Suchergebnisse - "Plasticity"

Psychedelics Reverse the Polarity of Long-Term Synaptic Plasticity in Cortical-Projecting Claustrum Neurons.

Autoren: Anderson TL Asadipooya A Ortinski PI

Quelle: ENeuro [eNeuro] 2025 Oct 29; Vol. 12 (10). Date of Electronic Publication: 2025 Oct 29 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE

MeSH-Schlagworte: Hallucinogens*/pharmacology , Neurons*/drug effects , Neurons*/physiology , Neuronal Plasticity*/drug effects , Neuronal Plasticity*/physiology , Claustrum*/drug effects , Claustrum*/physiology , Claustrum*/cytology , Cerebral Cortex*/drug effects , Cerebral Cortex*/physiology, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Action Potentials/drug effects ; Long-Term Potentiation/drug effects ; Neural Pathways/drug effects ; Neural Pathways/physiology ; Gyrus Cinguli/drug effects ; Gyrus Cinguli/physiology ; Amphetamines/pharmacology

Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior.

Autoren: Li M Zhao B Lu Z et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2513363122. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Ankyrins*/genetics , Ankyrins*/metabolism , Neuronal Plasticity*/physiology , Neuronal Plasticity*/genetics , Axon Initial Segment*/metabolism , Axon Initial Segment*/physiology , Behavior, Animal* , Cerebral Cortex*, Animals ; Mice ; Gene Knock-In Techniques ; Neurons/metabolism ; Mutation ; Male ; Action Potentials ; Axons/metabolism

D1-type dopamine receptors are critical for GABAergic synaptic plasticity in CA1 mouse hippocampal SST interneurons and pyramidal cells.

Autoren: Brzdąk P Lebida K Droździel P et al.

Quelle: Progress in neurobiology [Prog Neurobiol] 2025 Dec; Vol. 255, pp. 102845. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0370121 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5118 (Electronic) Linking ISSN: 03010082 NLM ISO Abbreviation: Prog Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Interneurons*/physiology , Interneurons*/drug effects , Interneurons*/metabolism , Receptors, Dopamine D1*/metabolism , Receptors, Dopamine D1*/physiology , Neuronal Plasticity*/physiology , Neuronal Plasticity*/drug effects , Pyramidal Cells*/physiology , Pyramidal Cells*/drug effects , Pyramidal Cells*/metabolism , CA1 Region, Hippocampal*/physiology , CA1 Region, Hippocampal*/drug effects , CA1 Region, Hippocampal*/metabolism , CA1 Region, Hippocampal*/cytology , GABAergic Neurons*/physiology , GABAergic Neurons*/drug effects, Animals ; Mice ; Mice, Inbred C57BL ; Male ; Somatostatin/metabolism ; Synapses/physiology ; Synapses/drug effects

Senkyunolide I rescues radiation-induced cognitive deficits by restoring synaptic plasticity.

Autoren: Li F Xu Y Guo S et al.

Quelle: Brain research [Brain Res] 2025 Dec 01; Vol. 1868, pp. 150007. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

MeSH-Schlagworte: Neuronal Plasticity*/drug effects , Neuronal Plasticity*/radiation effects , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/metabolism , Pyrones*/pharmacology, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/radiation effects ; Oxidative Stress/drug effects ; Maze Learning/drug effects ; Neuroprotective Agents/pharmacology

Sex-dimorphic oxytocin regulation of CA1-dependent spatial memory and synaptic plasticity in juvenile rats.

Autoren: Shehadeh E Rajan Narattil N Kritman M et al.

Quelle: Behavioral and brain functions : BBF [Behav Brain Funct] 2025 Nov 25; Vol. 21 (1), pp. 41. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101245751 Publication Model: Electronic Cited Medium: Internet ISSN: 1744-9081 (Electronic) Linking ISSN: 17449081 NLM ISO Abbreviation: Behav Brain Funct Subsets: MEDLINE

MeSH-Schlagworte: Oxytocin*/metabolism , Oxytocin*/physiology , Oxytocin*/pharmacology , Neuronal Plasticity*/physiology , Neuronal Plasticity*/drug effects , CA1 Region, Hippocampal*/physiology , CA1 Region, Hippocampal*/metabolism , CA1 Region, Hippocampal*/drug effects , Spatial Memory*/physiology , Spatial Memory*/drug effects, Animals ; Male ; Female ; Rats ; Receptors, Oxytocin/antagonists & inhibitors ; Receptors, Oxytocin/metabolism ; Sex Characteristics ; Long-Term Potentiation/drug effects ; Long-Term Potentiation/physiology ; Recognition, Psychology/physiology ; Recognition, Psychology/drug effects

Interactions between long- and short-term synaptic plasticity transform temporal neural representations into spatial.

