Výsledky vyhledávání - "Post-Synaptic Density"

IQSEC2/BRAG1 may modulate postsynaptic density assembly through Ca2+-induced phase separation.

Autoři: Bai G Huang R Nan X a další

Zdroj: The Journal of cell biology [J Cell Biol] 2025 Dec 01; Vol. 224 (12). Date of Electronic Publication: 2025 Oct 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Calcium*/metabolism , Post-Synaptic Density*/metabolism , Guanine Nucleotide Exchange Factors*/metabolism , Guanine Nucleotide Exchange Factors*/genetics , Guanine Nucleotide Exchange Factors*/chemistry, Animals ; Mice ; Synaptic Transmission ; Hippocampus/metabolism ; Humans ; Neuronal Plasticity ; Neurons/metabolism ; Mice, Inbred C57BL ; Synapses/metabolism ; Phase Separation

Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity.

Autoři: Jia B Shen Z Zhu S a další

Zdroj: Cell [Cell] 2025 Nov 13; Vol. 188 (23), pp. 6473-6491.e21. Date of Electronic Publication: 2025 Aug 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

Výrazy ze slovníku MeSH: Neuronal Plasticity* , Nerve Tissue Proteins*/metabolism , Nerve Tissue Proteins*/chemistry , Nerve Tissue Proteins*/genetics , Post-Synaptic Density*/metabolism, Animals ; Mice ; Humans ; Synaptic Transmission ; Autistic Disorder/metabolism ; Autistic Disorder/genetics ; Neurons/metabolism ; Synapses/metabolism ; Mutation ; Chromosome Deletion ; Chromosomes, Human, Pair 22 ; Microfilament Proteins ; Chromosome Disorders

SCR Disease Name: Telomeric 22q13 Monosomy Syndrome

Synaptic PSD-95 biology: from localization and interactors to N-terminus function.

Autoři: Alkaas A Kurup P Kanuru S a další

Zdroj: Journal of neurophysiology [J Neurophysiol] 2025 Nov 01; Vol. 134 (5), pp. 1588-1606. Date of Electronic Publication: 2025 Sep 30.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Disks Large Homolog 4 Protein*/metabolism , Synapses*/metabolism , Synapses*/physiology , Neuronal Plasticity*/physiology , Post-Synaptic Density*/metabolism, Animals ; Humans ; Protein Processing, Post-Translational

Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume.

Autoři: Yamada R Brandani GB Takada S

Zdroj: ELife [Elife] 2025 Sep 23; Vol. 14. Date of Electronic Publication: 2025 Sep 23.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Výrazy ze slovníku MeSH: Post-Synaptic Density*/metabolism , Post-Synaptic Density*/chemistry , Cell Membrane*/metabolism , Cell Membrane*/chemistry, Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, N-Methyl-D-Aspartate/chemistry ; Receptors, AMPA/metabolism ; Receptors, AMPA/chemistry ; Disks Large Homolog 4 Protein/metabolism ; Animals

Omega-3 fatty acid normalizes postsynaptic density related miRNAs and proteins in hippocampus and prevents DEHP-induced impairment of learning and memory in mice.

Autoři: Ding M Ma H Du H a další

Zdroj: PloS one [PLoS One] 2025 Jul 03; Vol. 20 (7), pp. e0313233. Date of Electronic Publication: 2025 Jul 03 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Výrazy ze slovníku MeSH: MicroRNAs*/metabolism , MicroRNAs*/genetics , Hippocampus*/drug effects , Hippocampus*/metabolism , Fatty Acids, Omega-3*/pharmacology , Diethylhexyl Phthalate*/toxicity , Post-Synaptic Density*/metabolism , Post-Synaptic Density*/drug effects , Memory*/drug effects , Learning*/drug effects , Memory Disorders*/chemically induced , Memory Disorders*/prevention & control, Animals ; Mice ; Male ; Receptors, N-Methyl-D-Aspartate/metabolism ; Neuroprotective Agents/pharmacology ; Homer Scaffolding Proteins/metabolism

The adaptor protein SKT interacts with PSD-95 and SHANK3 and affects synaptic functions.

Autoři: Morellato A De Gregorio M Angelini C a další

Zdroj: Cell reports [Cell Rep] 2025 Sep 23; Vol. 44 (9), pp. 116206. Date of Electronic Publication: 2025 Sep 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Disks Large Homolog 4 Protein*/metabolism , Nerve Tissue Proteins*/metabolism , Nerve Tissue Proteins*/genetics , Synapses*/metabolism , Post-Synaptic Density*/metabolism , Membrane Proteins*/metabolism , Adaptor Proteins, Signal Transducing*/metabolism, Animals ; Mice, Knockout ; Mice ; Dendritic Spines/metabolism ; Humans ; Protein Binding ; Neurons/metabolism ; rhoA GTP-Binding Protein/metabolism ; Microfilament Proteins

Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities.

