Search Results - "Polychlorinated Dibenzodioxins"

Loss of Dioxin Response Element-Mediated Induction of PKM2 Reprograms Hepatic Metabolism in Response to TCDD.

Authors: Orlowska K Nault R Zacharewski T

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 08; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 08.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Polychlorinated Dibenzodioxins*/toxicity , Polychlorinated Dibenzodioxins*/pharmacology , Pyruvate Kinase*/genetics , Pyruvate Kinase*/metabolism , Liver*/metabolism , Liver*/drug effects , Response Elements*/genetics, Animals ; Mice ; Hepatocytes/metabolism ; Hepatocytes/drug effects ; Receptors, Aryl Hydrocarbon/metabolism ; Receptors, Aryl Hydrocarbon/genetics ; Male ; Gene Expression Regulation/drug effects ; Mice, Inbred C57BL ; Thyroid Hormones/genetics ; Thyroid Hormones/metabolism

Long-term TCDD oral exposure changes gut microbial glycosylation patterns in female but not male C57BL/6 mice.

Authors: Reichert D Janssen S Rossi A et al.

Source: Archives of toxicology [Arch Toxicol] 2025 Nov; Vol. 99 (11), pp. 4467-4480. Date of Electronic Publication: 2025 Aug 06.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

MeSH Terms: Polychlorinated Dibenzodioxins*/toxicity , Polychlorinated Dibenzodioxins*/administration & dosage , Gastrointestinal Microbiome*/drug effects, Animals ; Female ; Male ; Mice, Inbred C57BL ; Glycosylation/drug effects ; Sex Factors ; Mice ; Feces/microbiology ; Liver/drug effects ; Dysbiosis/chemically induced ; Dysbiosis/microbiology ; Administration, Oral

Enhancement of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by lipopolysaccharide in developing zebrafish lacking canonical pattern recognition pathways.

Authors: Kitamura H Tanaka K Wang H et al.

Source: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2025 Nov; Vol. 297, pp. 110261. Date of Electronic Publication: 2025 Jul 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 100959500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-0456 (Print) Linking ISSN: 15320456 NLM ISO Abbreviation: Comp Biochem Physiol C Toxicol Pharmacol Subsets: MEDLINE

MeSH Terms: Lipopolysaccharides*/immunology , Lipopolysaccharides*/toxicity , Polychlorinated Dibenzodioxins*/immunology , Polychlorinated Dibenzodioxins*/toxicity , Edema*/chemically induced , Edema*/immunology, Pathogen-Associated Molecular Pattern Molecules/immunology ; Zebrafish

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Suppresses Mesenchymal Cell Proliferation and Migration Through miR-214-3p in Cleft Palate.

Authors: Dong X Chen Q Du H et al.

Source: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association [Cleft Palate Craniofac J] 2025 Nov; Vol. 62 (11), pp. 1930-1938. Date of Electronic Publication: 2024 Sep 24.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications in Association with American Cleft Palate-Craniofacial Association Country of Publication: United States NLM ID: 9102566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-1569 (Electronic) Linking ISSN: 10556656 NLM ISO Abbreviation: Cleft Palate Craniofac J Subsets: MEDLINE

MeSH Terms: MicroRNAs*/metabolism , MicroRNAs*/genetics , MicroRNAs*/drug effects , Cleft Palate*/chemically induced , Cleft Palate*/genetics , Cleft Palate*/pathology , Cleft Palate*/embryology , Cell Proliferation*/drug effects , Cell Movement*/drug effects , Polychlorinated Dibenzodioxins*/toxicity , Polychlorinated Dibenzodioxins*/pharmacology , Mesenchymal Stem Cells*/drug effects, Animals ; Mice ; Disease Models, Animal ; Real-Time Polymerase Chain Reaction ; Female

Cell type- and species-specific regulation of hepatic lncRNAs by TCDD-activated aryl hydrocarbon receptor.

Authors: Post GA Cholico GN Nault R et al.

