Výsledky vyhledávání - "Polycyclic Compounds"

Cost-effectiveness of trastuzumab deruxtecan as a second-line treatment for HER2-mutant advanced non-small cell lung cancer.

Autoři: Cai Q You S Huang J a další

Zdroj: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2468070. Date of Electronic Publication: 2025 Feb 24.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

Výrazy ze slovníku MeSH: Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/economics , Cost-Benefit Analysis* , Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/economics , Receptor, ErbB-2*/genetics , Trastuzumab*/economics , Trastuzumab*/therapeutic use , Antineoplastic Agents, Immunological*/economics , Antineoplastic Agents, Immunological*/therapeutic use , Polycyclic Compounds*/economics , Polycyclic Compounds*/therapeutic use, Humans ; China ; Docetaxel/economics ; Docetaxel/therapeutic use ; Quality-Adjusted Life Years ; United States ; Nivolumab/economics ; Nivolumab/therapeutic use ; Markov Chains ; Female ; Acrylamides/economics ; Mutation ; Aminoquinolines ; Camptothecin/analogs & derivatives ; Immunoconjugates

Mechanistic insights into Schisandrin C as the active anti-renal fibrosis ingredient of Schisandra chinensis: a network pharmacology analysis and transcriptomics integrated experimental verification.

Autoři: Yang X Qiaolongbatu X Shen R a další

Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Dec; Vol. 398 (12), pp. 17503-17523. Date of Electronic Publication: 2025 Jun 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Schisandra*/chemistry , Lignans*/pharmacology , Lignans*/therapeutic use , Polycyclic Compounds*/pharmacology , Polycyclic Compounds*/therapeutic use , Kidney*/drug effects , Kidney*/pathology , Kidney*/metabolism , Kidney Diseases*/drug therapy , Kidney Diseases*/pathology , Kidney Diseases*/genetics , Antifibrotic Agents*/pharmacology, Animals ; Zebrafish ; Fibrosis ; Network Pharmacology ; Cyclooctanes/pharmacology ; Cyclooctanes/therapeutic use ; Transcriptome/drug effects ; Humans ; Molecular Docking Simulation ; Signal Transduction/drug effects ; Disease Models, Animal

Overlooked environmental risks of type 2 diabetes: Evidence from a case-control study on the roles of dechlorane plus (DPs) and novel brominated flame retardants (NBFRs).

Autoři: Zheng J Chen Y Sun J a další

Zdroj: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Nov 15; Vol. 307, pp. 119468. Date of Electronic Publication: 2025 Nov 26.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

Výrazy ze slovníku MeSH: Flame Retardants*/toxicity , Flame Retardants*/adverse effects , Diabetes Mellitus, Type 2*/epidemiology , Diabetes Mellitus, Type 2*/chemically induced , Diabetes Mellitus, Type 2*/blood , Hydrocarbons, Chlorinated*/blood , Hydrocarbons, Chlorinated*/toxicity , Polycyclic Compounds*/blood , Polycyclic Compounds*/toxicity , Environmental Exposure* , Environmental Pollutants*/blood , Environmental Pollutants*/toxicity, Humans ; Case-Control Studies ; Male ; Female ; Middle Aged ; Aged ; Molecular Docking Simulation ; Adult ; China/epidemiology

Schisandrin B combined with vitamin D inhibits NLRP3 inflammasome to improve cognitive dysfunction and Alzheimer's disease.

Autoři: Wang Y Deng L Wang L a další

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 15; Vol. 1007, pp. 178268. Date of Electronic Publication: 2025 Oct 17.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/antagonists & inhibitors , Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Alzheimer Disease*/psychology , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/metabolism , Cognitive Dysfunction*/psychology , Inflammasomes*/metabolism , Inflammasomes*/antagonists & inhibitors , Polycyclic Compounds*/pharmacology , Polycyclic Compounds*/therapeutic use , Vitamin D*/pharmacology , Vitamin D*/therapeutic use , Lignans*/pharmacology , Lignans*/therapeutic use, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Hippocampus/drug effects ; Hippocampus/metabolism ; Cyclooctanes/pharmacology ; Cognition/drug effects ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Behavior, Animal/drug effects

Schizandrin ameliorates post-traumatic stress disorder-like behaviors via 5-HT 1A receptor in mice.