Autoři: Macha A Liebsch F Bruckisch EHW a další

Zdroj: Nature communications [Nat Commun] 2025 Sep 16; Vol. 16 (1), pp. 8293. Date of Electronic Publication: 2025 Sep 16.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Membrane Proteins*/chemistry , Membrane Proteins*/ultrastructure , Carrier Proteins*/metabolism , Carrier Proteins*/genetics , Carrier Proteins*/chemistry , Carrier Proteins*/ultrastructure , Post-Synaptic Density*/metabolism, Animals ; Humans ; Hippocampus/metabolism ; Hippocampus/cytology ; Cryoelectron Microscopy ; Neurons/metabolism ; Protein Multimerization ; Rats ; Protein Domains ; Mice

Modulating synaptic glutamate receptors by targeting network nodes of the postsynaptic density condensate.

Autoři: Jia B Zhu S Shen Z a další

Zdroj: Molecular cell [Mol Cell] 2025 Aug 21; Vol. 85 (16), pp. 3166-3183.e10. Date of Electronic Publication: 2025 Aug 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Výrazy ze slovníku MeSH: Post-Synaptic Density*/metabolism , Receptors, AMPA*/metabolism , Receptors, AMPA*/genetics , Neurons*/metabolism, Animals ; Neuronal Plasticity ; Rats ; Humans ; Synapses/metabolism ; Synaptic Transmission ; Hippocampus/metabolism ; Hippocampus/cytology

The postsynaptic density in excitatory synapses is composed of clustered, heterogeneous nanoblocks.

Autoři: Sun R Allen JP Mao Z a další

Zdroj: The Journal of cell biology [J Cell Biol] 2025 Jun 02; Vol. 224 (6). Date of Electronic Publication: 2025 Mar 27.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Post-Synaptic Density*/ultrastructure , Post-Synaptic Density*/metabolism , Neurons*/ultrastructure , Neurons*/metabolism , Synapses*/ultrastructure , Synapses*/metabolism, Animals ; Synaptosomes/ultrastructure ; Synaptosomes/metabolism ; Cryoelectron Microscopy ; Rats ; Synaptic Transmission ; Electron Microscope Tomography ; Cells, Cultured

Tubulin and GTP Are Crucial Elements for Postsynaptic Density Construction and Aggregation.

Autoři: Suzuki T Fujii T Kametani K a další

Zdroj: Journal of neurochemistry [J Neurochem] 2025 May; Vol. 169 (5), pp. e70085.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Tubulin*/metabolism , Tubulin*/physiology , Post-Synaptic Density*/metabolism , Post-Synaptic Density*/ultrastructure , Guanosine Triphosphate*/metabolism, Animals ; Microtubules/metabolism ; Microtubules/ultrastructure ; Rats ; Hippocampus/ultrastructure ; Hippocampus/metabolism ; Cells, Cultured

Sonication dissociates the synaptic cleft and allows purification of postsynaptic densities with associated postsynaptic membrane.

Autoři: Dosemeci A Tao-Cheng JH

Zdroj: Molecular brain [Mol Brain] 2025 May 30; Vol. 18 (1), pp. 47. Date of Electronic Publication: 2025 May 30.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101468876 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-6606 (Electronic) Linking ISSN: 17566606 NLM ISO Abbreviation: Mol Brain Subsets: MEDLINE

Výrazy ze slovníku MeSH: Post-Synaptic Density*/metabolism , Sonication*/methods , Synaptic Membranes*/metabolism, Animals ; Rats

Biochemical Properties of Synaptic Proteins Are Dependent on Tissue Preparation: NMDA Receptor Solubility Is Regulated by the C-Terminal Tail.

Autoři: Won S Sweeney CL Roche KW

Zdroj: Journal of cellular biochemistry [J Cell Biochem] 2025 Jan; Vol. 126 (1), pp. e30664. Date of Electronic Publication: 2024 Oct 06.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8205768 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4644 (Electronic) Linking ISSN: 07302312 NLM ISO Abbreviation: J Cell Biochem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, N-Methyl-D-Aspartate*/metabolism , Receptors, N-Methyl-D-Aspartate*/chemistry , Neurons*/metabolism , Neurons*/cytology , Disks Large Homolog 4 Protein*/metabolism , Disks Large Homolog 4 Protein*/chemistry , Synapses*/metabolism , Post-Synaptic Density*/metabolism , Nerve Tissue Proteins*/metabolism , Nerve Tissue Proteins*/chemistry, Humans ; Solubility ; Animals ; Rats ; Prosencephalon/metabolism ; Prosencephalon/cytology ; Cells, Cultured ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/cytology

The molecular infrastructure of glutamatergic synapses in the mammalian forebrain.

Autoři: Peukes J Lovatt C Leistner C a další

Zdroj: ELife [Elife] 2025 Sep 25; Vol. 13. Date of Electronic Publication: 2025 Sep 25.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Výrazy ze slovníku MeSH: Prosencephalon*/ultrastructure , Prosencephalon*/metabolism , Synapses*/ultrastructure , Synapses*/metabolism , Glutamic Acid*/metabolism, Animals ; Mice ; Electron Microscope Tomography ; Cryoelectron Microscopy ; Post-Synaptic Density/ultrastructure ; Post-Synaptic Density/metabolism ; Imaging, Three-Dimensional

The Beta Amyloid Core Hexapeptide Protects against Full-Length Beta Amyloid-Induced Alteration of Dendritic Spine Morphology and Density.