Source: Scientific reports [Sci Rep] 2025 Oct 24; Vol. 15 (1), pp. 37322. Date of Electronic Publication: 2025 Oct 24.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Polychlorinated Dibenzodioxins*/toxicity , Polychlorinated Dibenzodioxins*/pharmacology , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics , Liver*/metabolism , Liver*/drug effects , Liver*/pathology , Gene Expression Regulation*/drug effects, Animals ; Mice ; Rats ; Humans ; Species Specificity ; Male ; Hepatocytes/metabolism ; Hepatocytes/drug effects ; Mice, Inbred C57BL ; Fatty Liver/genetics ; Fatty Liver/pathology ; Fatty Liver/metabolism

Relevance of Aryl hydrocarbon receptor signalling in the inhibitory effect of environmental pollutant TCDD on promoter-specific aromatase (CYP19A1) expression in granulosa cells.

Authors: Sharma D Rani P Onteru SK et al.

Source: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2025 Dec; Vol. 138, pp. 109085. Date of Electronic Publication: 2025 Oct 25.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE

MeSH Terms: Granulosa Cells*/drug effects , Granulosa Cells*/metabolism , Aromatase*/genetics , Aromatase*/metabolism , Receptors, Aryl Hydrocarbon*/metabolism , Polychlorinated Dibenzodioxins*/toxicity , Environmental Pollutants*/toxicity , Endocrine Disruptors*/toxicity, Animals ; Female ; Promoter Regions, Genetic/drug effects ; Buffaloes ; Signal Transduction/drug effects ; Cells, Cultured ; Estradiol/metabolism ; Estrogens/metabolism

Naturally occurring highly chlorinated organic compounds in soils with elevated OCDD concentration.

Authors: Shelepchikov AA Kudryavtseva AD Nghiem TX

Source: Chemosphere [Chemosphere] 2025 Dec; Vol. 391, pp. 144723. Date of Electronic Publication: 2025 Oct 16.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE

MeSH Terms: Soil Pollutants*/analysis , Soil Pollutants*/chemistry , Soil*/chemistry , Polychlorinated Dibenzodioxins*/analysis , Hydrocarbons, Chlorinated*/analysis, Tandem Mass Spectrometry ; Environmental Monitoring ; Chromatography, High Pressure Liquid ; Vietnam

Exploring the role of hepatic lipid droplets in mouse liver toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: sequestration, biochemical alterations and gene regulation.

Authors: Hammoudeh N Soukkarieh C Hanano A

Source: Scientific reports [Sci Rep] 2025 Nov 19; Vol. 15 (1), pp. 40682. Date of Electronic Publication: 2025 Nov 19.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Liver*/drug effects , Liver*/metabolism , Liver*/pathology , Polychlorinated Dibenzodioxins*/toxicity , Lipid Droplets*/metabolism , Lipid Droplets*/drug effects , Gene Expression Regulation*/drug effects , Environmental Pollutants*/toxicity, Animals ; Male ; Female ; Mice ; Mice, Inbred BALB C

Evaluating the WHO toxic equivalency factors of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls for applicability to amphibians using an in vitro Ah receptor transactivation assay.

Authors: Collins CH Cook NE Powell WH et al.

Source: Environmental toxicology and chemistry [Environ Toxicol Chem] 2025 Nov 01; Vol. 44 (11), pp. 3297-3306.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8308958 Publication Model: Print Cited Medium: Internet ISSN: 1552-8618 (Electronic) Linking ISSN: 07307268 NLM ISO Abbreviation: Environ Toxicol Chem Subsets: MEDLINE

MeSH Terms: Receptors, Aryl Hydrocarbon*/genetics , Receptors, Aryl Hydrocarbon*/metabolism , Benzofurans*/toxicity , Polychlorinated Dibenzodioxins*/toxicity , Transcriptional Activation*/drug effects , Polychlorinated Biphenyls*/toxicity, Animals ; COS Cells ; Chlorocebus aethiops ; Xenopus laevis ; Amphibians ; Dibenzofurans/toxicity

Sublethal juvenile dioxin (TCDD) exposure alters sperm motility and whole-body vitellogenin parameters in adult male zebrafish (Danio rerio).

Authors: Meyer DN Gonzalez GF Cowart JR et al.