Autoři: Kim MS Son SR Han JE a další

Zdroj: Journal of psychiatric research [J Psychiatr Res] 2025 Nov; Vol. 191, pp. 578-589. Date of Electronic Publication: 2025 Oct 04.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Lignans*/pharmacology , Lignans*/administration & dosage , Stress Disorders, Post-Traumatic*/drug therapy , Stress Disorders, Post-Traumatic*/metabolism , Polycyclic Compounds*/pharmacology , Polycyclic Compounds*/administration & dosage , Cyclooctanes*/pharmacology , Cyclooctanes*/administration & dosage , Receptor, Serotonin, 5-HT1A*/metabolism , Receptor, Serotonin, 5-HT1A*/drug effects , Behavior, Animal*/drug effects , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/etiology, Animals ; Mice ; Disease Models, Animal ; Male ; Molecular Docking Simulation ; Depression/drug therapy ; Depression/etiology ; Anxiety/drug therapy ; Anxiety/etiology ; Mice, Inbred C57BL

Schisandrin-loaded β-cyclodextrin nanoparticles for atherosclerosis therapy.

Autoři: Huang Q Liu X Yu J a další

Zdroj: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2025 Nov; Vol. 70, pp. 102866. Date of Electronic Publication: 2025 Oct 10.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 101233142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-9642 (Electronic) Linking ISSN: 15499634 NLM ISO Abbreviation: Nanomedicine Subsets: MEDLINE

Výrazy ze slovníku MeSH: beta-Cyclodextrins*/chemistry , Atherosclerosis*/drug therapy , Atherosclerosis*/pathology , Atherosclerosis*/metabolism , Nanoparticles*/chemistry , Lignans*/chemistry , Lignans*/pharmacology , Lignans*/therapeutic use , Lignans*/administration & dosage , Polycyclic Compounds*/chemistry , Polycyclic Compounds*/pharmacology , Polycyclic Compounds*/therapeutic use , Polycyclic Compounds*/administration & dosage , Cyclooctanes*/chemistry , Cyclooctanes*/pharmacology , Cyclooctanes*/therapeutic use , Cyclooctanes*/administration & dosage, Animals ; Mice ; Oxidative Stress/drug effects ; Male ; Mice, Inbred C57BL ; Plaque, Atherosclerotic/drug therapy ; Plaque, Atherosclerotic/pathology ; Diet, High-Fat/adverse effects

Polycyclic musks in water, seafood, and agricultural food products: Recent updates on pretreatment and analytical methods.

Autoři: Chang QZ Zhang Y Jin YT a další

Zdroj: Journal of chromatography. A [J Chromatogr A] 2025 Oct 11; Vol. 1760, pp. 466291. Date of Electronic Publication: 2025 Aug 12.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE

Výrazy ze slovníku MeSH: Seafood*/analysis , Water Pollutants, Chemical*/analysis , Water Pollutants, Chemical*/isolation & purification , Polycyclic Compounds*/analysis , Polycyclic Compounds*/isolation & purification , Food Contamination*/analysis , Food Analysis*/methods, Solid Phase Extraction/methods ; Chromatography, Gas/methods

Late-Stage Sequential Functionalization of Arenes and Drug Molecules to Access Biaryls and Azahelicenes.

Autoři: Li L Zhou X Zhang H a další

Zdroj: The Journal of organic chemistry [J Org Chem] 2025 Oct 03; Vol. 90 (39), pp. 13927-13937. Date of Electronic Publication: 2025 Sep 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Biological Products*/chemistry , Biological Products*/chemical synthesis , Polycyclic Compounds*/chemistry , Polycyclic Compounds*/chemical synthesis , Aza Compounds*/chemistry , Aza Compounds*/chemical synthesis, Molecular Structure ; Catalysis ; Pharmaceutical Preparations/chemistry

[7]Helicene-backboned quaternary ammonium salts: synthesis, photophysical investigation, and lysosomal tracking.