Autoren: Yu Q Tsodyks M Sompolinsky H et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 25; Vol. 122 (47), pp. e2426290122. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Neuronal Plasticity*/physiology , Models, Neurological* , Neurons*/physiology , Synapses*/physiology, Animals ; Humans ; Mice ; Action Potentials/physiology ; Learning/physiology ; Neocortex/physiology ; Nerve Net/physiology

Modulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen's Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats.

Autoren: Wu L Yang C Ding Y et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Nov 20; Vol. 63 (1), pp. 100. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Hydrogen*/pharmacology , Hydrogen*/administration & dosage , Hydrogen*/therapeutic use , Neuronal Plasticity*/drug effects , Neuronal Plasticity*/physiology , Inflammasomes*/metabolism , Stress Disorders, Post-Traumatic*/drug therapy , Stress Disorders, Post-Traumatic*/metabolism , Anxiety*/drug therapy , Anxiety*/metabolism , Nanoparticles*/chemistry , Behavior, Animal*/drug effects, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Prefrontal Cortex/metabolism ; Prefrontal Cortex/drug effects ; Brain-Derived Neurotrophic Factor/metabolism

Stable Traits, Adaptive Brains: links between Visual Homeostatic Plasticity and Personality.

Autoren: Baroni M Cesari V Gemignani A et al.

Quelle: Neuroscience letters [Neurosci Lett] 2025 Nov 20; Vol. 868, pp. 138414. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE

MeSH-Schlagworte: Personality*/physiology , Neuronal Plasticity*/physiology , Homeostasis*/physiology , Brain*/physiology , Visual Perception*/physiology, Humans ; Male ; Female ; Adult ; Young Adult ; Sensory Deprivation/physiology ; Neuroticism

Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.

Autoren: Sakata JT Alonge KM Diethorn EJ et al.

Quelle: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Nov 12; Vol. 45 (46). Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Matrix*/physiology , Cognition*/physiology , Neuronal Plasticity*/physiology , Nerve Net*/physiology , Brain*/growth & development , Brain*/physiology , Neurons*/physiology, Humans ; Animals

HDAC3 Epigenetic Suppression by Electroacupuncture Restores AMPA Receptor Function and Synaptic Plasticity in Alzheimer's Disease Models.

Autoren: Li H Deng B Lin M et al.

Quelle: Neuromolecular medicine [Neuromolecular Med] 2025 Nov 04; Vol. 27 (1), pp. 72. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 101135365 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1174 (Electronic) Linking ISSN: 15351084 NLM ISO Abbreviation: Neuromolecular Med Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylases*/physiology , Histone Deacetylases*/genetics , Histone Deacetylases*/biosynthesis , Alzheimer Disease*/therapy , Alzheimer Disease*/genetics , Alzheimer Disease*/physiopathology , Receptors, AMPA*/physiology , Receptors, AMPA*/genetics , Receptors, AMPA*/biosynthesis , Epigenesis, Genetic* , Neuronal Plasticity*/physiology , Neuronal Plasticity*/genetics , Electroacupuncture*, Animals ; Mice ; Mice, Transgenic ; Long-Term Potentiation ; Disease Models, Animal ; Hippocampus/metabolism ; Amyloid beta-Protein Precursor/genetics ; Male ; Histones/metabolism ; Acetylation ; Mice, Inbred C57BL ; Humans

The neuroprotective effects of N-acetylcysteine in psychiatric and neurodegenerative disorders: From modulation of glutamatergic transmission to restoration of synaptic plasticity.