Source: Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2025 Oct; Vol. 287, pp. 107496. Date of Electronic Publication: 2025 Jul 16.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8500246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1514 (Electronic) Linking ISSN: 0166445X NLM ISO Abbreviation: Aquat Toxicol Subsets: MEDLINE

MeSH Terms: Sperm Motility*/drug effects , Zebrafish*/physiology , Polychlorinated Dibenzodioxins*/toxicity , Water Pollutants, Chemical*/toxicity , Vitellogenins*/metabolism, Animals ; Male ; Spermatozoa/drug effects ; Thyroid Hormones/metabolism

TCDD Induces Hepatocytes Lipid Deposition via Downregulation of MFN2.

Authors: Xing C Ai Y Wu Y et al.

Source: Journal of applied toxicology : JAT [J Appl Toxicol] 2026 Jan; Vol. 46 (1), pp. 250-258. Date of Electronic Publication: 2025 Aug 11.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1263 (Electronic) Linking ISSN: 0260437X NLM ISO Abbreviation: J Appl Toxicol Subsets: MEDLINE

MeSH Terms: Polychlorinated Dibenzodioxins*/toxicity , Hepatocytes*/drug effects , Hepatocytes*/metabolism , Lipid Metabolism*/drug effects , GTP Phosphohydrolases*/metabolism , GTP Phosphohydrolases*/genetics , Mitochondrial Proteins*/metabolism , Mitochondrial Proteins*/genetics , Environmental Pollutants*/toxicity , Fatty Liver*/chemically induced , Fatty Liver*/metabolism, Humans ; Reactive Oxygen Species/metabolism ; Animals ; Down-Regulation/drug effects ; Male ; Membrane Potential, Mitochondrial/drug effects ; Ubiquitination/drug effects ; Mice

Photodegradation of octachlorodibenzo-p-dioxin (OCDD) on suspended particles from pearl river: Kinetics and transformation mechanism.

Authors: Zhang J Xing Z Xu J et al.

Source: Journal of hazardous materials [J Hazard Mater] 2025 Sep 15; Vol. 496, pp. 139120. Date of Electronic Publication: 2025 Jul 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE

MeSH Terms: Water Pollutants, Chemical*/toxicity , Water Pollutants, Chemical*/chemistry , Water Pollutants, Chemical*/radiation effects , Photolysis* , Polychlorinated Dibenzodioxins*/toxicity , Polychlorinated Dibenzodioxins*/chemistry , Polychlorinated Dibenzodioxins*/radiation effects, Rivers/chemistry ; Kinetics ; Animals ; Reactive Oxygen Species/chemistry

Elucidating the correlation between polychlorinated dibenzo-p-dioxins and prostate cancer progression: Insights from gene expression and molecular docking.

Authors: Lin F Wei Y Chen CR et al.

Source: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Sep 15; Vol. 303, pp. 119009. Date of Electronic Publication: 2025 Sep 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH Terms: Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/chemically induced , Polychlorinated Dibenzodioxins*/toxicity, Male ; Humans ; Molecular Docking Simulation ; Animals ; Disease Progression ; Cell Line, Tumor ; Mice ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression/drug effects

The role of the ferroptosis pathway in the toxic mechanism of TCDD-induced liver damage in zebrafish.

Authors: Gao Y Chen H Lian H et al.

Source: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2025 Sep; Vol. 295, pp. 110213. Date of Electronic Publication: 2025 Apr 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 100959500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-0456 (Print) Linking ISSN: 15320456 NLM ISO Abbreviation: Comp Biochem Physiol C Toxicol Pharmacol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Zebrafish*/metabolism , Polychlorinated Dibenzodioxins*/toxicity , Liver*/drug effects , Liver*/metabolism , Liver*/pathology , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/etiology, Animals ; Oxidative Stress/drug effects ; Zebrafish Proteins/metabolism ; Zebrafish Proteins/genetics ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Cyclohexylamines/pharmacology ; Phenylenediamines/pharmacology

Hepatic AhR Activation by TCDD Induces Obesity and Steatosis via Hepatic Plasminogen Activator Inhibitor-1 (PAI-1).