Autoři: Deepshikha Bisht SS Lal N a další

Zdroj: Journal of materials chemistry. B [J Mater Chem B] 2025 Oct 01; Vol. 13 (38), pp. 12146-12153. Date of Electronic Publication: 2025 Oct 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE

Výrazy ze slovníku MeSH: Lysosomes*/chemistry , Lysosomes*/metabolism , Quaternary Ammonium Compounds*/chemistry , Quaternary Ammonium Compounds*/chemical synthesis , Polycyclic Compounds*/chemistry , Polycyclic Compounds*/chemical synthesis, Animals ; Mice ; Salts/chemistry ; Salts/chemical synthesis ; Molecular Structure ; RAW 264.7 Cells

Insights Into Anticancer Mechanisms of Schisandrin B: Isolation, Pharmacokinetics, and Preclinical Evidence.

Autoři: Yadav E Yadav PK

Zdroj: Chemistry & biodiversity [Chem Biodivers] 2025 Oct; Vol. 22 (10), pp. e00424. Date of Electronic Publication: 2025 Jun 07.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Výrazy ze slovníku MeSH: Lignans*/isolation & purification , Lignans*/pharmacology , Lignans*/chemistry , Lignans*/pharmacokinetics , Polycyclic Compounds*/isolation & purification , Polycyclic Compounds*/pharmacology , Polycyclic Compounds*/chemistry , Polycyclic Compounds*/pharmacokinetics , Cyclooctanes*/isolation & purification , Cyclooctanes*/pharmacology , Cyclooctanes*/chemistry , Cyclooctanes*/pharmacokinetics , Antineoplastic Agents, Phytogenic*/isolation & purification , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacokinetics , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/metabolism, Humans ; Cell Proliferation/drug effects ; Signal Transduction/drug effects ; Animals ; Schisandra/chemistry ; Schisandra/metabolism ; Apoptosis/drug effects

Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.

Autoři: Tang Z Guo C Wen N a další

Zdroj: Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2025 Nov 27; Vol. 30 (11), pp. 46410.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: IMR Press Country of Publication: Singapore NLM ID: 101612996 Publication Model: Print Cited Medium: Internet ISSN: 2768-6698 (Electronic) Linking ISSN: 27686698 NLM ISO Abbreviation: Front Biosci (Landmark Ed) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Apoptosis*/drug effects , Lignans*/pharmacology , Polycyclic Compounds*/pharmacology , Temozolomide*/pharmacology , Glioma*/pathology , Glioma*/metabolism , Glioma*/drug therapy , Mitochondria*/drug effects , Mitochondria*/metabolism, Humans ; Cell Line, Tumor ; Cyclooctanes/pharmacology ; Cell Survival/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Oxidative Stress/drug effects ; Drug Synergism

Legacy Dechlorane Plus in remediated electronic waste dismantling areas in East China: Multi-matrix exposure and isomer-specific bioaccumulation.

Autoři: Chen Q Guo C Jiang J a další

Zdroj: The Science of the total environment [Sci Total Environ] 2025 Nov 10; Vol. 1003, pp. 180712. Date of Electronic Publication: 2025 Oct 15.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE

Výrazy ze slovníku MeSH: Electronic Waste*/analysis , Hydrocarbons, Chlorinated*/analysis , Polycyclic Compounds*/analysis , Environmental Monitoring* , Environmental Exposure*/statistics & numerical data , Environmental Exposure*/analysis , Air Pollutants*/analysis, China ; Humans ; Isomerism

Lefamulin harbors promising anti-tuberculosis activity against multidrug-resistant Mycobacterium tuberculosis isolates.