Autoren: Chakraborty S Shankaranarayana Rao BS Tripathi SJ

Quelle: Neuropharmacology [Neuropharmacology] 2025 Nov 01; Vol. 278, pp. 110527. Date of Electronic Publication: 2025 May 23.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Acetylcysteine*/pharmacology , Acetylcysteine*/therapeutic use , Neuronal Plasticity*/drug effects , Neuronal Plasticity*/physiology , Neurodegenerative Diseases*/drug therapy , Neurodegenerative Diseases*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Mental Disorders*/drug therapy , Mental Disorders*/metabolism , Synaptic Transmission*/drug effects, Humans ; Animals ; Glutamic Acid/metabolism

β-Adrenergic Receptor Activation Modulates the Induction of Complex Spike-Dependent LTP by Regulating Multiple Forms of Heterosynaptic Plasticity.

Autoren: O'Dell TJ; Department of Physiology, David Geffen School of Medicine, and Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, California, USA.

Quelle: Hippocampus [Hippocampus] 2025 Nov; Vol. 35 (6), pp. e70043.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9108167 Publication Model: Print Cited Medium: Internet ISSN: 1098-1063 (Electronic) Linking ISSN: 10509631 NLM ISO Abbreviation: Hippocampus Subsets: MEDLINE

MeSH-Schlagworte: Long-Term Potentiation*/physiology , Long-Term Potentiation*/drug effects , Receptors, Adrenergic, beta*/metabolism , CA1 Region, Hippocampal*/physiology , CA1 Region, Hippocampal*/drug effects , Neuronal Plasticity*/physiology , Neuronal Plasticity*/drug effects , Synapses*/physiology , Synapses*/drug effects , Action Potentials*/physiology , Action Potentials*/drug effects, Animals ; Male ; Mice, Inbred C57BL ; Mice ; Adrenergic beta-Agonists/pharmacology ; Excitatory Postsynaptic Potentials/drug effects ; Excitatory Postsynaptic Potentials/physiology ; Electric Stimulation ; Hippocampus/physiology ; Hippocampus/drug effects

Cognitive function and synaptic plasticity in the hippocampus exposed to stress respond similarly to different probiotic mixtures.

Autoren: Taleblou Z Talaei SA Salami M

Quelle: Brain research [Brain Res] 2025 Nov 01; Vol. 1866, pp. 149916. Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

MeSH-Schlagworte: Probiotics*/pharmacology , Hippocampus*/drug effects , Hippocampus*/metabolism , Neuronal Plasticity*/drug effects , Neuronal Plasticity*/physiology , Stress, Psychological*/physiopathology , Cognition*/drug effects , Cognition*/physiology, Animals ; Rats ; Male ; Rats, Wistar ; Antioxidants/metabolism

Urolithin A improves Parkinson's disease-associated cognitive impairment through modulation of neuroinflammation and neuroplasticity.

Autoren: Xu N Du C Yu Y et al.

Quelle: Experimental neurology [Exp Neurol] 2025 Nov; Vol. 393, pp. 115395. Date of Electronic Publication: 2025 Jul 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

MeSH-Schlagworte: Neuronal Plasticity*/drug effects , Neuronal Plasticity*/physiology , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/etiology , Neuroinflammatory Diseases*/drug therapy , Neuroinflammatory Diseases*/etiology , Coumarins*/pharmacology , Coumarins*/therapeutic use, Animals ; Mice ; Mice, Transgenic ; Mice, Inbred C57BL ; Male ; Hippocampus/drug effects ; Hippocampus/pathology ; Parkinson Disease/complications ; Maze Learning/drug effects

Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin.

Autoren: Mongrédien R Anesio A Fernandes GJD et al.

Quelle: Biological psychiatry [Biol Psychiatry] 2025 Oct 15; Vol. 98 (8), pp. 612-623. Date of Electronic Publication: 2025 Mar 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE

MeSH-Schlagworte: Astrocytes*/drug effects , Astrocytes*/metabolism , Astrocytes*/physiology , Cocaine*/pharmacology , Neuronal Plasticity*/drug effects , Neuronal Plasticity*/physiology , Reward* , Extracellular Matrix Proteins*/metabolism , Extracellular Matrix Proteins*/genetics, Animals ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Mice ; Male ; Calcium Signaling/drug effects ; Mice, Inbred C57BL ; Mice, Knockout ; Dopamine Uptake Inhibitors/pharmacology

Monocular delay during visually guided actions is as effective as monocular deprivation in driving ocular dominance plasticity.