Authors: Oh SJ Im S Kang S et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Aug 30; Vol. 26 (17). Date of Electronic Publication: 2025 Aug 30.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics , Polychlorinated Dibenzodioxins*/toxicity , Obesity*/metabolism , Obesity*/chemically induced , Obesity*/pathology , Liver*/metabolism , Liver*/drug effects , Liver*/pathology , Fatty Liver*/metabolism , Fatty Liver*/chemically induced , Fatty Liver*/pathology , Plasminogen Activator Inhibitor 1*/metabolism, Animals ; Mice ; Mice, Inbred C57BL ; Male ; Mice, Knockout ; Lipid Metabolism/drug effects ; Hepatocytes/metabolism ; Basic Helix-Loop-Helix Transcription Factors

Effects of exposure of dairy cows to a mixture of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), dioxin-like (dl) polychlorinated biphenyls (PCBs), and non-dl-PCBs during the period of negative and positive energy balance on health traits and on aryl hydrocarbon receptor (AHR)-signaling.

Authors: Dänicke S Krause T Lamp J et al.

Source: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2025 Aug; Vol. 202, pp. 115560. Date of Electronic Publication: 2025 May 19.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE

MeSH Terms: Dioxins*/toxicity , Energy Metabolism*/drug effects , Polychlorinated Biphenyls*/toxicity , Polychlorinated Dibenzodioxins*/toxicity , Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics, Animals ; Cattle ; Female ; Dibenzofurans, Polychlorinated/toxicity ; Liver/drug effects ; Liver/metabolism ; Signal Transduction/drug effects ; Dibenzofurans/chemistry ; Dibenzofurans/metabolism

An epithelial cell culture model for sturgeon integument responds sensitively to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.

Authors: Nechat S Shadi M Schreier AD et al.

Source: Scientific reports [Sci Rep] 2025 Jul 24; Vol. 15 (1), pp. 26875. Date of Electronic Publication: 2025 Jul 24.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Polychlorinated Dibenzodioxins*/toxicity , Epithelial Cells*/drug effects , Epithelial Cells*/metabolism , Epithelial Cells*/cytology , Fishes*/metabolism, Animals ; Receptors, Aryl Hydrocarbon/metabolism ; Receptors, Aryl Hydrocarbon/genetics ; Cells, Cultured ; Cell Proliferation/drug effects

Shift in the urinary metabolome associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin activation of the hepatic aryl hydrocarbon receptor.

Authors: Sink WJ Fling R Yilmaz A et al.

Source: Scientific reports [Sci Rep] 2025 Jul 18; Vol. 15 (1), pp. 26035. Date of Electronic Publication: 2025 Jul 18.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics , Polychlorinated Dibenzodioxins*/toxicity , Metabolome*/drug effects , Liver*/metabolism , Liver*/drug effects , Liver*/pathology, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Methylamines/urine

Multi- and Transgenerational Histological and Transcriptomic Outcomes of Developmental TCDD Exposure in Zebrafish ( Danio rerio ) Ovary.

Authors: Paquette A Cavaneau E Haimbaugh A et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Jul 16; Vol. 26 (14). Date of Electronic Publication: 2025 Jul 16.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Zebrafish*/genetics , Polychlorinated Dibenzodioxins*/toxicity , Ovary*/drug effects , Ovary*/metabolism , Ovary*/pathology , Transcriptome*/drug effects, Animals ; Female ; Male ; Gene Expression Regulation, Developmental/drug effects

2,3,7,8-tetrachlorodibenzofuran modulates intestinal microbiota and tryptophan metabolism in mice.

Authors: Shen H Wang D Huang Y et al.

Source: Life sciences [Life Sci] 2025 Jul 15; Vol. 373, pp. 123679. Date of Electronic Publication: 2025 May 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

MeSH Terms: Tryptophan*/metabolism , Gastrointestinal Microbiome*/drug effects , Polychlorinated Dibenzodioxins*/toxicity , Benzofurans*/toxicity, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Environmental Pollutants/toxicity ; Indoles/metabolism ; Indoles/pharmacology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/drug effects