Autoři: Wu J Ji Y Zhang W a další

Zdroj: Microbiology spectrum [Microbiol Spectr] 2025 Nov 04; Vol. 13 (11), pp. e0225025. Date of Electronic Publication: 2025 Oct 08.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE

Výrazy ze slovníku MeSH: Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/isolation & purification , Antitubercular Agents*/pharmacology , Tuberculosis, Multidrug-Resistant*/microbiology , Tuberculosis, Multidrug-Resistant*/drug therapy , Polycyclic Compounds*/pharmacology, Microbial Sensitivity Tests ; Humans ; Drug Resistance, Multiple, Bacterial ; Drug Synergism ; Animals ; Diterpenes ; Thioglycolates

Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway.

Autoři: Zhu W Chen Y Wu X a další

Zdroj: Molecular medicine reports [Mol Med Rep] 2026 Jan; Vol. 33 (1). Date of Electronic Publication: 2025 Nov 07.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Ferroptosis*/drug effects , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/genetics , Lignans*/pharmacology , Lung Neoplasms*/metabolism , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Signal Transduction*/drug effects , Cyclooctanes*/pharmacology , Polycyclic Compounds*/pharmacology , Receptors, Transferrin*/metabolism , Receptors, Transferrin*/genetics , Coenzyme A Ligases*/metabolism , Coenzyme A Ligases*/genetics , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics, Humans ; Animals ; Mice ; Cell Line, Tumor ; YAP-Signaling Proteins ; A549 Cells ; Mice, Nude ; Xenograft Model Antitumor Assays ; Gene Expression Regulation, Neoplastic/drug effects ; Cell Survival/drug effects

A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor.

Autoři: Oken AC Turcu AL Tzortzini E a další

Zdroj: Nature communications [Nat Commun] 2025 Sep 15; Vol. 16 (1), pp. 8283. Date of Electronic Publication: 2025 Sep 15.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, Purinergic P2X7*/metabolism , Receptors, Purinergic P2X7*/chemistry , Receptors, Purinergic P2X7*/genetics , Receptors, Purinergic P2X7*/ultrastructure , Purinergic P2X Receptor Antagonists*/pharmacology , Purinergic P2X Receptor Antagonists*/chemistry , Drug Design* , Polycyclic Compounds*/chemistry , Polycyclic Compounds*/pharmacology, Humans ; Cryoelectron Microscopy ; Molecular Dynamics Simulation ; Adenosine Triphosphate/metabolism ; Ligands ; Adamantane/chemistry ; Adamantane/pharmacology ; HEK293 Cells

Cycloparaphenylene-Helicene Conjugates with Donor-Acceptor Structure for Bioimaging.

Autoři: Ge C Wang M Tian X a další

Zdroj: Chemistry, an Asian journal [Chem Asian J] 2025 Sep; Vol. 20 (17), pp. e00655. Date of Electronic Publication: 2025 Jun 05.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101294643 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1861-471X (Electronic) Linking ISSN: 1861471X NLM ISO Abbreviation: Chem Asian J Subsets: MEDLINE

Výrazy ze slovníku MeSH: Polycyclic Compounds*/chemistry , Polycyclic Compounds*/chemical synthesis, Humans ; A549 Cells ; Molecular Structure ; Cell Survival/drug effects ; Optical Imaging ; Nanoparticles/chemistry

Schisandrin A induces osteoblast differentiation to treat glucocorticoid-induced osteoporosis through activating Wnt pathway.