Autoren: Steinwurzel C Pennella G Morrone MC et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 06; Vol. 15 (1), pp. 34743. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Dominance, Ocular*/physiology , Vision, Monocular*/physiology , Sensory Deprivation*/physiology , Neuronal Plasticity*/physiology, Humans ; Male ; Adult ; Female ; Young Adult ; Psychomotor Performance/physiology ; Photic Stimulation ; Visual Perception/physiology

Impact of mild prenatal LPS-induced inflammation and postnatal stress on synaptic plasticity and neuroimmune responses in the prefrontal cortex of adult male mice.

Autoren: Namvarpour Z Azhdari S Lotfi R et al.

Quelle: Tissue & cell [Tissue Cell] 2025 Oct; Vol. 96, pp. 103007. Date of Electronic Publication: 2025 Jun 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE

MeSH-Schlagworte: Neuronal Plasticity*/drug effects , Neuronal Plasticity*/immunology , Prefrontal Cortex*/immunology , Prefrontal Cortex*/pathology , Prefrontal Cortex*/physiopathology , Lipopolysaccharides*/toxicity , Inflammation*/pathology , Inflammation*/chemically induced , Inflammation*/immunology , Prenatal Exposure Delayed Effects*/pathology , Prenatal Exposure Delayed Effects*/immunology , Stress, Psychological*, Animals ; Male ; Pregnancy ; Female ; Mice

Induction of plasticity and metaplasticity using noninvasive brain stimulation.

Autoren: Bhattacharya A Darmani G Udupa K et al.

Quelle: Trends in neurosciences [Trends Neurosci] 2025 Oct; Vol. 48 (10), pp. 792-807. Date of Electronic Publication: 2025 Aug 13.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishing Country of Publication: England NLM ID: 7808616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-108X (Electronic) Linking ISSN: 01662236 NLM ISO Abbreviation: Trends Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Neuronal Plasticity*/physiology , Brain*/physiology , Transcranial Direct Current Stimulation*/methods , Transcranial Magnetic Stimulation*/methods, Humans ; Animals ; Long-Term Synaptic Depression/physiology ; Long-Term Potentiation/physiology

Tuina Alleviates Anxiety-Like Behaviors Associated With Neuropathic Pain Through the Modulation of Synaptic Plasticity in the Anterior Cingulate Cortex.

Autoren: Na R Xu Y Yu T et al.

Quelle: Brain and behavior [Brain Behav] 2025 Oct; Vol. 15 (10), pp. e70965.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE

MeSH-Schlagworte: Gyrus Cinguli*/metabolism , Gyrus Cinguli*/drug effects , Gyrus Cinguli*/physiopathology , Neuralgia*/physiopathology , Neuralgia*/complications , Neuralgia*/therapy , Neuralgia*/drug therapy , Anxiety*/physiopathology , Anxiety*/drug therapy , Anxiety*/therapy , Neuronal Plasticity*/drug effects , Neuronal Plasticity*/physiology , Medicine, Chinese Traditional*/methods, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Disease Models, Animal ; Behavior, Animal/drug effects ; Receptors, AMPA/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism

Senolytic-sensitive p16 ^Ink4a + fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity.

Autoren: Lee JY Reyes N Woo SH et al.

Quelle: Cell stem cell [Cell Stem Cell] 2025 Dec 04; Vol. 32 (12), pp. 1869-1885.e8. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

MeSH-Schlagworte: Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Cyclin-Dependent Kinase Inhibitor p16*/metabolism , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Cancer-Associated Fibroblasts*/drug effects , Cell Plasticity* , Fibroblasts*/metabolism , Fibroblasts*/pathology, Animals ; Humans ; Mice ; Cellular Senescence ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/metabolism ; Tumor Microenvironment ; Stromal Cells/metabolism ; Stromal Cells/pathology ; Cell Line, Tumor