eadx1680. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH-Schlagworte: Ion Channel Gating* , Potassium Channels, Tandem Pore Domain*/chemistry , Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/genetics, Molecular Dynamics Simulation ; Potassium/metabolism ; Humans ; Binding Sites ; Patch-Clamp Techniques

The potassium channel K 2P 2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling.

Autoren: Lichtenberg S Vinnenberg L Steffen F et al.

Quelle: Nature communications [Nat Commun] 2025 Jul 18; Vol. 16 (1), pp. 6622. Date of Electronic Publication: 2025 Jul 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Endothelial Cells*/metabolism , Endothelial Cells*/cytology , Actins*/metabolism , Brain*/cytology , Brain*/metabolism , Brain*/blood supply , Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/genetics, Animals ; Mice ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Mice, Knockout ; Cell Adhesion ; Actin-Related Protein 2-3 Complex/metabolism ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/cytology ; Cofilin 1/metabolism ; Leukocytes/metabolism ; Cell Movement ; Actin Cytoskeleton/metabolism ; Mice, Inbred C57BL

Thermosensitivity of TREK K2P channels is controlled by a PKA switch and depends on the microtubular network.

Autoren: Cordeiro S Musinszki M

Quelle: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2025 Jul; Vol. 477 (7), pp. 953-966. Date of Electronic Publication: 2025 May 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 0154720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2013 (Electronic) Linking ISSN: 00316768 NLM ISO Abbreviation: Pflugers Arch Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/genetics , Cyclic AMP-Dependent Protein Kinases*/metabolism , Microtubules*/metabolism , Thermosensing*/physiology, Animals ; Humans ; HEK293 Cells ; Temperature ; Phosphorylation

The two-pore K ⁺ channel TREK-1 regulates pressure overload-induced cardiac remodeling.

Autoren: Johnson CML Nassal DM Winkle AJ et al.

Quelle: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2025 Jul 01; Vol. 329 (1), pp. H178-H190. Date of Electronic Publication: 2025 May 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/genetics , Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/deficiency , Ventricular Remodeling* , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology , Heart Failure*/physiopathology , Heart Failure*/metabolism , Heart Failure*/genetics , Heart Failure*/pathology , Ventricular Function, Left* , Hypertrophy, Left Ventricular*/physiopathology , Hypertrophy, Left Ventricular*/metabolism , Hypertrophy, Left Ventricular*/genetics , Hypertrophy, Left Ventricular*/pathology, Animals ; Mice, Knockout ; STAT3 Transcription Factor/metabolism ; Male ; Disease Models, Animal ; Mice ; Myocardial Contraction ; Action Potentials ; Mice, Inbred C57BL ; Phosphorylation

Cryo-EM structure of the human THIK-1 K2P K ⁺ channel reveals a lower Y gate regulated by lipids and anesthetics.

Autoren: Rödström KEJ Eymsh B Proks P et al.

Quelle: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Jul; Vol. 32 (7), pp. 1167-1174. Date of Electronic Publication: 2025 Feb 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/chemistry , Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/ultrastructure , Potassium Channels, Tandem Pore Domain*/genetics , Anesthetics*/pharmacology, Humans ; Cryoelectron Microscopy ; Halothane/pharmacology ; Halothane/chemistry ; Models, Molecular ; Binding Sites ; Ion Channel Gating/drug effects ; Protein Conformation

Increasing Temperature Activates TREK Potassium Currents in Vagal Afferent Neurons from the Nodose Ganglion.

Autoren: Rueda-Ruzafa L Campos-Ríos A Rivas-Ramírez P et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Sep 18; Vol. 26 (18). Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/metabolism , Nodose Ganglion*/metabolism , Nodose Ganglion*/cytology , Nodose Ganglion*/physiology , Neurons, Afferent*/metabolism , Neurons, Afferent*/physiology , Vagus Nerve*/metabolism , Vagus Nerve*/physiology, Animals ; Membrane Potentials ; Temperature ; Patch-Clamp Techniques ; Mice ; Male

TREK-1 and epilepsy: regulating the balance of K ⁺ and the glutamate release in astrocyte-neuron interactions.

Autoren: Yang J Li L Xu Y et al.

Quelle: Behavioral and brain functions : BBF [Behav Brain Funct] 2025 Aug 31; Vol. 21 (1), pp. 27. Date of Electronic Publication: 2025 Aug 31.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101245751 Publication Model: Electronic Cited Medium: Internet ISSN: 1744-9081 (Electronic) Linking ISSN: 17449081 NLM ISO Abbreviation: Behav Brain Funct Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/metabolism , Astrocytes*/metabolism , Epilepsy*/metabolism , Epilepsy*/physiopathology , Glutamic Acid*/metabolism , Neurons*/metabolism , Potassium*/metabolism, Humans ; Animals

The "TASK" of Breathing: Anesthetic Relevance of Background Two-Pore Domain Potassium Channels as Therapeutic Targets for Respiratory Control.

Autoren: Lin AY Turnbull CD Pandit JJ

Quelle: Anesthesia and analgesia [Anesth Analg] 2025 Jun 01; Vol. 140 (6), pp. 1414-1425. Date of Electronic Publication: 2025 Feb 13.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1310650 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-7598 (Electronic) Linking ISSN: 00032999 NLM ISO Abbreviation: Anesth Analg Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/drug effects , Potassium Channels, Tandem Pore Domain*/metabolism , Anesthetics*/adverse effects , Anesthetics*/pharmacology , Respiration*/drug effects, Humans ; Animals

LPS2336, a New TREK-1 Channel Activator Identified by High Throughput Screening.

Autoren: Boyer R Bony R Maugis M et al.

Quelle: Biomolecules [Biomolecules] 2025 May 20; Vol. 15 (5). Date of Electronic Publication: 2025 May 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

MeSH-Schlagworte: Potassium Channels, Tandem Pore Domain*/metabolism , Potassium Channels, Tandem Pore Domain*/agonists , Potassium Channels, Tandem Pore Domain*/genetics , High-Throughput Screening Assays* , Analgesics*/pharmacology , Analgesics*/chemistry, Animals ; Mice ; Humans ; Male ; Mice, Knockout ; Pain/drug therapy ; Small Molecule Libraries/pharmacology