Autoři: Ai Y Xie X Guo Y a další

Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Aug 30; Vol. 776, pp. 152230. Date of Electronic Publication: 2025 Jun 18.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Osteoblasts*/drug effects , Osteoblasts*/metabolism , Osteoblasts*/cytology , Osteoblasts*/pathology , Wnt Signaling Pathway*/drug effects , Lignans*/pharmacology , Lignans*/therapeutic use , Osteoporosis*/drug therapy , Osteoporosis*/chemically induced , Osteoporosis*/metabolism , Osteoporosis*/pathology , Cell Differentiation*/drug effects , Polycyclic Compounds*/pharmacology , Polycyclic Compounds*/therapeutic use , Glucocorticoids*/adverse effects , Cyclooctanes*/pharmacology , Cyclooctanes*/therapeutic use, Animals ; Mice ; Mice, Inbred C57BL ; Osteogenesis/drug effects ; Disease Models, Animal ; Male ; Bone Density/drug effects

Coenzyme A Tethering Mediates Dehydratase Substrate Promiscuity and Reaction Specificity in Platensimycin, Platencin, and Platensilin Biosynthesis.

Autoři: Fluegel LL Steele AD Kalkreuter E a další

Zdroj: Biochemistry [Biochemistry] 2025 Aug 05; Vol. 64 (15), pp. 3418-3431. Date of Electronic Publication: 2025 Jul 16.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Výrazy ze slovníku MeSH: Aminobenzoates*/metabolism , Aminobenzoates*/chemistry , Anilides*/metabolism , Anilides*/chemistry , Aminophenols*/metabolism , Aminophenols*/chemistry , Adamantane*/metabolism , Adamantane*/chemistry , Adamantane*/analogs & derivatives , Hydro-Lyases*/metabolism , Hydro-Lyases*/genetics , Hydro-Lyases*/chemistry , Polycyclic Compounds*/metabolism , Polycyclic Compounds*/chemistry , Coenzyme A*/metabolism , Coenzyme A*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry, Substrate Specificity ; Molecular Docking Simulation ; Kinetics ; Streptomyces/enzymology ; Streptomyces/metabolism ; Streptomyces/genetics

Pharmacokinetic/pharmacodynamic relationship of a novel pleuromutilin derivative p-furoylamphenmulin against Mycoplasma gallisepticum in vivo in chickens.

Autoři: Xia X Zhao H Li Y a další

Zdroj: Poultry science [Poult Sci] 2025 Aug; Vol. 104 (8), pp. 105249. Date of Electronic Publication: 2025 May 04.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Chickens* , Mycoplasma gallisepticum*/drug effects , Mycoplasma Infections*/veterinary , Mycoplasma Infections*/drug therapy , Mycoplasma Infections*/microbiology , Poultry Diseases*/microbiology , Poultry Diseases*/drug therapy , Anti-Bacterial Agents*/pharmacokinetics , Anti-Bacterial Agents*/pharmacology , Diterpenes*/pharmacokinetics , Diterpenes*/pharmacology , Diterpenes*/chemistry , Polycyclic Compounds*/pharmacokinetics , Polycyclic Compounds*/pharmacology, Animals ; Pleuromutilins ; Microbial Sensitivity Tests/veterinary ; Male ; Half-Life

Schisandrin A ‌ameliorates the diabetes-associated memory impairment by alleviating inflammation and ferroptosis.

Autoři: Ma G Lei M Guo S a další

Zdroj: Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2025 Jul 01; Vol. 57 (10), pp. 1647-1659.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: China Science Publishing & Media Ltd Country of Publication: China NLM ID: 101206716 Publication Model: Print Cited Medium: Internet ISSN: 1745-7270 (Electronic) Linking ISSN: 16729145 NLM ISO Abbreviation: Acta Biochim Biophys Sin (Shanghai) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Lignans*/pharmacology , Lignans*/therapeutic use , Polycyclic Compounds*/pharmacology , Polycyclic Compounds*/therapeutic use , Memory Disorders*/drug therapy , Memory Disorders*/etiology , Memory Disorders*/metabolism , Ferroptosis*/drug effects , Inflammation*/drug therapy , Inflammation*/metabolism , Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism, Animals ; Cyclooctanes/pharmacology ; Cyclooctanes/therapeutic use ; Male ; Rats ; Rats, Sprague-Dawley ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Prefrontal Cortex/pathology ; NF-E2-Related Factor 2/metabolism ; Sirtuin 1/metabolism ; Insulin Resistance