Autoři: Shontell RM Araki D Ormsbee KM a další

Zdroj: ENeuro [eNeuro] 2025 Sep 10; Vol. 12 (9). Date of Electronic Publication: 2025 Sep 10 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/drug effects , Dendritic Spines*/pathology , Amyloid beta-Peptides*/toxicity , Amyloid beta-Peptides*/metabolism , Oligopeptides*/pharmacology , Peptide Fragments*/pharmacology , Neurons*/drug effects , Neurons*/pathology , Neuroprotective Agents*/pharmacology, Animals ; Hippocampus/drug effects ; Hippocampus/pathology ; Hippocampus/cytology ; Male ; Female ; Mice, Inbred C57BL ; Cells, Cultured ; Mice ; Post-Synaptic Density/drug effects ; Post-Synaptic Density/pathology

Development of Peptide-Based Probes for Molecular Imaging of the Postsynaptic Density in the Brain.

Autoři: Fernandes EFA Palner M Raval NR a další

Zdroj: Journal of medicinal chemistry [J Med Chem] 2024 Jul 25; Vol. 67 (14), pp. 11975-11988. Date of Electronic Publication: 2024 Jul 09.

Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't

Informace o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Disks Large Homolog 4 Protein*/metabolism , Brain*/metabolism , Brain*/diagnostic imaging , Post-Synaptic Density*/metabolism, Animals ; Humans ; Rats ; Molecular Imaging/methods ; Fluorine Radioisotopes/chemistry ; Parkinson Disease/metabolism ; Parkinson Disease/diagnostic imaging ; Peptides/chemistry ; Peptides/metabolism ; Molecular Probes/chemistry ; Male ; Autoradiography ; Rats, Sprague-Dawley ; Tritium ; Pyridines ; Pyrrolidinones

BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing.

Autoři: Carlton AJ Jeng JY Grandi FC a další

Zdroj: Cell reports [Cell Rep] 2024 Apr 23; Vol. 43 (4), pp. 114025. Date of Electronic Publication: 2024 Apr 01.

Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, AMPA*/metabolism , Spiral Ganglion*/metabolism , Hearing*/physiology , Cochlea*/metabolism , Post-Synaptic Density*/metabolism , Receptors, G-Protein-Coupled*, Animals ; Mice ; Mice, Knockout ; Hair Cells, Auditory, Inner/metabolism ; Mice, Inbred C57BL ; Synapses/metabolism

Trans-synaptic molecular context of NMDA receptor nanodomains.

Autoři: Anderson MC Dharmasri PA Damenti M a další

Zdroj: Nature communications [Nat Commun] 2025 Aug 12; Vol. 16 (1), pp. 7460. Date of Electronic Publication: 2025 Aug 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, N-Methyl-D-Aspartate*/metabolism , Receptors, N-Methyl-D-Aspartate*/chemistry , Receptors, N-Methyl-D-Aspartate*/genetics , Synapses*/metabolism, Animals ; Rats ; Hippocampus/metabolism ; Hippocampus/cytology ; Neurons/metabolism ; Synaptic Transmission/physiology ; Disks Large Homolog 4 Protein/metabolism ; Post-Synaptic Density/metabolism ; Rats, Sprague-Dawley

Demixing is a default process for biological condensates formed via phase separation.

Autoři: Zhu S Shen Z Wu X a další

Zdroj: Science (New York, N.Y.) [Science] 2024 May 24; Vol. 384 (6698), pp. 920-928. Date of Electronic Publication: 2024 May 23.

Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't

Informace o časopise: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Výrazy ze slovníku MeSH: Biomolecular Condensates*/chemistry , Biomolecular Condensates*/metabolism , Phase Separation* , Post-Synaptic Density*/metabolism, Humans ; Disks Large Homolog 4 Protein/metabolism ; Membrane Proteins/metabolism ; Membrane Proteins/chemistry ; HeLa Cells

Phosphorylation-dependent membraneless organelle fusion and fission illustrated by postsynaptic density assemblies.

Autoři: Wu H Chen X Shen Z a další

Zdroj: Molecular cell [Mol Cell] 2024 Jan 18; Vol. 84 (2), pp. 309-326.e7. Date of Electronic Publication: 2023 Dec 13.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Výrazy ze slovníku MeSH: Biomolecular Condensates* , Post-Synaptic Density*/metabolism, Animals ; Phosphorylation ; Cell Physiological Phenomena ; Protein Binding ; Organelles/metabolism ; Mammals

Simple Method for the Preparation of Postsynaptic Density Fraction from Mouse Brain.

Autoři: Ito H Morishita R Nagata KI

Zdroj: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2794, pp. 71-78.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Post-Synaptic Density* , Synaptic Membranes*, Animals ; Mice ; Brain ; Cytoskeletal Proteins ; Laboratories